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All Journal Jurnal Penelitian Saintek Jurnal Ilmiah Farmasi JBIO: jurnal biosains (the journal of biosciences) KLOROFIL: Jurnal Ilmu Biologi dan Terapan GANDRUNG: Jurnal Pengabdian Kepada Masyarakat KLOROFIL: Jurnal Ilmu Biologi dan Terapan FORTE JOURNAL International Conference on Sciences Development and Technology Herbal Medicine Journal
Alfi Sapitri
Universitas Sari Mutiara Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Electrical & Electronics Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Physics Other

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UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN SEREH WANGI TERHADAP PERTUMBUHAN BAKTERI STREPTOCOCCUS MUTANS Ulfayani Mayasari; Alfi Sapitri
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 3, No 1 (2019): KLOROFIL: JURNAL ILMU BIOLOGI DAN TERAPAN
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v3i1.7854

Abstract

The lemongrass plants (Cymbopogon nardus) is one of the plants used as medicine such as strep throat, cough and colds. The purpose of this study was to determine whether the juice of fragrant lemongrass leaves has antibacterial activity against Streptococcus mutans bacteria that cause dental caries. The research method used is experimental with agar diffusion. The experiment consisted of four treatments namely at concentrations of 20%, 30%, 40% and 50% with three repetitions. The results showed fragrant lemongrass leaves at concentrations of 10%, 20%, 30% and 40% had an average inhibition zone diameter of 14,2 mm, 15,1 mm, 16,2 mm dan 17,3 mm. Fragrant lemongrass leaves can inhibit the growth of Streptococcus mutans.Keywords : Cymbopogon nardus, Antibacterial, Streptococcus mutans. 
UJI ANTIBAKTERI Virgin Coconut Oil DARI BERBAGAI MEREK TERHADAP BAKTERI Staphylococcus aureus dan Enterococcus faecalis Ulfayani Mayasari; Alfi Sapitri; Sri Maulida Putri
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 4, No 2 (2020): KLOROFIL: JURNAL ILMU BIOLOGI DAN TERAPAN
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v4i2.8970

Abstract

Virgin Coconut Oil (VCO) has the ability as an antivirus, antibacterial and antifungal, it is due to the content of lauric acid, caprylic acid, Staphylococeus aureus and Enterococcus faecalis are bacteria that act as normal flora in the human body. If it exceeds a certain limit, both of these bacteria can become pathogens. The purpose of this study is to find out Virgin Coconut Oil from various brands can inhibit the growth of Staphylococcus aureus and Enterococcus faecalis.Antibacterial power test is done by the diffusion method to use the cylinder cup, and antibacterial power measured by the diameter of the urea inhibiting microbial growth by using a caliper. Antibacterial test results for Staphylococeus aureus bacteria on brand “A” (96.3 mm), brand “B” (10.3 mm), brand “C” (11 mm).The average brand “D” (8.6 mm), and in the bacteria Enterococcus faecalis in the brand “A” (3mm), brand “B” (6,1 mm), brand “C” (5.6 mm). Virgin Coconut Oil from various merck able to inhibit Staphylococeus aureus and Enterococcus faecalis bacteria.
The immunomodulatory activity of ethanol extract of attarasa bark and fruit (Litsea cubeba (lour.) pers.) toward carbon clearance of mice (Mus musculus) Vivi Asfianti; Alfi Sapitri; Eva Diansari Marbun
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art20

