Article Per Year (5 Year)
p-Index From 2019 - 2024
0.983
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JFL : Jurnal Farmasi Lampung Jurnal Farmasi Indonesia Jurnal Insan Farmasi Indonesia
Nelly Suryani
Universitas Islam Negeri Syarif Hidayatullah Jakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Jurnal Farmasi Indonesia

 1 
Uji Stabilitas Spironolakton Terhadap Perubahan pH dengan Menggunakan Kromatografi Cair Kinerja Tinggi (KCKT) Nelly Suryani; Yardi Supandi; Ririn Astri Sabdowati
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (780.444 KB) | DOI: 10.31001/jfi.v16i1.450

Abstract

Spironolactone is an aldosterone diuretic antagonist for hypertension. In practice spironolactone is sometimes combined with other drugs, and in unconscious patients the drug must use a feeding tube and be susceptible to instability. The object of this study was to see the effect of pH changes on spironolactone tablets which were crushed and suspended in water. The method of measuring spironolactone levels using High Performance Liquid Chromatography based on methods in the United State Pharmacopeia. Spironolactone suspension was made at pH 3, 5, 7, and 9 with sampling time in minutes 0, 15, 30, 45, and 60. The results showed that the level of spironolactone at pH 3 was ≤ 0%, pH 5 was 74% - 100%, at pH 7 it was in the range of 27% - 61%, and at pH 9 was 38% - 54%. This explains that percent of spironolactone at pH 3.7, and 9 at all sampling times did not match the minimum therapeutic level in the monograph. Only at pH 5 does the level of spironolactone still match the levels specified in the monograph. In this study it can be concluded that changes in pH can significantly reduce spironolactone levels in suspension.
Co-Authors Astri Fajriani Delina Hasan Farida Sulistiawati Nia Fachrunisa Ofa Suzanti Betha Qurry Mawaddana Ririn Astri Sabdowati Shella Desilia Pratiwi Suci Ahda Novitri Vidia Arlaini Anwar Vivi Anggia, Vivi Yardi Supandi Yardi Yardi