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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Majalah Farmaseutik Jurnal Farmasi Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Insan Farmasi Indonesia

Muhamad Ansory, Hery

Fakultas Farmasi, Universitas Setia Budi Surakarta

Author-ID : 1000302

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Engineering Immunology & microbiology Medicine & Pharmacology Physics

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Molecular Docking Study of Nutmeg (Myristica Fragrans) Constituents as Anti-Skin Cancer Agents Fitriani, Ika Nur; Ansory, Hery Muhamad
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 6, No 1 (2021): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v6i1.47223

Molecular docking analysis was carried out to understand better the interaction between DHODH and inhibitor from nutmeg in this series. The nutmeg constituent binding orientations in the active site of DHODH was seen in a molecular docking analysis and helped design a potentially new inhibitor. This work aimed to study the molecular docking of nutmeg constituents with the DHODH inhibitor using a computer-aided drug design. Molecular docking using AutoDock 4.2 was done to explore the models of binding complexes. The 3D structure was derived using Discovery Studio to investigate the essential chemical interaction of complex structures. Dihydroguaiaretic acid was the most potent ligand having a docking score of -9.3 kcal/mol. This value was better than the standard drug 5-FU. The dihydroguaiaretic acid structure interacted with Tyr365 and Thr63 through a hydrogen bond similar to the native ligand. These results suggest that nutmeg seed could serve as the lead compound for potent DHODH inhibitors against skin.

SINTESIS TURUNAN KALKON DARI MIRISTISIN MINYAK PALA Hery Muhamad Ansory; Anita Nilawati
Prosiding SNST Fakultas Teknik Vol 1, No 1 (2017): PROSIDING SEMINAR NASIONAL SAINS DAN TEKNOLOGI 8 2017
Publisher : Prosiding SNST Fakultas Teknik

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.7 KB)

Telah dilakukan sintesis 4,5-metilendioksi-3-metoksi kalkon dari miristisin hasil isolasi minyak pala. Analisis terhadap produk sintesis dilakukan dengan menggunakan spektrometer FT-IR, dan 1H NMR. Isolasi miristisin dari minyak pala dengan distilasi fraksinasi pengurangan tekanan menghasilkan miristisin (7,45%). Isomerisasi miristisin dilakukan dengan menggunakan KOH-etanol pada temperatur 84°C selama delapan jam menghasilkan isomiristisin (95,01%) terdiri dari cis-isomiristisin dan trans-isomiristisin. Oksidasi isomiristisin dilakukan dengan menggunakan KMnO4 dalam suasana asam dengan bantuan katalis misel tween 80 pada temperatur <40°C menghasilkan 4,5-metilendioksi-3-metoksi benzaldehida (49,53%). Kondensasi antara 4,5-metilendioksi-3-metoksi benzaldehida dengan asetofenon dalam kondisi basa menghasilkan 4,5-metilendioksi-3-metoksi kalkon (55,31%).Kata kunci: Miristisin, minyak pala, pala, turunan kalkon

ANALISIS SENYAWA MINYAK ATSIRI BIJI PALA SECARA GC-MS DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP Escherichia coli DAN Staphylococcus aureus Hery Muhamad Ansory; Prietta Khania Kusuma Putri; Nur ‘Aini Hidayah; Anita Nilawati
Prosiding SNST Fakultas Teknik Vol 1, No 1 (2018): PROSIDING SEMINAR NASIONAL SAINS DAN TEKNOLOGI 9 2018
Publisher : Prosiding SNST Fakultas Teknik

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.179 KB)

