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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Bali Dermatology Venereology and Aesthetic Journal
Widyantari, Septiana
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Mucocutaneous Manifestations in HIV/AIDS Patients Hidayati, Afif Nurul; Harningtyas, Citra Dwi; Damayanti, Damayanti; Astari, Linda; Indramaya, Diah Mira; Listiawan, M. Yulianto; Utomo, Budi; Budiono, Budiono; Murtiastutik, Dwi; Widyantari, Septiana; Maylita Sari; Astindari, Astindari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 3 (2021): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.3.2021.156-161

Abstract

Background: The main target of human immunodeficiency virus (HIV) is cluster of differentiation 4 (CD4) T lymphocytes and several other immune cells that have CD4 receptors. They are also present in skin and mucosa, such as Langerhans cells (LC). Mucocutaneous lesions are one of the first clinical presentations of immunosuppression in HIV seropositive patients that manifest at different stages of the infection and require early diagnosis and prompt treatment. Purpose: To determine the clinical characteristics and the pattern of various mucocutaneous manifestations in Human immunodeficiency virus/Acquired immune deficiency syndrome (HIV/AIDS) patients at Intermediate Care and Infectious Diseases Dr. Soetomo General Academic Hospital Surabaya. Methods: This is a descriptive retrospective study with a cross-sectional design. The study subject was classified as all HIV-AIDS patients with mucocutaneous manifestations treated in Intermediate Care and Infectious Diseases Dr. Soetomo General Academic Hospital Surabaya in 2019. Result: Out of the 614 patients who participated in the study, 72.1% were males. The majority of patients were in the age group 25–49 years (75.4%). The most common risk factor was heterosexuality (41.7%). Based on the distribution of mucocutaneous manifestations, the most common mucocutaneous manifestation was candidiasis mucocutan 387 patients (49.4%) followed by the pruritic papular eruption (PPE) 118 patients (15.1%) and human papillomavirus infection 57 patients (7.3%). Conclusion: Mucocutaneous manifestations occur throughout the course of HIV infection, and they can be considered as good clinical indicators for the progression of the disease and underlying immune status in resource-poor settings.
A Rare Self-Limiting Adamantiades Behcet Diseasen in A Woman: A Case Report Fajrin, Farah Meriana; Damayanti; Hidayati, Afif Nurul; Murtiastutik, Dwi Murtiastutik; Astindari, Astindari; Widyantari, Septiana; Sari, Maylita
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 36 No. 1 (2024): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V36.1.2024.75-80

Abstract

Background: Adamantiades–Behçet is a genetically determined disorder with a probable environmental triggering factor and is an inflammatory disease representing vasculitis. Chronic relapsing progressive course, Dapson prevents problems in other organs. Case Report: A 31-year-old woman with chief complaints of a progressive painful ulcer on her genitalia in the last month, covered by pus and with a bad odor, and also recurrent tongue sores that healed spontaneously. Multiple partner sexual intercourse, joint pain, and an eye complaint were denied. Her husband has no history of previous sexually transmitted diseases. The labia majora region showed a solitary ulcer, sharply marginated, and covered with pus. The Haemophilus ducreyi, pathergy, VDRL, TPHA, and rapid test HIV all came back negative. Enterococcus faecalis, found in bacterial culture, is sensitive to Penicillin and glycopeptide. Histopathologically recited vasculitis with thrombus in the blood vessel marks Behcet disease. The patient was given Mefenamic Acid (3x500mg), doxycicline (2x100 mg), and a wet dressing. The ulcer decreased in size after 3 weeks of treatment. Discussion: Adamantiades-Behçett disease is characterized by chronic, recurrent oral aphthous ulcers, genital ulcers, skin lesions, ocular lesions, and arthritis or arthropathy. Viral and bacterial infections have been implicated in initiating immunopathologic pathways. The pathergy test is pathognomonic, but it is not specific and often gives a negative result. Histopathological examination is still the best option to establish the diagnosis. 
Profile of Scabies in Surabaya Boarding School Widyantari, Septiana; Rozita Maharani, Dinda; Muhammad Yulianto Listiawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 3 (2023): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.3.2023.199-202

