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All Journal Pharmaciana: Jurnal Kefarmasian JSFK (Jurnal Sains Farmasi & Klinis) Pharmaceutical Sciences and Research (PSR)
Rachmaini, Fitri
Fakultas Farmasi Universitas Andalas
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model Rahmad Abdillah; Fitra Fauziah; Putri Indah Lestari; Fitri Rachmaini
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (401.752 KB) | DOI: 10.12928/pharmaciana.v12i1.19667

Abstract

Averrhoa bilimbi L. is used widely as spices and traditional medicine, which contained several chemical compounds such as alkaloid, flavonoid, saponin, and tannin. The aim of this study is to discover the best dose of ethyl acetate fraction from A.bilimbi leaves, which have pharmacology activity on total cholesterol and triglycerides in the hypercholesterolemic model. Thirty adult male white mice were divided into six groups; each group was containing five animals. Five groups were given high-fat diet foods and PTU induced the animals to obtain hypercholesterolemia with a frequency of 1 time a day orally for 14 days, while the normal group was given vehicle (Na CMC 5%) and standard feed. On the 15th day the normal group was given vehicle (Na CMC 5%), negative control group was given high-fat feed, positive control group was given atorvastatin dose 0.26 mg/kg BW, and another group was given ethyl acetate fraction of A.bilimbi leaves dose 200, 400, and 800 mg/kg BW orally. All animal were treated until the 28th day. On day 29, the bloods were taken to determine the total cholesterol and trygliceride levels using clinical photometer 5010 v5+. The data was statistically analyzed using a one-way ANOVA followed by the Duncan Multiple Range Test.. This study indicates that administration of ethyl acetate fraction from A.bilimbi leaves can affect the total cholesterol levels and triglycerides in hypercholesterolemic mice (P<0.05). Ethyl acetate fraction dose 200 mg/kg BW shows the best activity in decreasing total cholesterol levels and triglycerides on mice hypercholesterolemic model (P<0.05).
The comparison between combination of candesartan-amlodipine and candesartan-furosemide on blood pressure in hypertensive patients with chronic kidney disease Fitri Rachmaini; Dian Ayu Juwita; Almahdy A; Rahmad Abdillah; Yolanda Mayestika Wati
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (446.191 KB) | DOI: 10.12928/pharmaciana.v12i2.21491

Abstract

Chronic renal disease is significantly increased by hypertension. Controlling blood pressure is critical in hypertensive individuals. Patients who have good blood pressure (BP) control can reduce morbidity and mortality. This study aimed to compare blood pressure reduction of candesartan-amlodipine with the candesartan-furosemide combination in hypertensive patients with chronic renal disease. The study was conducted by a cohort study design. Retrieval of medical record data was carried out prospectively during the period February-April 2019. The blood pressure reduction was assessed by changes in mean systolic and mean diastolic blood pressure and mean diastolic blood pressure and was analyzed statistically with the SPSS program. A total of 54 patients met the inclusion criteria, consisting of 27 patients receiving candesartan-amlodipine combination and 27 patients receiving candesartan-furosemide combination therapy. The results of the sociodemographic characteristics patients were male 30 patients (55.6%), age 56-65 years 24 patients (44.4%), senior high school education level 31 patients (57.4%). Candesartan-amlodipine and candesartan-furosemide combinations both decreased blood pressure in patients. However, the result of the statistical analysis revealed that there was no significant difference in blood pressure decline. (p> 0.05) between the two combinations.
Profil Terapi Antihipertensi dan Antihiperlipidemia Terhadap Fungsi Ginjal Pasien Diabetes Melitus Tipe 2 dengan Komplikasi Penyakit Ginjal Kronis di RSUP Dr. Hasan Sadikin Rachmaini, Fitri; Amalia, Lia; Rahayu, Cherry
Pharmaceutical Sciences and Research Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Chronic Kidney Disease (CKD) complication increases the risk of morbidity and mortality in type 2 diabetes mellitus (DMT2) patients. The presence of hypertension and dyslipidemia as comorbidity increases the risk of macrovascular and microvascular complications and further adding to the list of drugs used. Management of this comorbidity is essential to prevent cardiovascular events and minimize kidney damage. This study aimed to evaluate therapeutic profile of antihypertensive and antihyperlipidemia drugs towards kidney function in DMT2 patients with CKD complication at Dr. Hasan Sadikin Hospital. Study was done by using a prospective single cohort design with consecutive sampling technique and obtained 37 patients. Serum creatinine, ureum and eGFR values were collected from December 2017 to February 2018 and became the basis of analysis in this study. The result of this study showed that there was a significant decrease in creatinine serum (p < 0.05), ureum (p < 0.05) and a significant increase in eGFR value (p < 0.05) after three months therapy. Based on the result it can be concluded that therapeutic profile of antihypertensive and antihyperlipidemia can control kidney function in DMT2 patients with CKD complication after three months study based on serum creatinine, ureum and eGFR values.
Effect of Propolis on Bone Quality and Cortical Bone Thickness of Ovariectomized Female Wistar White Rats as A Model for Osteoporosis Juwita, Dian Ayu; Ahmadin, Almahdy; Rachmaini, Fitri; Abdillah, Rahmad; Fatma, Rosalia Medisa
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Abstract