Pala merupakan tanaman asli Indonesia. Bagian buah pala meliputi daging buah, kulit biji dan biji pala. Secara komersial biji pala merupakan bagian terpenting dari buah pala dan dapat dibuat menjadi berbagai produk antara lain minyak atsiri dan oleoresin. Kadar minyak atsiri pada biji pala yang banyak diperlukan sebagai obat berkadar minyak atsiri yang tidak kurang dari 5% volume berat. Penelitian tentang minyak atsiri saat ini banyak diarahkan untuk memanfaatkannya sebagai antimikroba penyakit yang disebabkan oleh bakteri atau jamur. Isolasi minyak biji pala dilakukan dengan metode destilasi air dan didapatkan rendemen sebanyak 0,301 %. Minyak atsiri biji pala dianalisis dengan GC-MS dan diuji aktivitas antibakteri terhadap Escherichia coli dan Staphylococus aureus. Analisis GC-MS bertujuan untuk mengetahui kandungan senyawa kimia. Hasil GC-MS diambil 5 senyawa yang mempunyai peak paling tinggi atau yang dominan. Senyawa tersebut yaitu γ-terpinene, 3-cyclohexene-1-ol,4-metthyl-1-(1-methylethyl), safrol, Miristisin, metil ester. Minyak atsiri biji pala diujikan terhadap bakteri Escherichia coli dan Stapylococus aureus dengan metode difusi dan dilusi. Hasil uji dengan metode dilusi tidak dapat ditentukan KHM dan KBM dikarenakan pelarut yang kurang cocok. Hasil uji difusi termasuk dalam kategori lemah untuk bakteri E. coli dan termasuk kategori kuat untuk bakteri S. aureus. Kata kunci : antibakteri, biji pala,GC-MS, senyawa.

COMPARISON OF ESSENTIAL OILS QUALITY FROM PARTS OF NUTMEG BASED ON MYRISTICINE LEVELS Hery Muhamad Ansory; Hardjono Sastrohamidjojo; Bambang Purwono
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Telah dilakukan isolasi minyak atsiri dari daging buah, fuli dan biji buah pala denganmenggunakan metode distilasi uap. Analisis kadar senyawa miristisin sebagai indikator darikualitas minyak pala dilakukan dengan menggunakan kromatografi gas dan spektrometer massa.Isolasi senyawa miristisin dilakukan dengan metode distilasi fraksinasi pengurangan tekanan.Analisis kemurnian miristisin dari hasil isolasi dilakukan dengan menggunakan kromatografi gas.Analisis struktur miristisin hasil isolasi dilakukan dengan menggunakan spektrofotometer inframerah dan 1H NMR.Hasil isolasi minyak pala dengan metode distilasi uap dari daging buah pala didapatkan0,75% dengan kadar miristisin 10,54%, fuli pala didapatkan 4,77% dengan kadar miristisin 38,45%dan biji pala didapatkan 6,62% dengan kadar miristisin 9,24%. Hasil isolasi senyawa miristisin dariminyak pala dengan metode distilasi fraksinasi pengurangan tekanan didapatkan dengan kadar92,13%.Kualitas minyak atsiri dari bagian fuli pala memiliki kualitas yang lebih baik dengankandungan miristisin sebesar 38,45%.

Penentuan Kadar Vitamin C dan Aktivitas Antioksidan Buah Carica (Vasconcellea cundinamarcensis) Wonosobo Hery Muhamad Ansory; Rinda Binugraheni; Argo Khoirul Anas
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

The content of vitamin C information in carica fruit is very important because it can improvethe marketability of this fruit. The potential of Carica fruit as antioxidants agent hasn’t beenstudied by the researchers. It’s made Carica fruit are interesting to be studied, so theresearchers conducted this study to determine the vitamin C contain and the antioxidant activityof Carica fruit that grows in Wonosobo.This study was started by the preparation of the Carica fruit to obatined Carica fruitsolution. So that the total content of organic acids, ascorbic acid, and antioxidant activity ofCarica fruit solution could be analyzed. The organic acid content analysis of Carica fruit solutionwas performed by alkalimetric method. The ascorbic acid content analyses were performed byUV-Vis Spectrophotometry, and analysis of antioxidant activity were performed with DPPHmethod.The organic acids total concentration of Carica fruit solution was equal to 0,4 N. Theascorbic acid concentration of Carica fruit solution was 1560 ppm and The C50 value of Caricafruit obtained from sample solution by 118x dilution or equivalent to 17 gram of Carica fruit.

