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All Journal Pharmaciana: Jurnal Kefarmasian MPI (Media Pharmaceutica Indonesiana) BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Prosiding Seminar Nasional Program Pengabdian Masyarakat
Octavia, Mega
Universitas Muhammadiyah Yogyakarta
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Journal : Pharmaciana: Jurnal Kefarmasian

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The effectiveness and cost of lansoprazole and pantoprazole for stress ulcer prophylaxis in intensive care unit Mega Octavia; Zullies Ikawati; Tri Murti Andayani
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.291 KB) | DOI: 10.12928/pharmaciana.v11i3.19617

Abstract

The incidence of bleeding is increased in high risk patients with critical conditions in Intensive Care Unit (ICU). Appropriate prophylaxis medicine is necessary to reduce the incidence of stress ulcer bleeding during hospitalization in ICU which further can minimize the cost of patient care in the ICU. Currently, lansoprazole and pantoprazole are used as a stress ulcers prophylaxis. Nevertheless, there has not been sufficient evidence proving their effectiveness. This study was aimed to compare the effectiveness and cost between iv lansoprazole and iv pantoprazole as a stress ulcer prophylaxis in ICU. In this retrospective observational study, the data were obtained from medical records of all patients admitted to ICU in a District Hospital in Yogyakarta from January 2014 until December 2016. Effectiveness of therapy were obtained from objective data in the medical record by looking at the incidence of major (clinically significant) and minor (overt gastrointestinal) bleeding. Chi-square analysis was performed to analyze the difference of bleeding incidence. The average cost was presented as Expected Monetary Value (EMV), which consisted of the cost of prophylaxis and treatment of bleeding. The difference in average cost was analyzed using independent t-test. A total of 119 patients were included in this study. There were 62 patients in the lansoprazole group and 47 patients in the pantoprazole group. Forty eight patients (77,4%) from lansoprazole group and 35 patients (61,4%) from pantoprazole group did not experience any GI bleeding. There was no statistical difference in the incidence of GI bleeding between the two groups (CI 95%, P-value = 0.057). The EMV of lansoprazole group was higher than pantoprazole group IDR 645.122,57 and IDR 511.629,39 respectively. In conclusion, there was no significant difference regarding the effectiveness between iv lansoprazole and iv pantoprazole as stress ulcer prophylaxis. Costs for the prophylaxis of stress ulcers is lower on the use of pantoprazole compared to lansoprazole.
Co-Authors Abdul Samad Aji Winanta Aji Winanta Andy Eko Wibowo Asni Fathul J Dhiva Andarika F Dyani Primasari Sukamdi Fanny Rohimatul Azizah Putri Inayati Murwani Rahayu Indriastuti Cahyaningsih, Indriastuti Ingenida Hadning Ingenida Hadning M. Fariez Kurniawan Muhammad Thesa Ghozali Pinasti Utami, Pinasti Pramitha Esha Nirmala Dewi Susi Susilowati Syagata, Anindhita Syahbi Tri Murti Andayani Tyas Fabandari Dewi Hapsari Vella Laili Damarwati Zullies Ikawati Zullies Ikawati