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All Journal HAYATI Journal of Biosciences Folia Medica Indonesiana Jurnal Matematika dan Ilmu Pengetahuan Alam Prosiding Seminar Biologi Journal of Tropical Biodiversity and Biotechnology Health Notions Biosaintifika: Journal of Biology & Biology Education Jurnal Vokasi Indonesia Jurnal Respirologi Indonesia Berkala Penelitian Hayati Jurnal Vokasi Indonesia

Dwi Winarni

Department Of Biology, Faculty Of Science And Technology, Airlangga University, Surabaya

Author-ID : 418198

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 22 Documents Claim Missing Document

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Struktur Komunitas Teripang di Pantai Timur Surabaya Winarni, Dwi
Jurnal Matematika dan Ilmu Pengetahuan Alam Vol 17, No 1 (2015)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (50.452 KB)

The objectives of this research were to obtain diversity, relative abundance, distribution, and habitat preference of sea cucumber species along east Surabaya coastal. Identification, data distribution, relative abundance and habitat preference of sea cucumbers were observed at 12 sites along Surabaya east coastal. Parameters to describe environment were water depth, brightness level of water, pH (water and substrate), salinity (water and substrate) and the texture of substrate. The texture of substrate was determined based on particles diameter of substrate (ASTM method). The research revealed that during September 2009 until October 2010, physical and chemical parameters of environment didnât change relatively, and the sea cucumber community in east Surabaya coastal composed of seven species, namely Phyllophorus dobsoni, Paracaudina australis, Cholochirus quadrangularis, Holothuria sanctori, Holothuria sp., H. forskali, and H. turriscelsa. Phyllophorus dobsoni was the most abundant species and could be found almost at all sampling sites while sandy substrate was the preferred habitat.Keywords: sea cucumber, distribution, habitat preference, east Surabaya coastal

Bee Pollen Effect on Blood Glucose Levels in Alloxan-induced Male Wistar Rats Rahayu, Aprilia Nurcahyaning; Wirjatmadi, Bambang; Adriani, Merryana; M., Soenarnatalina; Winarni, Dwi; Hartiningsih, Sri
Health Notions Vol 2 No 1 (2018): January, 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Okra Polysaccharides Improves Spleen Weight and B-Lymphocytes Proliferation in Mice Infected by Staphylococcus aureus Wahyuningsih, Sri Puji Astuti; Pramudya, Manikya; Putri, Intan Permata; Savira, Nadyatul Ilma Indah; Winarni, Dwi; Suhargo, Listijani; Darmanto, Win
Biosaintifika: Journal of Biology & Biology Education Vol 9, No 3 (2017): December 2017
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v9i3.11284

Okra (Abelmoschus esculentus) is reported to have various biological functions such as antioxidant, anticancer and anti-inflammation. However, only few studies have been reported immunomodulatory activities of okra to prevent disease caused by bacteria infection. In this study, the immunomodulatory activities of polysaccharides from okra pods were investigated further through the spleen weight and B-lymphocytes proliferation in mice infected by Staphylococcus aureus. Okra polysaccharides were obtained by water extraction and ethanol precipitation. Okra polysaccharides with doses of 25, 50, 75, and 100 mg/kg BW were orally administrated to mice with or without Staphylococcus aureus infection. Spleen weight was evaluated in both treatment group and control group. B-lymphocytes proliferation was evaluated by MTT assay using LPS induction. Results showed that okra polysaccharide at the doses of 50, 75, and 100 mg/kg increased spleen weight (p < 0.05) significantly. While at the dose of 75 and 100 mg/kg, it increased the B-lymphocytes proliferation (p < 0.05) significantly. There is positive correlation between the spleen weight and B-lymphocytes proliferation by 73.3%. These result reveal that okra polysaccharide could improve the immune response and be utilized as a novel candidate of neutraceutical.

The Effect of Dayak Onion Bulb-Stem (Eleutherine Palmifolia (L.,) Merr.) Extract on Blood Glucose Levels of Mouse Suffered Diabetes Mellitus Arwati, Niluh; Wijatmadi, Bambang; Adriani, Merryana; Meilanani, Soenarnatalina; Winarni, Dwi; Hartiningsih, Sri
Health Notions Vol 2 No 3 (2018): March 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.312 KB)

