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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Islamic Pharmacy
Ma'arif, Burhan
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Journal of Islamic Pharmacy

 1 
CYTOTOXIC ACTIVITY AND PHYSICOCHEMICAL PROPERTIES OF GENDARUSIN A-E COMPOUNDS ON ESTROGEN ALFA RECEPTORS (2JF9) Indrawijaya, Yen Yen Ari; Octavia, Nur Ika; Mutiah, Roihatul; Bhagawan, Weka Sidha; Ma'arif, Burhan
Journal of Islamic Pharmacy Vol 4, No 1 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i1.9037

Abstract

Estrogen Alfa (ERα) is a receptor used as the main marker to identify the presence of tumors in the breast.compounds Gendarusin A-E have anticancer activity by inhibiting the poliferation of cancer cells and inducing apoptosis. The purpose of this research are to predict the cytotoxic activity, physicochemical properties, and toxicity of the gendarusin A-E compound. The predictions of physicochemical properties were tested in compliance with the Five Lipinski Rules and the results of the ADME process (absorption, distribution, metabolism, and excretion) using the application pkCSM Online tool. Prediction of cytotoxic activity using Molegro Virtual Docker (MVD) by validating receptors and molecular docking. Cancer receptor protein used in Estrogen Alfa with PDB code 2JF9. Toxicity prediction using the Protox II Online tool. The results of this study indicate that the Gendarusin A-E compound didn’t completed the Five Lipinski Rules. Gendarusin A-E compounds had activity against receptors Estrogen Alpha which is shown by the results of RMSD 2 and Gendarusin A compounds had the smallest Rerank Score of -70.9817 compared to other compounds. Gendarusin B compound had the highest LD50  1212 mg / kg and classified in grade 4.
Analisis in Silico Senyawa Fitokimia dari Fraksi n-Heksana Daun Semanggi (Marsilea crenata Presl.) sebagai Agen Neuroprotektif Ma'arif, Burhan; Jatmiko, Ricky Arie; Megawati, Dewi Sinta; Annisa, Rahmi; Sugihantoro, Hajar; Muchlisin, Muhammad Artabah; Laswati, Hening; Agil, Mangestuti
Journal of Islamic Pharmacy Vol 5, No 1 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i1.9180

Abstract

Estrogen deficiency causes various health problems in postmenopausal women, including neurodegenerative disease. Phytoestrogens emerged as a group of compounds that can replace the estrogen function in the body, and prevent the neurodegenerative disease to occur. Semanggi (Marsilea crenata Presl.) is a typical plant in Surabaya, Indonesia, that contain phytoestrogens. The aim of this research was to determine the metabolite profile of n-hexane fraction of Semanggi leaves using UPLC-QToF-MS/MS, and then to predict the neuroprotective activity of compounds with in silico study using PyRX 0.8 software. The 100 ppm of n-hexane fraction of Semanggi leaves in DCM and methanol were injected 5 µl each into the UPLC-QToF-MS/MS, and then analyzed by Masslynx 4.1 software to determine the compounds. The compounds from metabolite profiling then prepared with SwissADME webtool and Avogadro 1.90.0 software, molecular docking was done using Autodock Vina and Biovia Discovery Studio Visualizer 2016 to 3OLS protein. Metabolite profiling process shows a total of 34 predictable compounds and 28 unknown compounds. From in silico study, it shows a total of 7 compounds that are predicted to have activities similar to estrogen. This result indicate that n-hexane fraction of Semanggi leaves has potential as a neuroprotective agent for treatment for postmenopausal women who experience estrogen deficiency.Keywords: Marsilea crenata Presl., phytoestrogens, metabolite profiling, in silico, neuroprotective
Analisis Kandungan Logam Berat Cd, Hg, dan Pb Daun Semanggi (Marsilea crenata Presl.) di Desa Semen, Kecamatan Pagu, Kabupaten Kediri Ma'arif, Burhan; Muti'ah, Roihatul; Suryadinata, Arief; Nashichuddin, Ach; Karawid, Galih Elsy
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.9356

Abstract

Semanggi (Marsilea crenata Presl.) berpotensi untuk diolah menjadi produk obat herbal karena khasiat yang dimilikinya. Namun, tanaman semanggi (Marsilea crenata Presl.) memiliki kemampuan fitoremediasi sehingga berdampak pada penimbunan logam berat yang berbahaya untuk kesehatan tubuh. Penelitian ini dilakukan untuk mengetahui kandungan logam berat Cd, Hg dan Pb pada daun semanggi di Kabupaten Kediri (Desa Semen, Kecamatan Pagu) untuk dibandingkan dengan Perka BPOM No. 12 tahun 2014 terkait batas logam berat untuk simplisia. Metode yang digunakan yaitu menggunakan Atomic Absorption Spectroscopy (AAS) pada sampel simplisia daun tanaman semanggi dan juga sampel tanah sebagai pembanding. Dari hasil pengujian sampel simplisia daun semanggi di Kabupaten Kediri (Desa Semen, Kecamatan Pagu) terdapat (Cd) dengan kadar 4,16 ppm. Hasil ini menunjukkan tidak memenuhi standar Perka BPOM No. 12 tahun 2014 karena melewati batas minimum Cd sebesar ≤ 0,3 ppm.
Co-Authors Annisa, Rahmi Arief Suryadinata Dewi Sinta Megawati, Dewi Sinta Hening Laswati Indrawijaya, Yen Yen Ari Jatmiko, Ricky Arie Karawid, Galih Elsy M. Artabah Muchlisin Mangestuti Agil Muti'ah, Roihatul Mutiah, Roihatul Nashichuddin, Ach Octavia, Nur Ika Retno Widyowati Sugihantoro, Hajar Weka Sidha Bhagawan