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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Yohania Premita
Undergraduate Student of Medical Education, Faculty of Medicine, Dentistry and Nursing Science, Universitas Prima Indonesia, Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Staphylococcus aureus Riris Grace Aprilia; Yohania Premita; Boyke Marthin Simbolon; Riyani Susan Bt. Hasan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.644

Abstract

Background: Diseases due to infection where one of the causes is Staphylococcus aureus is one of the biggest problems faced today. Treatment using penicillin antibiotics tends to cause resistance and side effects, so people prefer to overcome them by means of self-medication or the use of traditional ingredients such as betel leaf. The purpose of the study was to examine the effect of green betel leaf extract (Piper betle L.) on the growth of Staphylococcus aureus on the antibacterial activity. Methods: This study is experimental research in vitro using a well diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 5%, 10%, 15%, and 20%. Results: The average diameter of the inhibition zones was 9.82 mm, 9.11 mm, 9.28 mm, and 9.01 mm at concentrations of 5%, 10%, 15%, and 20%, sequentially. Conclusion: The antibacterial activity of betel leaf extract in the overall concentration and the most optimal concentration was 5% at 9.82 mm.
Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Candida albicans Yohania Premita; Riris Grace Aprilia; Boyke Marthin Simbolon; Riyani Susan Bt. Hasan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.645

Abstract

Background: Candida albicans is a fungus that often results in opportunistic infections in humans, called candidiasis. People generally practice self-medication to treat candidiasis with azole antifungals. However, this causes resistance due to inappropriate drug or dose selection. Betel leaf extract, which contains active compounds with antifungal properties such as phenols, tannins, and flavonoids, can be used as alternative medicine. The purpose of this study was to determine whether there was an effect of green betel leaf extract (Piper betle L.) on the growth of Candida albicans. Methods: This study is an experimental study and uses the disc diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 40%, 60%, 80%, and 100%. Results: The mean inhibition zone diameters were 9.12 mm, 8.79 mm, 8.18 mm, and 8.55 mm at concentrations of 40%, 60%, 80%, and 100%, sequentially. Conclusion: Betel leaf extract has an antifungal effect, with the most effective concentration being 40%.
Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Staphylococcus aureus Riris Grace Aprilia; Yohania Premita; Boyke Marthin Simbolon; Riyani Susan Bt. Hasan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.644

Abstract

Background: Diseases due to infection where one of the causes is Staphylococcus aureus is one of the biggest problems faced today. Treatment using penicillin antibiotics tends to cause resistance and side effects, so people prefer to overcome them by means of self-medication or the use of traditional ingredients such as betel leaf. The purpose of the study was to examine the effect of green betel leaf extract (Piper betle L.) on the growth of Staphylococcus aureus on the antibacterial activity. Methods: This study is experimental research in vitro using a well diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 5%, 10%, 15%, and 20%. Results: The average diameter of the inhibition zones was 9.82 mm, 9.11 mm, 9.28 mm, and 9.01 mm at concentrations of 5%, 10%, 15%, and 20%, sequentially. Conclusion: The antibacterial activity of betel leaf extract in the overall concentration and the most optimal concentration was 5% at 9.82 mm.
Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Candida albicans Yohania Premita; Riris Grace Aprilia; Boyke Marthin Simbolon; Riyani Susan Bt. Hasan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.645

Abstract

Background: Candida albicans is a fungus that often results in opportunistic infections in humans, called candidiasis. People generally practice self-medication to treat candidiasis with azole antifungals. However, this causes resistance due to inappropriate drug or dose selection. Betel leaf extract, which contains active compounds with antifungal properties such as phenols, tannins, and flavonoids, can be used as alternative medicine. The purpose of this study was to determine whether there was an effect of green betel leaf extract (Piper betle L.) on the growth of Candida albicans. Methods: This study is an experimental study and uses the disc diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 40%, 60%, 80%, and 100%. Results: The mean inhibition zone diameters were 9.12 mm, 8.79 mm, 8.18 mm, and 8.55 mm at concentrations of 40%, 60%, 80%, and 100%, sequentially. Conclusion: Betel leaf extract has an antifungal effect, with the most effective concentration being 40%.
Co-Authors Riris Grace Aprilia Riyani Susan Bt. Hasan Riyani Susan Bt. Hasan Simbolon, Boyke Marthin