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All Journal Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi JCES (Journal of Character Education Society) ad-Dawaa : Journal of Pharmaceutical Sciences

Ahmad Najib

Fakultas Farmasi Universitas Muslim Indonesia

Author-ID : 2485527

Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Published : 19 Documents Claim Missing Document

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PENGUJIAN AKTIVITAS ANTIOKIDAN EKSTRAK TERPURIFIKASI DAUN TEH HIJAU DAN JATI BELANDA Abd. Malik; Aktsar Roskiana Ahmad; Ahmad Najib
Jurnal Fitofarmaka Indonesia Vol 4, No 2 (2017): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Teh hijau memiliki nama spesies Camellia sinensis (L.) Kuntze, family Theaceae dan Jati belanda (Guazuma ulmifolia Lam.) termasuk kedalam family sterculiaceae. Ekstrakse dengan metode maserasi termodifikasi microwave dengan pelarut air. Purifikasi ekstrak dengan menggunakan pelarut dengan tingkat kepolaran yang berbeda-beda dimulai dengan petroleum eter, kloroform, etil asetat dan metanol. Pengujian aktivitas antioksidan dengan metode peredaman radikal DPPH. Hasil penelitian dipeoleh rendamen ekstrak terpurifikasi ekstrak teh hijau 13,33 % dan jati belanda 46,66 %.Pengujian antioksidan menunjukkan nilai IC50 jati belanda yaitu 10,13 ppm, lebih besar dibandingkan teh hijau yaitu 31,13 %.

PENGEMBANGAN TARGET TERAPI PADA HEPATITIS C Ahmad Najib
As-Syifaa Jurnal Farmasi Vol 1, No 2 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v1i2.102

For the development of new, specific anti-HCV drugs, an understanding of the HCV life cycle in particular the genomic organization and polyprotein processing, is essential. It has resulted in the development of several agents that target specific stages of the life cycle, the so-called specifically targeted antiviral therapy for HCV (STAT-C) drugs. Potential processes for viral inhibition include virus entry into the host cell, proteolytic processing, RNA replication, and the assembly and release of the new virions. Among the most promising new agents in development are the protease and polymerase inhibitors, as discussed below. RNA-targeted therapies, such as antisense oligonucleotides, ribozymes and small interfering RNA (siRNA)-targeting structures, have shown substantial success at inhibiting the HCV life cycle in vitro, but not in vivo. The structural viral envelope proteins E1 and E2, as well as their assembly, represent other potentialantiviral targets. Analogous to a recently developed HIV cell fusion inhibitor, detailed understanding of HCV cell fusion and cell entry could permit the development of specific HCV entry inhibitors.Key Word : HCV, Antiviral, Target Specific

PEMERIKSAAN FARMAKOGNOSTIK DAN PROFIL KROMATOGRAFI LAPIS TIPIS TUMBUHAN SARANG SEMUT (Myrmeco diapendans Merr. & Perry) ASAL KABUPATEN TELUK BINTUNI PAPUA BARAT Abd Kadir; Ahmad Najib; Fazlur Rachman
As-Syifaa Jurnal Farmasi Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Pharmacognostic assay and Profile of Thin Layer Chromatography Myrmecodia Plant (Myrmecodia pendens Merr & Perry) from Bintuni Bay, west Papua. Morphologycal Identification showed that Myrmecodia Plant (Myrmecodia pendens Merr & Perry) include magnoliopsida class with steep root system. Leaf anantomy from the leaf showed that anomositic type stomata.Powder extracbility of Myrmecodia Plant (Myrmecodia pendens Merr & Perry) including total ash is 33,92% and insoluble acid ash is 7,78%. While in the water soluble extractive 15,09% and aethanol soluble extractive 5,40%. Chemical identification on the tuberous powder showed that it is consist of tannin (pirogalotanin) and flavanoid. Profile of Thin layer chromatography obtained total spot more diethyl ether extract equel to 8 spot and n-butanol extract equal to 5 spot with n-hexene : ethyl acetate (8:2( and Chloroform : methanol : water (10:6:0,5).Key words : Pharmacognostic, Myrmecodia pendens, Thin layer chromatography

