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All Journal Jurnal Teknik Kimia USU Jurnal Teknik Kimia USU Molekul: Jurnal Ilmiah Kimia
Pambudi, Wisnu
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology

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Pengaruh Waktu Iradiasi Ultrasonik dengan Aktivasi Kalium Hidroksida terhadap Sifat Fisis Karbon Aktif dari Serbuk Karet End Life Tire Arifin, Uma Fadzilia; Adetya, Nais Pinta; Pambudi, Wisnu; Listyalina, Latifah; Ratnaningsih, Wahyu
Jurnal Teknik Kimia USU Vol. 13 No. 2 (2024): Jurnal Teknik Kimia USU
Publisher : Talenta Publisher (Universitas Sumatera Utara)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jtk.v13i2.15549

Abstract

Processing End Life Tire (ELT) rubber powder into activated carbon is an alternative for handling tire waste. One way to improve physical properties such as proximate characteristics, surface area and pore diameter of activated carbon is through chemical activation assisted by ultrasonic irradiation. This research aims to determine the effect of ultrasonic irradiation time with potassium hydroxide (KOH) activation on the quality of ELT rubber activated carbon. Activated carbon was synthesized and activated using 30% KOH at various ultrasonic irradiation times, namely 0 minutes, 15 minutes, 30 minutes, 45 minutes and 60 minutes. Based on the characterization results, activated carbon with an ultrasonic irradiation time of 30 minutes is the active carbon that has the most superior properties. The proximate characteristics of activated carbon meet the active carbon quality requirements of SNI 06–3730–1995 and have the highest surface area, namely 401.11 m2/g and pore diameter of 2.1652 nm, which is included in the mesoporous structure category so that it has the potential to be applied as an adsorbent for heavy metals from contaminated fluid.
Molecular Docking Analysis of Hydroxy Chalcones and Flavones from Anisaldehyde and Veratraldehyde as EGFR Inhibitors: Predicting Anticancer Potential Pambudi, Wisnu; Haryadi, Winarto; Matsjeh, Sabirin; Anwar, Chairil
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.8956

Abstract

This study aimed to investigate the potential of hydroxy chalcone and flavone derivatives as inhibitors of the epidermal growth factor receptor (EGFR) with anticancer properties. Molecular docking simulations were conducted using Autodock Tools 1.5.6 and Discovery Studio visualizer. The EGFR protein structure with the PDB code 1M17 was utilized as the receptor, explicitly targeting the binding pocket. Redocking of the reference ligand erlotinib yielded a binding energy of -7.51 kcal mol-1 with an RMSD of 0.54 Å, confirming the accuracy of the docking protocol. The hydroxy chalcone and flavone derivatives exhibited binding energies ranging from -6.50 to -7.67 kcal mol-1 when interacting with the EGFR protein. Among the studied compounds, compound 2',5'-dihydroxy-3,4-dimethoxychalcone (1g) displayed the lowest binding energy. Interactions involving amino acids such as Met769, Ala719, Thr766, Lys721, and Glu738 were identified as crucial hydrogen bonding interactions between the ligands and the EGFR protein. These findings suggest that 2',5'-dihydroxy-3,4-dimethoxychalcone holds strong potential as a tyrosine kinase inhibitor, positioning it as a promising candidate for further development as an anticancer agent. The outcomes of the computational analysis conducted through the pkCSM online platform indicated that the chemical 2',5'-dihydroxy-3,4-dimethoxychalcone had favorable pharmacokinetic characteristics and showed low toxicity levels. Keywords: molecular docking, hydroxy chalcone, flavone, egfr, ADMET
Pengaruh Waktu Iradiasi Ultrasonik dengan Aktivasi Kalium Hidroksida terhadap Sifat Fisis Karbon Aktif dari Serbuk Karet End Life Tire Arifin, Uma Fadzilia; Adetya, Nais Pinta; Pambudi, Wisnu; Listyalina, Latifah; Ratnaningsih, Wahyu
Jurnal Teknik Kimia USU Vol. 13 No. 2 (2024): Jurnal Teknik Kimia USU
Publisher : Talenta Publisher (Universitas Sumatera Utara)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jtk.v13i2.15549

Abstract

Processing End Life Tire (ELT) rubber powder into activated carbon is an alternative for handling tire waste. One way to improve physical properties such as proximate characteristics, surface area and pore diameter of activated carbon is through chemical activation assisted by ultrasonic irradiation. This research aims to determine the effect of ultrasonic irradiation time with potassium hydroxide (KOH) activation on the quality of ELT rubber activated carbon. Activated carbon was synthesized and activated using 30% KOH at various ultrasonic irradiation times, namely 0 minutes, 15 minutes, 30 minutes, 45 minutes and 60 minutes. Based on the characterization results, activated carbon with an ultrasonic irradiation time of 30 minutes is the active carbon that has the most superior properties. The proximate characteristics of activated carbon meet the active carbon quality requirements of SNI 06–3730–1995 and have the highest surface area, namely 401.11 m2/g and pore diameter of 2.1652 nm, which is included in the mesoporous structure category so that it has the potential to be applied as an adsorbent for heavy metals from contaminated fluid.
Co-Authors Adetya, Nais Pinta Chairil Anwar Listyalina, Latifah Ratnaningsih, Wahyu Sabirin Matsjeh Uma Fadzilia Arifin, Uma Fadzilia Winarto Haryadi