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UJI ANALGETIK KOMBINASI EKSTRAK DAUN LIDAH BUAYA DAN EKSTRAK JAHE TERHADAP MENCIT YANG DIINDUKSI ASAM ASETAT Wijaya, Wendi; Raynard A.K., Panta Leon; Simbolon, Boyke Marthin
(Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Vol 5, No 4 (2020): JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat)
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37887/jimkesmas.v5i4.14991

Lidah buaya dan jahe merupakan tanaman yang memiliki berbagai macam manfaat dalam bidang Kesehatan,salah satunya digunakan sebagai obat tradisional yang digunakan masyarakat untuk mengobati nyeri. Telahdilakukan penelitian Uji Analgetik Kombinasi Ekstrak Daun Lidah Buaya dan Ekstrak Jahe Terhadap Mencit yangDiinduksi Asam Asetat. Penelitian ini bertujuan untuk mengetahui seberapa baik efek analgetik yangterkandung pada kombinasi ekstrak daun lidah buaya dan ekstrak jahe dalam menurunkan nyeri. Penelitian inimerupakan penelitian eksperimental yang menggunakan 25 ekor mencit yang terdiri dari 5 kelompok sebagaihewan uji coba pada uji analgetik dengan metode induksi kimia yaitu menggunakan asam asetat sebagai zatpenginduksi nyeri dan dinilai melalui pengamatan jumlah geliat yang ditunjukkan mencit setelah diintervensi.Pada hasil yang didapatkan, ekstrak lidah buaya dan ekstrak jahe memiliki kandungan senyawa yang bersifatanalgetik yaitu alkaloid dengan flavonoid dan memiliki persentase daya analgetik yang lebih dari 50 % sertamemiliki efek analgetik yang lebih besar pada dosis 100 mg/kgBB dibandingkan dengan kontrol positif dariintervensi yang dilakukan yaitu asam mefenamat, dengan perbedaan daya analgetik sebesar 6,64 %.Kata Kunci : Analgetik, Kombinasi ekstrak daun lidah buaya dan ekstrak jahe, asam asetat, mencit

Combination of Low Dose Ketamine, Paracetamol, and Tramadol for Opioid Induces Hyperalgesia in Lung Cancer with Intra Abdominal Metastases Boyke Marthin Simbolon; Mual Kristian Sinaga
JAI (Jurnal Anestesiologi Indonesia) Vol 12, No 2 (2020): Jurnal Anestesiologi Indonesia
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v12i2.28427

Background: Opioid induced hyperalgesia or OIH is one of exaggerated response to pain secondary to using of the opioid itself. High dosage of opioid in long term (days to weeks) relate to increased OIH occurrence.Case: Female, 58 yrs, BMI 17.77, complained severe abdominal pain with NRS 8/10. Patient suffered from lung cancer stage 3 with intra abdominal metastases. Previously patient had received analgesic paracetamol 1gr TID, dexketoprofen 25mg TID, parecoxib 40mg OD, morphine 10mg BD and fentanyl patch 50 µg. Then fentanyl was given 25 µg IV twice with interval of 15 minutes. Patient still complained for pain and eventually pain severity increased to NRS 10/10. Afterwards patient was given low dose ketamin 0.1mg/kg slow IV push, paracetamol 1gr IV, and tramadol 50mg IV. After 15 minutes observation, pain decreased to NRS 5/10.Discussion: Decreasing total dose of opioid consumed may decresed OIH. It may be performed by improving analgesia by using combination of analgesic and intervention strategy.Conclusion: combination of low dose ketamine (0.1mg/kg), paracetamol, and tramadol may be benefit for patient with opioid induces hyperalgesia in lung cancer stage 3 with intra abdominal metastases.

The Effect of Moringa Oleifera Extract on Sperm Quality and Quantity of Diabetes Wistar Rat Meldawati; Novita Dwi Febrianty; Herisa Putri Anggraini; Boyke Marthin Simbolon
Archives of The Medicine and Case Reports Vol. 2 No. 1 (2021): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v2i1.15

Diabetes mellitus is a condition in which blood glucose levels increase in a person's body which can result in chronic disorder. The effect of diabetes on a male reproductive system can affect sperm quality and disrupt the spermatogenesis process. Moringa oleifera leaves are rich in antioxidants such as flavonoids, vitamin A, vitamin E, and vitamin C, and contain selenium which helps lower bloodssugar levels. This study was conductedtto determine the effect of administering Moringa oleifera leaf extract on the quality andiquantity ofssperms in Wistar rats with diabetes mellitus. This research is an experimental studyiusing pre-andipost-randomized,controlled group design. This study examinediblood sugarllevels, density, motility, andiviability ofssperm cells. This experimental test was dividediinto 4 groups: one as a control group andtthree groups as treatment groups induced with alloxan and given ethanol extract of Moringa leaves with doses of 250, 500, and,750mg/kgBB. The results showed that the ethanol extract of Moringa leaves showedssignificant improvements in various doses (P-value ≤ 0.05).

