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Aryadi Arsyad
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INDONESIA
Nusantara Medical Science Journal
Published by Universitas Hasanuddin
ISSN : 24609757     EISSN : 25977288     DOI : -
Core Subject : Science,
Nusantara Medical Science Journal (NMSJ) is an open access, peer-reviewed journal published by Faculty of Medicine, Hasanuddin University twice a year in June and December. NMSJ encompasses all basic and molecular aspects of medical sciences, with an emphasis on the molecular studies of biomedical problems and molecular mechanisms. Subjects suitable for publication include, but are not limited to the following fields of Cardiovascular; Allergy and immunology; Cancer and stem cells; Endocrinology; Gastroenterology; Tropical and Infectious Disease; and Internal medicine.
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Articles 75 Documents
BREAST CANCER CHEMOTHERAPY RESPONSE IN WAHIDIN SUDIROHUSODO HOSPITAL, MAKASSAR Prihantono Prihantono; Haryasena Haryasena; Daniel Sampepajung
Nusantara Medical Science Journal Volume I No. 1 Januari-Maret 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v0i1.2202

Abstract

ABSTRACTIntroduction: Treatments of breast cancer are multidisciplinary. Chemotherapy isone of the most important modalities and has become the standard of breast cancertreatment of in the adjuvant or neoadjuvant setting. Evaluation is needed in order tounderstand the effectivity of the chemotherapy regiment, to improve the servicesystem and to share with other centers. Objectives: to understand thecharacteristics of chemotherapy patients, types of regimen, settings chemotherapyand neoadjuvant chemotherapy response of breast cancer. Methods: Aretrospective study was done by reviewing the administrative data of cancer patientswho were treated in the surgical oncology Wahidin Sudirohusodo Hospital, Makassarin 2014. Results: During 2014 has been carried out chemotherapy for 247 breastcancer patients, used as neoadjuvan setting 145 cases (59 %) and Adjuvan 102cases (41%). The regimen used are CAF 155 cases ( 63%), TAC 55 cases ( 22%), TA 20 cases (8%), GC 11 cases ( 5%), dan Vinoralbine 6 cases (2%).Cumulative Clinical Response are: complete response 3 cases (2%), partialresponse 112 cases (78%), stable disease 23 cases (15%), and progresive disease9 (5%). Chemoterapy response by subtype: Luminal 67%, Her2 70%, Triple Negatif88%. Conclusions: Breast cancer clinical response to various chemotherapyregimens are good, regimen and subtype affect the response to chemotherapy.Keywords: breast cancer, chemotherapy, clinical response
DETECTION OF NONTUBERCULOUS MYCOBACTERIA (NTM) IN ISOLATES FROM SUSPECTED TUBERCULOSIS USING PCR IS6110 GENE Andi Nur Asrinawaty; Muh Nasrum Massi; Rizalinda Sjahril
Nusantara Medical Science Journal Volume I No. 1 Januari-Maret 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v0i1.2203

Abstract

ABSTRACT  Introduction: NTM is a group of mycobacterium other than M.tuberculosis complex and M.Leprae, which found in the environment and can be pathogenic. Objectives: This study aim was to detect NTM isolates using PCR on target genes IS 6110. Methods: This study was conducted in Laboratory of Microbiology, Faculty of Medicine, Hasanuddin University and Laboratorium microbiology in Hasanuddin University Hospital. 14 sample isolates of NTM from sputum of suspected tuberculosis patients. The method using PCR IS6110 gene. Results: The results showed that of 14 samples, 8 positive samples with M. tuberculosis and 6 samples negative. Conclusions: IS6110 PCR can be used to detect NTM isolates from sputum of suspected tuberculosis patients. Keywords : NTM, PCR, IS6110, M.tuberculosis
SPIRITUAL PSYCHOTHERAPY EFFECT TO INCREASE CD4+ COUNT IN HIV /AIDS PATIENTS M Faisal Idrus; Jayalangkara Jayalangkara; Syamsu Syamsu; Ilham Ilham
Nusantara Medical Science Journal Volume I No. 1 Januari-Maret 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v0i1.2205