Dayak onions (Eleutherine Palmifolia (L.) Merr.) bulb stem contains phtyochemical contents, which act as antidiabetic compounds, such as eleutherol, eleuthocide A, and eleutherinoside B, as well as antioxidant compounds, which include triterpenoid, poliphenol, and flavonoid. Dayak onions was able to be used as the antidiabetic, since it had the ability to lower the blood glucose level and prevent from the free radicals, thus supressing the oxidative stress condition. This research had purpose to analyze the effect of Dayak onions bulb-stem as antioxidant and anti diabetic drugs. The research used experimental method with the population in this research was 25 male white mice strain wistar. The concentration of Dayak onions bulb-stem extracts were 300mg.kgBW-1, 400mg.kgBW-1, and 500mg.kgBW-1. Data analysis used Tukey HSD Test with 95% of  significance degree and was continued using manova test (average group ratio test). The result showed that. the extract of Dayak onions bulb-stem had the antidiabetical and antioxidant activity, which could lower the blood glucose levels and malondialdehid on the male white mice strain Wistar with the optimum effective doze of 500 mg.kgBW-1.   Keywords: Dayak onions bulb-stem, Blood glucose level, Malondialdehid (MDA)

The Effect of Dayak Onion Bulb-Stem (Eleutherine Palmifolia (L.,) Merr.) Extract on Blood Glucose Levels of Mouse Suffered Diabetes Mellitus Niluh Arwati; Bambang Wirjatmadi; Merryana Adriani; Soenarnatalina Meilanani; Dwi Winarni; Sri Hartiningsih
Health Notions Vol 2, No 3 (2018): March
Publisher : Humanistic Network for Science and Technology (HNST)

Dayak onions (Eleutherine Palmifolia (L.) Merr.) bulb stem contains phtyochemical contents, which act as antidiabetic compounds, such as eleutherol, eleuthocide A, and eleutherinoside B, as well as antioxidant compounds, which include triterpenoid, poliphenol, and flavonoid. Dayak onions was able to be used as the antidiabetic, since it had the ability to lower the blood glucose level and prevent from the free radicals, thus supressing the oxidative stress condition. This research had purpose to analyze the effect of Dayak onions bulbstem as antioxidant and anti diabetic drugs. The research used experimental method with the population in this research was 25 male white mice strain wistar. The concentration of Dayak onions bulb-stem extracts were 300mg.kgBW-1, 400mg.kgBW-1, and 500mg.kgBW-1. Data analysis used Tukey HSD Test with 95% of significance degree and was continued using manova test (average group ratio test). The result showed that. the extract of Dayak onions bulb-stem had the antidiabetical and antioxidant activity, which could lower the blood glucose levels and malondialdehid on the male white mice strain Wistar with the optimum effective doze of 500 mg.kgBW-1.Keywords: Dayak onions bulb-stem, Blood glucose level, Malondialdehid (MDA)

Bee Pollen Effect on Blood Glucose Levels in Alloxan-induced Male Wistar Rats Aprilia Nurcahyaning Rahayu; Bambang Wirjatmadi; Merryana Adriani; Soenarnatalina M.; Dwi Winarni; Sri Hartiningsih
Health Notions Vol 2, No 1 (2018): January
Publisher : Humanistic Network for Science and Technology (HNST)

Bee pollen, as an active ingredient in diabetes mellitus (DM) prevention and treatment, is able to reduce oxidative reactions and to regenerate cells. This study aimed to determine bee pollen effect on blood glucose levels of rats which induced by alloxan. This study used a completely randomized design with Pre-Post Test design and Control Group design. The subjects were 25 male wistar rats which divided randomly into 5 groups: (1) negative control group (non-DM rats); (2) positive control group (DM rats without bee pollen); (3) P1 group (DM rats with 0.25 g/day bee pollen); (4) P2 group (DM rats with 0.63 g/day bee pollen); and (5) P3 group (DM rats with 1.25 g/day bee pollen). Alloxan inducing was used to cause rats under DM or hyperglycemic conditions. The data were analyzed by Manova test and Tukey HSD test. Statistical analysis showed that bee pollen effectively had an effect on decreasing fasting blood glucose (FBG) levels in treatment groups with 0.002. Differences test showed a difference between positive control group and treatment groups, but there was no difference between all treatment groups. However, the bee pollen dosage which giving the lowest average of FBG was 0.25 g on P1 group. Keywords: Bee pollen, Blood glucose level, Alloxan

Toksisitas Kronis Polisakarida Krestin dari Ekstrak Coriolus Versicolor pada Histologi Ginjal dan Kadar Kreatinin Serum Mus Musculus L. SRI PUJI ASTUTI WAHYUNINGSIH; ISTUNING MA’UNAH; DWI WINARNI
Prosiding Seminar Biologi Vol 2 No 1 (2016): Prosiding Seminar Nasional From Basic Science to Comprehensive Education
Publisher : Jurusan Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/psb.v2i1.2631