Estrogen deficiency increases the rate of osteoporosis, especially in menopausal women, by altering the bone tissue microarchitecture. Propolis has compounds that could be used as an alternative therapy to treat estrogen deficiency and to protect against bone damage. This study aims to determine the effect of propolis on bone quality and cortical bone thickness of femoral metaphysis in ovariectomized female Wistar white rats as a model for menopausal osteoporosis. The rats were divided into five groups: negative control group (not subjected to ovariectomy), sham group (subjected to ovariectomy), and treatment groups that were subjected to ovariectomy and given propolis orally at a dose of 180 mg/kg BW, 360 mg/kg BW, and 720 mg/kg BW for 30 days. Bone quality and cortical bone thickness testing were undertaken on the 31st day. The osteoblast and osteoclast cell examination was evaluated using an Olympus BX 51 light microscope at 400x magnification for bone quality and the Betaview program, Beta 3.1MP Sony Exmor CMOS Sensor camera at 40x magnification for cortical bone thickness. Data were analyzed using the one-way ANOVA and continued with Duncan’s multiple range tests. It was found that propolis had a significant effect on the ratio of osteoblast and femur bone osteoclasts (p0.05). The administration of propolis at a dose of 180 mg/kg BW, 360 mg/kg BW, and 720 mg/kg BW had an effect in decreasing the ratio of osteoblasts and metaphysical osteoclast cells of femoral metaphysics. However, propolis administration did not affect the thickness of the femoral metaphysical cortical bone
Drugs Related Problems (DRPs) Pada Pasien Penyakit Ginjal Kronik (PGK) Di RSUP Dr. M. Djamil Dian Ayu Juwita; Fitri Rachmaini; Rahmad Abdillah; Meliani Meliani
Jurnal Sains Farmasi & Klinis Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.184-189.2022

Abstract

Penyakit Ginjal Kronis (PGK) ditandai dengan penurunan fungsi ginjal secara ireversibel yang dapat mempengaruhi proses eliminasi obat dari dalam tubuh. Drugs Related Problems (DRPs) merupakan suatu peristiwa terkait pengobatan bersifat aktual ataupun potensial yang dapat mempengaruhi hasil terapi pasien. Penelitian ini bertujuan untuk mengetahui persentase kejadian DRPs dan hubungan antara kejadian DRPs dengan kondisi pulang pasien didiagnosis PGK. Penelitian ini dilakukan secara retrospektif. Pengumpulan data dilakukan melalui rekam medis pasien pada tahun 2021. Analisis data dilakukan secara deskriptif dan uji korelasi Spearman Rank. Sebanyak 74 pasien memenuhi kriteria inklusi, terdiri dari 44 pasien laki-laki (59,46%) dan 30 pasien perempuan (40,54%). Rentang usia pasien PGK terbanyak adalah 46-55 tahun, yakni 22 pasien (29,73%). Ditemukan kejadian DRPs yakni indikasi tanpa terapi pada 7 pasien (35%), dosis obat kurang pada 1 pasien (5%), dan dosis obat berlebih pada 12 pasien (60%). Pada penelitian ini 67 orang pasien (90,54%) pulang dengan kondisi perbaikan, 5 orang pasien (6,76%) pulang dengan kondisi belum sembuh, dan 2 orang pasien (2,74%) meninggal. Dapat disimpulkan bahwa pada terdapat kejadian DRPs meliputi indikasi tanpa terapi, dosis obat kurang, dan dosis obat berlebih yang ditemukan pada pasien dengan Penyakit Ginjal Kronis (PGK) dalam penelitian ini. Tidak ada hubungan bermakna antara kejadian DRPs dengan kondisi pulang pasien (p>0,05).
Pengaruh Penggunaan Obat Antihipertensi Terhadap Tekanan Darah Dan Proteinuria Pada Pasien Preeklampsia Berat Di RSUP Dr. M. Djamil Fitri Rachmaini; Dian Ayu Juwita; Rahmad Abdillah; Melvi Auliya Rifqi
Jurnal Sains Farmasi & Klinis Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.175-183.2022

