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All Journal Jurnal Keperawatan Muhammadiyah JSMARTech : Journal of Smart Bioprospecting and Technology
Utari, Dwi
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing

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Pengaruh Self-Efficacy Enhancing Intervention Program (SEEIP) Secara Online Terhadap Self-Efficacy Dalam Manajemen Diri Penderita Diabetes Mellitus Tipe II Di Puskesmas Juli I Siregar, Rinco; Gultom, Rumondang; Simamora, Marthalena; Pardede, Jek Amidos; Utari, Dwi
Jurnal Keperawatan Muhammadiyah Vol 6, No 2 (2021): JURNAL KEPERAWATAN MUHAMMADIYAH
Publisher : UNIVERSITAS MUHAMMADIYAH SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jkm.v6i2.7747

Abstract

Objective: The objective of this study was to determine the effect of Self-Efficacy Enhancing Intervention Program (SEEIP) with online method on Self-Efficacy in Self-Management in Type 2 Diabetes Mellitus (T2DM) at Juli I Public Health CentreMethods: This study was a pre-experimental pre-test and post-test with only one group design. The population wasT2DM at Juli I Public Health Center in 2020. The sample size was 22 participants, selected by purposive sampling technique. Diabetes Management Self-Efficacy Scale (DMSES) was used to measure the Self-Efficacy in Self- Management of T2DM patients. Data were analyzed using paired t-testResults: The results of the study showed that the means score of Self- Management of T2DM before receiving SEEIP was 39,00 (SD: 15,455) and 90,23 (SD: 7,571)after receiving the SEEIP. Paired t-test showed that there was a significant difference on Self- Efficacy in Self-Management in T2DM at Juli I Public Health Centre in 2020Conclusion:  SEEIP could improve self-efficacy in self-management for Type 2 diabetes mellitus at Juli I Public Health Centre.
Molecular Docking Chlorogenic Acid and Isomer Compound as Cyclooxygenase-2 (COX-2) Inhibitor in Atherosclerosis Nurarifa, Ratna; Rachmawati, Devi Era; Utari, Dwi
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.22

Abstract

Atherosclerosis is an inflammatory disease caused by oxidized LDL. Chloroghenic acid (CGA) is a polyphenol compound and its isomers such as Caffeoylquinic acid (CQA) and Feruloylquinic acid (FQA) can increase the activity of antioxidant activity and can significantly reduce total cholesterol in the blood. Cyclooxygenase (COX) is an enzyme that correlates with the inflammatory process. COX is divided into two isoforms, COX-1 and COX-2. Prostanoid synthesis via the action of cyclooxygenase-2 (COX-2) is a component of the inflammatory response. All prepared compound of Chlorogenic acid (CGA) and its isomer, Caffeolycquinic acid (CQA) and Feruloylquinic acid (FQA) is used for molecular docking by using HEX 8.0.0. Visualization process is done by using Discovery Studio Client 4.1 software. The results showed docking between COX-2 with CGA compounds and its isomers also drug Ibuprofen shows energy binding COX-2 - CGA of -320 kcal / mol, COX-2 - CQA of -298 kcal / mol, COX-2 - FQA of -282 kcal / mol, and COX-2 - Ibuprofen of -230 kcal / mol. The docking results show the CGA compound and its isomers have smaller energy bindings than the drug Ibuprofen. This shows that the CGA compound and its isomers are better than the Ibuprofen drug so that it has the potential as an anti-inflammatory which can be used to prevent the formation of atherosclerosis.
Co-Authors Gultom, Rumondang Nurarifa, Ratna Pardede, Jek Amidos Rachmawati, Devi Era Simamora, Marthalena Siregar, Rinco