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INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 3, Issue 2, May - August, 2021" : 5 Documents clear
Effect of nicotine- and tar-removed cigarette smoke extract on cancer metastasis Yuta Takahashi; Takuya Araki; Ayumu Nagamine; Hideaki Yashima; Daisuke Nagano; Kyoko Obayashi; Koujirou Yamamoto
Indonesian Journal of Pharmaceutics Vol 3, Issue 2, May - August, 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i2.35909

Abstract

Cigarette smoking is known to impact the promotion of carcinogenesis and tumor metastasis. On the other hand, some components in smoke were found to have health-promoting effects, and cancer suppressor effects of components in tobacco smoke have attracted attention. Although some studies showed the cancer suppressive effect of cigarette smoke extract (CSE) in vitro study, the effect of CSE administration on cancer is controversial. In this study, we investigated the effect of CSE-administration on tumor metastasis in a spontaneous tumor metastasis model using B16-BL6 cells, which is more clinical conditions. C57BL/6NCr mice were subcutaneously inoculated B16-BL6 cells into the footpad of the right rear leg. CSE was intraperitoneally administrated for 28 days from the day of inoculation. At 2 weeks after inoculation, the primary focus was excised. Subsequently, survival days of the mice were recorded to determine the effect of CSE-administration on spontaneous metastasis. The effect of CSE, α, β-unsaturated ketones, and aldehydes on B16-BL6 cell invasiveness were confirmed by matrigel invasion assay. Survival days of mice injected with 100% CSE was significantly shortened than that of control. B16-BL6 cell invasiveness was accelerated by the treatment with 0.1% CSE and 3 μM of crotonaldehyde. Intraperitoneal CSE-administration may progress spontaneous metastasis of B16-BL6 cells via enhancement of B16-BL6 cell invasiveness. As the cause, we found that crotonaldehyde contained in CSE may enhance the invasion ability of cancer cells. To clarify the cancer-suppressing effect of tobacco components, the effect of crotonaldehyde-removed CSE on tumor should be assessed in detail. Keywords: cigarette smoke extract (CSE), metastasis, crotonaldehyde (CA), B16-BL6 mouse melanoma cells, invasion 
Structure-Based Virtual Screening and Molecular Dynamics of Quercetin and Its Natural Derivatives as Potent Oxidative Stress Modulators in ROS-induced Cancer Abd. Kakhar Umar; James H. Zothantluanga
Indonesian Journal of Pharmaceutics Vol 3, Issue 2, May - August, 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i2.35849

Abstract

Quercetin derivatives are known to have significant anticancer activity. The activity is strongly influenced by the type and position of the substituent group. By studying the structural pattern of quercetin and its impact on their binding affinity, the development of quercetin-based drugs can be optimized. The study aimed to determine the impact of 3D structure, type, and position of quercetin moiety on its activity against ROS-modulating enzymes that play a role in the induction and growth of ROS-induced cancer. The 23 natural quercetin derivatives were docked to 7 ROS-modulating enzymes using Autodock Vina to determine their binding affinity and interaction. The interaction stability was further studied through molecular dynamics simulation using the CABS Flex 2.0 server. Determination of crucial amino acid targets of the quercetin group was determined using DockFlin. Finally, the toxicity of each test ligand was determined using the pkCSM server. The highest binding affinity for SOD and NOX was produced by quercetin 3'-glucoside with the binding energy of -10.2 and -12.8 kcal/mol. Quercetin 3,4'-diglucoside had the highest binding affinity for CAT and GR at -11.5 and -10.5 kcal/mol, respectively. Routine produced the highest binding affinity at LOX (-10.9). Quercetin 3-O-xyloside and quercetin 3-O-rhamnoside-7-O-glucoside had the highest binding affinity in XO with a value of -10.4 kcal/mol. The glucose and prenyl groups are beneficial for quercetin in interacting with all ROS-modulating enzymes except XO. In contrast, the methoxy group negatively affects all interactions of quercetin with receptors. The perfect fit between the binding pocket and the 3D structure of the ligand greatly benefits the ligand in accessing more amino acids in the binding pocket. Their interaction stability and toxicity show that quercetin 3'-glucoside, quercetin 3,4'-diglucoside, and rutin are potent oxidative stress modulators in treating ROS-induced cancer.
Review: Saffron’s Activity as an Active Ingredient in Cosmetics Irna Roniawati; Norisca Aliza Putriana; Adinda Naswa Putri; Yuniar Alfain Nur’aini
Indonesian Journal of Pharmaceutics Vol 3, Issue 2, May - August, 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i2.34876