Abstract

Kondisi preeklampsia dapat berkembang menjadi eklampsia yang beresiko meningkatkan angka kematian bagi ibu dan janin. Obat antihipertensi dapat digunakan untuk pengobatan preeklampsia. Penelitian ini bertujuan mengetahui pengaruh penggunaan obat antihipertensi terhadap nilai tekanan darah dan proteinuria pasien didiagnosis preeklampsia berat. Metode yang digunakan adalah retrospektif cross-sectional. Pengumpulan data dilakukan melalui rekam medis dari Januari sampai Desember 2021. Data disajikan dalam 76 pasien memenuhi kriteria inklusi. Hasil penelitian menunjukkan terdapat 19 pasien (23%) menggunakan monoterapi antihipertensi metildopa atau nifedipin, 30 pasien (39,47%) menggunakan kombinasi metildopa dan nifedipin, dan empat pasien (5,26%) menggunakan kombinasi metildopa, nifedipin dan furosemide. Rata-rata penurunan tekanan darah sistolik dan diastolik (TDS/TDD) paling besar yaitu 85,25 mmHg dan 29,5 mmHg. Sedangkan rata-rata penurunan nilai proteinuria paling besar yaitu 2. Berdasarkan hasil tersebut diketahui bahwa terdapat pengaruh signifikan penggunaan obat antihipertensi terhadap TDS (p=0,000), TDD (p=0,000), dan nilai proteinuria (p=0,002). Penurunan nilai tekanan darah dan proteinuria lebih efektif terjadi pada terapi kombinasi dibandingkan dengan monoterapi.
Profil Tingkat Pengetahuan dan Edukasi Penggunaan Suppositoria pada Pasien Rawat Jalan di Rsup Dr. M. Djamil Padang Hansen Nasif; Fitri Rachmaini; Hafifah Putri Jayusman; Safira Pramilita Gunawan
Jurnal Sains Farmasi & Klinis Vol 9, No 3 (2022): J Sains Farm Klin 9(3), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.3.271-276.2022

