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All Journal VALENSI Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Jurnal Ilmu Dasar POSITRON Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kelautan Tropis Journal Of Chemical Process Engineering (JCPE) ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Pure and Applied Chemistry Journal Of Chemical Process Engineering
Winda Rahmalia
1. Jurusan Kimia, Fakultas MIPA, Universitas Tanjungpura 2. Chemistry Insight Center Fakultas MIPA, Universitas Tanjungpura
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Acute Oral Toxicity of Cincalok Oil in Wistar Rats Siti Nani Nurbaeti; Inarah Fajriaty; Fajar Nugraha; Hadi Kurniawan; Winda Rahmalia; Thamrin Usman; Dwi I. Prayitno
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 2 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i2.26343

Abstract

Cincalok is a West Kalimantan traditional fermented food that has an opportunity to be developed into supplement products as a source of omega 3 and astaxanthin. This study was designed to observe the acute toxicity of Cincalok oil in female rats for its safety profile using AOT 425 program. Cincalok oil for the acute (2000 and 5000 mg/kg) toxicity studies was administered orally according to the OECD guidelines 425. The rat’s body and organs weight were observed then signs of toxicity were assessed. LD50 was being determined at the end of the study. The result showed that a single dose of Cincalok oil at 2000 or 5000 mg/kg had no lethal effect, behavioral change, a significant change in rat’s bodyweights, or any lesion on the rat’s organs. The LD50 of Cincalok oil for oral administration was higher than 5000 mg/kg and categorized as practically non-toxic.Keywords: Acute Toxicity, Cincalok Oil, LD50.
Co-Authors Adhitiyawarman, Adhitiyawarman Andi Hairil Alimuddin Angie Islammiyati Annisa Bella Maharani Ayu Widya Sari Deni Pranata Dwi I. Prayitno Dwi Imam Prayitno Dwi Imam Prayitno Esi Amelyanti Fajar Nugraha Fajriaty, Inarah Fara Chitra Gusrizal Gusrizal Hadi Kurniawan Hairunnisa Hairunnisa Hamdil Mukhlishin Imelda H. Silalahi Imelda Hotmarisi Silalahi Inda Putrinesia Intan Syahbanu Intan Syahbanu Intan Syahbanu Lia Destiarti M Syahwandi Mas Inda Putrinesia Mauludia Mauludia Nia Dahlia Nico Gustian Nimas Ade Kusdayanti Nur Ridha An Nisa Nurlina Nurlina Nurlina Nurlina, Nurlina Nurul Asyikin Puji Ardiningsih R. Rudiyansyah Ramadhy, Wahyu Febri Risya Sasri Sabrina Maulidya Amir Septiani Septiani Septiani Septiani Septiani Septiani Septiani Shofiyani, Anis Siti Nani Nurbaeti Thamrin Usman Thamrin Usman Titin Anita Zahara Titin Anita Zahara Titin Anita Zaharah Uray Amira Naselia Uray Amira Naselia Uray Amira Naselia Utin Widiatannur Wahyu Febri Ramadhy Yoga Pratama Zulenda Zulenda