Abstract

Abstract Background: Attarasa (L.a cubeba (Lour.) Pers.) is a potential Indonesian medicinal plant that is used as a cold remedy, head ulcers, antimicrobials, antioxidants, and anticancer drugs. Objective: This research was conducted to analyze the immunomodulatory effect of bark (EEKBA) and fruit of attarasa ethanolic extract (EEBA) by detecting its phagocytosis activity in male mice using carbon clearance method.Method: Total of 24 male mice were divided into 6 groups. Extract was orally administered to mices for 7 days at the dose of 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW. Imboost® suspension at the dose of 32.5 mg/kg BW and CMC-Na 1 % suspension was orally administered in positive control, negative control and normal groups. On the 8th day, 0.1 ml carbon suspension was given through intravenous tail injection. The blood samples were withdrawn at 5, 10, 15, and 20 minutes after injection of carbon suspension to find out the carbon absorbance contained in the blood that was measured using spectrophotometer then the carbon elimination speed, phagocytic index, and the stimulation index has been calculatedResult: EEKBA and EEBA at the dose of 400 mg/kg BW induced the higher carbon elimination rate in mice compared to EEKBA and EEBA dose of 100 and 200 mg/kg BW. Phagocytic index of macrophage in mice given with EEKBA and EEBA at dose of 100, 200, dan 400 mg/kg BW were 3.429, 3.501, and 3.925 for EEKBA consecutively; 4.289, 4.375 and 4.732 for EEBA respectively. Stimulation index of macrophage in mice given with EEKBA and EEBA at dose of 100, 200, and 400 mg/kg BW were 1.00; 1.20, 1,02; 1,23, and 1,13; 1,33. Based on the results of statistical test, EEKBA and EEBA administration at the dose of 100, 200, and 400 mg/kg BW stimulate the phagocytosis activity of the macrophage of male mice and significantly has different result compared to normal control group (p < 0.05). Phagocytosis activity was best shown at the mice group that administered EEKBA and EEBA at dose of 400 mg/kg BW and was shown not significantly different compared to positive control group (p > 0.05).  Conclusion: EEKBA and EEBA have immunomodulatory effect by increasing the phagocytosis activity of mice.Keywords: immunomodulatory, Litsea cubeba, carbon clearance, phagocytosis activity Intisari Latar belakang: Attarasa (Litsea cubeba (Lour.) Pers.) merupakan tumbuhan obat potensial Indonesia yang digunakan sebagai obat flu, borok dikepala, antimikroba, antioksidan dan antikanker.Tujuan: Penelitian ini dilakukan untuk dapat mengamati efek imunomodulator Ekstrak Etanol Kulit Batang (EEKBA) dan Ekstrak Etanol Buah Attarasa (EEBA) terhadap aktivitas fagositosis pada mencit jantan dengan menggunakan metode carbon clearance.Metode: Sebanyak 24 ekor mencit jantan dibagi menjadi 6 kelompok. Ekstrak diberikan secara per oral selama 7 hari pada mencit jantan dengan dosis 100, 200, dan 400 mg/kg BB. Suspensi imboost® dengan dosis 32,5 mg/kg BB, suspensi CMC-Na 1% diberikan pada kelompok kontrol positif, negatif, dan normal. Pada hari ke-8 disuntikkan suspensi karbon 0,1 ml secara intravena di ekor mencit. Sampel darah dikumpulkan pada menit ke-5, 10, 15, dan 20 setelah diinjeksi dengan suspensi karbon untuk mengetahui absorbansi karbon dalam darah yang diukur menggunakan spektrofotometer kemudian dihitung kecepatan eliminasi karbon, indeks fagositosis, dan indeks stimulasinya.Hasil: EEKBA and EEBA dosis 400 mg/kg BB menghasilkan kecepatan eliminasi karbon yang paling tinggi dibandingkan dengan EEAB dan EEAF 100 dan 200 mg/kg BB. Indeks fagositosis yang dihasilkan dari pemejanan EEKBA and EEBA dosis 100, 200, dan 400 mg/kg BB terhadap hewan uji yaitu 3,429; 4,289; 3,501; 4,375 dan 3,925; 4,732. Indeks stimulasi makrofag yang diperoleh setelah hewan uji dipejani dengan EEKBA and EEBA dosis 100, 200, dan 400 mg/kg BB yaitu 1,00; 1,20, 1,02; 1,23, dan 1,13; 1,33. Berdasarkan hasil uji statistik, pemberian EEKBA and EEBA pada dosis 100, 200, dan 400 mg/kg BB dapat meningkatkan aktivitas fagositosis pada mencit jantan dan terdapat perbedaan yang signifikan dengan CMC-Na 1% dan kelompok normal (p<0,05). Aktivitas fagositosis yang paling baik ditemukan pada pemberian EEKBA and EEBA dengan dosis 400 mg/kg BB dengan perbedaan yang tidak signifikan terhadap kelompok hewan uji yang diberi Imboost® (p>0,05).Kesimpulan: EEKBA and EEBA mempunyai efek imunomodulator dengan meningkatkan aktivitas fagositosis pada mencit jantanKata kunci: imunomodulator, Litsea cubeba, carbon clearance, aktivitas  fagositosis.
PENENTUAN AKTIVITAS EKSTRAK ETANOL CABAI MERAH DALAM MENGHAMBAT PERTUMBUHAN BAKTERI Alfi Sapitri; Eva Diansari Marbun; Ulfayani Mayasari
Jurnal Penelitian Saintek Vol 26, No 1 (2021)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v26i1.39859