Abstract

ABSTRACT  Introduction: HIV / AIDS is a viral infection that causes decrease of immunity system characterized by decrease CD4+ T lymphocyte counts. Low CD4 T-cell counts are considered due to destruction of lymphocytes T by human immunodeficiency virus. The spiritual psychotherapy is a form of psychiatric treatment that provides peace, and happiness of the soul. Peace of mind is expected to generate individual immune response. Objectives: Objective  to determine the effect of spiritual psychotherapy to CD4 T-cell count. Methods: This is a quasi experimental study pretest-posttest control group design of 40 sample with HIV / AIDS who were selected by purposive sampling. This research was conducted in the HIV / AIDS Working Group and hospital inpatient BLU. Dr. Wahidin Sudirohusodo. Makassar. The samples were divided into two groups, the treatment group of 10  inpatient who received intensive spiritual psychotherapy, 10 sample from Lapas Bolangi and 20 control group who did not receive supportive psychotherapy. Statistical analysis using the Wilcoxon test. Results: The results of the analysis of CD4 + serum between the treatment and control groups was significantly different (p<0.05). After treatment, the CD4 T-cell count in the inpatient group increased serum from 15 to 160, but  in the other groups (group bolangi from 446.50 to 365.50 and the control group from 424.5 to 201.0) was decreased, especially in the control group (Tables 2 and 3). Table 4 shows that of the 10  inpatient samples group, all had increased levels of CD4 + serum, whereas in the group Bolangi only 3 samples (30%) among the 10 sample of the control group , of 20 sample only 1 person (5%) had increase of CD4 + serum , and 19 sample (95%) had decrease.   Keywords: Spiritual Psychotherapy – relaxation - CD4 count
THE ROLE OF HYPERLACTATEMIA STATUS AS A PROGNOSTIC PARAMETER IN CRITICALLY ILL NENONATES A Dwi Bahagia; Ema Alasiry; Djauharia A.M; Hanna Kurniawati
Nusantara Medical Science Journal Volume I No. 1 Januari-Maret 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v0i1.2206

Abstract

ABSTRACT   Introduction:  Hypoxia and hypoperfussion is often found in neonates in an intensive care unit, however the clinical manifestations can only be found after cellular hypoxia and tissue perfussion disorder occur. Objective:  The study aims to find the ability of hyperlactatemia  status as a prognostic parameter  for infants in Neonatal Intensive Care Unit Level IIIA. Methods : The research was a cohort prospective study using bivariat and multivariat analysis in NICU of Dr. Wahidin Sudirohusodo Hospital from June 2012 to April 2013. The analysis of the lactate level on samples that met the inclusion and exclusion criterias was done immediately after the neonates get into the NICU level IIIA. The capliary lactate level was measured using hand held analyser. The samples were distributed into groups of hyperlactatemia and without hyperlactatemia followed by outcome observation (death or good recovery). The number of subjects were 102 patients consisted of  69 males and 33  females.  Results : The study showed the incidence of hyperlactatemia at NICU leve IIIA was 53,9%. Hyperlactatemia ((p=0.000; IK95% 4.11-56.75.00; AOR 15.28) and chronological age <24 hours (p=0.014; IK95% 1.5037.04; AOR 7.47) was significant in determining the patient’s outcome. Conclusions: The study found that hyperlactatemia status and cronological age less than 24 hours were prognostic factors for patient’s outcome related to elevated mortality risk.   Keywords: Hyperlactatemia, NICU, Critically ill infants
SERUM FERRITIN AND IRON LEVELS IN ADOLESCENCE OBESITY Irfan Idris; Ilhamjaya Patellongi; Rosdiana Natsir; Agussalim Bukhari; Hastuti Hastuti; Surya Surya
Nusantara Medical Science Journal Volume I No. 1 Januari-Maret 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v0i1.2208

Abstract

ABSTRACT Introduction: It has been reported that obese children have a higher incidence of high ferritin and transferrin saturation than non obese children. The excessive iron stores can cause type 2 diabetes among patients with hemochromatosis, and this event could also occurred in obesity. Objectives: This study sought to know the level of serum ferritin and iron (ferrum) in adolescent obesity which could lead to initiate insulin resistance. Methods: Fifty five adolescence women (3 obese, 22 overweight, and 30 normal weight) involved in this study. The obesity was determined by body mass index (BMI), which are obese if BMI > 30 kg/m2; overweight if BMI 25-30 kg/m2; and normal weight if BMI < 25 kg/m2. The serum level of iron and ferritin assessed by kit analyzer with immunochemiluminescent methods, after drawing 2 ml blood from cubital vein. Conclusions: We concluded that serum ferritin and iron (ferrum) higher in obese group than overweight and normal weight group, although it was not statistically significance (Kruskall Wallis test p > 0.05). It was appeared that serum ferritin and iron tended to elevated following the raising of body mass index (BMI).  Keywords : obesity, serum ferritin, serum iron (ferrum)
EFFECT OF BRAIN GYM ON COGNITIVE FUNCTION IN ELDERLY WITH POST ISCHEMIC STROKE Jumraini Tammasse; Sri Wahyun
Nusantara Medical Science Journal Volume I No. 1 Januari-Maret 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v0i1.2209