Abstract

ABSTRAKSuppositoria merupakan sediaan obat dengan cara penggunaan khusus, yang mengharuskan pasien memiliki pengetahuan tentang cara penggunaan suppositoria yang benar. Penelitian ini bertujuan melihat perbedaan tingkat pengetahuan penggunaan suppositoria sebelum dan sesudah diberikan edukasi. Penelitian ini merupakan suatu  penelitian analitik, pengambilan sampel dilakukan secara purposive sampling. Sampel penelitian didapatkan dari 43 responden yang merupakan pasien rawat jalan yang menebus resep suppositoria di Depo Farmasi Rawat Jalan RSUP Dr. M. Djamil Padang. Teknik pengambilan data melalui pre-test/post-test design menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya dan edukasi melaui media leaflet. Analisis yang dilakukan menggunakan uji Wilcoxon. Hasil yang didapatkan pada saat pre-test tingkat pengetahuan responden yang dominan terdapat dalam kategori cukup 60,47% dan post-test yang dominan dalam kategori baik 90,70%. Hasil penelitian menunjukkan terdapat perbedaan yang bermakna pada skor pengetahuan responden antara sebelum dan sesudah pemberian edukasi (p= 0,000). Dapat disimpulkan bahwa terdapat  perbedaan skor pengetahuan pasien yang menggunakan suppositoria sebelum dan sesudah diberikan edukasi.Kata kunci: Pengetahuan; Edukasi; Suppositoria; Leaflet; Pre-test; Post-test ABSTRACTSuppositories are drug with a spesial way of use,with required the  patients to have knowledge of how to use suppositories correctly. This research  aim to study the difference in the level of knowledge in usage of suppositories before and after being given education. An analytical  research, by purposive sampling.The research sample was obtained from 43 respondents who were outpatients who bought suppository prescription to Outpatient Pharmacy Depot, at Dr. M. Djamil public hospital in Padang. Data collection techniques through pre-test/post-test design using questionnaires that have been tested for validity and reliability and education through leaflet media (p=0.000). The analysis was carried out using Wilcoxon's test. The results obtained during the pre-test showed that the dominant respondent's level of knowledge was in the sufficient category 60.47% and the post-test dominant in the good category 90.70%. The results showed that there was a significant difference in the level of knowledge of respondents between before and after giving education through leaflet media (p= 0.000). It can be concluded that there are differences in the level of knowledge  patients who use suppositories before and after being given education. Keyword: Knowledge; Education; Suppositories; Leaflet; Pre-test; Post-test
Profil Tingkat Pengetahuan dan Edukasi Penggunaan Suppositoria pada Pasien Rawat Jalan di Rsup Dr. M. Djamil Padang Hansen Nasif; Fitri Rachmaini; Hafifah Putri Jayusman; Safira Pramilita Gunawan
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 No 3 (2022): J Sains Farm Klin 9(3), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.3.271-276.2022

Abstract

ABSTRAKSuppositoria merupakan sediaan obat dengan cara penggunaan khusus, yang mengharuskan pasien memiliki pengetahuan tentang cara penggunaan suppositoria yang benar. Penelitian ini bertujuan melihat perbedaan tingkat pengetahuan penggunaan suppositoria sebelum dan sesudah diberikan edukasi. Penelitian ini merupakan suatu  penelitian analitik, pengambilan sampel dilakukan secara purposive sampling. Sampel penelitian didapatkan dari 43 responden yang merupakan pasien rawat jalan yang menebus resep suppositoria di Depo Farmasi Rawat Jalan RSUP Dr. M. Djamil Padang. Teknik pengambilan data melalui pre-test/post-test design menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya dan edukasi melaui media leaflet. Analisis yang dilakukan menggunakan uji Wilcoxon. Hasil yang didapatkan pada saat pre-test tingkat pengetahuan responden yang dominan terdapat dalam kategori cukup 60,47% dan post-test yang dominan dalam kategori baik 90,70%. Hasil penelitian menunjukkan terdapat perbedaan yang bermakna pada skor pengetahuan responden antara sebelum dan sesudah pemberian edukasi (p= 0,000). Dapat disimpulkan bahwa terdapat  perbedaan skor pengetahuan pasien yang menggunakan suppositoria sebelum dan sesudah diberikan edukasi.Kata kunci: Pengetahuan; Edukasi; Suppositoria; Leaflet; Pre-test; Post-test ABSTRACTSuppositories are drug with a spesial way of use,with required the  patients to have knowledge of how to use suppositories correctly. This research  aim to study the difference in the level of knowledge in usage of suppositories before and after being given education. An analytical  research, by purposive sampling.The research sample was obtained from 43 respondents who were outpatients who bought suppository prescription to Outpatient Pharmacy Depot, at Dr. M. Djamil public hospital in Padang. Data collection techniques through pre-test/post-test design using questionnaires that have been tested for validity and reliability and education through leaflet media (p=0.000). The analysis was carried out using Wilcoxon's test. The results obtained during the pre-test showed that the dominant respondent's level of knowledge was in the sufficient category 60.47% and the post-test dominant in the good category 90.70%. The results showed that there was a significant difference in the level of knowledge of respondents between before and after giving education through leaflet media (p= 0.000). It can be concluded that there are differences in the level of knowledge  patients who use suppositories before and after being given education. Keyword: Knowledge; Education; Suppositories; Leaflet; Pre-test; Post-test
Pengaruh Penggunaan Obat Antihipertensi Terhadap Tekanan Darah Dan Proteinuria Pada Pasien Preeklampsia Berat Di RSUP Dr. M. Djamil Fitri Rachmaini; Dian Ayu Juwita; Rahmad Abdillah; Melvi Auliya Rifqi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.175-183.2022

