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All Journal Indonesian Journal of Applied Sciences At-Taqaddum THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Jurnal Peduli Masyarakat Indonesian Journal of Global Health research Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) Jurnal Kesehatan Kusuma Husada Jurnal Farmasetis

Muhammad Taufiq Qurrohman

Sekolah Tinggi Ilmu Kesehatan Nasional

Author-ID : 2698814

Religion Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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AKTIVITAS ANTIANGIOGENESIS EKSTRAK BERAS HITAM (Oryza sativa L. indica) PADA CHORIOALANTOIC MEMBRANE (CAM) SEBAGAI KANDIDAT ANTIKANKER ANTIANGIOGENESIS ACTIVITY OF BLACK RICE (Oryza sativa L. indica) ON CHORIOALANTOIC MEMBRANE (CAM) AS ANTICANCER CANDIDATE Fitria Diniah Janah Sayekti; Muhammad Taufiq Qurrohman
Indonesian Journal of Applied Sciences Vol 8, No 1 (2018)
Publisher : Universitas Padjadjaran

AbstrakAngiogenesis memberikan kontribusi pada karsinogenesis atau pertumbuhan sel kanker yang tidak terkendali. Pertumbuhan tumor atau kanker dapat dikontrol melalui penghambatan angiogenesis. Salah satu bahan alam yang berpotensi sebagai bahan pangan fungsional prevensi kanker adalah beras hitam. Penelitian ini bertujuan untuk mempelajari dan mengetahui aktivitas antiangiogenesis ekstrak beras hitam (Oryza sativa L. indica) pada Chorioallantoic Membrane (CAM) sebagai kandidat antikanker. Parameter yang diamati dalam penelitian adalah banyaknya pembuluh darah baru atau respon angiogenesis pada CAM setelah pemberian ekstrak beras hitam dengan konsentrasi masing-masing 20, 25, 50, 60 dan 75 µg/mL. Ekstrak beras hitam menghambat pembentukan pembuluh darah pada CAM. Rata-rata jumlah pembuluh darah pada konsentrasi ekstrak beras hitam 20, 25, 50, 60 dan 75 µg/mL berturut-turut adalah 27,6; 21,0; 3,67; 3,0; 2,0. Pada kontrol dengan larutan NaCl 0,9 %, jumlah rata-rata pembuluh darah adalah adalah 35,33. Kata Kunci : Beras hitam (Oryza sativa L. indica), angiogenesis, antikanker AbstractAngiogenesis contributes to uncontrolled carcinogenesis or cancer cell growth. Tumor or cancer growth can be controlled through inhibition of angiogenesis. One of the natural ingredients that have the potential as a cancer prevention functional food ingredient is black rice. This study aims to study and determine the antiangiogenesis activity of black rice extract (Oryza sativa L. indica) on the Chorioallantoic Membrane (CAM) as an anticancer candidate. The parameters observed in the study were the number of new blood vessels or the response of angiogenesis to CAM after the administration of black rice extract with a concentration of 20, 25, 50, 60 and 75 µg / mL, respectively. The higher the concentration of black rice extract showed a decrease in the number of blood vessels formed. The average number of blood vessels at concentrations of black rice extract 20, 25, 50, 60 and 75 µg / mL were 27.6; 21.0; 3.67; 3.0; 2.0. In the control with 0.9% NaCl solution, the average number of blood vessels was 35.33. Keywords: Black rice ( Oryza sativa L. indica), angiogenesis, anticancer

Pengaruh Kombinasi Buah Jeruk Nipis dan Buah Mengkudu Terhadap Mortalitas Pediculus humanus capitis Fitria Diniah Janah Sayekti; Muhammad Taufiq Qurrohman; Damar Ajeng Priyandari; Chris Srikandini
At-Taqaddum Vol 12, No 1 (2020)
Publisher : Quality Assurance Institute (LPM) State Islamic University Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/at.v12i1.5148

Head lice (Pediculus humanus capitis) greatly interferes with human activity because it can cause itching of the head, redness and severe infections. The use of natural insecticides is recommended, because natural insecticides are considered safer. Potential anti lice plants are lime and noni. The combination of the two is believed to have a more effective effect on head lice mortality. This study aims to study and determine the effect of a combination of lime juice and noni on the mortality of Pediculus humanus capitis. The concentration of lime and noni which are used are 25%, 50%, 75% and 100%, respectively. The combination of test materials used was 25% limes 75% noni; 50% lime 50% noni; 75% lime and 25% noni, negative control and positive control. The combination of the extract of noni and lime juice had the highest mortality effect on Pediculus humanus capitis with a concentration of 25% combination of lime; 75% noni.

