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Moulid Hidayat
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Peran FBXW7 pada Stem Cell Normal dan Cancer Stem Cell Hidayat, Moulid; Fariz, Nurwidya
Jurnal Kedokteran Vol 5 No 2 (2016)
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

F-box and WD40 repeat domain-containing 7 (FBXW7) adalah protein F-box yang merupakan komponen sistem ubiquitin proteasome yang berhubungan dengan beberapa protein onkogenik penting seperti Notch, c-Myc, cyclin E and c-Jun dalam mengatur proses pertumbuhan dan perkembangan sel, metabolism sel, diferensiasi dan apoptosis. Beberapa studi terkini menunjukkan bahwa FBXW7 berperan dalam perkembangan beberapa stem cell, mencakup proses self-renewal, multipotensi, diferensiasi, dan survival. Cancer stem cell (CSC) diketahui merupakan salah satu penyebab resistensi tumor terhadap berbagai kemoterapi, kekambuhan dan metastasis tumor. FBXW7 berperan terhadap kondisi quiescence pada CSC dengan mengatur substrat downstream c-Myc. Kondisi quiescence pada CSC dapat diinhibisi dengan memblokade peran FBXW7 melalui pathway upstream and downstream FBXW7 sehingga diharapkan dapat mengatasi resistensi dan kekambuhan tumor. Artikel telaah pustaka ini akan memaparkan peran FBXW7 pada stem cell normal dan pada cancer stem cell hubungannya dengan pengembangan terapi.
INTERLEUKIN-6 DAN POTENSI TERAPI INHIBISI INTERLEUKIN-6 DALAM TATA LAKSANA COVID-19 Fariz Nurwidya; Itsna Arifatuz Zulfiyah; Moulid Hidayat
Unram Medical Journal Vol 10 No 3 (2021): Jurnal Kedokteran volume 10 nomor 3 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i3.595

Abstract

Infeksi SARS-CoV-2 dapat menyebabkan disregulasi respons imunitas tubuh yang menimbulkan sekresi sitokin proinflamasi yang berlebihan, menyebabkan kondisi yang disebut sebagai badai sitokin. Badai sitokin ini memiliki peran penting dalam progresi penyakit COVID-19 karena dapat menyebabkan disfungsi multi organ, gangguan koagulasi, dan kematian. Sitokin proinflamasi yang paling banyak mengalami peningkatan selama badai sitokin pada pasien COVID-19 adalah IL-6. Dari pengetahuan ini, peneliti mulai mencari tahu kemungkinan digunakannya terapi inhibisi IL-6 sebagai bagian dari tata laksana COVID-19. Tiga macam terapi inhibisi IL-6 yang sedang diteliti adalah inhibitor reseptor IL-6, antagonis IL-6, dan inhibitor JAK. Ketiga agen terapi inhibisi IL-6 ini terbukti dapat memperbaiki klinis dan mengurangi mortalitas pasien COVID-19 dengan gejala berat. Akan tetapi, pemberian terapi inhibisi IL-6 masih belum memberikan hasil yang konsisten pada pasien COVID-19 yang disertai dengan gejala kritis sehingga pemberian pada kelompok ini harus lebih hati-hati. Oleh karena itu, penelitian lebih lanjut mengenai efektivitas dan keamanan terapi ini harus tetap dilakukan.
PELATIHAN TERAPI OKSIGEN PADA TENAGA KESEHATAN DI RUMAH SAKIT UMUM UNIVERSITAS MATARAM Moulid Hidayat; Prima Belia Fathana; Devi Ramadhona; Wahyu Sulistya Affarah
Jurnal Abdi Insani Vol 8 No 3 (2021): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v8i3.442

Abstract

Oksigen merupakan substrat penting bagi kehidupan manusia. Pengambilan oksigen dari lingkungan melalui kerja paru memberikan asupan substrat penting untuk proses produksi energi. Pada kondisi gawat napas, pemberian oksigen merupakan hal yang sangat esensial untuk menjaga homeostasis tubuh dan mencegah kerusakan organ lebih lanjut. Sehingga, pengetahuan akan indikasi pemberian oksigen, berapa dosis oksigen yang tepat, bagaimana cara memberikan oksigen yang benar, dan apa yang harus diperhatikan dalam pemberian oksigen sangat perlu dikuasai dengan baik. Pada era pandemi Covid-19 ini, penggunaan terapi oksigen sangat masif, sehingga perlunya dilakukan penyegaran kembali mengenai terapi oksigen terhadap tenaga kesehatan di lingkungan Rumah Sakit Universitas Mataram agar penggunaan oksigen dapat lebih tepat guna, dan optimal. Meningkatkan pengetahuan tenaga kesehatan di Rumah Sakit Universitas Mataram mengenai terapi oksigen. Kegiatan pelatihan ini dilakukan dengan menggunakan metode ceramah interaktif dan dilanjutkan dengan sesi tanya jawab dan diskusi. Pengetahuan peserta dinilai berdasarkan pre-test dan post-test. Kegiatan pelatihan dihadiri oleh 35 orang tenaga kesehatan yang khusus berasal dari instalasi rawat isolasi, instalasi gawat darurat, dan instalasi perawatan kritis (intensive care unit (ICU)) Rumah Sakit Universitas Mataram. Pada pelatihan ini, terdapat peningkatan pengetahuan yang bermakna, dengan selisih skor peningkatan pengetahuan sebesar 10.89 (p=0.0225 (<0.05), 95% KI 1.551-19.06). Peningkatan pengetahuan tenaga kesehatan melalui kegiatan pelatihan terapi oksigen dibutuhkan untuk pelayanan kesehatan sehari-hari pasien dengan kegawatan napas.
Challenges on tuberculosis care in health care facilities during COVID-19 pandemic: Indonesian perspective Wira Winardi; Hendra Wahyuni; Moulid Hidayat; Aditya Wirawan; Fariz Nurwidya; Mohammad N. Uddin; Mohamad Yusup
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.80