Abstract

ABSTRACT  Introduction: This study to determine brain gym practice effect on cognitive function of elderly post ischemic stroke. Methods: This study was an experimental test conducted at Makassar, South Sulawesi from June 23rd, 2014 to December 16th, 2014. Thirty two subjects were divided into experimental and control groups in the same number. The brain gym movements will be performed in the experimental group. Control group did not perform the brain gym movements. The experimental group exercised twice a week for twelve weeks. Pre-test and post-test using The Consortium to Establish Registry of Alzheimer Diseases – Neurophysiological Battery (CERAD- NB) was performed to all subjects before and after twelve weeks intervention. The difference of CERAD-NB score between pre-test and post-test was analyzed using Mann Whitney U and Wilcoxon Sink Rank Test. Results: The study showed there was a significant improvement on cognitive function in experimental group and a significant decline of cognitive function in the control group. There was also significant difference in CERAD-NB score with Mann Whitney test (p<0,05) between the experimental group and the control group. Brain gym gives a positive effect on cognitive function in the elderly with post ischemic stroke.     Key words : Brain gym, cognitive function, elderly post ischemic strok
THE ASSOCIATION OF POLYMORPHISM PROMOTER VEGF PROMOTER GENE POLYMORPHISM AND VEGF SERUM LEVEL WITH THE TYPE OF AGE-RELATED MACULAR DEGENERATION Andi M Ichsan; Habibah S Muhiddin; Nasrum Massi; Budu Budu
Nusantara Medical Science Journal Volume 1 No. 2 April - Juni 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v1i2.2211

Abstract

ABSTRACT Introduction: One of the potential genetic links to Age-related macular degeneration (AMD) is vascular endothelial growth factor (VEGF). The aim of this study was to investigate the association of polymorphism promoter VEGF gene and VEGF serum level with the type of AMD. Methods: Genomic DNA was extracted from peripheral blood of 66 samples, consist of wet and dry AMD, and age-matched controls. DNA was subjected to polymerase chain reaction amplification at the position -460 coupled with the restriction fragment length polymorphism. VEGF serum level was measured by Enzyme-linked Immunosorbent Assay. Results: The polymorphism promoter VEGF gene demonstrated significant association with the type of AMD (p=0.004, OR=3.1 95% CI 1.1-8.6) and the risk for increasing VEGF serum level (p=0.011, OR=3.2 95% CI 1.18.9). Despite there was no significant association between dry and wet AMD with VEGF serum level (p=0.081), but this study revealed significant increased of VEGF serum level in AMD patients, compared to those in control’s serum (p<0.001). Finally, there was coassociation between polymorphism and VEGF level with the type of AMD (p<0.001). Conclusion: This study reveals the significant association between promoter VEGF gene polymorphism and VEGF serum level with the type of AMD of Indonesian patients.  Keywords: AMD, VEGF gene polymorphism; VEGF serum level.
SPECTRUM AND OUTCOME OF PEDIATRIC RENAL DISEASES IN DR. WAHIDIN SUDIROHUSODO HOSPITAL MAKASSAR Husein Albar
Nusantara Medical Science Journal Volume 1 No. 2 April - Juni 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v1i2.2212