Abstract

Penelitian ini bertujuan untuk melakukan uji fitokimia terhadap ekstrak etanol Cabai merah (Capsicum annum L.) dan uji aktivitasnya terhadap pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli. Pengujian aktivitas antibakteri ini menggunakan metode difusi agar dengan menggunakan kertas cakram dengan tiga kali pengulangan. Ekstrak etanol cabai merah dibuat dengan konsentrasi 45, 60, 75, dan 90%. Uji aktivitas antibakteri dilakukan dengan metode Kirby Bauer. Media yang digunakan sebagai uji antibakteri pada penelitian ini yaitu Mueller-Hinton Agar (MHA). Hasil skrining fitokimia terhadap ekstrak etanol cabai merah menunjukkan adanya senyawa metabolit sekunder. Senyawa metabolit sekunder tersebut yaitu alkaloid, flavonoid, tanin, saponin, dan Steroid/triterpenoid. Steroid berfungsi sebagai antimikroba. Hasil penelitian ini juga mengungkapkan adanya kandungan senyawa capsaicin yang terkenal sebagai senyawa aktif antimikroba. Ekstrak etanol cabai merah memiliki aktivitas antibakteri terhadap bakteri Staphylococcus aureus dan Escherichia coli zona bening terendah pada konsentrasi 45% dan zona bening tertinggi pada konsentrasi 90%. Dapat disimpulkan bahwa ekstrak cabai merah memiliki aktivitas antibakteri terhadap penghambatan pertumbuhan bakteri.THE ABILITY OF RED CHILI ETHANOL EXTRACT IN INHIBITHING THE GROWTH OF BACTERIAThis study aimed to perform a phytochemical test on the ethanolic extract of red chili (Capsicum annum L.) and test its activity against the growth of Staphylococcus aureus and Escherichia coli bacteria. This antibacterial activity test used the agar diffusion method using disc paper with three repetitions. Red chili ethanol extract was made with concentrations of 45%, 60%, 75% and 90%. The antibacterial activity test was carried out using the Kirby Bauer method. The medium used as an antibacterial test in this study was Mueller-Hinton Agar (MHA). The results of phytochemical screening of red chili ethanol extract showed the presence of secondary metabolites. The secondary metabolites are alkaloids, flavonoids, tannins, saponins, and steroids/triterpenoids. Steroids serve as  antimicrobials. The results of this study also revealed the presence of capsaicin compounds which are known as active antimicrobial compounds. Red chili ethanol extract had antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria in the lowest clear zone at a concentration of 45% and the highest clear zone at a concentration of 90%. It can be concluded that red chili extract has antibacterial activity against bacterial growth inhibition.
ACTIVITY ETHANOL EXTRACT, ETHYLE ACETATE FRACTION, N-HEXAN FRACTION OF SOFO-SOFO LEAVES (Acmella cf) Against Propionibacterium acnes AND Staphylococcus epidermidis AS ANTIBACTERIES Eva Diansari Marbun; Alfi Sapitri; Vivi Asfianti
JBIO: jurnal biosains (the journal of biosciences) Vol 7, No 1 (2021): Jurnal Biosains
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v7i1.23492