Abstract

Indonesia is among the top three countries globally with the highest tuberculosis  burden. During the past decades, Indonesian health authorities have struggled to improve tuberculosis care quality in health care facilities by optimizing the regulation and strengthening the private sector contributions. The coronavirus disease 2019 (COVID-19) pandemic has hardly affected the Indonesian health care system, including the National Tuberculosis Control Program. While the end of the COVID-19 pandemic in Indonesia is uncertain, the measure to control tuberculosis must not be weakened. Early identification and measurement of the problem size are essential to decide the most appropriate approach to maintain the sustainability of National Tuberculosis Control Program, particularly in health care facilities during the COVID-19 pandemic. This article points out the possible threats to the sustainability of TB care in Indonesia during the COVID-19 pandemic, including some approaches to overcome those problems.
Hubungan Kadar D-dimer dan C-Reactive Protein terhadap Berat Gejala pada Pasien COVID-19 Sang Ayu Nyoman Putri Pradnyasari; Moulid Hidayat; Prima Belia Fathana
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.864

Abstract

Background: Coronavirus disease 19 (COVID-19) is an acute respiratory infectious disease by SARS-CoV-2. This disease was discovered in Wuhan, China. In some cases, COVID-19 can be life-threatening due to an uncontrolled inflammatory phase characterized by increased levels of D-dimer and C-reactive protein (CRP) in the body. This condition can lead to complications such as ARDS, shock, and even death. This study aims to determine the relationship between D-dimer and CRP levels with the disease severity in COVID-19 patients at the Mataram University Hospital. Methods: This study is an observational analytic study with a cross-sectional design. Data collection took place in March-May 2022 at the Mataram University Hospital. Subjects were selected using consecutive sampling methods through medical record data. The statistical test used the Chi-square and Mann-Whitney comparative tests. Results: A total of 64 subjects were selected, of which 48 subjects underwent a D-dimer examination and 58 underwent a CRP examination. Most subjects were in the age group 18-59 years (64.1%), with the male gender (56.3%). There were 10 subjects (20.8%) had normal D-dimer levels, and 38 subjects (79.2%) had elevated D-dimer levels. Normal CRP levels were found in 6 subjects (10.3%), and 52 subjects (89.7%) had elevated CRP levels. The results of the bivariate test analysis showed p-value = 0.002 for D-dimer levels with severe symptoms, and CRP levels with severe symptoms showed p-value = 0.02. Conclusion: There is a significant correlation statistically and clinically between D-dimer and C-reactive protein levels with the disease severity in COVID-19 patients.
Relationship of Comorbidity and Age to the Severity of Clinical Symptoms of COVID-19 at Mataram University Hospital I Made Arya Yogiswara Mahayasa; Moulid Hidayat; Prima Belia Fathana; Indana Eva Ajmala
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): January - March
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.4581

Abstract

COVID-19 disease is a disease that arises due to infection with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The purpose of this study was to determine differences in clinical symptoms in elderly and non-elderly patients, as well as patients who had comorbidities and did not have comorbidities. This research is a type of cross-sectional study that was conducted by reviewing the medical records of COVID-19 patients undergoing treatment at Mataram University Hospital in 2021. Data was collected using a consecutive sampling technique. The statistical test used is the Chi-square comparative test. To assess the relationship of age and comorbidities to the severity of symptoms in COVID-19 patients. In this study, 86 subjects were selected based on the inclusion and exclusion criteria applied. The majority of subjects were in the 15-59 year age group, namely 66 (23.3%). With male sex 51 (60.5%) people. The majority of patients with comorbidities experienced severe/critical symptoms 16 (44.4%) and patients without comorbids experienced no symptoms or experienced mild symptoms 35 (35%). The majority of elderly patients experienced severe-critical symptoms 9 (45%) and the majority of non-elderly patients experienced no symptoms or experienced mild symptoms 42 (63.6%). The results of the bivariate analysis test showed a p-value = 0.001 for comorbids with severe symptoms, and a p-value = 0.003 for age with severe symptoms. There is a significant relationship between comorbidities and age on the severity of symptoms in COVID-19 patients.
SEMINAR AWAM: KENALI ASMA DAN TANGANI DENGAN TEPAT Jurnal Pepadu; Indana Eva Ajmala; Rina Lestari; Prima Belia Fathana; Moulid Hidayat
Jurnal Pepadu Vol. 4 No. 1 (2023): Jurnal Pepadu
Publisher : LPPM UNIVERSITAS MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/pepadu.v4i1.2236