ISOLASI DAN IDENTIFIKASI KOMPONEN KIMIA FRAKSI n-HEKSANA DAUN TUMBUHAN JERINGAU (Acorus calamus Linn.) Ari Wahyuni; Abd Kadir; Ahmad Najib
As-Syifaa Jurnal Farmasi Vol 4, No 1 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Isolation and identification of n-Hexane faction from Sweet Flag leaves (Acorus calamus Linn.) was done. The aim of research is determine the chemical compound on it leaf, which was commonly used as the traditional medicine. Sample from 250 grams of dried Sweet Flag leaf, macerate using methanol, produce 21.563 grams dried extract. Isolation of n-hexane faction using column chromatography method with various mobile phases. The isolate identified by UV and IR spectroscopy method. From the data result show that the isolate has a specific compound.Key words : Isolation, Acorus calamus, UV-Vis, IR

PELATIHAN PEMBUATAN MINYAK AROMATERAPI PADDINGING Risda Waris; Asni Amin; Ahmad Najib
JCES (Journal of Character Education Society) Vol 3, No 2 (2020): JULI
Publisher : Universitas Muhammadiyah Mataram

Abstrak: Analisa situasi masyarakat Desa Paddinging, mayoritas masyarakat bekerja sebagai petani dan hanya memanfaatkan hasil tani sebagai mata pencaharian. Masyarakat tidak lagi memiliki kegiatan keseharian selain bertani oleh sebab itu membuat minyak aromaterapi memiliki peluang besar yang dapat dilakukan ibu PKK bahkan kedepannya jika rutin dan terorganisir bisa menambah pendapatan masyarakat desa. Program ini bisa membantu meningkatkan pengetahuan warga untuk mengolah jahe dan sereh menjadi minyak aromaterapi. Dengan demikian tujuan pengabdian masyarakat ini adalah memberikan pelatihan dasar cara membuat minyak aromaterapi. Pelaksanaan program kerja dilakukan dengan metode pendekatan, diskusi, pelatihan dan praktek lapangan. Langkah-langkah program telah terlaksana dan mencapai hasil sesuai yang diharapkan yaitu pelatihan dan pendampingan pembuatan minyak aromaterapi berbahan jahe, sereh, kayu manis dan cengkeh yang di beri label “Minyak Aromaterapi Cap Paddinging” sebagai obat pegal-pegal, meringankan sakit kepala, melancarkan peredaran darah bahkan antinyamuk. Pemberdayaan masyarakat dalam pembuatan minyak aromaterapi sebagai kelompok sasaran dilakukan melalui pendekatan, diskusi, pelatihan dan praktek lapangan membuat minyak aromaterapi Cap Paddinging.Abstract: Analysis of the community situation of Paddinging village, the majority of people work as farmers and only utilize the crops as a livelihood. People no longer have daily activities other than farming because it makes aromatherapy oil has a great opportunity that PKK mother can do even in the future if routine and organized can increase the income of village people. This Program can help increase the knowledge of residents to cultivate ginger and lemongrass into aromatherapy oils. Thus the purpose of this community devotion is to provide basic training on how to make aromatherapy oils. Implementation of a work program is done by approach method, discussion, training, and field practice. The steps of the program have been carried out and achieved the results as expected is the training and mentoring the making of aromatherapy-based oils ginger, lemongrass, cinnamon, and clove labeled "Aromatherapy oil Cap Paddinging" as medicine aches, relieves headaches, blood circulation even mosquito repellent. Community empowerment in the manufacture of aromatherapy oil as a target group is done through the approach, discussion, training, and practice of the field making aromatherapy oil Cap Paddinging.

Penentuan Kadar Flavonoid Ekstrak Etil Asetat Daun Sukun (Artocarpus altilis) A. Trihadi Kusuma; Andi Adelah; Zainal Abidin; Ahmad Najib
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 1 No 1 (2018)
Publisher : Universitas Islam Negeri Alauddin Makassar

Daun sukun (Artocarpus altilis) merupakan salah satu obat tradisional yang sudah lama digunakan untuk mengatasi berbagai penyakit. Beberapa senyawa yang telah diketahui mampu mengambat pertumbuhan kanker yang terdapat dalam daun sukun adalah senyawa golongan flavonoid. Penelitian ini bertujuan untuk menentukan kadar flavonoid ekstrak etil asetat daun sukun. Sampel diekstrak menggunakan metode maserasi dengan pelarut etil asetat. Penentuan kadar flavonoid menggunakan spektrofotometri yang diukur pada panjang gelombang 435 nm, dengan pembanding kuersetin (QE). Hasil penelitian ini menunjukkan kandungan flavonoid pada ekstrak etil asetat daun sukun adalah 29,442±1,20 mgQE/g.

