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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Sain Veteriner Jurnal Ilmiah Perikanan dan Kelautan Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Biotechnology UNEJ e-Proceeding Biosaintifika: Journal of Biology & Biology Education Journal of Aquaculture and Fish Health Indian Journal of Forensic Medicine & Toxicology Berkala Penelitian Hayati Jurnal Kedokteran Hewan
Win Darmanto
Fakultas Sains & Teknologi Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Journal : Indian Journal of Forensic Medicine

 1 
Renal Protective Effects of Gamma-Mangostin in Streptozotocin-Induced Diabetic Mice Saikhu Akhmad Husen1,2, Salamun1 , Arif Nur Muhammad Ansori3 , Suhailah Hayaza4 , Raden Joko Kuncoro
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10562

Abstract

This study was aimed to investigate the ability of gamma-mangostin to reduce plasma blood urea nitrogen (BUN) and creatinine and ameliorates the impaired renal proximal tubular cells in diabetic mice. Antioxidant assay was conducted by using male BALB/c mice. Mice were divided into two groups, they were normal control (KN) and streptozotocin-induced diabetic mice. Streptozotocin (STZ) induction was performed using multiple low-dose of 30 mg/kg body weight injected for five consecutive days. Diabetic mice have divided into three subgroups; diabetic control (KD), diabetic mice treated with acarbose (KA), and diabetic mice treated with gamma-mangostin. The gamma-mangostin treatment group was categorized based on the dose given; P1 (1 mg/kg BW), P2 (2 mg/kg BW), and P3 (4 mg/kg BW). Interestingly, gamma-mangostin administration was found to be able to lower plasma BUN and creatinine and ameliorate the impaired renal proximal tubular cells in diabetic mice significantly. Therefore, gamma-mangostin has demonstrated high antioxidant activity. The proof suggests that gamma-mangostin is a lead compound candidate for clinical management or prevent diabetes mellitus.
Adverse Effects of Mercury Exposure in DDW Strain Mice during Organogenesis Win Darmanto1 , Saikhu Akhmad Husen2 , Arif Abu Hasan3 , Raden Joko Kuncoroningrat Susilo4, Suhailah
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12277

Abstract

Mercury (Hg) was known as a teratogenic which is distributed in tissue. This study aims to determine theretention and embryotoxicity of Hg-exposed pregnant mice. Thirty female mice was treated with HgCl2(mercuric chloride). HgCl2 (5 and 6 kg/mg BW) was inducted in pregnant mice at 9 and 11 gestational days.Hg levels were measured in hair, uterus, liver, kidney, brain, blood, placenta, visceral fetus, and fetus brain onthe 18th day of gestation using the atomic absorption spectrophotometry (AAS) method. Embryotoxicity teston the fetus was carried out after the surgery took place. Scales and calipers are used to calculate fetal weightand crown rump length. Statistical tests were analyzed using the SPSS 21 program. The results showed thatthe liver, kidney, brain, visceral fetal, and fetal brain were significantly increased (P < 0.05) in the treatmentgroup at pregnant mice. Hg also produced a significant difference (P < 0.05) on the decrease in live fetuses,fetuses, body weight, and crown rump length and an increase in resorbed fetuses. Hg accumulation in thebody apparently can cause adverse effects in pregnant mice.
Co-Authors Agoes Soegianto Agus Abadi Alifah Hayati Andita Ayu Mandasari Aulanni'am, Aulanni'am Bambang Poernomo Betti Lukiati Binti Yunaida Diah Titik Mutiarawati Djoko Agus P. Dwi Winarni Eko Prihiyantoro Eko Prihiyantoro Endang Dewi Masithah Harianto Notopuro I.B. Rai Pidada Intan Permata Putri Is Yuniar Juliana Christyaningsih Lailatul Lutfiyah, Lailatul Listijani Suhargo, Listijani Mammed Sagi Manikya Pramudya Mochammad Amin Alamsjah Mufasirin Nadyatul Ilma Indah Savira Nanik Siti Aminah Natalia Tri Astuti Nunuk Dyah Retno Lastuti Nurmalasari Darsono P Kumaladewi Pieter Kakisina Ria Harmonis Rr. Juni Triastuti Samekto Wibowo Sapto Andriyono Sri Kadarsih Soedjono Sri Puji Astuti Sri Puji Astuti Wahyuningsih, Sri Puji Astuti Sukardiman Susilowati, Rina Priastini Suvia Widyaningrum Tri Dewanti W. Widhi Dyah Sawitri YULIA IRNIDAYANTI Yuni Kilawati