Abstract

Sofo-sofo leaves are traditional medicinal plants that have been known by the Nias people to cure fever, coughs, diarrhea and antimicrobial infections on the skin surface. The  purpose  of  this  study  was  to determine the antibacterial activity of ethanol extract, n-hexane fraction and ethylacetate fraction Sofo-sofo leaf (Acmella cf) against Propionibacterium acnes and Staphylococcus epidermidis. Simplicia powder was characterized and phytochemical screening was performed. Furthermore, it was isolated using 96% ethanol solvent and fractionated with  n-hexane and ethylacetate to obtain extracts. Then test the antibacterial activity of each extract against Propionibacterium acne and Staphylococcus epidermidis by using a diffusion method disc paper. The research results obtained water content 5.66%, water soluble extract content 27.33%, ethanol soluble extract content 13.61%, total ash  content 14.39%, and  acid insoluble ash content 6.25%. The highest antibacterial activity was given by ethylacetate extract at a concentration of 2% (23.4 ± 0.2) compared to ethanol extract with a concentration of 2% (21.06 ± 0.85) and 2% concentrated n-hexane extract (19.36 ± 0.16) against the Propionibacterium acne bacteria. The highest antibacterial activity was ethyl acetate extract at a concentration of 2% (23.24 ± 0.23), ethanol extract with a concentration of 2% (16.36 ± 1.76) and n-hexane extract at a concentration of 2% (15.36 ± 0 , 11) against Staphylococcus epidermidis bacteria. The  antibacterial activity results were analyzed by the one way ANOVA test method. Based on these results it can be concluded that there are differences between treatment groups, which is indicated by a significant value <0.05.
UJI ANTIBAKTERI Virgin Coconut Oil DARI BERBAGAI MEREK TERHADAP BAKTERI Staphylococcus aureus dan Enterococcus faecalis Ulfayani Mayasari; Alfi Sapitri; Sri Maulida Putri
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 4, No 2 (2020): KLOROFIL: JURNAL ILMU BIOLOGI DAN TERAPAN
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v4i2.8970

Abstract

Virgin Coconut Oil (VCO) has the ability as an antivirus, antibacterial and antifungal, it is due to the content of lauric acid, caprylic acid, Staphylococeus aureus and Enterococcus faecalis are bacteria that act as normal flora in the human body. If it exceeds a certain limit, both of these bacteria can become pathogens. The purpose of this study is to find out Virgin Coconut Oil from various brands can inhibit the growth of Staphylococcus aureus and Enterococcus faecalis.Antibacterial power test is done by the diffusion method to use the cylinder cup, and antibacterial power measured by the diameter of the urea inhibiting microbial growth by using a caliper. Antibacterial test results for Staphylococeus aureus bacteria on brand “A” (96.3 mm), brand “B” (10.3 mm), brand “C” (11 mm).The average brand “D” (8.6 mm), and in the bacteria Enterococcus faecalis in the brand “A” (3mm), brand “B” (6,1 mm), brand “C” (5.6 mm). Virgin Coconut Oil from various merck able to inhibit Staphylococeus aureus and Enterococcus faecalis bacteria.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN SEREH WANGI TERHADAP PERTUMBUHAN BAKTERI STREPTOCOCCUS MUTANS Ulfayani Mayasari; Alfi Sapitri
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 3, No 1 (2019): KLOROFIL: JURNAL ILMU BIOLOGI DAN TERAPAN
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v3i1.7854

Abstract

The lemongrass plants (Cymbopogon nardus) is one of the plants used as medicine such as strep throat, cough and colds. The purpose of this study was to determine whether the juice of fragrant lemongrass leaves has antibacterial activity against Streptococcus mutans bacteria that cause dental caries. The research method used is experimental with agar diffusion. The experiment consisted of four treatments namely at concentrations of 20%, 30%, 40% and 50% with three repetitions. The results showed fragrant lemongrass leaves at concentrations of 10%, 20%, 30% and 40% had an average inhibition zone diameter of 14,2 mm, 15,1 mm, 16,2 mm dan 17,3 mm. Fragrant lemongrass leaves can inhibit the growth of Streptococcus mutans.Keywords : Cymbopogon nardus, Antibacterial, Streptococcus mutans. 
UJI ANTIBAKTERI EKSTRAK ETANOL DAUN BIDARA ARAB (Ziziphus jujuba Mill) TERHADAP BAKTERI S. aureus DAN S. epidermidis: UJI ANTIBAKTERI EKSTRAK ETANOL DAUN BIDARA ARAB (Ziziphus jujuba Mill) TERHADAP BAKTERI S. aureus DAN S. epidermidis Eva Diansari Marbun; Alfi Sapitri; Artha Yuliana Sianipar
FORTE JOURNAL Vol 2 No 1 (2022): Vol. 2 No. 1 (2022) : Edisi Januari
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v2i1.200