Abstract

Asma adalah penyakit pernapasan kronis umum yang mempengaruhi 1–18% populasi di berbagai negara. Telah terjadi peningkatan tajam dalam prevalensi global, morbiditas, mortalitas, dan beban ekonomi yang terkait dengan asma selama 40 tahun terakhir. Saat ini sebagian besar penderita asma merupan asma tidak terkontrol. Pengetahuan mengenai asma sangat penting dalam mencapai kontrol asma. Pasien dan keluarga pasien yang memahami penyakit asma dengan baik secara sadar akan menghindari faktor-faktor pencetus serangan, menggunakan obat secara benar dan berkonsultasi kepada dokter secara tepat. Tujuan kegiatan ini adalah meningkatkan pengetahuan masyarakat mengenai pengertian, gejala, penyebab dan pencetus, pengobatan dan pencegahan asma. Narasumber melakukan presentasi, dilanjutkan dengan diskusi. Peningkatan pengetahuan diukur dengan pre-test dan post-test yang dianalisa dengan menggunakan t-paired test. Kegiatan diikuti oleh 33 peserta dari anggota DWP RSUD Provinsi NTB dan anggota PORPI cabang NTB. Setelah diberikan materi oleh narasumber, terdapat peningkatan pengetahuan yang bermakna pada peserta seminar. Selisih skor peningkatan pengetahuan adalah 14,7532 (p 0.002, 95% IK -23.6579-(-5.8484). Terdapat peningkatan pengetahuan peserta seminar mengenai asma.
Differences in RDW Values of COVID-19 Patients with Pneumonia and Without Pneumonia at RSUM and RSUDP NTB Indri Setiawati; Moulid Hidayat; Rina Lestari
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.5849

Abstract

Pneumonia coinfection in COVID-19 patients can be an important risk factor for patient mortality. Red blood cell distribution width (RDW) is a predictor that can determine clinical outcomes in patients with respiratory tract infections and serious illnesses, so researchers want to conduct research to determine the difference in RDW values in COVID-19 patients with and without pneumonia at RSUM and RSUDP NTB. The design of this research is cross sectional. The sampling technique used was consecutive sampling. There were 110 COVID-19 patient data used in this research. Data collection uses medical record notes. The statistical analysis used was the Mann-Whitney test. The average age of patients was 48 years ± 16 years. Most of the subjects were male (53.6%). The most common comorbidity was diabetes mellitus (21.8%). The average RDW values in COVID-19 patients with and without pneumonia were 13.9% and 13.1%. The difference in the mean RDW value in the two groups is 0.8%. This study found that clinically there were differences in the RDW values of COVID-19 patients with pneumonia and without pneumonia at RSUM and RSUDP NTB.
ARDS (Acute Respiratory Distress Syndrome) in Pediatric and Adult Zulfa Hasyimiyyah Ihtisyam; Latifah Mukhlisatunnafsi; M. Fardi Anugrah; Moon Fahira; Putu Diwyandaani Priyahita; Theophany Margareta Kurniawan; Moulid Hidayat
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.5767

Abstract

Acute Respiratory Distress Syndrome (ARDS) is a serious medical condition that occurs when lungs become severely inflamed, which inhibits the ability to take in the oxygen and eliminate carbon dioxide. The purpose of this article is to find out more about the clinical manifestation, pathophysiology, diagnosis, and treatment of ARDS. The literatures that used for this literature review are from National Center for Biotechnology Information (NCBI), Google scholar, and Proquest. The result for this literature review is the development of ARDS is associated with inflammation in lung’s epithelium, endothelium, and interstitium which consist three phases which is exudative, proliferative, and fibrotic phases. The Berlin Criteria issued by the American-European Consensus Conference (AECC) in 2021 used for ARDS diagnosis. The treatments for ARDS could used pharmacotherapy and non-pharmacotherapy.
Co-Authors Aditya Wirawan Devi Ramadhona Fariz Nurwidya Hendra Wahyuni I Made Arya Yogiswara Mahayasa Indana Eva Ajmala Indana Eva Ajmala Indri Setiawati Itsna Arifatuz Zulfiyah Jurnal Pepadu Latifah Mukhlisatunnafsi M. Fardi Anugrah Mohamad Yusup Mohammad N. Uddin Moon Fahira Prima Belia Fathana Putu Diwyandaani Priyahita Rina Lestari Rina Lestari Sang Ayu Nyoman Putri Pradnyasari Theophany Margareta Kurniawan Wahyu Sulistya Affarah Wira Winardi Zulfa Hasyimiyyah Ihtisyam