Abstract

ABSTRACT Objectives: To find out thespectrum and outcome of renal diseases in children hospitalized in the pediatric ward of dr. Wahidin Sudirohusodo Hospital Makassar. Methods: We carried out a retrospective review of standard medial recordof all childrenhospitalizedinthe pediatric ward of the dr.Wahidin Sudirohusodo Hospital Makassar. Review was based on the final diagnosis on their medical records to investigate the spectrum and outcome of the pediatric renal diseasesfrom January 2009 to December 2013. Results: A total number of 9573 children were admitted during the study period, out of which 580 had renal diseases accounting for 16.5% of all pediatric admission. Age of the patients ranged from 10 months to 16.7 years with mean age of 7.39 years and majority of the cases aged 5-10 years (37.2%). Boys (55.3%)were more encountered than girls(44.7%) with a boy to girl ratio of 1.2:1 and most of the patients were in good nutritional status (48.6%). According to their final diagnosis, the commonness pediatric renal diseases in this hospital was Acute Post Streptococcal Glomerulonephritis (27.6%), followed by Nephrotic Syndrome (25.2%), Urinary Tract Infection (19.1%), and  Others are Acute Glomerulonephritis (8.3%), Acute Kidney Injury(5.1%), Chronic Kidney Injury(5.0%), Wilm’s Tumor(4.7%), Hydronephrosis (3.4%), Henoch-Schoenlein Nephritis (0.9%), and Lupus Nephritis (0.7%).  Length of stay of the patients was mostly in 7-14 days (46.0%) and varying from 3 up to 28 days. Mortality in pediatric patients of renal diseases in this study was 11.2% and usually in those entering the hospital with late deteriorating conditionand die before getting optimal treatment. Conclusions: In conclusion, our study shows that pediatric renal disease in the pediatric ward of dr. Wahidin Sudirohusodo Teaching Hospital Makassar accounts for 16.5%of all pediatric admission and APSGN was the commonest pediatric renal disease, followed by NS and UTI. It seems that spectrum of pediatric renal diseases in dr. Wahidin Sudirohusodo Hospital Makassar was relatively similar to that reported from other developing countries. Mortality in patients with pediatric renal diseases in our study was 11.2% and usually in those entering the hospital with late deteriorating condition and die before getting optimal treatment.  Key words: Spectrum, Outcome, Renal Disease, Children, Makassar.
ROLES OF VITAMIN C AND VITAMIN E ON DOXORUBICIN-INDUCED RENAL AND LIVER TOXICITY IN RATS Yulia Yusrini Djabir; Usmar Usmar; Elly Wahyudin; Sukamto S Mamada; Ika Reskia N Hamka; Dila Pramitha S. Putri; Irma Amalia
Nusantara Medical Science Journal Volume 1 No. 2 April - Juni 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v1i2.2213

Abstract

ABSTRACT Introduction: Doxorubicin (DOX) is a chemotherapy agent that has potent effects against various cancer types. However, DOX may elicit renal and liver toxicity. Objectives: To examine the role of vitamin C and vitamin E in reducing DOX renal and liver toxicity. Methods: Male rats (220-330 g) were assigned to one of the treatment groups. Group I was healthy controls. Group II was given DOX (20 mg/kg b.wt). Group III was given vitamin C (250 mg/kg b.wt) for 7 days prior to DOX injection. Group IV was given vitamin E (250 mg/kg b.wt) for 7 days prior to DOX injection. Group V was given oil vehicle for 7 days prior to DOX injection. Results: Vitamin C was effective to reduce both renal and liver dysfunction. However, vitamin E protective effects were only convincing in lowering DOX-induced renal toxicity but not liver toxicity. Both vitamins prevented elevated DOX-induced oxidative stress. Conclusion: Both vitamin C and vitamin E can help to reduce DOX toxicity in rat kidney, but only vitamin C that has clear benefits on improving liver toxicity after DOX injection. Keywords: Doxorubicin, renal toxicity, liver toxicity, vitamin E, vitamin C
CHARACTERISTIC OF HYDATIDIFORM MOLE PATIENTS IN PATHOLOGY ANATOMY LABORATORY HASANUDDIN UNIVERSITY Rina Masadah
Nusantara Medical Science Journal Volume 1 No. 2 April - Juni 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v1i2.2214

Abstract

ABSTRACT Background: Hydatidiform Mole (complete and partial) is one of Gestational Trophoblastic Diseases (GTD) characterized by the occurrences of trophoblastic cell proliferation and abnormal placenta flakes. It can develop into malignancy, metastasis, and cause death. Therefore, characteristic data of the patients in applying preventive program and optimal therapy are required. This research evaluates the frequency and distribution of the hydatidosa mole patients and its type in the annual period from 2012 to 2015 and several responsible risk factors, such as age and obstetric history of the patients. Methods: reviews of histopatology specimen of hydatidiform mole were conducted as many as 255 cases which met the inclusion criteria in the period of January 2012 to September 2015. The review particularly determines the histopathology diagnosis of hydatidiform mole and its type. Results: The number of hydatidiform mole patients in the period of January 2012 to September 2015 is 255 patients. Approximately 70.65% cases of those are categorized as completed hydatidiform mole. The highest frequency of mole occurs in the range of ages from 21 to 25 years old (24.19%). About 28.57% cases occur on the first pregnancy and 7 out of 255 are recurrent case of mole pregnancy. Conclusions: The occurrences of hydatidiform mole found in Pathology Anatomy Laboratory of Medical Faculty of Hasanuddin University are quite high, and the cases of completed hydatidiform mole are in the highest number. The numerous patients of hydatidiform mole are commonly found in the youngster group and low gravidity.  Keywords: gestational trophoblastic disease, hydatidiform mole