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All Journal Jurnal Ilmiah Farmasi PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL ILMU KEFARMASIAN INDONESIA
Fifteen Aprila Fajrin
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Materials Science & Nanotechnology Medicine & Pharmacology

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AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN SELEDRI (Apium graveolens L) PADA MENCIT JANTAN Fifteen Aprila Fajrin
Jurnal Ilmiah Farmasi Vol. 6 No. 1 (2009)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTCelery (Apium graveolens L.) is one of plants that initially only used for cooking. Based onthe research by Wolski, et al., 2002, celery contains chemical compound such as tannins andpolyphenols. Tannins may be useful as an anti-diarrheal because of the adstringent effect. Thisstudy aims to determine the antidiarrheals activity of celery leaf in male mice strain Balb-C that wasinduced by castor oil. The ethanolic extract of celery leaves divided into three dose group (5,10 and20 mg/kgBW). This research was done by two methods, protection of castor oil induced diarrheaand intestinal transit. After five hours treatment, frequency of defecation, number of soft/liquidfeses and weight of stools were calculated. The gastrointestinal transit rate was expressed as thepercentage of longest distance traversed by the charcoal divided by the total length of the smallintestine.From the protection of castor oil induced diarrhea method, ethanol extract of celery 20mg/20gBW doses decrease frequency of defecation, quantity of the soft / liquid stool and weight ofstool after 5 hours treatment in male mice that had been induced by castor oil. The effectiveness ofethanol extract 20mg/20gBW dose equivalent to loperamid 0.06mg/20gBW (one way anova test atthe α = 95%). Besides, the ethanol extract of celery can prolong intestinal transit of mice, but lowerthan loperamid 0.06mg/20g (one-way anova test at the α = 95%).Keywords: antidiarrheal, castor oil, celery, intestinal transit, taninns
Profil Lipid dan Gambaran Histopatologi Aorta Tikus Hiperlipidemia dengan Pemberian EKSTRAK Kopi Hijau Fransiska Maria Christianty; Diana Holidah; Fifteen Aprila Fajrin; Monica Cinuradha Aura Salsabina; Andrean Roni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (576.056 KB) | DOI: 10.35814/jifi.v18i1.718

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The high prevalence and risk of death from cardiovascular disease has led to the development of alternative treatments derived from nature. Green coffee has not undergone a roasting process. The product is claimed as a weight loser, even though the cardiovascular effects are still controversial. This study aim was to determine the impact of green coffee bean extract on rat lipid profiles and aortic histopathology. Green coffee bean extract made by a re-maceration method using 96% ethanol. Rats were induced with high-fat diet then treated with green coffee bean extract at a dose of 200; 400; and 800 mg/kg BB. Rats were sacrificed, blood was taken for lipid profile measurements and observations were made on histopathological preparations of rat aorta. The results showed that administration of green coffee bean extract (especially doses of 200 mg/kg BW) for 14 days in hyperlipidemic mice could significantly improve lipid profiles, except HDL levels. Microscopic observations showed that green coffee bean extract could enhance the rat aorta histopathology even though it did not match normal conditions. We can conclude that green coffee bean extract has potential effects to be developed as an alternative to traditional medicine that has antihyperlipidemic effects and cardiovascular protective effects.
AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN SELEDRI (Apium graveolens L) PADA MENCIT JANTAN Fifteen Aprila Fajrin
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 09 No. 01 April 2012
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v9i1.686

Abstract

ABSTRAK Latar belakang : Seledri (Apium graveolens L.) merupakan salah satu tanaman yang awalnya hanya digunakan sebagai pelengkap masakan. Berdasarkan dari penelitian yang dilakukan oleh Wolski, et al., 2002 menyatakan bahwa seledri mengandung senyawa kimia tanin dan polifenol. Berdasarkan literatur, tanin terbukti dapat bermanfaat sebagai anti diare. Penelitian ini bertujuan untuk mengetahui aktivitas antidiare daun seledri pada mencit jantan galur Balb-C. Metode : Ekstrak etanol daun seledri terbagi menjadi tiga peringkat dosis (5,10 dan 20 mg/kgBB). Metode yang digunakan adalah metode proteksi terhadap minyak jarak (castor oil) dan metode transit intestinal. Hasil Pengamatan metode proteksi terhadap minyak jarak (castor oil) berupa frekuensi defekasi, konsistensi feses lembek/cair dan bobot feses selama 5 jam pengamatan. Berdasarkan metode transit dihitung rasio jarak yang ditempuh marker (norit) terhadap panjang usus mencit seluruhnya. Hasil dan Pembahasan : Hasil uji pada mencit yang telah dibuat diare dengan induksi castor oil diperoleh bahwa ekstrak etanol daun seledri dosis 20 mg/20gBB dapat menurunkan frekuensi defekasi, jumlah feses lembek/cair dan bobot feses selama 5 jam pengamatan pada mencit jantan yang telah diinduksi castor oil. Efektivitas ekstrak etanol dosis 20 mg/20gBB setara dengan loperamid dosis 0,06 mg/20gBB (berdasarkan uji anova one way pada taraf kepercayaan 95%). Berdasarkan metode transit intestinal diperoleh bahwa ekstrak etanol daun seledri dapat meningkatkan transit intestinal mencit, namun masih lebih kecil jika dibandingkan dengan loperamid dosis 0,06mg/20gBB (berdasarkan uji anova one way pada taraf kepercayaan 95%). Kata kunci : Tanin, Seledri, Castor oil, Transit intestinal, Anti diare. ABSTRACT Introduction : Celery (Apium graveolens L.) is one of plants that initially only used for cooking. Based on the research by Wolski, et al., 2002, celery contains chemical compound such as tannins and polyphenols. Tannins may useful as an anti-diarrheal because of adstringent effect. This study aims to determine the antidiarrheals activity of celery leaf in male mice strain Balb-C that was induced by castor oil. Method : The ethanol extract of celery leaves divided by three dose group (5,10 and 20 mg/kgBW). This research was done by two methods, protection of castor oil induced diarrhea and intestinal transit. After five hours treatment, frequency of defecation, number of soft/liquid feses and weight of stool was calculated. Besides, ratio of distance traversed by norit by the total lenght of small intestine. Result and Discussion : From the protection of castor oil induced diarrhea method, ethanol extract of celery 20 mg/20gBW doses decrease frequency of defecation, quantity of the soft / liquid stool and weight of stool after 5 hours treatment in male mice that had been induced by castor oil. The effectiveness of ethanol extract 20mg/20gBW dose equivalent to loperamid 0.06mg/20gBW (one way anova test at the α = 95%). Besides, the ethanol extract of celery induce intestinal transit of mice, but lower than loperamid 0.06mg/20g (one-way anova test at the α = 95%). Key words : Taninns, Celery, Castor oil, Intestinal transit, Antidiarrheal
Co-Authors Andrean Roni Diana Holidah Fransiska Maria Christianty Monica Cinuradha Aura Salsabina