Abstract

Background: Scabies is a skin infection caused by infection and susceptibility to the variant mite Sarcoptes scabiei hominis and its derivatives. Scabies disease can be transmitted through direct contact with mites and causes itching on the human body, which can develop into secondary infections. Purpose: to determine the characteristics of scabies according to age, location of lesions, and signs of lesions in students of Surabaya Boarding School on December 2021. Methods: This study is a cross-sectional descriptive study with data collection through interviews and clinical examinations. Results: Scabies included 40 cases out of 86 respondents. Scabies cases occurred in boys aged between 13 and 15 (37%). The largest proportion of lesions were found all over the body, including between the fingers (75%), between the fingers and arms (15%), between the toes and legs (7%), and underarms (3%). The most common lesions were erythema papules and crusts in 57%, erythema papules, pustules, and crusts in 28%, and erythematous macules only in 18%. Conclusion: The importance of education for children about scabies, personal hygiene behavior, environmental hygiene, and other variables that affect the incidence of scabies. It is important that all affected household members are treated and their living environment properly disinfected to ensure tick removal and ultimately prevent further transmission.
Condyloma Accuminata In Pregnancy Overlapping With Bacterial Vaginosis Widyantari, Septiana; Rozita Maharani, Dinda; Koesandrini, Kinanthi; Setyaningrum, Trisniartami
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 3 (2023): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.3.2023.226-230

Abstract

Background: Human Papilloma Virus (HPV) 6 and 11 are most commonly detected in genital warts, known as condyloma acuminata. Bacterial vaginosis (BV) is the most frequent vaginal infection in women aged 15 to 44 years. There may be an association between condyloma acuminata and BV. Purpose : To report a case of condyloma accuminata in a pregnant patient with combination bacterial vaginosis. Case: A 24-year-old, 8-week pregnant woman came to the clinic with a chief complaint of multiple warts in the genital area since 3 months prior to the hospital visit. The bumps on the vulva were small, and at first only one but then spread to surrounding areas. The bumps were itchy and painful. Complaints of vaginal discharge or fluor albus of yellowish-white gray color, accompanied by itchy and a fishy odor that appeared three months ago and worsened in the last two weeks. Examination results led to the diagnosis of condyloma acuminata and BV in the patient. The patient's condition improved after being given 90% trichloroacetic acid (TCA), electrocautery, and metronidazole. Discussion: Pregnancy decreases cell-mediated immunity, which may decrease immune tolerance and local physiologic changes and ultimately increase HPV infection in pregnancy. HPV infection is associated with a vaginal microbiota imbalance, making pregnant women prone to vaginal infections such as BV. Conclusion: Condyloma accuminata and BV often occur in high-risk groups for sexually transmitted infections, one of which is pregnant women. It is necessary to screen for sexually transmitted infections (STIs) in pregnant women to prevent complications.
Large acrochordon of labium majora: an unusual location Citrashanty, Irmadita; Luthfidyaningrum, Hamidah; Murtiastutik, Dwi; Hidayati, Afif Nurul; Widyantari, Septiana; Astindari, Astindari; Sari, Maylita
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 1 (June 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/93p62v41

Abstract

Background: Acrochordon is a soft, round or oval, pedunculated papilloma that can be tan or brown in color. Although acrochordons most commonly appear in the neck, axilla, and groin, they can also appear in unusual sites, such as penis, vulva, and perineum. Most of the lesions are small pedunculated papules or nodules approximately 2–6 mm, but rarely, particularly on the lower section of the trunk, large pedunculated acrochordons can be found. Here we present a large acrochordon on the labium majora. Case Description: A 25 years old woman came to an outpatient clinic because there was a mass on her right labium majora ever since she gave birth three years prior. The size of the mass started off relatively small but has grown significantly over time. From dermatological examination in external genitalia region, there was a solitary, pedunculated, skin-colored mass measuring 10 × 3 cm, attached to right labium majora. There was no redness, ulceration, bleeding or discharge. Cautery excision with local anesthetic was performed to removed the mass. The histopathological examination of the specimen revealed polypoidal tissue lined by epidermal layer, there are proliferation and dilation of capillaries containing erythrocytes in the dermis layer, mild infiltration of lymphocytes and histiocytes. No evidence of malignancy. Conclusion: We report an unusual location of acrochordon presenting with large size. Due to its atypical presentation, it may be confused with a malignancy, necessitating a pathological test. Total excision of the mass is recommended.
Co-Authors Afif Nurul Hidayati, Afif Nurul Astindari Astindari, Astindari Budi Utomo Budiono Budiono Damayanti Damayanti Damayanti Diah Mira Indramaya Dwi Murtiastutik Fajrin, Farah Meriana Harningtyas, Citra Dwi Irmadita Citrashanty, Irmadita Koesandrini, Kinanthi Linda Astari, Linda Luthfidyaningrum, Hamidah M. Yulianto Listiawan Maylita Sari Maylita Sari, Maylita Murtiastutik, Dwi Murtiastutik Rozita Maharani, Dinda Trisniartami Setyaningrum