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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Tropical and Infectious Disease Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal PAEDAGOGIA Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Indonesian Journal of Medicine Journal of Maternal and Child Health Jurnal Epidemiologi Kesehatan Indonesia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Aisyah : Jurnal Ilmu Kesehatan JURNAL ETIKA KEDOKTERAN INDONESIA Jurnal Pengabdian Masyarakat Sasambo Proceedings of the International Conference on Nursing and Health Sciences The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Smart Society Empowerment Journal
Tri Nugraha Susilawati
Department Of Microbiology, Faculty Of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
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Journal : Indonesian Journal of Tropical and Infectious Disease

 1 
Genital Tract Infection during Pregnancy and its Association with Preterm Delivery Tri Nugraha Susilawati; Yohanes Aditya Adhi Satria
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i3.11460

Abstract

Genital tract infection (GTI) remains a significant health concern. It is estimated that in 2016, there were 370 million people who suffer from chlamydia, gonorrhea, and trichomoniasis; and 708 million others suffer from genital herpes and condyloma acuminatum. It has been reported that in pregnant women, GTI is associated with preterm delivery. The mechanisms of GTI-associated preterm delivery need to be further understood to prevent neonatal mortality and morbidity that could be the risk factor for neonates’ growth and development disorders. This article aims to describe various types of GTI and the associated pathogenesis causing preterm birth. A literature search was conducted to retrieve recent articles published in English from online databases including Pubmed, ScienceDirect, and Google Scholar. This literature study found that GTI evokes inflammatory responses that trigger several mechanisms leading to preterm delivery. The inflammatory responses in GTI include the production of proinflammatory cytokines and robust activation of neutrophils. The key mechanisms that stimulate preterm delivery in GTI include the events of early uterine contraction, preterm premature rupture of membranes, and induction of cervical ripening; which are under normal circumstances in a full-term pregnancy, those mechanisms are regulated by progesterone and prostaglandin levels along with suppression of the inflammatory responses. In conclusion, this paper has described the underlying mechanisms of preterm delivery in pregnant women with ISG. However, such mechanisms remain unclear in candida and gonococcal infection; thus, prompting the need for further studies. 
Co-Authors Adisetya Wicaksono Ainor Rohmah Atik Susianto Benedictus Aditya Satya Laksana Adji Bhisma Murti Brian wasita Brian Wasita Brian Wasita Budiyanti Wiboworini Darmayanti, Aquartuti Tri Defitaria Permatasari Dewi Pratiwi Diana Nurrohima Dono Indarto Dono Indarto DONO INDARTO Erindra Budi Cahyanto Erindra Budi Cahyanto HERU SULASTOMO Heru Sulastomo Jusup, Sinu Andhi Kezia Elian Devina Kezia Elian Devina Kusmadewi Eka Damayanti Leli Saptawati Marisa Rizqiana Niniek Purwaningtyas Niniek Purwaningtyas Ratna Dwi Restuti Ratna Kusumawati Ratna Kusumawati Riska Larasati Saputri, Nurul Aini Suria Satria, Yohanes Aditya Adhi Setyo Sri Rahardjo Setyo Sri Rahardjo Sigit Setyawan Sri Wulandari Sri Wulandari Susianto, Atik Sutarno Sutarno Triyanta Yuli Pramana Triyanta Yuli Pramana Uki Retno Budihastuti Usman Sudarmaji Usman Sudarmaji Vitri Widyaningsih Wijiwinarsih, Amallia Winda Rahayuningtyas Winda Rizki Pebrina Batubara Yasinta Nofia Yohanes Aditya Adhi Satria Yuliana Heri Suselo