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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal SOLMA Pharmaceutical Sciences and Research (PSR)
Ema Dewanti
Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta
Medicine & Pharmacology Other

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Neuropharmacological Activity of Nut Grass (Cyperus Rotundus L.) Rhizome Fraction Dwita, Lusi Putri; Dewanti, Ema; Ladeska, Vera; Sediarso, Sediarso; Muntashir, Adnan; Safni, Ulfa; Sari, Rahma Wulan
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.145 KB) | DOI: 10.12928/pharmaciana.v8i2.8938

Abstract

Research in the area of herbal neuropharmacological effects has increased markedly over the past decades. This research was aimed to further investigate neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring hypnotic-siccative and anticonvulsant activities. The exploratory behavior test was performed using Hole Board method while motor coordination was assessed using Rotarod Test. The result showed that the 70% ethanol fraction of Cyperus rotundus rhizome in has significant (p <0,05) neuropharmacological activities. All three fractions tested (ethanol, ethyl acetate, and n-hexane), the ethanol fraction showed the best hypnotic-sedative and anticonvulsant activities. Ethanol Cyperus rotundus rhizome fraction could decrease the duration of HLE equal to sodium valproate and potentiated the phenobarbital-induced sleep by decreasing the onset and prolonging the duration of sleep. The highest dose of 70% ethanol fraction of Cyperus rotundus rhizome (356.7 mg/kg) showed the best anxiolytic activity comparable to diazepam (p> 0.05). In conclusion, Teki ladang (Cyperus rotundus) rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetics drugs. 
Membangun Karakter Anak Sejak Dini Melalui Komunikasi Efektif Dalam Mereduksi Bullying Pada Kelompok Bermain, TK A, dan TK B Hifzhul Amanah Ladeska, Vera; Prastiwi, Rini; Dewanti, Ema
Jurnal SOLMA Vol 8 No 2 (2019): Jurnal Solma
Publisher : Uhamka Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (913.762 KB) | DOI: 10.29405/solma.v8i2.3115

Abstract

Perilaku bullying disekolah merupakan salah satu permasalahan sosial yang kini sangat banyak ditemukan dan memiliki dampak negatif pada kondisi psikologis dan sosial siswa yang pada akhirnya akan mempengaruhi proses belajar mengajar siswa di sekolah. Banyak guru dan orang tua di sekolah taman kanak-kanak tidak menyadari bahwa perilaku anak didiknya sudah mengarah dan memperlihatkan tindakan bully. Perilaku bullying harus dicegah sedini mungkin agar menghasilkan anak didik yang sehat dalam pergaulan sosialnya. Program pengabdian masyarakat ini merupakan program pelatihan preventif untuk mencegah dan meminimalkan bully disekolah . Kegiatan dilaksanakan diruang aula  Kelompok Bermain (KB), TK A dan TK B Hifzhul Amanah Perumnas Klender yang diikuti oleh staf guru, para siswa, orang tua murid. Metode yang dipakai adalah penjelasan materi berupa ceramah, interaktif dalam diskusi, pendekatan komunikasi dengan anak didik melalui permainan. Mitra menyambut positif kegiatan ini dan terbukti dari antusiasnya peserta dalam berdiskusi karena tema yang diadakan sangat sesuai dengan problema dunia anak sekarang. Karena adanya keterbatasan waktu mitra mengharapkan adanya kelanjutan kegiatan pada periode yang akan datang. Hasil dari kegaiatan ini diharapkan mitra akan membentuk suatu  kebijakan antibullying yang disepakati oleh siswa, guru .membangun komunikasi dan interaksi antar civitas akademika, penegakan aturan/sanksi/disiplin sesuai kesepakatan. Sangat penting guru dan orang tua memiliki pengetahuan dan ketrampilan mengenai pencegahan dan cara mengatasi bullying pada anak usia dini  sehingga terhindar dari dampak negative dikemudian hari.
Uji Efek Antiinflamasi Fraksi Air Daun Mahkota Dewa (Phaleria macrocarpa (Shecff.) Boerl.) terhadap Tikus Putih (Rattus norvegicus L.) Eff, Aprilita Rina Yanti; Dewanti, Ema; Adelina H, Melisha
Pharmaceutical Sciences and Research Vol. 1, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Inflammation occurs as the attempt of body to inactivate organisms that attack the body, removing irritants and regulate tissue repair. One of the medicinal plants used empirically as antiinflammation is the leaf of Mahkota Dewa (Phaleria macrocarpa (Schecff.) Boerl). This study investigated the effect of anti-inflammatory water fraction of leaf Mahkota Dewa using oedema induction method with caragenin in rat. Water fraction of Mahkota Dewa was given at the dose 0.5 g/kg BW ,1 g/kg BW and 2 g/kg BW. Sodium diclofenac was used as a positive control and CMC as negative control. The result showed water fractions of three doses can inhibit inflammation at 27.35%, 18.58%, and 20.17%, respectively. The water fraction at the dose 0.5 g/kgBW showed the largest percentage of oedema inhibition compared to other treatment groups.
Co-Authors . Issoegianti Adelina H, Melisha Aprilita Rina Yanti Aprilita Rina Yanti Eff Ladeska, Vera Lusi Putri Dwita Muntashir, Adnan Nyoman Puniawati Rini Prastiwi, Rini Safni, Ulfa Sari, Rahma Wulan Sediarso Sediarso, Sediarso