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Kemandirian Keluarga Dalam Merawat Klien Skizofrenia Cut Dian Sukma Sari; Kartini Hasballah; Asnawi Abdullah
Jurnal Ilmu Keperawatan Vol 5, No 2 (2017): Jurnal Ilmu Keperawatan (JIK) Volume V No.2 Juli-Desember 2017
Publisher : Jurnal Ilmu Keperawatan

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Abstract

AbstrakSkizofrenia merupakan gangguan psikotik kronis yang memiliki dampak tidak hanya masalah bagi penderita tapi bagi keluarganya juga. Dampak skizofrenia mempengaruhi kemandirian keluarga dalam merawat anggota keluarga dengan skizofrenia. Dengan menggunakan metode survey analitik dan dengan pendekatan cross sectional study penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi kemandirian keluarga dalam merawat klien skizofrenia. Populasi dalam penelitian ini adalah keluarga yang merawat anggota keluarga dengan skizofrenia di wilayah kerja Puskesmas Batoh kota Banda Aceh berjumlah 42 orang. Pengumpulan data pada penelitian ini dilakukan dengan teknik total sampling. Instrumen pengumpulan data menggunakan skala likert dengan metode pengumpulan data secara angket. Data dianalisa secara univariat, bivariat  menggunakan Chi-Square Test dan multivariat menggunakan uji statistik Binary Logistic. Hasil penelitian diketahui bahwa tidak terdapat hubungan antara faktor usia dengan kemandirian keluarga (p value=0,158), tidak terdapat hubungan antara faktor pendidikan dengan kemandirian keluarga (p value=1,000), terdapat hubungan yang signifikan antara faktor struktur keluarga dengan kemandirian keluarga (p value=0,000), terdapat hubungan yang signifikan antara faktor budaya dengan kemandirian keluarga (p value= 0,009) dan terdapat hubungan yang signifikan antara faktor lingkungan dengan kemandirian keluarga (p value=0,000). Hasil penelitian ini menunjukkaan bahwa faktor yang paling dominan mempengaruhi kemandirian keluarga klien skizofrenia di Wilayah Kecamatan Batoh Kota Banda Aceh adalah struktur keluarga dengan nilai p adalah 0,039 dan nilai odd ratio (OR) sebesar 11,172 serta lingkungan dengan nilai p adalah 0,032 dan nilai odd ratio (OR) sebesar 23,870Kata kunci : kemandirian, keluarga, skizofrenia. AbstractSchizophrenia is a chronic psychotic disorder that affects not only problems for the sufferer but for the family as well. The impact of schizophrenia affects family independence in caring for family members with schizophrenia. By using analytical survey method and with cross sectional study approach, this study aims to determine the factors that influence the family independence in caring for schizophrenic clients. The population in this study is the family who cared for family members with schizophrenia in the work area of Batoh City Health Center Banda Aceh amounted to 42 people. Data collection in this research is done by total sampling technique. Instrument of data collection using likert scale with data collection method by questionnaire. Data were analyzed by univariate, bivariate using Chi-Square Test and multivariate using Binary Logistic statistic test. The result showed that there was no correlation between age factor and family independence (p value = 0,158), there was no correlation between education factor and family independence (p value = 1,000), there was significant correlation between family structure factor and family independence (p value = 0,000), there is a significant correlation between culture factor and family independence (p value = 0,009) and there is significant relation between environmental factor and family independence (p value = 0,000). The results of this study indicate that the most dominant factor influencing the independence of the family of schizophrenic clients in the Batoh sub-district of Banda Aceh is the family structure with p value is 0.039 and the odd ratio (OR) of 11,172 and the environment with p value is 0.032 and the odd ratio OR) of 23.870Keywords : independence, family, schizophrenia
Antibacterial activity of secondary metabolite compounds from leaf of Eclipta alba L. Hassk Kartini Hasballah; . Murniana; Nurdin Saidi
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 2, No 1 (2012): Life Sciences
Publisher : Syiah Kuala University

