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All Journal Jurnal Kesehatan Andalas INDONESIAN JOURNAL OF PHARMACY Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia
Dwitya Elvira
Allergy And Clinical Immunology Subdivision, Department Of Internal Medicine, Faculty Of Medicine, Universitas Andalas / M. Djamil Hospital, Padang, West Sumatera, Indonesia Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Target Therapy in Systemic Lupus Erythematosus: A Narrative Literature Review Muhamad Delfin; Raveinal; Dwitya Elvira
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.876

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the presence of autoantibodies against cells and involves many organ systems in the body. The Lupus Foundation of America estimates that around 1.5 million cases occur in America and at least 5 million cases occur worldwide. Every year it is estimated that there are around 16 thousand new cases of SLE. Various pro- and anti-inflammatory cytokines such as transforming growth factor (TGF), interleukin-10, B cell activating factor (BAFF), interferon-α, interleukin-17, and interleukin-23 play an important pathogenic role. Disruption of apoptotic cells and immune complexes is an important contributor to the development of this disease. Loss of immune tolerance increases antigenic load, excessive role of T cells, impaired B cell suppression and impaired transition of the immune response from T helper 1 (Th1) to Th2 which causes hyperactivity of B cells and produces pathogenic autoantibodies. The management of cases of severe or refractory SLE to conventional therapy has attracted a lot of attention in recent years, so that many researchers have developed several targeted therapies that have been tested on SLE, such as anti-CD 20 and CD 22 antibodies and BAFF inhibitors found in B lymphocyte cells. The Rituximab anti-CD 20 antibody target has been clinically proven to be able to improve the severity of SLE, while the effectiveness of other targeted therapies is still under research.
Co-Authors Adrial Adrial Alexander Kam Arina Widya Murni Azia Putri Al Jamil Dian Pertiwi Dinda Aprilia Efrida Efrida Elvia Fataya Eva Decroli Fadrian Fadrian Gustia Anugrahwati Hendriati, Hendriati Ilmiawati, Ilmiawati Muhamad Delfin Muhammad Iqbal Andreas Mustafa Noer Netti Suharti Raveinal Raveinal Raveinal RAVEINAL RAVEINAL Rido Wandrivel Rizka Nadia Rizqy Auliya Lubis Roza Kurniati Roza Kurniati Saptino Miro Siti Nurhajjah Suci Maulida Yuliarni Syafrita Yulistini, Yulistini