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Cabe Jawa (Piper retrofractum Vahl.) : PENGGUNAAN TRADISIONAL, FITOKIMIA dan AKTIVITAS FARMAKOLOGI Piper retrofractum Vahl. : Traditional Uses, Phytochemical and Pharmacological Activities Fahrauk Faramayuda; Sufyan Zainul Arifin; Akhirul Kahfi Syam; Elfahmi Elfahmi
Perspektif Vol 20, No 1 (2021): Juni 2021
Publisher : Puslitbang Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/psp.v20n1.2021.26-34

ABSTRAK Cabe jawa (Piper retrofractum Vahl.) adalah tanaman daerah tropis asli Indonesia yang dijumpai juga di negara Asia Tenggara seperti Thailand dan Malaysia, dan sejak dahulu telah digunakan secara turun-temurun sebagai bahan tambahan makanan ataupun obat tradisional. Secara tradisional di masyarakat, buah cabe jawa dapat digunakan dalam ramuan untuk mengobati demam, perut kembung, mulas, muntah, mengatasi gangguan pencernaan, merangsang nafsu makan, dan lemah syahwat. Akarnya sering digunakan untuk mengobati sakit gigi, luka dan kejang, serta bagian daunnya digunakan juga untuk obat kumur. Beberapa penelitian menyebutkan aktivitas farmakologi cabe Jawa memiliki efek afrodisiaka, antipiretik, antihiperurisemia, antikanker, dan antimikroba. Pengujian klinis terhadap cabe jawa telah dilakukan dan potensial dikembangkan menjadi obat tradisional golongan fitofarmaka. Cabe jawa memiliki aktivitas sebagai imunostimulan, lebih tinggi dibandingkan dengan kelompok imunostimulan fitofarmaka. Cabe jawa mempunyai potensi sebagai anti-photoaging, aktivitas antituberkular, antiproliferasi, aktivitas larvasida, dan aktivitas sitotoksik. Studi fitokimia senyawa metabolit sekunder utama yang terkandung dalam cabe jawa antara lain beberapa jenis alkaloid seperti piperine, pipernonaline, guineensine, piperoctadecalidine, minyak atsiri buah cabe jawa mengandung tiga komponen utama yaitu yaitu β-caryophyllene (17%), pentadecane (17,8%) dan β- bisabollene (11,2%) . Selain senyawa utama tersebut, terdapat senyawa baru pada buah cabe jawa, diantaranya; senyawa amida, amida glikosida, fenilpropanoid glikosida, dan alkaloid. Sebagai afrodisiaka bagian yang digunakan adalah buahnya dan senyawa piperin yang diduga bertanggung jawab terhadap aktivitas tersebut. Piperin merupakan senyawa utama dan zat berkhasiat yang terkandung dalam buah cabe jawa dan berfungsi sebagai penurun demam, mengurangi rasa sakit, antioksidan, mengurangi peradangan, antitumor, dan sebagai imunomodulator. Berdasarkan aktifitas farmakologi yang baik dari cabe jawa maka studi atau penelitian-penelitian pada tanaman ini harus terus dilakukan seperti pengembangan formulasi dan upaya perbanyakan tanaman karena populasi cabe jawa jumlahnya terbatas. Media terbaik dalam induksi kalus tanaman cabe jawa adalah Murrashige Skoog (MS) yang ditambah 6-Benzil Amino Purin (BAP) dan Naphtalene Acetic Acid (NAA).ABSTRACT Piper retrofractum vahl. is a tropical plant native to Indonesia which is also found in Southeast Asian countries such as Thailand and Malaysia, and has been used for generations as a food additive or traditional medicine. Traditionally in the community, P. retrofractum fruit can be used in potions to treat fever, flatulence, heartburn, vomiting, overcome digestive disorders, stimulate appetite, and impotence. The roots are often used to treat toothaches, wounds, and seizures, and the leaves are also used for mouthwash. Several studies have stated that the pharmacological activity of P. retrofractum has aphrodisiac, antipyretic, anticancer, and antimicrobial effects. Clinical testing on P. retrofractum has been carried out and has the potential to be developed into a traditional medicine of the phytopharmaceutical class. P. retrofractum has activity as an immunostimulant, which is higher than the phytopharmaceutical immunostimulant group. P. retrofractum has potential as anti-photoaging, antitubercular, antiproliferative, larvicidal activity, and cytotoxic activity. Phytochemical studies of the main secondary metabolites contained in P. rectofractum include several types of alkaloids such as piperine, pipernonaline, guineensine, piperoctadecalidine, fruit essential oils. Javanese chili contains three main components, namely-caryophyllene (17%), pentadecane (17.8%) and -bisabollene (11.2%). In addition to these main compounds, there are new compounds in P. retrofractum fruit, including; amide compounds, amide glucosides, phenylpropanoid glucosides, and alkaloids. As an aphrodisiac, the part used is the fruit and the piperine compound which is thought to be responsible for this activity. Piperine is the main compound and efficacious substance contained in P. retrofractum fruit and functions as a fever reducer, pain reliever, antioxidant, reducing inflammation, antitumor, and immunomodulator. Based on the good pharmacological activity of P. retrofractum , studies or researches on this plant must continue to be carried out such as formulation development and plant propagation efforts because the population of P. retrofractum is limited. The best medium for callus induction of cabe jawa was Murashige Skoog (MS) with 6-Benzyl Amino Purine (BAP) and Naphtalene acetic (NAA) added.