Sintesis senyawa 2,4-Dihidroksiasetofenon dan Uji Aktivitasnya sebagai Antioksidan Laksmiari Sekar Nirwani; Hery Muhamad Ansory; Anita Nilawati
Jurnal Farmasi Indonesia Vol 15 No 1 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Antioxidant is very important to keep human’s health because of its capability to reduce freeradical. Acetophenone and its derivates are reported as potential antioxidant. The aim of thisresearch was to find antioxidant activity of 2,4-dihydroxyacetophenone compound synthesizedfrom resorcinol.The research was performed by synthesizing 2,4-dihydroxyacetophenon through Friedel-Crafts acylation from resorsinol. The structure of the compound was elucidated using gaschromatography, mass spectrometer, infrared spectrophotometer, and antioxidant test wasusing DPPH method.The results showed that product was succesfully synthesized. Yellowish-orange solid wasobtained from synthesis with 86,14% of yield and confirmed as 2,4-dihydroxyacetophenone.The product showed weak antioxidant activity with 36,72 ppm of IC50

Pemisahan Senyawa 1,4-terpineol dan Safrol dari Minyak Atsiri Biji Pala (Myristica Fragrans Houtt) dan Uji Aktivitas Antibakteri Terhadap Shigella dysenteriae Tiara Dwi Ayunani; Ines Tri Hastuti; Hery Muhamad Ansory; Anita Nilawati
Jurnal Farmasi Indonesia Vol 15 No 1 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Nutmeg were plants that used as material in food, medicine, perfume and cosmeticsindustries. Nutmeg essential oil contain 1,4-terpineol and safrol compounds that predected haveantibacterial activity.Sparation of 1,4-terpineol and safrol compound from nutmeg essential oil was carried outby fractional distillation method at 95 mmHg and 200- 225C֯. Analysis of nutmeg essential oil andsparation carried out by GC-MS and antibacterial activity tests with diffusion and dilution methods.The Analysis results showed that nutmeg seed essential oil contain 5 mayor compounds,α-pinena, sabinen, 2-β-pinen, terpineol and miristisin, the sparation result contain 40.05%1-4 and20.34% safrol. The diffusion test showed that 1.25% nutmeg seed essential oil have 12,11mminhibition zone that classified as strong inhibition, and the sparation result have 9,66mm inhibitorzone that classified as moderately inhibition. The dilution test result of nutmeg essential oil andthe separation result have activity for bactericidal has the same at consentration 1.25%.

Aktivitas Antibakteri Pada Senyawa Turunan Kalkon Hasil Sintesis Dari Miristisin Buah Pala Anita Nilawati; Hery Muhammad Ansory
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Nutmeg is a native Indonesian herb that has been used for food purposes such as spices and herbs, and the food industry. Miristisin is a typical compound that determines the quality of nutmeg oil and has several functional groups like allyl, phenyl, and ether. Kalkon derived compounds are secondary metabolites of flavonoids that have biological activities such as anticancer, cytotoxic, antimicrobial and antimalarial. The antibacterial properties are closely related to the α, β-unsaturated and the substituent of both aromatic rings, such as methylenedioxy groups, methoxy, Cl, Br, OH and so on. The aims of this study are to determine the antibacterial activity of kalkon derived from miristisin.Antibacterial activity test was performed on Escheresia Coli (E. Coli) and Staphylococcus Aureus (S. Aureus) bacteria. Antibacterial activity test was done by diffusion method by using disc from kalkon derivative compound in acetone with 1,25%; 2.5%, 5% and 10% of concentration. The positive control of Ciprofloxacin 5μg and negative control of acetone solvent. The inhibit zone of each concentration are determine the antibacterial activity the result of antibacterial test showed ihibition diameter zone at 1.25%; 2.5%, 5% and 10% concentration in E. Coli bacteria were 13mm, 19mm, 22 mm and 26 mm, respectively, whereas in S. aureus bacteria were 7 mm, 7 mm, 9 mm and 19 mm, respectively. The results of the test showed the greater of sample concentration, the greater antibacterial activity. Strong antibacteria activity was shown in E.Coli bacteria with concentration of 10%, while at the same concentration showed moderate activity in S.Aureus bacteria.