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian polisakarida krestin ekstrak Coriolus veriscolor pada toksisitas kronis terhadap histologi ginjal dan kadar kreatinin serum Mus musculus. Dua puluh lima mencit betina, umur 8-10 minggu, berat 25-30 g dibagi menjadi 5 kelompok perlakuan dengan 5 ulangan. Kelompok perlakuan adalah kontrol (K) yang diberi akuades 0,2 mL selama 4 bulan, perlakuan (P1, P2, P3 dan P4) diberi polisakarida krestin dari ekstrak jamur C. veriscolor dengan dosis yang berbeda yaitu: 0,5; 1; 2; dan 4 mg/kg BB selama 4 bulan. Akhir dari perlakuan, ginjal diambil untuk dilihat histologinya dan isolasi serum darah untuk diukur kadar kreatinin. Data sel ginjal normal, sel yang bengkak, dan kadar kreatinin dianalisis dengan Anova dan Duncan. Data nekrosis dianalisis dengan Brown-Forsythe dan Games Howell. Polisakarida krestin diberikan secara oral. Histologi ginjal (degenerasi dan nekrosis tubuli ginjal) diidentifikasi pada slide ukuran 4 µm. Kadar kreatinin diukur dengan metode Jaffe reaction. Hasil penelitian menunjukkan bahwa perlakuan P1 sudah tampak adanya pembengkakan 32,80% dan nekrosis sel 8,88%. Perlakuan P2 mempunyai jumlah pembengkakan sel 38,28% dan nekrosis sel 12,08%. Perlakuan P3 dengan jumlah pembengkakan sel 62,24% dan nekrosis sel 13,08%. Perlakuan P4 mempunyai jumlah pembengkakan sel 53,28% dan nekrosis sel 21,40%. Jumlah sel ginjal yang normal semakin turun seiring dengan kenaikan dosis PSK. Kadar kreatinin pada K, P1, P2, P3 dan P4 menunjukkan kadar kreatinin yang normal pada masing-masing perlakuan, yaitu 0,40; 0,64; 0,72; 0,80 dan 0,80 mg/dL. Pemberian polisakarida krestin (PSK) dari ekstrak C. veriscolor pada toksisitas kronis menyebabkan pembengkakan, nekrosis sel, tetapi tidak meningkatkan kadar kreatinin serum mencit secara signifikan. Kata Kunci: polisakarida krestin, Coriolus veriscolor, toksisitas kronis, histologi ginjal, kadar kreatinin

Gynura procumbens Adventitious Root Extract Altered Expression of Antioxidant Genes and Exert Hepatoprotective Effects Against Cadmium-Induced Oxidative Stress in Mice Sugiharto; Dwi Winarni; Anjar Tri Wibowo; Ufairanisa Islamatasya; Idqa Nurtri Bhakti; Nabilatun Nisa; Boon Chin Tan; Yosephine Sri Wulan Manuhara
HAYATI Journal of Biosciences Vol. 29 No. 4 (2022): July 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.4.479-486

Exposure to cadmium (Cd) could increase of reactive oxygen species (ROS) and changes in expression of antioxidant genes. Gynura procumbens is a medicinal plant that is rich in phenolic and flavonoid compounds. The aimed of study to evaluate the hepatoprotective effect of G. procumbens adventitious root (GAR) extract against Cd toxicity, especially expression rate of hepatic antioxidant genes. Twenty-five male mice were treated as follows: P1 (control), P2 (Cd100mg/L), P3 (GAR100mg/L + Cd100mg/L), P4 (GAR200mg/L + Cd100mg/L), and P5 (GAR300mg/L + Cd100mg/L). The samples (blood and liver) were collected for analysis of malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities, and their relative gene expression were determined. The hematological assay showed Cd-treated administered with GAR extract increased the number of red blood cells (RBC), haemoglobin concentration (HGB), hematocrit (HCT), mean corpuscular volume (MCV), and mean corpuscular haemoglobin (MCH), but reduced the level of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In addition, the GAR extract decreased the MDA production, but increased the activities of SOD and CAT. These enzymatic activities were positively correlated with their respective gene transcripts. Our study revealed that GAR extract administration showed marked hepatoprotective effects against Cd-induced oxidative stress.

