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Ketut Mulyadi
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Ekspresi Protein Ki-67 pada Biopsi Kolonoskopi Adenoma dan Karsinoma Kolorektal Ni Made Maharini Rahayu; Moestikaningsih .; Ketut Mulyadi
Majalah Patologi Indonesia Vol 23 No 3 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Background Neoplastic lesion in colorectal could be adenoma and colorectal carcinoma (CRC). An invasion in muscularis mucosa is a criteria for colorectal carcinoma. Diagnosis is formed with histopatologic interpretation. In colorectal-biopsy preparation interpretation, determining limited invasion is sometimes difficult so that it needs other diagnostic tools. The aim of this study was to evaluating the difference of Ki-67 mean expression in colorectal adenoma and CRC. Methods This study was cross-sectional study on colorectal adenoma and CRC. Cases were diagnosed by colonoscopy-biopsy between 2011 and 2012. It did re-interpretation of HE preparation of adenoma or colorectal carcinoma diagnosis and determination of the degree of differentiation of those adenoma and colorectal carcinoma. Immunohistochemical Ki-67 staining was interpreted with light microscope. The percentage of the stained tumour cells was counted. The difference of mean in Ki-67 expression of colorectal adenoma and CRC was analyzed with t-test with significance level at p
Ekspresi P16INK4a pada Squamous Cell Carcinoma Serviks Uteri dan Cervical Intraepithelial Neoplasia 1, 2, 3 Luh Yeni Laksmini; Moestikaningsih .; Gede Raka Widiana; Ni Putu Sriwidyani; Ketut Mulyadi
Majalah Patologi Indonesia Vol 23 No 3 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Background Cervical cancer is the second most common cancer in female in the world. In Bali, in 2008, cervical cancer is the second most common malignancy after breast cancer. This cancer has known to develop from precancerous lesions, cervical intraepithelial neoplasia (CIN).There is difficulty to determine grade of dysplasia of the uterine cervix and to predict wheather the lesion has potency of progression. The expression of P16INK4a has correlation with degree of cervical dysplasia and carcinoma. The aim of this study is to evaluate expression of P16INK4a in squamous cell carcinoma (SCC) of cervix uteri and CIN1, CIN2, CIN3. Methods A cross sectional analytic study was performed on 60 samples that divided into 10 CIN1, 10 CIN2, 10 CIN3, and 30 SCC. Samples were tooken from block paraffin archive from Private Laboratory in Denpasar and Anatomical Pathology Laboratory Sanglah Hospital, during January 1st 2011 until Juny 30th 2013. Immunostaining was performed to determine the expression score of P16INK4a. Expression of P16INK4a was determined by for scoring system base on staining grade and intensity. The result was analyzed by Kruskal Wallis test with level of significance α at p
Hubungan Derajat Diferensiasi dan Tingkat Kedalaman Invasi Tumor terhadap Densitas Sel Limfosit T CD3+ dan Limfosit B CD20+ pada Adenokarsinoma Kolorektal Novitasari Novitasari; Ketut Mulyadi; Luh Putu Iin Indrayani Maker
Majalah Patologi Indonesia Vol 26 No 2 (2017): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Latar belakangPemahaman mengenai lingkungan mikro lokal tumor sebagai salah satu faktor prognosis dan prediktif masih perlu ditingkatkan. Salah satunya adalah respon imun adaptif in situ (intratumoral dan peritumoral). Infiltrat sel-sel imun bersifat sangat heterogen antar tipe tumor dan antar pasien. Penelitian ini bertujuan untuk mengukur densitas sel limfosit T CD3+ dan limfosit B CD20+ intratumoral dan peritumoral pada berbagai kelompok derajat diferensiasi dan tingkat kedalaman invasi tumor sebagai bukti adanya respon imun adaptif in situ pada karsinoma kolorektal (KKR).MetodePenelitian ini menggunakan metode analitik potong lintang dengan sampel sebesar 46 kasusyang kemudian dilakukan pulasan imunohistokimia CD3 dan CD20. Perbedaan ekspresi pada masing-masing kelompok dianalisis dengan uji One Way Anova dan Kruskal-Wallis, sedangkan hubunganantara variabel bebas dan tergantung dinilai dengan uji multipel regresi linear dengantingkat kemaknaan (α)=0,05.HasilHasil uji statistikmemperlihatkan perbedaan bermakna densitas sel limfosit T CD3+ intratumoral antar kelompok derajat diferensiasi (p=0,000) dan tingkat kedalaman invasi tumor (p=0,042); densitas sel limfosit B CD20+ intratumoral dengan tingkat kedalaman invasi tumor (p=0,029); dan densitas sel limfosit B CD20+ peritumoral dengan derajat diferensiasi (p=0,021) dan tingkat kedalaman invasi tumor (p=0,000). Pada uji multipel regresi linear, didapatkan hubungan yang bermakna antara derajat diferensiasi terhadap densitas sel limfosit T CD3+ intratumoral (p=0,000) dan tingkat kedalaman invasi tumor terhadap sel limfosit B CD20+ peritumoral (p=0,000).KesimpulanTerdapathubungan antara derajat diferensiasi dan tingkat kedalaman invasi tumor dengan densitas sel limfosit T CD3+ intratumoral dan limfosit B CD20+ peritumoral pada adeno-karsinoma kolorektal sebagai bukti adanya respon imun adaptif pada keganasan.
Co-Authors I Gde Raka Widiana Luh Putu Iin Indrayani Maker Luh Yeni Laksmini Moestikaningsih . Ni Made Maharini Rahayu Ni Putu Sriwidyani Novitasari Novitasari