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Nusantara Medical Science Journal
Published by Universitas Hasanuddin
ISSN : 24609757     EISSN : 25977288     DOI : -
Core Subject : Science,
Materials Science & Nanotechnology Neuroscience
Nusantara Medical Science Journal (NMSJ) is an open access, peer-reviewed journal published by Faculty of Medicine, Hasanuddin University twice a year in June and December. NMSJ encompasses all basic and molecular aspects of medical sciences, with an emphasis on the molecular studies of biomedical problems and molecular mechanisms. Subjects suitable for publication include, but are not limited to the following fields of Cardiovascular; Allergy and immunology; Cancer and stem cells; Endocrinology; Gastroenterology; Tropical and Infectious Disease; and Internal medicine.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Volume 1 No. 3 Juli - September 2016" : 5 Documents clear
THE COMPARISON OF THERAPEUTIC EFFECTS AND THE SIDE EFFECTS IN THE USE OF VARIOUS DOSAGES OF GABAPENTIN ON PATIENTS WITH NEUROPHATIC PAIN Yusnita Usman
Nusantara Medical Science Journal Volume 1 No. 3 Juli - September 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v1i3.2228

Abstract

ABSTRACTIntroduction:  The use of gabapentin  for the treatment of neuropathic  is found to provide a good effect of the therapeutic  while the side effects still can be tolerated.  This study aims to describe the difference in pain score reduction and incidence of drug side effects in patients who suffering from neuropathic  pain receiving Gabapentin  therapy of 300 mg in once a day, compared  with the use of Gabapentin  of 300 mg in twice a day. The re- search  was conducted  at Neurology  Department  of Hasanuddin  University  Hospital  in Makassar  from 19th   of April to 8th  of June 2016. Methods:  It was a prospective  cohort study using 50 samples selected with the consecutive  sampling technique. The samples were divided into two groups. The first group (n=25) received  Gabapentin  of 300 mg in once a day; while the second group (n=25) received Gabapentin of 300 mg in twice a day. Each group was examined  in terms of the pain score reduction  using the Visual Analog Scale (VAS) and the incidence of side effects using a questionnaire after the first and the second  week of the medical  treatment.  Results:  The results  revealed  that the use of Gabapentin  of 300 mg in once a day and Gabapentin  of 300 mg in twice a day for two weeks in reducing pain scores (examined based on VAS) resulted in the value of 4.12 and4.92 with P=0,000 (P<0,05). This showed a significant difference between the two groups. Conclusion: The use of Gabapentin of 300 mg in twice a day for two weeks, as a therapy of neuropathic  pain  at Neurology  Departement of Hasanuddin  University  Hospital  in Makassar,  resulted in a better decrease in pain scores. Meanwhile,  side effects with the highest  percentage  found  in the group using Gabapentin  of 300 mg in once a day, in comparison with the group using Gabapentin 300 mg in twice a day were drowsiness and dizziness. Keywords: Neuropathic  pain, Gabapentin,  Dosage Variation, Pain scores
THE ROLE OF DIABETES MELLITUS, DYSLIPIDEMIA, AND SMOKING AS RISK FACTORS IN ACUTE ISCHEMIC STROKE INCIDENCE AMONG HYPERTENSIVE SUBJECT Nurlia Nurlia
Nusantara Medical Science Journal Volume 1 No. 3 Juli - September 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v1i3.2229

Abstract

ABSTRACTIntroduction: Stroke is a leading cause of disability in the elderly, and the second leading cause of the death worldwide. This study aims to analyze the role of risk factors for diabe- tes mellitus (DM), dyslipidemia, and smoking in hypertensive patients who suffer an acute ischemic  stroke.  Methods:  This study used a case-control  design  in hypertensive pa- tients who suffered  an acute ischemic  stroke as the case group,  and hypertensive pa- tients without ischemic stroke as a control group. The samples were selected  using the consecutive  technique based on some inclusion criteria. Data were analyzed statistically with the Chi-Square  test. The test results were considered  significant if p <0.05. Further- more,  logistic regression  analysis was performed  to find out the strength of the relation- ship with the odds ratio (OR). Layer analysis  also conducted  to validate the strength of dyslipidemia  and smoking.  Results:   Among these three risk factors,  diabetes  had the most significant  role (p <0.001) and it had 7-15 times stronger   (Exp (B) 7.023; 95% CI3.205-15.394) to cause  acute  ischemic  stroke  in hypertensive subjects,  compared  to dyslipidemia  and smoking.  Conclusion:  The results  of the research  indicated  that all three of these risk factors  play a role in causing  acute ischemic  stroke in hypertensive subjects compared to the control. Keywords: diabetes mellitus,dislipidemia, smoking,  acute ischemic stroke, hypertensive subjects
CONTRIBUTION OF INFLAMMATION PROCESS (hsCRP LEVELS) IN MIGRAINE DURING ICTAL PHASE Audry Devisanty Wuysang
Nusantara Medical Science Journal Volume 1 No. 3 Juli - September 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v1i3.2225

