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All Journal Indonesian Journal of Applied Sciences At-Taqaddum Meditory : The Journal of Medical Laboratory Jurnal Analis Kesehatan Journal of Dedicators Community AL-HAYAT: Journal of Biology and Applied Biology Cendekia Journal of Pharmacy Indonesian Journal of Global Health research
Fitria Diniah Janah Sayekti
Sekolah Tinggi Ilmu Kesehatan Nasional
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : AL-HAYAT: Journal of Biology and Applied Biology

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Description of polimorfism FTO Gene (Fat and Mass Obesity associated) rs9939609 on Obesity and Non Obesity Subject Fitria Diniah Janah Sayekti; Alfian Marfianto
Al-Hayat: Journal of Biology and Applied Biology Vol 6, No 2 (2023)
Publisher : Fakultas Sains dan Teknologi, UIN Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/ah.v6i2.16547

Abstract

Obesity is a major risk factor for several chronic diseases and is a major health and economic burden on society. The FTO gene (Fat and Mass Obesity associated) was identified as a gene that has an influence on the incidence of obesity according to Genome-wide Association Studies. Examination of the FTO gene polymorphism rs9939609 using 15 samples of obese subjects and 15 samples of non-obese subjects at Prodia Pusat Jakarta employees. This study used descriptive research to describe the polymorphism or variation of the FTO (Fat mass and obesity-associated) gene rs9939609 in obese and non-obese objects among Prodia Pusat Jakarta employees. In this study, non-obese subjects obtained 100% AT allele results. This indicates that genetically there is a potential risk factor for obesity. In obese subjects, 60% of the TT alleles were found. Genetically it should not be a risk allele for the risk of obesity. This can be caused by lifestyle or diet. In this study, an AA allele of 6.67% was found, indicating a greater risk of obesity. From the study, it was concluded that the percentage of the FTO gene polymorphism rs9939609 in obese and non-obese subjects in Prodia Pusat Jakarta employees was the AT allele 100% for obese subjects and for obese subjects. non-obese subject of 33.33%. The AA allele is 6.67% for obese subjects, and the TT allele is 60% for obese subjects.
Co-Authors Alfian Marfianto Alvindo Thiananda Devi Chris Srikandini Damar Ajeng Priyandari Dwi Haryatmi Ema Rochayani Damairia Karina Winda Rofifah Lingka Elliesia Putri Santosa Muhammad Taufiq Qurrahman Muhammad Taufiq Qurrohman Sherrin Karina Putri Vector Stephen Dewangga Yayi Aullia Ramadhani