Efek Reaksi Isomerisasi Pada Miristisin Terhadap Potensinya Sebagai Tabir Surya Secara in-vitro Hery Muhamad Ansory; Ika Nur Fitriani
Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i1.1094

Myristicin has an alkenyl benzene structure with a double bond that is not conjugated with a benzene ring with good sunscreen activity, the change of the double bond to the conjugated position can be done by an isomerization reaction. This change will result in the molecule having longer delocalized double bonds and is expected to increase its activity as a sunscreen. The purpose of this study was to see the effect of changes in myristicin structure on its activity as a sunscreen. The isomerization reaction was carried out by reflux method using 20% KOH catalyst in ethanol for 5 hours. Sunscreen activity test was carried out in-vitro using a UV spectrophotometer. The results of the isomerization reaction obtained isomyristicin in the form of a clear light yellow liquid that dissolves in ethanol (1: 1) with a% yield of 84% and a purity of 90% E: Z (6: 1). The results of the sunscreen activity test showed changes that were not much different between myristicin and isomyristicin, which indicated that the isomerization reaction had no significant effect on sunscreen activity.

Potensi Krim Ekstrak Etanol Daun Stroberi (Fragaria x ananassa var Duchesne) sebagai Tabir Surya Petrick Gilang Pambudi; Suhartinah Suhartinah; Hery Muhamad Ansory
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.1133

Ekstrak daun stroberi dilaporkan memiliki aktivitas tabir surya yang baik. Formulasi sediaan yang baik menjadi hal yang diperlukan untuk tahapan berikutnya. Penelitian ini bertujuan untuk mengetahui mutu fisik dari sediaan krim dan menentukan nilai SPF krim ekstrak etanol daun stroberi (Fragaria x ananassa var duchesne) sebagai tabir surya. Metode ekstraksi yang digunakan adalah refluks dengan pelarut etanol 96%. Analisis kandungan ekstrak dilakukan dengan kromatografi lapis tipis (KLT). Konsentrasi ekstrak yang digunakan untuk membuat krim tabir surya adalah 0,250% ; 0,500% dan 1,000%. Evaluasi yang dilakukan pada sediaan adalah uji mutu fisik, uji stabilitas sediaan dan aktivitas tabir surya baik in vivo dengan uji iritasi pada kulit manusia dan in vitro dengan spektrofotometri UV-Vis. Hasil penelitian ekstrak etanol daun stroberi didapatkan rendemen sebanyak 20,5% dan uji KLT menunjukan bahwa ekstrak daun stroberi positif mengandung flavonoid dan tanin. Krim ekstrak etanol daun stroberi yang paling baik pada konsentrasi 1,000% dengan nilai SPF sebesar 52,90.

Co-Authors Afif Meilana Sindani Putri Alfian Bagas Pratama Anita Nilawati Anita Nilawati Anita Nilawati Argo Khoirul Anas Bambang Purwono Detyari Faza Auliya Hardjono Sastrohamidjojo Ika Nur Fitriani Ika Nur Fitriani Inaratul Rizkhy Hanifah Ines Tri Hastuti Laksmiari Sekar Nirwani Nur 'Aini Hidayah Nur ‘Aini Hidayah Nur ‘Aini Hidayah Nuraini Harmastuti Petrick Gilang Pambudi Prietta Khania Kusuma Putri Prietta Khania Kusuma Putri Prietta Khania Kusuma Putri Rina Herowati Rinda Binugraheni, Rinda Sasqia Indri Maharani Suhartinah Suhartinah Suhartinah Suhartinah Tiara Dwi Ayunani Windia Wulantika

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