Abstract

ABSTRACTIntroduction: C-reactive protein (CRP), an acute phase protein and a marker of inflammation,has been associated with the risk of cardiovascular disease. CRP has also been suggested tobe abnormal among migraineurs, possibly due to repeated vascular inflammation. Methods:This case-control study was conducted in Wahidin Sudirohusodo General Hospital, Makassar,Indonesia, from June 2013 to January 2014. The aim of this study is to investigate the role ofinflammation in the pathophysiology of an ictal and interictal period of migraine.  A t otal  of  82patients participated in this study [16 males (19.5%) and 66 females (80.5%)]. The age of ictalperiod patients range between 19-57 years old (median 28, mean 29.54 ± 8.92) and interictalperiod patients range between 20-48 years (median 26, 28,90 ± 7,91). Results: This studyshowed mean hs-CRP level was significantly higher in the ictal period compared to interictalperiod of migraine (6.64 vs 1.87 mg/L). hs-CRP >3mg/L (high risk of cardiovascular event) wasmore common in ictal (78.3%) compared to interictal patients (21,7%), while hs-CRP <1mg/L(low risk of cardiovascular event) was more common in interictal (64.9%) compared to ictalperiod patients (35.1%) (OR=6.646). The contribution of hs-CRP to the ictal period of a migrainewas 17.2%. Conclusion: This study reinforces the view that inflammation processplays some roles in the pathophysiology of a migraine, especially in the ictal period.Keywords: hs-CRP, migraine, ictal.
THE EFFECT OF PHYSICAL ACTIVITY AND ANXIETY LEVEL OF TRIMESTER III MOTHERS ON INFANT’S BIRTH BODY WEIGHT Emi Barus
Nusantara Medical Science Journal Volume 1 No. 3 Juli - September 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v1i3.2226

Abstract

ABSTRACTIntroduction: One  of the causes of infant  death  in Indonesia is complications from baby’s birth weight, this complication can be prevented and managed to reduce infant mortality rate. The aims of the research were to determine the types of physical activi- ties,  anxiety levels,  and  cortisol level  of trimester III pregnant women, the effect  of physical activity on infants’ birth body weight, the effect of anxiety and cortisol levels on infants’ birth  body  weight, and the effect  of anxiety on cortisol level.  Methods: The research was a longitudinal study conducted in Rumah Sakit Kesehatan Daerah Ibu dan Anak  (RSKDIA) Siti Fatimah, Makassar. The  subjects were  trimester pregnant women selected using purposive sampling technique consisting of 55 people. The data were analyzed using chi-square test. Results: The results of the research indicate that the respondents who did light-mild physical activities were 35 people (63.6%) generally gave birth to normal birth body weight, while ones who did strenuous activity were 20 people  (36.4%) gave birth to low birth weight  (LBW)  infants. Respondents with light- mild anxiety consisting of 35 people  (63.6%) generally gave  birth to normal infants, while the ones with severe  anxiety consisting of 20 people  (36.4%) gave birth to LBW infants. Meanwhile, respondents with normal cortisol level gave  birth to normal birth body weight infants, i.e. 35 people  (63.6%), while the ones with high cortisol level con- sisting  of 20 people  (36.4%) gave  birth  to LBW  infants. Conclusion: Based  on the results, there was an effect of physical activities, anxiety levels,  and cortisol level on infants’ birth body weight. Keywords: physical activity, anxiety levels, cortisol, infants’ birth body weight
EXPRESSION OF ESTROGEN RECEPTOR (ER), PROGESTERONE RECEPTOR (PR), AND HUMAN EPI- DERMAL GROWTH FACTOR RECEPTOR-2 (HER-2) IN GROWTH AND METASTASES OF BREAST CANCER Husni Cangara
Nusantara Medical Science Journal Volume 1 No. 3 Juli - September 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v1i3.2227

Abstract

ABSTRACTIntroduction: Breast cancer is a multifactorial disease as a result of interaction between ge- netic and environmental factors such as hormonal, infection, chemical material, and radiation. Until now, it took as the most occurred of cancer in women, which have the highest mortality in the world. However, its cause still unknown. According to epidemiologic and clinical - laboratory studies, it was found that there are many risk factors which have important roles in female breast cancer like menarche, menopause, endogenous and exogenous hormones, family his- tory (genetics), parity, lactation, obesity, physical activity, diet, alcohol, smoking, environmental factors and history of biopsy and breast examination. The aims of this study to evaluate and compare the clinicopathological features in the four breast cancer subtypes defined by immu- nohistochemistry expression of ER, PR, and HER-2: ER/PR+, HER-2+ (Luminal B); ER/ PR+,HER-2- (Luminal A); ER/PR-, HER-2+ (HER-2 type) and ER-/PR-, HER-2- (Triple nega- tive) type. Methods: This study was a retrospective study of 89 invasive breast cancer. Clini- cal and pathologic features of the four subtypes were compared. Results: ER/PR+, HER2+; ER/PR+, HER2-; ER/PR-, HER2+; and ER/PR-,HER2- types were 10 (11.2%), 35 (39.3%), 27 (30.3%), and 17 (19.1%) samples. Subjects with ER/PR-, HER2- where are likely to be younger (p<0.001). In tumor subtypes with HER2+, the number of subjects with poorly differentiated was larger than the total number of well and moderate differentiated (p < 0.001). There was no significant difference of metastatic to lymph node status in all subtypes. Conclusion: Subtype luminal A of breast cancer have a high number than other subtypes. There was a correlation between overexpression of HER-2 with poorly differentiated of breast cancer but not with a metastatic capability of tumor cells to lymph nodes. Keywords : Luminal A, Luminal B, Her-2 type, Triple negative, breast cancer

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