Uji Efek Analgesik Ekstrak Buah Andaliman (Zanthoxylum Acanthopodium) Terhadap Nyeri Pada Mencit (Mus Musculus) Yang Diinduksi Asam Asetat Mei Riauly Wira; Petri Lumban Gaol; Boyke Marthin Simbolon
Jurnal Infokes Vol 11 No 2 (2021): Jurnal Ilmiah Rekam Medis dan Informatika Kesehatan
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/infokes.v11i2.1299

Pain is an unpleasant sensory and emotional experience which is the result of stimulus by damaged tissue or chemical mediators which can be experienced by range of intensity, quality, duration, distribution and location. Pain can be resolved pharmacologically by non-opioid (NSAID, salicylates) or opioid (morphine) drugs. Alternatively, pain also can be resolved by non-pharmacological intervention such as hot/cold compress, TENS, behavior therapy, or relaxation therapy. Andaliman (Zanthoxylum acanthopodium), generally used as spices in North Sumatera, also can be utilized as pain killer (analgesic). Objective: To determine the effectivity of Andaliman fruit extract (Zanthoxylum acanthopodium) as analgesic in mice (Mus muscular). Methods: This research is an experimental study with posttest only control group design. Experiment conducted to the mice by using 1% acetate acid to induce pain and then intervened by using mefenamic acid or Andaliman fruit extract in different doses and followed by observation of the pain response for 60 minutes with 5 minutes intervals between observation. Result: Andaliman fruit extract in the dose of 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW have analgetic effectivity more than 50% compared to mefenamic acid with effectivity of 93,16%, 89,21%, and 112,01% respectively. Conclusion: Andaliman fruit extract is an effective analgesic.

Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Staphylococcus aureus Riris Grace Aprilia; Yohania Premita; Boyke Marthin Simbolon; Riyani Susan Bt. Hasan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.644

Background: Diseases due to infection where one of the causes is Staphylococcus aureus is one of the biggest problems faced today. Treatment using penicillin antibiotics tends to cause resistance and side effects, so people prefer to overcome them by means of self-medication or the use of traditional ingredients such as betel leaf. The purpose of the study was to examine the effect of green betel leaf extract (Piper betle L.) on the growth of Staphylococcus aureus on the antibacterial activity. Methods: This study is experimental research in vitro using a well diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 5%, 10%, 15%, and 20%. Results: The average diameter of the inhibition zones was 9.82 mm, 9.11 mm, 9.28 mm, and 9.01 mm at concentrations of 5%, 10%, 15%, and 20%, sequentially. Conclusion: The antibacterial activity of betel leaf extract in the overall concentration and the most optimal concentration was 5% at 9.82 mm.

Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Candida albicans Yohania Premita; Riris Grace Aprilia; Boyke Marthin Simbolon; Riyani Susan Bt. Hasan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.645

Background: Candida albicans is a fungus that often results in opportunistic infections in humans, called candidiasis. People generally practice self-medication to treat candidiasis with azole antifungals. However, this causes resistance due to inappropriate drug or dose selection. Betel leaf extract, which contains active compounds with antifungal properties such as phenols, tannins, and flavonoids, can be used as alternative medicine. The purpose of this study was to determine whether there was an effect of green betel leaf extract (Piper betle L.) on the growth of Candida albicans. Methods: This study is an experimental study and uses the disc diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 40%, 60%, 80%, and 100%. Results: The mean inhibition zone diameters were 9.12 mm, 8.79 mm, 8.18 mm, and 8.55 mm at concentrations of 40%, 60%, 80%, and 100%, sequentially. Conclusion: Betel leaf extract has an antifungal effect, with the most effective concentration being 40%.

Antidiabetic Effectiveness Test of Andaliman Fruit (Zanthoxylum acanthopodium) Extract on Histopathological Changes in Peripheral Nerves: An In Vivo Study Larisma Simanullang; Sionia Delaroza Doloksaribu; Riyani Susan Bt. Hasan; Boyke Marthin Simbolon
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i14.664