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Abstract

Two secondary metabolite compounds of steroid and triterpenoid derivates had been extracted from the leaf of Eclipta alba L. Hassk. The extraction of the compounds was carried out by maceration and then isolated by column chromatography. Structural elucidation was established using GC-MS. Both of the compounds showed antibacterial activity against S. mutans, A. viscosus, and L. kaesal at the concentration of 5%, 10%, and 25%. 
6. Cytotoxic Potential of n-Hexane Extract of Calotropis gigantea L. Leaves Kartini Hasballah; Murniana Murniana; Al Azhar; Nurul Rahmi
The International Journal of Tropical Veterinary and Biomedical Research Vol 1, No 1 (2016): Vol. 1 (1) May 2016
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (169.387 KB) | DOI: 10.21157/ijtvbr.v1i1.5080

Abstract

The present study was done to determine the cytotoxic potential of n-hexane extract of Calotropis gigantea L. leaves and its fractions. Here, dried leaves of C. gigantea L. were macerated using n-hexane to obtain crude extract of 21.16 g (1.03%). The components of n-hexane extract of C. gigantea L. leaves were separated with vacuum-liquid chromatography resulted 4 fractions which are A (0.5 g), B (0.9g), C (5.29 g), and D (6.25 g). Phytochemical screening indicated that the extract contained various secondary metabolic compounds such as steroids, terpenoids, saponins, flavonoids, coumarins, and phenolics. Cytotoxic potenital of the crude extract of C. gigantea L. and its fractions was examined using brine shrimp lethality test (BSLT). The LC50 values of C. gigantea’s n-hexane extract and its fractions that determined by Finney method were 272.27 (n-hexane extract), 31.62 (fraction A), 43.65 (fraction B), 33.89 (fraction C) and 20.98 (fraction D) ?g/mL, respectively. The most active was D fraction contained terpenoids, flavonoids, and phenolics which were assumed contribute to its cytotoxic potential. These results suggested that n-fraction of C. gigantea might possess antitumor or pesticidal activities..
The Role of Gut Microbiota-derived Tryptophan Metabolites in Mycobacterium tuberculosis Infection: A Mini-Review Novi Maulina; Zinatul Hayati; Kartini Hasballah; Zulkarnain Zulkarnain; Baidillah Zulkifli
The International Journal of Tropical Veterinary and Biomedical Research Vol 7, No 2 (2022): Vol. 7 (2) November 2022
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (911.502 KB) | DOI: 10.21157/ijtvbr.v7i2.30165

Abstract

The gut microbiota has a major contribution in human physiology and influences disease pathogenesis, including in tuberculosis (TB) lung infection. Gut-lung axis has demonstrated the interplay of these two organs, mediated by metabolites produced by the gut microbes or derived from host molecules transformation. Tryptophan (Trp) is one of the essential aromatic amino acids catabolized as kynurenine, serotonin (5-hydroxytryptamine), and indole derivatives, including indole propionic acid (IPA), via 3 pathways. The latter was microbiota-derived Trp catabolism, which has known to have an immunomodulatory role, as ligands for Aryl hydrocarbon Receptor (AhR). Intriguingly, Mycobacterium tuberculosis required Trp as a nitrogen source, especially in CD4+ T cells-generated stress, to survive in the phagosome of macrophage and to cause disease. Recently, IPA is identified as a new anti-mycobacterial compound, which is specific and has broad spectrum of anti-mycobacterial activity. The structural similarity of this gut microbiota-derived metabolite and Trp allows IPA to inhibit the TrpE anthranilate synthase in Trp biosynthesis pathway in Mtb. In this review, we summarize findings from recent work by focusing on the role of Trp metabolites in host cells in TB infection.  A better understanding of this chemical signal could potentially serve as a novel strategy for managing this chronic inflammatory disease.