POTENSI ANTIBAKTERI EKSTRAK ETANOL HERBA MENIRAN HIJAU (Phyllanthus niruri Linn.) DALAM MENGHAMBAT PERTUMBUHAN STAPHYLOCOCCUS AUREUS Vector Stephen Dewangga; Muhammad Taufiq Qurrohman
Jurnal Kesehatan Kusuma Husada Vol. 10 No. 2, Juli 2019
Publisher : Universitas Kusuma Husada Surakarta

Penggunaan bahan alam semakin meningkat dan masih menjadi andalan di beberapa negara berkembang. Penelitian kali ini menggunakan ekstrak etanol dari herba Phyllanthus niruri Linn. Dalam usaha menghambat pertumbuhan Staphylococcus aureus. S. aureus merupakan salah satu mikroflora normal di wajah yang berperan dalam infeksi jerawat. Penelitian ini merupakan penelitian eksperimental menggunakan Rancangan Acak Lengkap dengan 7 perlakuan dan 5 ulangan. Perlakuan yang digunakan adalah pemberian ekstrak etanol herba P. niruri Linn. untuk konsentrasi 5%; 25%; 50%; 75%; 100%, pengenceran menggunakan pelarut DMSO 10%. Kontrol positif menggunakan ciprofloxacin, sedangkan kontrol negatif menggunakan DMSO 10%. Zona hambat yang diperoleh dianalisis menggunakan uji Kolmogorov–Smirnov dan uji homogenitas Levene. Apabila variansi data homogen, maka dilanjutkan analisis dengan Anova yang dilanjutkan dengan uji Post Hoc. Dari perhitungan kontrol negatif, variasi konsentrasi (5%, 25%, 50%, 75%, 100%) dan kontrol positif diperoleh rata-rata zona radikal berturut sebesar 6 mm; 7,46 mm; 7,52 mm; 7,6 mm; 8,52 mm; 8,98 mm; 31,08 mm. Semua variasi konsentrasi ekstrak etanol herba P. niruri Linn. mampu menghasilkan zona hambat radikal dengan zona hambat terbesar tetap dijumpai pada kontrol positif. Hal ini menunjukkan bahwa konsentrasi ekstrak etanol herba P. niruri Linn. yang semakin besar akan berbanding lurus dengan peningkatan aktivitas penghambatan, namun belum seoptimum kontrol positif. The use of natural materials is increasing and is still a mainstay in several developing countries. This research was used ethanol extract from herb Phyllanthus niruri Linn. in an effort to inhibit the growth of Staphylococcus aureus. S. aureus is one of the normal microflora on the face that helps infection. This research is an experimental study used a completely randomized design with 7 preparations and 5 replications. The treatment used ethanol extract of P. niruri Linn herb. for a concentration of 5%; 25%; 50%; 75%; 100%, the dilution used 10% DMSO solvent. Positive controls used ciprofloxacin, while negative controls used DMSO 10%. The inhibition zone obtained was analyzed using the Kolmogorov-Smirnov test and the Levene homogeneity test. If the data variance is homogeneous, then the analysis is continued with ANOVA followed by the Post Hoc test. From the calculation of negative controls, various concentration (5%, 25%, 50%, 75%, 100%) and positive controls obtained an average radical zone of 6 mm; 7.46 mm; 7.52 mm; 7.6 mm; 8.52 mm; 8.98 mm; 31.08 mm. All variations in the concentration of ethanol extract of P. niruri Linn. herbs able to produce a radical inhibition zone with the largest inhibition zone still found in positive controls. This showed that the greater concentration of ethanol extract of P. niruri Linn. herb. will be directly proportional to the increase in inhibition activity, but not optimal as much as positive control.