Abstract

Bidara arab (Ziziphus jujuba Mill) merupakan tumbuhan semak atau pohon  berduri yang digunakan sebagai obat tradisional. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri EEDBA (Ziziphus jujuba Mill) terhadap bakteri S. aureus dan S.epidermidis. Pembuatan EEDBA dilakukan dengan cara perkolasi menggunakan etanol 96%. Pengujian aktivitas antibakteri dilakukan dengan cara difusi menggunakan kertas cakram (Uji Kirby-Bauer). Hasil penelitian EEDBA sebagai antibakteri berdasarkan parameter luas zona hambat terhadap bakteri S. aureus dengan konsentrasi 2% rata-rata yaitu 11,2 mm, 3% yaitu 12,2 mm, 4% yaitu 13,4 mm, 5% yaitu 16,0 mm. Sedangkan bakteri S.epidermidis pada konsentrasi 2 % rata-rata yaitu 12,0 mm, 3% yaitu 14,6 mm, 4% yaitu 15,8 mm, 5% yaitu 16,6 mm serta diameter kontrol positif keduanya rata-rata yaitu 27,2 mm. Berdasarkan analisis statistik pada anova menunjukkan EEDBA (Ziziphus jujuba Mill) bisa menghambat pertumbuhan bakteri S. aureus dan S.epidermidis dengan sangat nyata (Fh>Ft;α=0,05).
Porang Cultivation Techniques for Improving the Welfare of the Sipahutar Village Community 1 Owen De Pinto Simanjuntak; Alfi Sapitri; Vivi Asfianti
GANDRUNG: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 2 (2022): GANDRUNG: Jurnal Pengabdian Kepada Masyarakat
Publisher : Fakultas Olahraga dan Kesehatan, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/gandrung.v3i2.2112

Abstract

Basically, there are many plants that are efficacious and have economic value, one of which is porang.Amorphophallus muelleri Blume is a type of porang that grows in Indonesia and has high economic value because the tubers contain glucomannan. Glucomannan is useful in food, health, cosmetics, and other industries. The benefits of glucomannan in health are lowering cholesterol levels, normalizing triglyceride levels in the blood, controlling blood sugar levels, and improving intestinal performance. The purpose of this activity is the use of porang as a companion plant that is cultivated to increase economic income in Sipahutar I Village, Sipahutar District, North Tapanuli Regency. The stages of the research method are 1) tissue culture techniques to obtain porang seedlings en masse, including making subcultures, maintaining culture results, and observing culture results; 2) Focus Group Discussion (FGD) method in the form of outreach and training on porang cultivation, production, maintenance, and marketing (digital marketing).
Antibacterial Activity of Kasturi Orange (Citrus microcarpa Bunge) to Inhibit Propionibacterium acnes Ulfayani Mayasari; Fanny Novita; Alfi Sapitri; Rizki Amelia Nasution
International Conference on Sciences Development and Technology The 1st ICoSDTech 2021
Publisher : International Conference on Sciences Development and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.845 KB)

Abstract

Kasturi orange (Citrus microcarpa Bunge) is one of the plants that can be used as medicine, for example to treat coughs, itching or body odor removal. The purpose of this study was to determine whether Kasturi oranges were able to inhibit the growth of Propionabacterium acnes bacteria that causes acne. The research method used is experimental. The experiment consisted of 4 treatments and three repetitions. The results showed that the diameters of the inhibition zones obtained by lime juice at concentrations of 25%, 50%, 75%, 100% were 3.86 mm, 7.13 mm, 9 mm, 11.1 mm. Based on the results obtained, it can be concluded that Kasturi orange juice is able to inhibit the growth of the Propionibacterium acnes bacteria.
Co-Authors Ahmad Fadli Ahmad Hafizullah Ritonga Artha Yuliana Sianipar Denny Satria Fanny Novita Marbun, Eva Diansari Owen De Pinto Simanjuntak Prima Jaya Nazara Rizki Amelia Nasution Sri Maulida Putri Ulfayani Mayasari Ulfayani Mayasari Ulfayani Mayasari Ulfayani Mayasari Vivi Asfianti