Abstract

Saffron (Crocus sativus) is a plant that has been widely used in Asia, especially in the health sector. This can be related to other than that saffron is also known for its use as a cosmetic because Saffron has various kinds of pharmacological activities beneficial to human skin. Today's cosmetic users prefer cosmetics with herbal or natural ingredients, especially in Indonesia. This happens because it is considered that herbal cosmetics are safer and harmless in long-term use. Therefore, it is necessary to do related act ivities of saffron as a cosmetic ingredient. This is narrative research where the data is obtained from PubMed, Science Direct, and Google Scholar with keywords Saffron, Saffron for cosmetics, and others. There were eight references, with inclusion criteria being national and international journals and national websites published in 2011-2021, especially regarding the study of saffron activity as an ingredient for cosmetics. Then the data is analyzed narratively. It was found that Saffron (Crocus sativus) contains compounds that have a cosmetic activity such as safranal which can be used as a perfume, crocin as an antioxidant and as anti-dark spot, crocin, safranal, and crocetin as anti-UV, crocin, and crocetin as an anti-inflammatory and as coloring pigment in cosmetics, vitamin C, flavonoids and zinc as a face toner, kaempferol, crocin and crocetin as anti-wrinkle, zeaxanthin, lycopene, carotene, crocetin, picrocrocin, kaempferol, and crocin as anti-aging. Saffron (Crocus sativus) has various beneficial activities for the skin, so it can be used as an ingredient in making cosmetics.Keywords : Cosmetics, Herbal, Saffron, Herbal Cosmetics, Active Ingredient
Phase Transitions Among of Valsartan Polymorphs due to Grinding and Humidity Variations Yoga Windhu Wardhana; Risanteni Riskasari; Fikri Alatas
Indonesian Journal of Pharmaceutics Vol 3, Issue 2, May - August, 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i2.35312

Abstract

Phase transition between drugs with polymorphisms needs attention due to unconscious changes in quality. Valsartan (VAL) is a drug model with polymorphic events to be studied here. Two polymorphic forms were obtained from recrystallization with various organic solvents such as acetonitrile and n-butyl acetate.  With untreated materials (from the market) were used as a comparison in this study. The phase transition of each polymorph was studied through grinding and humidity variations (RH 75% and 98%) treatment. The polymorph characterization was observed by microscope light polarization (PLM), Fourier Transform Infrared (FTIR), and Powdered X-ray Diffractometer (PXRD). The transition among polymorphic VAL was monitored by PXRD. There were significant differences in morphology, IR spectra, and diffractograms pattern. Found that the untreated VAL was amorphous, whereas the others were in high crystallinity. The polymorph form from n-butyl acetate was a metastable one that transformed easier into stable crystalline (from acetonitrile) than another polymorph.Keywords : Valsartan, Phase transition, Polymorphism, Recrystallization    
Development of a quantitative method for sunitinib N-oxide Yuya Ishikawa; Takuya Araki; Miki Takenaka Sato; Hideaki Yashima; Daisuke Nagano; Koujirou Yamamoto
Indonesian Journal of Pharmaceutics Vol 3, Issue 2, May - August, 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i2.37368

Abstract

We developed a simple method for quantifying sunitinib N-oxide (SNO) in human serum using a supported liquid extraction (SLE) method and liquid chromatography/tandem mass spectrometry (LC-MS/MS) to assess the impact of SNO on adverse drug reactions (ADRs) caused by sunitinib. SNO was extracted using an SLE method and analyzed using an Xevo-TQ (Waters) LC-MS/MS system. SNO and voriconazole (internal standard; ISTD) were detected in ESI positive mode, with transitions at 415.4/326.3 for SNO and 350.1/281.1 for voriconazole. The retention times of SNO and voriconazole were 2.25 and 2.67 min, respectively, and good calibration curve was obtained from 0.1–5.0 ng/mL for SNO. The regression equation (weight = 1/x2) describing the calibration curve in human serum was y = 2.81 × 10-9 x2 + 0.000253 x – 0.00202 (R2 = 0.990), where y is the peak area ratio of SNO against the ISTD and x is the nominal concentration of SNO. The intra- and inter-assay accuracy varied between -2.4 and 15.6% and all data except the limit of quantification (LOQ) were within ±10%. The precision varied between 6.7–15.4% and all data except LOQ were under 15%. The mean recovery ratio of SNO was 90.3 ± 4.9%, and the mean matrix factor was 0.96 ± 0.031. This is the first report of a method to quantify SNO in blood. This method will help in elucidating the effects of SNO in humans, contribute to the elucidation of the ADRs expression factors associated with sunitinib, and aid in optimizing treatment with sunitinib.

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