PENGHAMBATAN PERTUMBUHAN Klebsiella pneumoniae DENGAN EKSTRAK ETANOL DARI LIMBAH KULIT PISANG KEPOK (Musa paradisiaca L.) Vector Stephen Dewangga; Muhammad Taufiq Qurrohman
Jurnal Kesehatan Kusuma Husada Vol. 11 No. 2, Juli 2020
Publisher : Universitas Kusuma Husada Surakarta

Pisang kepok (Musa paradisiaca L.) adalah buah yang mudah ditemukan, akan tetapi kulit buahnya selama ini jarang dimanfaatkan. Pada kulit buah M. paradisiaca L. terkandung flavonoid, alkaloid, tanin, saponin, dan terpenoid yang berperan sebagai senyawa antibakteri. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol limbah kulit M. paradisiaca L. mampu menghambat pertumbuhan Klebsiella pneumoniae. Metode penelitian yang digunakan adalah analitik eksperimental, sampel kulit M. paradisiaca L. diperoleh dari pedagang keripik pisang kepok di Kabupaten Karanganyar. Ekstrak etanol 96% kulit M. paradisiaca L. dibuat dengan menggunakan metode perkolasi, sedangkan uji aktivitas antibakteri dilakukan dengan metode Kirby-Bauer. Hasil penelitian menunjukkan bahwa ekstrak etanol 96% limbah kulit M. paradisiaca L. mampu menghambat pertumbuhan bakteri K. pneumoniae, pada konsentrasi 20%; 40%; 60%; 80% dan 100%, dengan rata-rata zona hambat berturut-turut 6,10 mm; 6,35 mm; 6,95 mm; 7,35 mm; dan 7,80 mm. Ekstrak etanol 96% kulit M. paradisiaca L. mampu membentuk zona hambat radikal pada semua konsentrasi terhadap pertumbuhan K. pneumoniae, namun tidak mampu menghasilkan zona hambat radikal setara dengan kriteria sensitif antibiotik ciprofloxacin 5 µg berdasarkan CLSI 2018 terhadap pertumbuhan K. pneumoniae. Banana kepok (Musa paradisiaca L.) is a fruit that is easily found, but the peel of the fruit has rarely been used. The peel of M. paradisiaca L. contains flavonoids, alkaloids, tannins, saponins, and terpenoids which act as antibacterial compounds. This study aims to determine whether the ethanol extract of M. paradisiaca L. peel can inhibit the growth of Klebsiella pneumoniae. The research method used was an experimental analytic, M. paradisiaca L. peel samples were obtained from banana chips traders in Karanganyar. Ethanol extract 96% of the skin of M. paradisiaca L. was prepared using the percolation method, whereas the antibacterial activity test was carried out by the Kirby-Bauer method. The results showed that the 96% ethanolic extract of M. paradisiaca L.peel was able to inhibit the growth of K. pneumoniae in 20%; 40%; 60%; 80% and 100% concentrations, with mean inhibitory zones in order 7,46 mm; 7,52 mm; 7,60 mm; 8,52 mm; dan 8,98 mm. 96% of ethanolic extract M. paradisiaca L. skin was able to form radical inhibitory zones at all concentrations of K. pneumoniae growth, but was unable to produce radical inhibitory zones equivalent to the 5µg ciprofloxacin antibiotic sensitive criteria based on CLSI 2018 on the growth of K. pneumoniae.

Combination of Corn, Cassava and Yellow Sweet Potato as Media Growth of Candida Albicans Muhammad Taufiq Qurrahman; Fitria Diniah Janah Sayekti; Dwi Haryatmi
Indonesian Journal of Global Health Research Vol 4 No 3 (2022): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Fungal infections are quite common in people in tropical countries including Indonesia. Candida albicans is a fungus that can cause infection in humans. Infection caused by Candida albicans is called candidiasis. Diagnosis of Candida albicans with a culture system aims to identify and confirm the results of microscopic examination. Alternative media for fungal growth from various carbohydrate sources have been widely used. Alternative media for fungal growth used included corn, cassava and sweet potato. This study aims to determine the growth of Candida albicans on media with a combination of corn, cassava and sweet potato. The source of data was obtained from primary data, namely data on the results of differences in growth observed from the number of Candida albicans colonies formed on a combination of corn, cassava, and yellow sweet potato media. Data analysis was carried out by statistical tests, including normality test and homogeneity test. If the normality test and homogeneity test meet the requirements, then proceed with the ANOVA and post hoc tests. The results showed that the growth of Candida albicans after 48 hours of incubation, the average number of colonies on corn-cassava media was 58.4x1011 CFU/ml colonies with a colony diameter of 1 mm. Colonies on yellow sweet potato-corn media were 51.5x1011 CFU/ml with a diameter of 1 mm. Colonies on PDA media were 24.8x1011 CFU/ml with a diameter of 1-2mm. In this study, it can be seen that there is a significant difference (p<0.05) in the growth of Candida albicans fungal colonies in each group of media with the highest colony growth, namely on corn and cassava media.