Postprandial Bioassay and Radical Scavenging on n-Hexane Fraction of Cordia myxa L. Leaf Virsa Handayani; Aktsar Roskiana Ahmad; Nur Rezky Khairun Nisaa; La Hamidu; Ahmad Najib
Jurnal Fitofarmaka Indonesia Vol 9, No 3 (2022): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i3.917

Cordia myxa L. is empirically used as an antidiabetic medication. The aim of this study is to determine the in-vivo effect of Cordia myxa L. n-hexane fraction on reducing blood sugar levels and their relationship with the anti-free-radical activity assay using DPPH (1,1-diphenyl-2-Picrylhydrazyl). The n-hexane fraction of Cordia myxa L. was used as a sample in the post-prandial assay which was analyzed using the ANOVA statistical test followed by Post-Hoc test. The results showed that there were significant in the extract using a 500 mg dose. In the anti-free-radical test using DPPH (1,1-diphenyl-2-Picrylhydrazyl) at maximum wavelength of 516 nm, 16.49 µg /mL IC50 value was obtained. For comparison, Quercetin with IC50 0.13 µg/mL was used. This shows that the sample has strong anti-free radical inhibitory potential ranged from 10 µg/mL to 50 µg/mL. The data from the calculation showed that there is a correlation between its effect of lowering high blood sugar level and anti-free radical activity

Studi Komparasi Aktivitas Antiradikal Bebas Ekstrak Metanol Kulit Buah Pisang Ambon (Musa acuminata Colla) Muda dan Matang dengan Metode DPPH Abd. Malik; Reni Fauziah; Ahmad Najib
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.1062

Ambonese banana fruit peel has antioxidant, antimicrobial, and anti-inflammatory activities. This search aims to investigate the potential of free radical scavengers based on the binding of DPPH free radicals (1,1-Diphenyl-2-picryl Hidrazil). Ambonese banana fruit peel was extracted by maceration using methanol. Free radical activity assay on sample measured by inhibition of DPPH using spectrophotometer UV-Vis at a wavelength at 516 nm. Identification by the TLC method showed that the peel extract of Ambonese banana was active as free radical scavengers where the DPPH solution changed in color from purple to yellow after being sprayed. The calculation results in IC50 values of each sample methanol extract of unripe Ambonese banana fruit peel is 11.78 µg/mL, while the methanol extract of the ripe Ambonese banana fruit peel is 151.56 µg/mL. The standard quercetin has IC50 values of 4.44 µg/mL. The result showed that the methanol extract from the Ambonese banana fruit peel (Musa acuminata Colla) has antioxidantactivity.

Studi Penambatan Molekuler Senyawa Tectoquinone Terhadap Enzim α-Glukosidase Ahmad Najib; Rais Razak; Izzatul Fikril Mujtahid
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.1059

The investigation focused on conducting an in silico screening of chemical compounds isolated from Syzygium oblanceolatum (C.B.Rob) to identify potential bioactive compounds that could act as inhibitors of α-Glucosidase. This screening involved tectoquinone as the potential inhibitor for α-Glucosidase and employed the Autodock Vina Docking process. The target enzyme, α-Glucosidase, was used as the receptor with 20 binding sites on the enzyme receptor 1LWJ and the Autodock Vina program was utilized for this purpose. The values of ∆Gbind and the lowest RMSD were determined for each of the 20 targeted binding sites on 1LWJ, representing the free energy change (∆G) resulting from the docking. The docking results demonstrated that the free energy change (∆G) for the 20 targeted binding sites ranged from -6.346 kcal/mol to -9.720 kcal/mol. The most favorable free energy change (∆G) was observed at the 16th binding site with a value of -9.720 kcal/mol, while the highest was recorded at the 18th binding site with a value of -6.346 kcal/mol.

Co-Authors A Amaliah Dahlia A. Trihadi Kusuma Abd Kadir Abd. Malik Abdullah Mahmud Aktsar Roskiana Ahmad Andi Adelah Andi Herlinda Ari Wahyuni Asni Amin Aswar Aswar Bafadal, Mentarry Fazlur Rachman Hamidu, La Izzatul Fikril Mujtahid Linda Erviana Nur Rezky Khairun Nisaa Nurhawa Vitalia Nurul Purnama Wati Rais Razak Reni Fauziah Rezki Amriati Syarif Rezki Amriati Syarif Risda Waris Risda Waris Risda Waris Saida I. Suradji Selpida Handayani Siti Sya'diyah Virsa Handayani, Virsa Zainal Abidin

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