Article Per Year (5 Year)
p-Index From 2019 - 2024
1.8
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing) Journal of Dedicators Community Berdikari: Jurnal Pengabdian Masyarakat Indonesia INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Community Development Journal Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Community Development Journal: Jurnal Pengabdian Masyarakat International Islamic Medical Journal Journal of Health Community Service Wisanggeni : Jurnal Pengabdian Masyarakat
Handayani Handayani
Fakultas Kedokteran, Universitas Nahdlatul Ulama, Surabaya, Jawa Timur, Indonesia
Religion Arts Humanities Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY

 1 
Effect of Bay Leaf (Syzygium polyanthum) Extract on Antioxidant Activity, MDA Levels, and Liver Histopathology Feature of Ethambutol Induced Wistar Rats Bambang Edi Suwito; Lea Maera Shanty; Retna Gumilang; Handayani Handayani; Renata Alya Ulhaq
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 4 No 2 (2022): Enhanced knowledge of laboratory medicine's role in healthcare
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v4i2.2471

Abstract

Bay leaf extract (Syzygiun polianthum) is one herbal elemnt that may be used to lessen liver function issues, lessen symptops of nausea, vomiting, discomfort and improve adherence and the effectiveness of tuberculossi treatment. The objective of this study was to determine the effect of bay leaf (Syzygium polyanthum) extract on antioxidant activity, Malondialdehyde (MDA) levels, and liver histopathology of ethambutol-induced Wistar rats. This research is a laboratory experiment. Antioxidant activity of Bay Leaf Extract was evaluated by comparing vitamin C with spectrophotometry methods. White Wistar rats were separated into 6 groups and uset to test the lebel of MDA and livers histopathology. Group 1 serves as the control group and received DMSO (placebo); Group 2 was received ethambutol 50mg/kg BW; Group 3 was received ethambutol and silymarine with dose 50mh/kg BW. Group 4-6 had been given ethambutol and extra ethanol extract of bay leaves of 75,150, dan 300mg/kg BW, respectively. The results of the spectrophotometry showed that the Bay Leaf Extract had antioxidant activity comparable to that of vitamin C, with an IC50 of 11.4 g ± (4.4%). One-Way ANOVA test results obtained p = 0.002 (p<0.05) while the Kruskal-Wallis test results obtained the Asymp. Sig value 0.105> 0.05. There was a significance difference in each group’s MDA levels (p=0.002). Although there was no significant difference in the liver histopathology of treated rats (p>0.05). While bay leaf extract significantly lowers MDA levels in ethambutol-induced Wistar rats, it has no discernible impact on the liver histopathology of ethambutol-induced Wistar rats. Bay leaf extract possesses antioxidant activity comparable to vitamin C.
Co-Authors Aditya Bhayusakti Afira Febriani Agus Aan Adriansyah Akbar Reza Muhammad Algristian, Hafid Andik Ferdiantoro Arie Kusumo Dewi Ary Andini Athiyatul Ulya Bambang Edi Suwito Bintarti, Tri Wahyuni Budiarti, Rizqi Putri Nourma Chilyatuz Zahroh Dewi Masithah Dian Dakwatul Choiriya Diaz Syafrie Abdillah Ebeth Jeremy Selly Elok Tamarah Endah Budi Permana Putri Eppy Setiyowati Fitria Agustina Hafizh Auliyan Sodali Lea Maera Shanty Melky Malae Muhammad Raffli Rahayu Anggraini Ratna Sofaria Munir Renata Alya Ulhaq Renny Novi Puspitasari Retna Gumilang Retno Ayu Yuliastuti Retno Diah Putri Ekayanti Rizki Nurmalya Kardina Rofi’usyani Rofi’usyani Shafira Nur Lailia Yanis Kartini Youwan Tobing Lukiyono