Background: Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated blood sugar levels, and the increase in sugar levels is triggered by low insulin production or the ineffective use of insulin by the body (relatively). Diabetic neuropathy is a complication that often attacks DM patients and is the highest complication of diabetes. This study aims to test the effectiveness of Andaliman fruit (Zanthoxylum acanthopodium) extract on the improved histopathology of Peripheral nerve in alloxan-induced Wistar rats (Rattus norvegicus). Methods: This study is an experimental study using 24 Wistar rats, which were grouped into 6 groups (1: normal, 2: negative control, 3: positive control, 4-6: DM + andaliman extract 150mg/kgBW, 250 mg/kgBW, 350 mg /kgBB). Data analysis used SPSS to determine differences in the histological conditions of peripheral nerves. Results: The administration of andaliman fruit extract at a dose of 350 mg/kgBW was most effective in inhibiting the proliferation of Schwann cells, which showed the potential of andaliman fruit extract in preventing the progression of diabetic neuropathy. The administration of andaliman fruit extract at a dose of 350 mg/kgBW also showed the most effective potential in inhibiting the inflammatory process in the peripheral nerves, which is believed to be responsible for peripheral nerve cell damage. Conclusion: Andaliman fruit (Zanthoxylum acanthopodium) extract is effective against improving the histopathology of peripheral nerves in alloxane-induced Wistar rats (Rattus norvegicus).

Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Staphylococcus aureus Riris Grace Aprilia; Yohania Premita; Boyke Marthin Simbolon; Riyani Susan Bt. Hasan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.644

Background: Diseases due to infection where one of the causes is Staphylococcus aureus is one of the biggest problems faced today. Treatment using penicillin antibiotics tends to cause resistance and side effects, so people prefer to overcome them by means of self-medication or the use of traditional ingredients such as betel leaf. The purpose of the study was to examine the effect of green betel leaf extract (Piper betle L.) on the growth of Staphylococcus aureus on the antibacterial activity. Methods: This study is experimental research in vitro using a well diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 5%, 10%, 15%, and 20%. Results: The average diameter of the inhibition zones was 9.82 mm, 9.11 mm, 9.28 mm, and 9.01 mm at concentrations of 5%, 10%, 15%, and 20%, sequentially. Conclusion: The antibacterial activity of betel leaf extract in the overall concentration and the most optimal concentration was 5% at 9.82 mm.

Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Candida albicans Yohania Premita; Riris Grace Aprilia; Boyke Marthin Simbolon; Riyani Susan Bt. Hasan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.645

Background: Candida albicans is a fungus that often results in opportunistic infections in humans, called candidiasis. People generally practice self-medication to treat candidiasis with azole antifungals. However, this causes resistance due to inappropriate drug or dose selection. Betel leaf extract, which contains active compounds with antifungal properties such as phenols, tannins, and flavonoids, can be used as alternative medicine. The purpose of this study was to determine whether there was an effect of green betel leaf extract (Piper betle L.) on the growth of Candida albicans. Methods: This study is an experimental study and uses the disc diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 40%, 60%, 80%, and 100%. Results: The mean inhibition zone diameters were 9.12 mm, 8.79 mm, 8.18 mm, and 8.55 mm at concentrations of 40%, 60%, 80%, and 100%, sequentially. Conclusion: Betel leaf extract has an antifungal effect, with the most effective concentration being 40%.

Antidiabetic Effectiveness Test of Andaliman Fruit (Zanthoxylum acanthopodium) Extract on Histopathological Changes in Peripheral Nerves: An In Vivo Study Larisma Simanullang; Sionia Delaroza Doloksaribu; Riyani Susan Bt. Hasan; Boyke Marthin Simbolon
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i14.664

Background: Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated blood sugar levels, and the increase in sugar levels is triggered by low insulin production or the ineffective use of insulin by the body (relatively). Diabetic neuropathy is a complication that often attacks DM patients and is the highest complication of diabetes. This study aims to test the effectiveness of Andaliman fruit (Zanthoxylum acanthopodium) extract on the improved histopathology of Peripheral nerve in alloxan-induced Wistar rats (Rattus norvegicus). Methods: This study is an experimental study using 24 Wistar rats, which were grouped into 6 groups (1: normal, 2: negative control, 3: positive control, 4-6: DM + andaliman extract 150mg/kgBW, 250 mg/kgBW, 350 mg /kgBB). Data analysis used SPSS to determine differences in the histological conditions of peripheral nerves. Results: The administration of andaliman fruit extract at a dose of 350 mg/kgBW was most effective in inhibiting the proliferation of Schwann cells, which showed the potential of andaliman fruit extract in preventing the progression of diabetic neuropathy. The administration of andaliman fruit extract at a dose of 350 mg/kgBW also showed the most effective potential in inhibiting the inflammatory process in the peripheral nerves, which is believed to be responsible for peripheral nerve cell damage. Conclusion: Andaliman fruit (Zanthoxylum acanthopodium) extract is effective against improving the histopathology of peripheral nerves in alloxane-induced Wistar rats (Rattus norvegicus).

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