Cabe Jawa (Piper retrofractum Vahl.) : PENGGUNAAN TRADISIONAL, FITOKIMIA dan AKTIVITAS FARMAKOLOGI Piper retrofractum Vahl. : Traditional Uses, Phytochemical and Pharmacological Activities Fahrauk Faramayuda; Sufyan Zainul Arifin; Akhirul Kahfi Syam; Elfahmi Elfahmi
Perspektif Vol 20, No 1 (2021): Juni 2021
Publisher : Puslitbang Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/psp.v20n1.2021.26-34

ABSTRAK Cabe jawa (Piper retrofractum Vahl.) adalah tanaman daerah tropis asli Indonesia yang dijumpai juga di negara Asia Tenggara seperti Thailand dan Malaysia, dan sejak dahulu telah digunakan secara turun-temurun sebagai bahan tambahan makanan ataupun obat tradisional. Secara tradisional di masyarakat, buah cabe jawa dapat digunakan dalam ramuan untuk mengobati demam, perut kembung, mulas, muntah, mengatasi gangguan pencernaan, merangsang nafsu makan, dan lemah syahwat. Akarnya sering digunakan untuk mengobati sakit gigi, luka dan kejang, serta bagian daunnya digunakan juga untuk obat kumur. Beberapa penelitian menyebutkan aktivitas farmakologi cabe Jawa memiliki efek afrodisiaka, antipiretik, antihiperurisemia, antikanker, dan antimikroba. Pengujian klinis terhadap cabe jawa telah dilakukan dan potensial dikembangkan menjadi obat tradisional golongan fitofarmaka. Cabe jawa memiliki aktivitas sebagai imunostimulan, lebih tinggi dibandingkan dengan kelompok imunostimulan fitofarmaka. Cabe jawa mempunyai potensi sebagai anti-photoaging, aktivitas antituberkular, antiproliferasi, aktivitas larvasida, dan aktivitas sitotoksik. Studi fitokimia senyawa metabolit sekunder utama yang terkandung dalam cabe jawa antara lain beberapa jenis alkaloid seperti piperine, pipernonaline, guineensine, piperoctadecalidine, minyak atsiri buah cabe jawa mengandung tiga komponen utama yaitu yaitu β-caryophyllene (17%), pentadecane (17,8%) dan β- bisabollene (11,2%) . Selain senyawa utama tersebut, terdapat senyawa baru pada buah cabe jawa, diantaranya; senyawa amida, amida glikosida, fenilpropanoid glikosida, dan alkaloid. Sebagai afrodisiaka bagian yang digunakan adalah buahnya dan senyawa piperin yang diduga bertanggung jawab terhadap aktivitas tersebut. Piperin merupakan senyawa utama dan zat berkhasiat yang terkandung dalam buah cabe jawa dan berfungsi sebagai penurun demam, mengurangi rasa sakit, antioksidan, mengurangi peradangan, antitumor, dan sebagai imunomodulator. Berdasarkan aktifitas farmakologi yang baik dari cabe jawa maka studi atau penelitian-penelitian pada tanaman ini harus terus dilakukan seperti pengembangan formulasi dan upaya perbanyakan tanaman karena populasi cabe jawa jumlahnya terbatas. Media terbaik dalam induksi kalus tanaman cabe jawa adalah Murrashige Skoog (MS) yang ditambah 6-Benzil Amino Purin (BAP) dan Naphtalene Acetic Acid (NAA).ABSTRACT Piper retrofractum vahl. is a tropical plant native to Indonesia which is also found in Southeast Asian countries such as Thailand and Malaysia, and has been used for generations as a food additive or traditional medicine. Traditionally in the community, P. retrofractum fruit can be used in potions to treat fever, flatulence, heartburn, vomiting, overcome digestive disorders, stimulate appetite, and impotence. The roots are often used to treat toothaches, wounds, and seizures, and the leaves are also used for mouthwash. Several studies have stated that the pharmacological activity of P. retrofractum has aphrodisiac, antipyretic, anticancer, and antimicrobial effects. Clinical testing on P. retrofractum has been carried out and has the potential to be developed into a traditional medicine of the phytopharmaceutical class. P. retrofractum has activity as an immunostimulant, which is higher than the phytopharmaceutical immunostimulant group. P. retrofractum has potential as anti-photoaging, antitubercular, antiproliferative, larvicidal activity, and cytotoxic activity. Phytochemical studies of the main secondary metabolites contained in P. rectofractum include several types of alkaloids such as piperine, pipernonaline, guineensine, piperoctadecalidine, fruit essential oils. Javanese chili contains three main components, namely-caryophyllene (17%), pentadecane (17.8%) and -bisabollene (11.2%). In addition to these main compounds, there are new compounds in P. retrofractum fruit, including; amide compounds, amide glucosides, phenylpropanoid glucosides, and alkaloids. As an aphrodisiac, the part used is the fruit and the piperine compound which is thought to be responsible for this activity. Piperine is the main compound and efficacious substance contained in P. retrofractum fruit and functions as a fever reducer, pain reliever, antioxidant, reducing inflammation, antitumor, and immunomodulator. Based on the good pharmacological activity of P. retrofractum , studies or researches on this plant must continue to be carried out such as formulation development and plant propagation efforts because the population of P. retrofractum is limited. The best medium for callus induction of cabe jawa was Murashige Skoog (MS) with 6-Benzyl Amino Purine (BAP) and Naphtalene acetic (NAA) added.

