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All Journal International Journal of Public Health Science (IJPHS) Pharmaciana: Jurnal Kefarmasian Jurnal Surya Medika JURNAL ILMU KEFARMASIAN INDONESIA Pharmacoscript Ahmad Dahlan Medical Journal Annals of Mathematical Modeling

Endang Darmawan

Universitas Ahmad Dahlan

Author-ID : 2410128

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Public Health

Published : 14 Documents Claim Missing Document

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Analisis Survival Suhu Tubuh pada Pasien Pneumonia yang Diberikan Vitamin D Arief Rafsanjani; Endang Darmawan; Nurcholid Umam Kurniawan
Jurnal Surya Medika (JSM) Vol 5 No 2 (2020): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Pneumonia is caused due to an infection in the lungs so antibiotics need to be administered for its management. Giving antibiotic combination therapy gives pretty good results in some cases, but the problem of mortality rates that occur is still high, it is necessary to be given additional therapy to increase the patient's cure rate. One of the adjuvant therapies that can be given is vitamin D. vitamin D is known to play a role in the body’s defense function, both in natural and adaptive immunity and plays a role in the body’s defense in cases of infections, allergies, malignancies, and autoimmune. This research was an experimental Double-Blind Randomized Clinical Trial. The study subjects were pediatric patients aged six months to 18 years who were divided into two groups, namely the intervention group (n = 35) and the control group (n = 35). The intervention group received vitamin D, while the control group received a placebo. Data observed were body temperature. This study aimed to determine the effectiveness of vitamin D based on the parameters of fever in pediatric patients with pneumonia infections treated at the Muhammadiyah Bantul Hospital. The results of this study prove that vitamin D is able to provide a chance of survival on the third day after the administration of vitamin D

Profil Penggunaan Obat Kombinasi Risperidone-Clozapine dan Risperidone dengan Antipsikotik Lain pada Pasien Gangguan Mental Psikotik di Rumah Sakit Jiwa Grhasia Yogyakarta Mexsi Mutia Rissa; Endang Darmawan; Arum Siwinarni
Jurnal Surya Medika (JSM) Vol 5 No 2 (2020): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Approximately 7% of Indonesia's population experience mental disorders psychosis. Yogyakarta Special Region is the second-highest incidence of psychotic mental disorders with a rate of 10 per 1000 population and 80% of those treated in mental hospitals with schizophrenia. Pharmacotherapy management in patients with psychotic mental disorders with the use of antipsychotics, both single and combination. Antipsychotics are classified as atypical antipsychotics and typical antipsychotics. Both groups of antipsychotics have the same pharmacological activity, namely blocking dopamine D2 receptors. The study design is prospective. Inclusion criteria for adult patients (18-65 years), who are inpatient, get risperidone-clozapine antipsychotic therapy and risperidone with other antipsychotics and have complete data. Data obtained from medical records and analyzed with univariate tests to describe the distribution of patients. Bivariate testing to compare the two treatment groups. The number of samples at the end of the study were 32 patients who were divided into 2 groups of antipsychotic antipsychotics, risperidone-clozapine, and risperidone with other antipsychotics. The results of this study show that the therapeutic group that is often used is the combination of risperidone-clozapine compared to risperidone with other antipsychotics in patients with psychotic mental disorders at Yogyakarta Grhasia Mental Hospital.

Survival Analisis Suhu Tubuh pada Pasien Diare yang Diberikan Vitamin D Sutrimo Usali R; Endang Darmawan; Nurcholid Umam Kurniawan
Jurnal Surya Medika (JSM) Vol 5 No 2 (2020): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Diarrhea is a disease that attacks the digestive system, and most caused by microorganisms (bacteria and viruses) Diarrhea is still the second largest cause of death in the world after pneumonia and is still a public health problem in developing countries like Indonesia. Vitamin D is a potential mediator in regulating the immune system to become the body's defense against infection. This study aims to determine the effectiveness of vitamin D based on body temperature parameters. The study was conducted using a double-blind randomized clinical trial experimental research design, in which researchers conducted clinical trials in the control group (placebo) and there was a comparison group (vitamin D adjuvant). Vitamin D provides a better chance of survival as well as a better chance of a decrease in body temperature compared to patients who do not get vitamin D therapy as an adjuvant (additional). Significant results occurred on days 3, 5 and 6.

Narrative Review: Nano Kapsul Ekstrak Biji papaya (Carica Papaya L.) sebagai Antifertilitas Shinta Nur Fajriyah; Yuliana Eka Lestari; Nadiatul Istiqamah Suaka; Endang Darmawan
Jurnal Surya Medika (JSM) Vol 6 No 2 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i2.1688

Papaya (Carica Papaya L.) is a plant commonly found in Indonesia. Interestingly, its seeds traditionally used as antifertility. All parts of the Carica Papaya tree can be used for human needs from the fruit, leaves, seeds, sap, and stems. Carica Papaya seed extract contains secondary metabolite compounds in class Triterpenoids, flavonoids, alkaloids, saponins, and tannins which have functioned as antifertility. Nanocapsule is an innovation of nanoparticle dosage form with small particle size, that can accelerate the drug to the target. This Narrative Review purposed to determine the usefulness of the nanocapsules of Carica Papaya seed extract as antifertility. This research is a Narrative Review. A total of 36 articles that met the inclusion and exclusion criteria were analyzed descriptively, which include the efficacy of Carica Papaya, nanocapsules, and antifertility. The articles used include articles published in national journals and international journals. The result of the Narrative Review is presented in descriptive form. The results of the research show that Carica Papaya can be used traditionally to treat skin diseases, diarrheal disease, overcoming digestive disorders, and by research can be used as antifertility, The size of the nanoparticles obtained in the study ranged from 76.47 nm to 693.8 nm, and Carica Papaya seed extract is used as an antifertility by reducing sperm quantity, semen pH, spermatogenesis process, interfering the action of pituitary gonads, by preclinical reducing the number of ovum quality and the number of de Graff Follicles in female mice. Overall, it can be concluded that Carica Papaya nanocapsules in particle sizes between 76.46 nm to 693.8 nm can be used as antifertility that preclinically can affect the reproduction of female and male mice.

