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All Journal Jurnal Ilmu Kesehatan Masyarakat Abdi Laksana Edu Masda Journal Edu Dharma Journal: Jurnal penelitian dan pengabdian masyarakat Jurnal Kefarmasian Indonesia
Fahriati, Andriyani Rahmah
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Journal : Jurnal Kefarmasian Indonesia

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Formulation of Instant Granules from Ethanolic Extract of Melinjo Peel (Gnetum gnemon L) Extract as Anti-Hyperuricemia Sari, Diah Permata; Fahriati, Andriyani Rahmah; Maelaningsih, Firdha Senja
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6290

Abstract

Melinjo (Gnetum gnemon L) is extensively found in Indonesia, and all of its components are highly employed, with the fruit being the most commonly used. However, melinjo fruit can induce hyperuricemia if ingested excessively since it contains purines, which can raise uric acid levels. Several investigations have found that melinjo peel can lower uric acid levels in experimental rats in vivo. As a result, the goal of this study is to create and evaluate immediate granule formulations of melinjo peel extract. Plant determination, standardization of specified parameters, standardization of non-specific parameters, formulation, and physical and chemical assessment of instant granules of melinjo peel extract are all steps of the technique. This study employed two instant granule formulations of melinjo peel extract FI and FII with varying PVP concentrations (1g FI and 3g FII). Flow time testing, angle of repose testing, compressibility index testing, water content testing, and dissolving time testing were all part of the physical examination of instant granules. The chemical evaluation took the form of a UV-Vis spectrophotometer study of total flavonoid levels in instant extracts and granules. The FI and FII instant granule formulas had a yellow color, the flow time test results were in a good category (44 g/s and 81 g/s), the angle of repose test results was in the very good flow properties category (19° and 16°), the compressibility test results, the water content test, and the dissolving time test were performed in triplo, in 0, 7th, and 14th day, and the results were in a good category. In conclusion, the physical features of instant granules of FI and FII melinjo peel extracts fulfilled the requirements for all test parameters and had a high possibility to be produced as anti hyperuricemia preparations.
Co-Authors Al-Hafiz, Mohammad Alexandre, Nahla Dany Amalia, Tania Rizki Andriati, Riris Arief, Ilham Aulia, Gina Ayuningtyas, Gita DIAH PERMATA SARI, DIAH PERMATA FIRGIANTI, REZA Fitriani, Reka Herdaningsih, Sulatri Ilmi, Ayatun Fil Ismaya, Nurwulan Adi Jaya, Fadly Putra Kristiyowati, Anis Dwi MAELANINGSIH, FIRDHA SENJA Nur Hasanah Nurihardiyanti Nurihardiyanti, Nurihardiyanti Rita Dwi Pratiwi Saputri, Laras Tri Sari Indah, Fenita Purnama Sayyidah, Sayyidah Utami, Rahayu Budi Werawati, Ayu Yanuar, Muhammad Cahyadi