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All Journal Majalah Patologi Indonesia Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES)
Nana Liana
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Humanities Health Professions Medicine & Pharmacology Public Health

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Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Adenokarsinoma Kolorektal Nana Liana; Noza Hilbertina; Loli Devianti; Husna Yetti
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (432.332 KB) | DOI: 10.55816/mpi.v31i1.490

Abstract

BackgroundColorectal carcinoma is the third most common malignancy in the world. Colorectal carcinoma is a heterogeneous tumor withdifferent clinical pathologic features and prognostic values. For the same tumor-stage, patients could have difference prognosis andit has been suggested that the angiogenesis might be correlated with the prognosis, especially expression of vascular endothelialgrowth factor (VEGF) as the main pro-angiogenic factor. High VEGF expression in colorectal adenocarcinoma is associated withincreased blood vessels in invasive tumor area, cell proliferation and metastases. However, relation VEGF expression with thedegree of differentiation and lymphovascular invasion is not known.MethodsThis was a retrospective observational study with cross sectional approach. Samples were obtained from 39 paraffin blocks withdiagnosis adenocarcinoma not otherwise specific (NOS) in four Anatomical Pathology Laboratory in West Sumatera 2018 andevaluated for degree of differentiation and lymphovascular invasion. VEGF expressions in tumor cell were analyzed usingimmunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant.ResultsColorectal adenocarcinoma with high grade differentiation entirely had high VEGF expression (100%), while low gradedifferantiation with high VEGF expression was 60.7%. Lymphovascular invasion positive was mostly found with high VEGFexpression (80.6%). Statistical analysis showed significant association between VEGF expression with degree of differentiation(p=0.017) and lymphovascular invasion (p=0.028).ConclusionThe conclusion was VEGF expression had significant association with degree of differentiation and lymphovascular invasion ofcolorectal adenocarcinoma.
EDUKASI POLA MAKAN GIZI SEIMBANG DI BULAN RAMADHAN Dita Hasni; Sri Nani Jelmila; Nana Liana; Ruhsyahadati
Abdika Sciena Vol 1 No 2 (2023): JURABDIKES Volume I No 2, December 2023
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/jurabdikes.v1i2.104

Abstract

kepada tubuh untuk beristirahat khususnya pada organ pencernaan. Selain itu, berpuasa juga memberikan kesempatan tubuh untuk proses detoksifikasi dan regenerasi sistem imun. Pada saat berpuasa, terjadi perubabahan pola hidup seperti perubahan pola makan dan tidur yang dapat mempengaruhi kebugaran tubuh. Kurangnya pengetahuan mengenai pola makan yang baik selama berpuasa menjadi faktor yang dapat mempengaruhi kebugaran tubuh dalam melaksanakan ibadah ramadhan. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan masyarakat tentang pola makan yang baik selama menjalani ibadah puasa ramadhan. Kegiatan dilaksanakan pada hari Minggu, 05 Maret 2023 di Masjid Rahmatan Lil’alamin Kota Padang. Kegiatan dihadiri oleh 20 orang peseerta yang merupakan ibu-ibu majlis taklim. Kegiatan ini telah berhadil meningkatkan pengetahuan peserta tentang pola makan dengan gizi seimbang pada bulan ramadhan. Diharapkan pengetahuan ini dapat diterapkan oleh peserta dalam kehidupan sehari-hari agar tetap fit dalam menjalankan ibadah puasa ramadhan.
Co-Authors Dita Hasni Husna Yetti Loli Devianti Noza Hilbertina Ruhsyahadati Sri Nani Jelmila