The Protective Effect of Gynura procumbens Adventitious Root against Lead Acetate Toxicity in Mice Sugiharto Sugiharto; Dwi Winarni; Ufairanisa Islamatasya; Abdul Hakim Muhsyi; Ahimsa Buena Merpati; Yosephine Sri Wulan Manuhara
Journal of Tropical Biodiversity and Biotechnology Vol 7, No 2 (2022): August
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.69453

Lead induced oxidative stress contributes to increase the productivity of reactive oxygen species (ROS) and to disrupt the antioxidant balance. Gynura procumbens adventitious root (GPAR) methanol extract contains abundant phenolic and flavonoids compounds as antioxidants and can be used as traditional medicinal plants. The objective of this study is to evaluate the protective effect of GPAR against lead acetate toxicity in mice to haematological parameter, histological of hepatic cells, and activities of antioxidant enzymes. The data obtained from five groups of treatment: P1 (control), P2 (Pb acetate-100 mg/L), P3 (GPAR-100 mg/L + Pb acetate-100 mg/L), P4 (GPAR-200 mg/L + Pb acetate-100 mg/L), P5 (GPAR-300 mg/L + Pb acetate-100 mg/L). The results indicated that administration of methanol extract of GPAR can prevent the decreasing of haematological parameter, maintain the percentage of normal hepatic cells, activities of superoxide dismutase (SOD), and catalase (CAT) due to lead acetate treatment. The effective dose of GPAR extract was 300 mg/L. This study provides that methanol extract of G. procumbens adventitious root exerts protective effects against lead acetate toxicity in mice.

PROVISION OF ARAK BALI REDUCES SPERMATOZOA QUALITY OF WHITE RATS (Rattus norvegicus) Ni Wayan Sukma Antari; Alfiah Hayati; Dwi Winarni
Folia Medica Indonesiana Vol. 52 No. 4 (2016): OCTOBER - DECEMBER 2016
Publisher : Faculty of Medicine, Universitas Airlangga

This study aimed to determine the effect of arak bali on the quality of spermatozoa include morphology, motility, viability, membrane integrity of spermatozoa rat (Rattus norvegicus). The study was conducted in two phases: the first phase of the deployment of questionnaires conducted in five districts in Bali to determine the type and frequency of arak bali consumption and phase II made arak bali giving treatment in experimental animals. This study used 24 male rats (170-200 grams), divided into four groups: one control and three treatments (by arak bali containing 40% alcohol as much as 0.1 and 0.5 mL and 0.1 mL much alcohol synthesis, for 45 days. the results showed that of the five districts in Bali, most people consume arak bali commercial and most of the frequency of consumption of the week more than one bottle (350 mL). the provision of arak bali in experimental animals, degrade the quality (morphology, motility, viability, membrane integrity), the greater the volume given declining spermatozoa quality.

Co-Authors Abdul Hakim Muhsyi Agoes Soegianto Ahimsa Buena Merpati Alfiah Hayati Alifah Hayati Amalia Nur Mashita Anjar Tri Wibowo Aprilia Nurcahyaning Rahayu Arwati, Niluh Bambang Wirjatmadi Bambang Wirjatmadi Bambang Wirjatmadi Binti Yunaida Boon Chin Tan Dicky Darmawan Erlyn Nurul Fauziah Husen, Saikhu Akhmad I.B. Rai Pidada Idqa Nurtri Bhakti Inggit Almira Inne Ninda Resita Intan Permata Putri ISTUNING MA’UNAH Khaleyla, Firas Listijani Suhargo, Listijani M., Soenarnatalina Manikya Pramudya Merryana Adriani Merryana Adriani Merryana Adriani Muhammad Fajar Nabilatun Nisa Nadyatul Ilma Indah Savira Ni Wayan Sukma Antari Nia Adiani Primarastri Niluh Arwati Priyo, Tri Anggono Rahayu, Aprilia Nurcahyaning Rosmanida Rosmanida S A Husein Saikhu Ahmad Husen Saikhu Akhmad Husen Saikhu Akhmad Husen Salamun Salamun Sarwan Adi Kusumo Septian Hary Kalqutny Soenarnatalina M. Soenarnatalina Meilanani Soenarnatalina Meilanani, Soenarnatalina Sri Hartiningsih Sri Hartiningsih Sri Hartiningsih Sri Puji Astuti Wahyuningsih, Sri Puji Astuti Sugiharto Suhariningsih Tri Anggono Priyo Tri Nurhariyati Ufairanisa Islamatasya Ufairanisa Islamatasya Wijatmadi, Bambang Win Darmanto Y Sri Wulan Manuhara Yoan Asri Triantara Yosephine Sri Wulan Manuhara

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