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All Journal International Journal of Public Health Science (IJPHS) Jurnal Keperawatan Jiwa (JKJ): Persatuan Perawat Nasional Indonesia Journal of Biomedicine and Translational Research Global Medical and Health Communication MNJ (Malang Neurology Journal) Journal of Dedicators Community J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Caring : Jurnal Pengabdian Masyarakat ZAHRA: JOURNAL OF HEALTH AND MEDICAL RESEARCH Journal of Nursing Science Update Indonesian Nursing Journal of Education and Clinic (Jurnal Pendidikan dan Praktik Keperawatan Indonesia)
Alfrina Hany
Universitas Brawijaya
Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Journal of Biomedicine and Translational Research

 1 
Effect of Aerobic Exercise on Left Ventricular Connexin43 Expression and Distribution in Juvenile and Young Adult Rats Rustiana Tasya Ariningpraja; ‪Dewi Irawati Soeria Santoso; Ahmad Aulia Jusuf; Alfrina Hany
Journal of Biomedicine and Translational Research Vol 7, No 1 (2021): April 2021
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v7i1.10690

Abstract

Background: Gap Junction (GJ) plays a role in supporting the heart electricity. Connexin43 (Cx43) as the main protein constituent of GJ in left cardiac ventricle, will increase in number and slightly redistributed to the lateral sides of cardiomyocytes after aerobic exercise in adulthood. The effects of aerobic exercise that begin at childhood are not well known.Objective: This study aims to observe the effect of aerobic exercise which started from childhood on left ventricle Cx43 distribution.Methods: This study was conducted on 28 male Juvenile (4 weeks) and young adult (8 weeks) rats, divided into 7 groups: 1) Juvenile rats undergoing 4 weeks of exercise (E-J4); 2) Control E-J4 (C-J4); 3) Juvenile rats undergoing 8 weeks of exercise (E-J8); 4) Control EJ-8 (C-J8); 5) Juvenile rats undergoing 12 weeks of exercise (E-J12; 6); Young adult rats undergoing 8 weeks of exercise (E-Yo8); 7) Control E-J12 and E-Yo8 (C-JY128). Exercise group will undergo different length of duration, starting from week 4 until 12 weeks. Cx43 was identified by immunohistochemical staining and analyzed with ImageJ software. Comparison was analyzed using independent t-test.Results: Insignificant lower of total Cx43 expression in E-J4 (64200.45 + 4243.676 total area, p >0.05) compared to control. In contrast, a significant higher of total Cx43 expression was observed in EJ-8, EJ-12 and E-Yo8 (80152.95 + 3760.481, p = 0.001; 75596.775 + 3976.333, p = 0,002; 81216.85+ 2475.768, p = 0,000). Slightly higher of lateral Cx43 redistribution occurred in all aerobic exercise, with significant lateralization in E-J8 and E-Yo8.Conclusion: Aerobic exercise increases Cx43 and slightly redistributed to lateral myocytes under normal condition both in juvenile and young adult rats.
Co-Authors Ahmad Aulia Jusuf Ahmad Hasyim Wibisono Aura Tasya Amalia Ayut Merdikawati Bintari Ratih Kusumaningrum Dewi Irawati Soeria Santoso Dewi Purnama Sari Dewi Purnama Sari Dina Dewi Sartika Lestari Ismail Efris Kartika Sari Endang Susilowati Eni Yulistianingsih Esther Palupi Fatma, Endah Panca Lydia Heri Kristianto Ika Herani Indah Kumala Sari Klara Yunita Inuq Thomas Kuswantoro Rusca Putra LInda WIeke Noviyanti Lusy Asa Akhrani Magdalena Ayu Christanti Masruroh Rahayu Masruroh Rahayu Mifetika Lukitasari Niswatul Asyiroh Nurona Azizah Rustiana Tasya Ariningpraja Syahrun Syahrun Syahrun Syahrun Yati Sri Hayati Yuyun Yueniwati