Obat Herbal dari Akar Manis (Glycyrrhiza glabra L.) untuk Pencegahan dan Pengobatan Infeksi Virus H1N1, H5N1 dan COVID-19: Systematic Review Sulutaniyah Sulutaniyah; Endang Darmawan
Jurnal Surya Medika (JSM) Vol 8 No 1 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i1.2603

Herbs have been used as a form of traditional medicine since ancient times. Licorice is one of the herbs that has long been used as medicine. This plant contains different plant compounds, such as glycyrrhizin, 18β‐glycyrrhetinic acid, glabrins A and B, and isoflavones, showing various pharmacological activities. Pharmacological experiments have shown that different extracts and pure compounds of this species exhibit broad biological properties, including antibacterial, anti-inflammatory, antiviral, antioxidant, and antidiabetic activities. This systematic review aims to determine the effectiveness of herbal medicine from licorice (Glycyrrhiza glabra L.) to prevent and treat H1N1, H5N1, and COVID-19 virus infections from various previous research results. This research is a systematic review using the PRISMA method. A total of 8 articles that met the inclusion and exclusion criteria were continued for analysis. A total of 8 articles discuss the effectiveness of licorice on the H1N1, H5N1, and COVID-19 viruses. The articles used include articles published in national journals and international journals. The results showed that 1) Licorice root is effectively used for the prevention and treatment of H1N1, H5N1, and COVID-19 virus infections, 2) Glycyrrhizic acid (GA) is the main compound for the development of potential anti-influenza virus agents. Overall, it can be concluded that licorice and some of its derivatives have the potential as anti-influenza agents for H1N1, H5N1, and COVID-19.

Analisis Kaplan Meier terhadap Perbaikan Klinis Batuk pada Pasien Pneumonia Anak yang Diberikan Terapi Tambahan Vitamin D Arief Rafsanjani; Endang Darmawan; Nurcholid Umam Kurniawan; Tri Puspita Yuliana; Aditya Noviadi Rakhmatullah
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2632

Pneumonia is the leading cause of death in children under five years of age and contributed to 14% of total global child deaths in 2013. Pneumonia is an inflammation of the lungs caused by bacteria, viruses, fungi, parasites and attacks the lung parenchyma. After receiving antibiotic therapy, the cure rate for pneumonia is relatively high, but the mortality rate due to pneumonia infection is still high. Therefore there needs to be an effort to add therapy to improve patient clinical outcomes. Vitamin D plays a role in the body's defense function, both in natural and adaptive immunity and in the body's defense in cases of infection, malignancy, and autoimmunity. This study was an experimental double-blind, randomized clinical trial that was analyzed using Kaplan Meier. The research subjects were children aged six months to 18 years divided into two treatment groups, namely the treatment group (n = 35) and the control group (n = 35). The treatment group received vitamin D, while the control group a placebo. The data taken included the results of clinical studies of patients. This study indicates that vitamin D is effective in accelerating the cough frequency of patients infected with pneumonia.

Modulasi Neurotransmitter pada Gangguan Kognitif Hewan Coba dengan Nanoemulsi Ekstrak Ipomoea aquatica Forsk Nadiatul Istiqamah Suaka; Salma Ersyara Putri Nugraha; Rizka Arum Pratiwi; Rahmadia Nurafifah; Endang Darmawan
Jurnal Surya Medika (JSM) Vol 7 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i2.2693

Alzheimer's is a type of dementia characterized by a progressive decline in cognitive function, including all intellectual functions, causing a person to experience difficulties in carrying out daily activities. Ipomoea aquatica Forsk is a plant that has a high antioxidant content that can improve cognitive behavior, memory and increase neurotransmitters. The purpose of this study was to determine the modulating effect of the neurotransmitter nanoemulsion extract of Ipomoea aquatica Forsk on cognitive impairment in experimental animals. This study used 5 groups of mice consisting of a normal control group, a sick control group, a drug control group with two dose levels, namely nanoemulsion extract of Ipomoea aquatica Forsk 200 mg/kg BW and 400 mg/kg BW, and a comparison group, each group consisted of 5 mice. All groups were induced by trimethyltin (TMT) except the normal group. The memory image was obtained from the Morris Water Maze test which was analyzed by one-way repeated measure ANOVA. The Ipomoea aquatica Forsk extract nanoemulsion with a dose of 200 mg/kg BW was able to improve the cognitive function of experimental animals, which was indicated by the Ipomoea aquatica Forsk extract test results showing almost the same MWM results as mice were given donepezil.

Co-Authors Aditya Noviadi Rakhmatullah Adnan, Adnan Akrom, Akrom Arief Rafsanjani Arum Siwinarni Dini Mardhiyani Fatwa Hasbi Mexsi Mutia Rissa Muhammad Muhlis Nadiatul Istiqamah Suaka Nurcholid Umam Kurniawan Nurcholid Umam Kurniawan Prita Anggraini Kartika Sari Rahmadia Nurafifah Rizka Arum Pratiwi Rizma Nurfadjrin Salma Ersyara Putri Nugraha Shinta Nur Fajriyah Simeftiany Indrilemta Lomo Sugiyarto Sulutaniyah Sulutaniyah Sutrimo Usali R Sutrimo Usali R Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Tri Julia Purnamasari Tri Puspita Yuliana Yuliana Eka Lestari Zaky Nurfaiz

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