EFEKTIVITAS VARIASI KONSENTRASI TEPUNG TALAS SEBAGAI MEDIA ALTERNATIF PERTUMBUHAN JAMUR Candida albicans Marchamtia Sarah Nur Awalia Fajari; Muhammad Taufiq Qurrohman
Journal of Indonesian Medical Laboratory and Science Vol 2 No 2: Oktober 2021
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v2i2.56

Taro flour (Colocasia esculenta (L.) Schott) has 77%% carbohydrate. A high carbohydrate source has the potential to be used as an alternative media in supporting the examination of Candida albicans fungal culture. Candida albicans is one of the fungi causing candidiasis. Therefore, this study aims to see the effectiveness of the variations of taro flour concentrations as an alternative media to the growth of fungus Candida albicans. The type of the study was experimental with a post test only control group design. The subjects of the study were taro flour media with concentrations of 0,12%, 0,24%, and 0,36% tested on fungus Candida albicans, which was inoculated by spread plate with PDA (Potato Dextrose Agar) media used as control. The data collection was performed by calculating the colony of Candida albicans, which grew in each media. The mean colony of each media on PDA, taro flour 0,12%, 0,24%, 0,36% were 15.5 colonies, 18.8 colonies, 19.5 colonies, and 20.8 colonies, respectively. The effectiveness test showed that all taro flour concentrations have a percentage more than 100%. The variation of taro flour has the growth effect of fungus Candida albicans. Thus, the higher the concentration of taro flour media, the more colony the number of Candida albicans grew. The effectiveness test showed that all taro flour concentrations was classified as very effective.

PENGARUH VARIASI KONSENTRASI SARI PATI BUAH SUKUN SEBAGAI ALTERNATIF MEDIA SEMI SINTETIK PADA PERTUMBUHAN JAMUR Candida albicans Reza Yuliana; M. Taufiq Qurrohman
Journal of Indonesian Medical Laboratory and Science Vol 3 No 1: April 2022
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v3i1.67

Gold standard examination Candida sp. is a culture test. The abundance natural resources in Indonesia encourages researchers to take advantage the wealth of natural resources to create alternative semi-synthetic media for mushroom growth from breadfruit. The purpose of this study was determining the effective concentration of alternative semi-synthetic media of breadfruit essence as growth medium for the fungus Candida albicans. This research is experimental study. Observations were made macroscopically and confirmed microscopically. The results showed that average growth of the colonies on PDA media was 15.50, for the alternative breadfruit media the average of colonies was 24.50 (100% concentration), 19.75 (90% concentration), 19.50 (80% concentration), 16.00 (70% concentration), 15.50 (60% concentration). The results of the ANOVA test obtained value <0.05, so H1 was accepted there was a significant difference in the average growth of fungi in the media of breadfruit essence. The conclusion from this research is that the concentration of 60% breadfruit essence is the effective for growing Candida albicans.

Efektifitas Ekstrak Lidah Mertua (Sansevieria trifasciata var laurentii) Sebagai Antifungi Candida albicans Prasasti Kusumaning Paramastri; Muhammad Taufiq Qurrohman
THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Vol 5, No 2 (2022): The Journal Of Muhammadiyah Medical Laboratory Technologist
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jmlt.v5i2.13478

Candidiasis is a disease caused by Candida albicans, this disease has a mortality rate of > 25%, mainly affecting adults, with a frequency of women 2 - 3 times more than men (Raningsih et al., 2018). A commonly used fungi drug is ketoconazole. but it has many side effects so it is necessary to find for alternatives to natural ingredients, namely the leaf of lidah mertua (Sansevieria trifasciata var laurentii) because it contains compounds saponins, flavonoids, triterpenoids, and steroids as antifungals The leaf of lidah mertua were extracted by maceration technique. The purpose of this research was to determine the effect of antifungi of ethanol extract the leaf of Lidah Mertua (Sansiviera trifasciata var Laurentii) against the fungus Candida albicans. This research was experimental using the disc diffusion method with a spread plate technique in the inhibition zone formed at concentrations of 25%, 20%, 15%, 10%, 5%, positive control and negative control. The results of the One way Anova test is known that differ significantly. From the results of this research, it can be concluded that the ethanol extract of the leaves of the leaf of lidah mertua (Sansevieria trifasciata var laurentii) has an effect on the antifungal activity of Candida albicans Keywords : Candida albicans, Leaf of Lidah Mertua, Antifungal, Ketokonazole