KARAKTERISASI FARMAKOGNOSI DAUN FALOAK (Sterculia quadrifida R.Br): CHARACTERIZATION OF PHARMACOGNOSY OF FALOAC LEAVES (Sterculia quadrifida R.Br) Fahrauk Faramayuda; Julia Ratnawati; Akhirul Kahfi Syam
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 2 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i2.322

Faloak secara empiris digunakan sebagai antimikroba, megobati penyakit tifus, mengatasi gangguan pada hati, laksatif, dan antimalaria. Faloak merupakan salah satu tumbuhan yang secara empiris digunakan sebagai obat tradisional di Nusa Tenggara Timur. Selanjutnya dari hasil penelitian ini dapat digunakan untuk studi dan pengembangan aktivitas biologi ekstrak daun faloak menjadi produk farmasi. Ekstraksi menggunakan cara maserasi dengan pelarut etanol dan menghasilkan rendemen 8,84% b/b. Parameter standarisasi ekstrak menunjukkan bobot jenis ekstrak 0,7543 ± 0,0060 g/mL, kadar sari larut air 54 ± 1,15% b/b, sari larut etanol 88,48 ± 1,05% b/b, kadar abu total 10,47 ± 0,16% b / b, abu larut air 8,01 ± 0,99% b / b, abu tidak larut asam 0,39 ± 0,03% b/b. Ekstrak etanol daun faloak mengandung flavonoid, kuinon, polifenol, steroid-triterpenoid, dan monoterpen-sesquiterpen. Ekstrak dianalisis kandungan kimianya menggunakan kromatografi lapis tipis (KLT) dengan fase diam silica F254 dan menggunakan fasa gerak n-heksana: etil asetat (1:1), hasilnya terdapat bercak dengan Rf 0,21 memberi warna biru pada UV 365 nm dan bercak hitam berlatar hijau pada UV 254 nm. Total kandungan flavonoid pada ekstrak etanol daun faloak 5,31 ± 0,29% b / b dan total kandungan polifenol 1,79 ± 0,03% b / b. Dari hasil karakterisasi ini bisa menjadi dasar pemgembangan tanaman faloak menjadi bahan baku obat tradisional terstandar dan acuan untuk melakukan uji aktivitas farmakologi.

Sosialisasi Penanganan Pasca Panen Bahan Baku Rempah Obat Tradisional Fahrauk Faramayuda; Soraya Riyanti; Akhirul Kahfi Syam; Ari Sri Windyaswari; Yeni Karlina; Remare Halomoan Limbong; Anggita Esa Putri Fitrichia; Ananda Tunjung Pertiwi; Trialisa Aprilia; Ema Mutya; Renti Mutiara Dewi; Dwi Ayu Pratiwi; Usi Septiani; Esanda Zulfi Amedea; Yesi Wulandari; Adinda Fitriani; Ami Soega Dwigantina
Kawanad : Jurnal Pengabdian kepada Masyarakat Vol. 1 No. 2 (2022): October
Publisher : Yayasan Kawanad

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56347/kjpkm.v1i2.52

Community service activities carried out by students of Universitas Jenderal Achmad Yani were carried out on August 29, 2022, taking place in a medicinal plant garden, Faculty of Pharmacy, Universitas Jenderal Achmad Yani which was attended by UMKM Spice Nusantara Bandung participants. The socialization carried out was the presentation and delivery of post-harvest processing materials (wet sorting, washing, drying, and dry sorting) and the standardization of traditional raw materials. Conventional medicine is a form of treatment efforts in the community to support health which is currently being recommended by the government. Communities can use the toga as an economical and efficient measure to maintain body immunity because the community can obtain and use the toga quickly and simply to maintain family health. The postharvest process greatly determines the existence of active compounds that are efficacious for treatment. Incorrect postharvest management can change, reduce, or destroy the active substance of a plant into a substance that has no therapeutic effect and can even endanger health. The results of the participant's level of understanding were carried out post-test with the results of what is the purpose of post-harvest processing (100%), the sequence of post-harvest processing (80%), what is the general drying temperature (100%), a medicinal plant has good quality and efficacy then we need to know (80%), and what is the function of the washing process (90%) with the conclusion that socialization activities can significantly increase the knowledge of participants from MSMEs regarding planting, post-harvest processing, and the properties of medicinal plants significantly.

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