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All Journal EKSAKTA: Journal of Sciences and Data Analysis Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Universa Medicina Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Healthy-Mu Journal Refleksi Pembelajaran Inovatif JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Zainuri Sabta Nugraha
Departemen Anatomi Fakultas Kedokteran Universitas Islam Indonesia
Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : EKSAKTA: Journal of Sciences and Data Analysis

 1 
The Effect of Subchronic Administration of Soursop (Annona muricata) Leaf Aqueous Extract In Bax Expression on Gastric Glandular and Non Glandular Mucosal Epithelium of Rat (Rattus norvegicus) Ety Sari Handayani; Zainuri Sabta Nugraha; Chandra Muhammad Rauf; Yusa Muhammad Thoriq; Nurul Hidayah
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 3, ISSUE 1, February 2022
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol3.iss1.art7

Abstract

Soursop leaf water extract (SLWE) contains acetogenin compounds which are mitochondrial complex I inhibitors. This compound can reduce cellular ATP production and induce apoptosis via bax pathways, causing side effects on cells. Gaster is a digestive organ that has direct contact with acetogenin. Gastric cells contain mitochondria and undergo physiological apoptosis.This study aims to determine the effect of subchronic administration of SLWE on bax expression on glandular/non glandular mucosal epithelium gastric of rats. This study was conducted at Research Laboratorium, Medical Faculty, UII, 2019. This study uses post test only control group design. The subjects were 10 female rats, Spraque-dawley strain which was divided into 2 groups; the treatment and the control group. The treatment group received extract of SLWE at a dose of 1000 mg/kgBB/day for 30 days, while the control group received aquades, both were administered using sonde. Observation of bax expression was performed on each IHC preparation with bax antibody. The difference in bax expression between the control and treatment groups was tested by t-test. There were significant differences in the number of bax expressions in gastric glandular mucosa (p 0.038) and non-glandular gastric mucosa (p 0.027) between the treatment group and the control group. There was an effect of subchronic administration of SLWE on bax expression on mucosalepithelium for both, glandular and non-glandular of rat gaster. There were differences in the number of glandular gastric as well as non-glandular gastric mucosa epithelium which exerted bax between the control and treatment groups
Co-Authors . Harijadi Arie Nugroho Chandra Muhammad Rauf Ety Sari Handayani Ety Sri Handayani Febiawan Ismunandar Fitriyanto, Raden Edi Fuad Khadafianto Ika Fidianingsih Kinasih D S Kuswati Kuswati Kuswati, Kuswati Muchamad Marwan Muhammad Yusuf Hisyam Nurul Hidayah NURUL HIDAYAH Prilly i Raleka Pahlevawati Sahdella Sahdella Soedjono Aswin Untung Widodo Wimpy Wimpy Yusa Muhammad Thoriq Yusi Maulina