Identifikasi Telur Cacing Nematoda Usus pada Anak Balita Dwi Haryatmi; Muhammad Taufiq Qurrahman; Tri Harningsih; Livana PH
Jurnal Farmasetis Vol 11 No 1 (2022): Jurnal Farmasetis: Mei 2022
Publisher : LPPM Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.284 KB)

Penyakit kecacingan merupakan salah satu penyakit yang kurang mendapat perhatian tetapi masih banyak terjadi dimasyarakat. Nematoda merupakan salah satu jenis cacing parasit yang paling sering ditemukan pada tubuh manusia. Beberapa cacing nematoda usus yang menjadi masalah kesehatan adalah kelompok “Soil Transmitted Helminth (STH)”. Penelitian ini bertujuan untuk mengetahui gambaran infeksi nematoda usus pada anak-anak balita di Desa Menuran, Baki, Sukoharjo. Metode penelitian ini menggunakan penelitian deskriptif. Teknik sampling yang digunakan adalah quota sampling. Subjek penelitian 12 anak balita Desa Menuran. Pemeriksaan telur cacing atau larva menggunakan metode direct tinja. Hasil penelitian menunjukkan dalam tinja seluruh responden tidak ditemukan adanya telur cacing atau larva. Anak-anak balita di Desa Menuran tidak mengalami infeksi cacing dan pengetahuan orang tua anak-anak balita di Desa Menuran tentang infeksi cacing sudah baik.

Pencegahan Kerusakan Hati dan Penyakit Alzheimer Akibat Konsumsi Alkohol Terselubung dengan Pola Hidup Sehat Salsabila Shafa Dhiya; Intan Nur Ramadhan; Muhammad Taufiq Qurrohman; Noviana Dewi; Ariyanti Ariyanti
Jurnal Peduli Masyarakat Vol 5 No 2 (2023): Jurnal Peduli Masyarakat: Juni 2023
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jpm.v5i2.1821

Edukasi bahaya alkohol terselubung dalam makanan dan minuman terhadap resiko kerusakan organ hati dan penyakit alzheimer bertujuan untuk meningkatkan kewaspadaan ibu-ibu dalam menyiapkan makanan bagi keluarga. Ibu yang teredukasi terkait bahaya alkohol terselubung diharapkan dapat mengedukasi anggota keluarga sehingga terhindar dari resiko kerusakan hati dan penyakit Alzheimer. Edukasi ini diberikan kepada 18 Ibu PKK di Kelurahan Bentakan dengan menggunakan metode presentasi dan demonstrasi terkait pola hidup sehat. Berdasarkan hasil analisis dengan menggunakan paired sampel t-test dengan membandingkan nilai pre test dan dan post test diperoleh nilai p 0,000 < 0,05 maka dikatakan bahwa terdapat perbedaan yang signifikan antara mean pre-test dan mean post-test. Perbedaan signifikan tersebut dapat disimpulkan bahwa peserta mengalami peningkatan pengetahuan yang bermakna terkait materi antara sebelum diberikan dengan setelah diberikan materi penyuluhan. Kegiatan pengabdian ini memiliki tingkat kepuasan peserta 4,2 dari skala 1-5 yang artinya telah memuaskan peserta terkait materi maupun penyaji.

Co-Authors Adila Purnama Putri Antik Murwani Ariyanti Ariyanti Chris Srikandini Damar Ajeng Priyandari Dwi Haryatmi Fitria Diniah Janah Sayekti Intan Nur Ramadhan livana ph Marchamtia Sarah Nur Awalia Fajari Muhammad Andriyansyah Sanky Putra Noviana Dewi Prasasti Kusumaning Paramastri Reza Yuliana Salsabila Shafa Dhiya Syifa Aurelya Fitri Tri Harningsih Vector Stephen Dewangga

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