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Sugihantoro, Hajar
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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Pengaruh Variasi Konsentrasi Propilen Glikol Sebagai Enhancer Terhadap Sediaan Transdermal Patch Ibuprofen In Vitro Misnamayanti, Misnamayanti; Sugihantoro, Hajar; Fauziyah, Begum
Journal of Islamic Pharmacy Vol 4, No 2 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i2.8029

Abstract

Ibuprofen is an anti-inflammatory class of non-steroidal propionic acid used in the treatment of osteoarthritis, analgesics, and antipyretics. Ibuprofen made in a transdermal patch to avoid side effects of irritation to the stomach, first pass effect on application oral. This aims of the research to determine the physical characteristics of the patch, the effect of propylene glycol concentration (150 mg, 200 mg, 250 mg) on the thickness patch, pH, and the rate of penetration as increase in penetration of the ibuprofen transdermal patch. Patch preparations were made in 3 draft formulas with varying concentrations of propylene glycol 150 mg, 200 mg, and 250 mg. The method used for penetration testing is Franz diffusion cells. The results of physical characteristics are clear, odorless, dry, not cracked, 300 folds, thickness ranges from 0.142 to 0.184. The concentration of propylene glycol effects (p-value 0.05) the penetration and no effect (p-value 0.05) the pH test. Increasing the concentration of propylene glycol causes an increase medicine that penetrate the skin.Keywords: Ibuprofen, transdermal patch, propylene glycol
Analisis in Silico Senyawa Fitokimia dari Fraksi n-Heksana Daun Semanggi (Marsilea crenata Presl.) sebagai Agen Neuroprotektif Ma'arif, Burhan; Jatmiko, Ricky Arie; Megawati, Dewi Sinta; Annisa, Rahmi; Sugihantoro, Hajar; Muchlisin, Muhammad Artabah; Laswati, Hening; Agil, Mangestuti
Journal of Islamic Pharmacy Vol 5, No 1 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i1.9180

Abstract

Estrogen deficiency causes various health problems in postmenopausal women, including neurodegenerative disease. Phytoestrogens emerged as a group of compounds that can replace the estrogen function in the body, and prevent the neurodegenerative disease to occur. Semanggi (Marsilea crenata Presl.) is a typical plant in Surabaya, Indonesia, that contain phytoestrogens. The aim of this research was to determine the metabolite profile of n-hexane fraction of Semanggi leaves using UPLC-QToF-MS/MS, and then to predict the neuroprotective activity of compounds with in silico study using PyRX 0.8 software. The 100 ppm of n-hexane fraction of Semanggi leaves in DCM and methanol were injected 5 µl each into the UPLC-QToF-MS/MS, and then analyzed by Masslynx 4.1 software to determine the compounds. The compounds from metabolite profiling then prepared with SwissADME webtool and Avogadro 1.90.0 software, molecular docking was done using Autodock Vina and Biovia Discovery Studio Visualizer 2016 to 3OLS protein. Metabolite profiling process shows a total of 34 predictable compounds and 28 unknown compounds. From in silico study, it shows a total of 7 compounds that are predicted to have activities similar to estrogen. This result indicate that n-hexane fraction of Semanggi leaves has potential as a neuroprotective agent for treatment for postmenopausal women who experience estrogen deficiency.Keywords: Marsilea crenata Presl., phytoestrogens, metabolite profiling, in silico, neuroprotective
Tingkat Kepuasan Konsumen terhadap Pelayanan Kefarmasian di Apotek Ganesha Farma Kabupaten Lamongan Nisa', Zahrotun; Sugihantoro, Hajar; Syahrir, Ach; Wijaya, Dhani
Journal of Islamic Pharmacy Vol 6, No 1 (2021): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v6i1.11273

Abstract

Pharmaceutical service is a form of health service in pharmacy as an inseparable unit that plays a significant role in improving the quality of life of patients and also increasing patient satisfaction. Based on the preliminary study, the services whose provided by the Ganesha Farma Pharmacy staff are less satisfying to consumers, related to the friendliness of the pharmacy staff and the lack of provision of drug information by pharmacy staff. Therefore, in this study, it is expected to know the level of customer satisfaction at the Ganesha Farma Pharmacy, Lamongan Regency. The purpose of this study was to determine the level of customer satisfaction with pharmaceutical service at Ganesha Farma Pharmacy in Lamongan Regency.  The type of research was descriptive with a quantitative approach.  The sampling method was non-probability sampling with the purposive sampling technique. The samples obtained were 100 respondents.  The method of calculating the level of customer satisfaction was the Customer Satisfaction Index (CSI) method.  The results showed that the level of satisfaction at the reliability dimension of 70.8% (satisfied), responsivenesss 68.8% (satisfied), assurance 69% (satisfied), empathy 69.8 (satisfied), tangible 69.4% (satisfied). The conclusion of this study is the level of customer satisfaction towards pharmaceutical services at Ganesha Farma Pharmacy, Lamongan Regency is 69.56% with the satisfied category.Keywords: Level of customer satisfaction, Pharmacy, Pharmaceutical services
Co-Authors Annisa, Rahmi Begum Fauziyah Dewi Sinta Megawati, Dewi Sinta Dhani Wijaya, Dhani Hening Laswati Jatmiko, Ricky Arie M. Artabah Muchlisin Ma'arif, Burhan Mangestuti Agil Misnamayanti, Misnamayanti Nisa', Zahrotun Syahrir, Ach