Abstract

Kondisi preeklampsia dapat berkembang menjadi eklampsia yang beresiko meningkatkan angka kematian bagi ibu dan janin. Obat antihipertensi dapat digunakan untuk pengobatan preeklampsia. Penelitian ini bertujuan mengetahui pengaruh penggunaan obat antihipertensi terhadap nilai tekanan darah dan proteinuria pasien didiagnosis preeklampsia berat. Metode yang digunakan adalah retrospektif cross-sectional. Pengumpulan data dilakukan melalui rekam medis dari Januari sampai Desember 2021. Data disajikan dalam 76 pasien memenuhi kriteria inklusi. Hasil penelitian menunjukkan terdapat 19 pasien (23%) menggunakan monoterapi antihipertensi metildopa atau nifedipin, 30 pasien (39,47%) menggunakan kombinasi metildopa dan nifedipin, dan empat pasien (5,26%) menggunakan kombinasi metildopa, nifedipin dan furosemide. Rata-rata penurunan tekanan darah sistolik dan diastolik (TDS/TDD) paling besar yaitu 85,25 mmHg dan 29,5 mmHg. Sedangkan rata-rata penurunan nilai proteinuria paling besar yaitu 2. Berdasarkan hasil tersebut diketahui bahwa terdapat pengaruh signifikan penggunaan obat antihipertensi terhadap TDS (p=0,000), TDD (p=0,000), dan nilai proteinuria (p=0,002). Penurunan nilai tekanan darah dan proteinuria lebih efektif terjadi pada terapi kombinasi dibandingkan dengan monoterapi.
Drugs Related Problems (DRPs) Pada Pasien Penyakit Ginjal Kronik (PGK) Di RSUP Dr. M. Djamil Dian Ayu Juwita; Fitri Rachmaini; Rahmad Abdillah; Meliani Meliani
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.184-189.2022

Abstract

Penyakit Ginjal Kronis (PGK) ditandai dengan penurunan fungsi ginjal secara ireversibel yang dapat mempengaruhi proses eliminasi obat dari dalam tubuh. Drugs Related Problems (DRPs) merupakan suatu peristiwa terkait pengobatan bersifat aktual ataupun potensial yang dapat mempengaruhi hasil terapi pasien. Penelitian ini bertujuan untuk mengetahui persentase kejadian DRPs dan hubungan antara kejadian DRPs dengan kondisi pulang pasien didiagnosis PGK. Penelitian ini dilakukan secara retrospektif. Pengumpulan data dilakukan melalui rekam medis pasien pada tahun 2021. Analisis data dilakukan secara deskriptif dan uji korelasi Spearman Rank. Sebanyak 74 pasien memenuhi kriteria inklusi, terdiri dari 44 pasien laki-laki (59,46%) dan 30 pasien perempuan (40,54%). Rentang usia pasien PGK terbanyak adalah 46-55 tahun, yakni 22 pasien (29,73%). Ditemukan kejadian DRPs yakni indikasi tanpa terapi pada 7 pasien (35%), dosis obat kurang pada 1 pasien (5%), dan dosis obat berlebih pada 12 pasien (60%). Pada penelitian ini 67 orang pasien (90,54%) pulang dengan kondisi perbaikan, 5 orang pasien (6,76%) pulang dengan kondisi belum sembuh, dan 2 orang pasien (2,74%) meninggal. Dapat disimpulkan bahwa pada terdapat kejadian DRPs meliputi indikasi tanpa terapi, dosis obat kurang, dan dosis obat berlebih yang ditemukan pada pasien dengan Penyakit Ginjal Kronis (PGK) dalam penelitian ini. Tidak ada hubungan bermakna antara kejadian DRPs dengan kondisi pulang pasien (p>0,05).
Co-Authors Abdillah, Rahmad Ahmadin, Almahdy Almahdy A Dian Ayu Juwita Fatma, Rosalia Medisa Fitra Fauziah Hafifah Putri Jayusman Hansen Nasif LIA AMALIA Meliani Meliani Melvi Auliya Rifqi Putri Indah Lestari Rahayu, Cherry Safira Pramilita Gunawan Yolanda Mayestika Wati