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All Journal The Journal of Pure and Applied Chemistry Research CHEMPUBLISH JOURNAL Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) ALKIMIA : Jurnal Ilmu Kimia dan Terapan JOURNAL OF CHEMICAL NATURAL RESOURCES (JCNaR)
Madyawati Latief
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Anti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia) Muhaimin Muhaimin; Muhammad Irhash Shalihin; Madyawati Latief
The Journal of Pure and Applied Chemistry Research Vol 10, No 2 (2021): Edition May-August 2021
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2021.010.02.584

Abstract

Premna serratifolia known as bebuas has long been used by Malay comunity for both food and traditional medicine. The most notable advantage of this plant is to heal woman after childbirth and to raise the notion that contains anti-inflammatory bioactive compounds. In this study, the hexane extract of bebuas was only contained steroids. Meanwhile the ethanol extract contained various secondary metabolites such as phenolics, alkaloids, flavonoids, steroids and saponins. The ethanol extract was further separated since the targeted compound isolate was an alkaloid. The isolate obtained was a yellow crystal which transformed to yellow oil after being exposed to air. The anti-inflammatory evaluation of the compound gave a result with a strong activity with ED50 = 4.06 mg/KgBW. Characterization by UV-Vis and FT-IR showed that the isolate’s spectra pattern had similarities with bufotenine. It revealed that the isolate shared the same basic skeleton with the bufotenine, especially the indole skeleton. Furthermore, it also shared the same physical form with bufotenine. These evidences strengthened the assumption that the isolate was an indole alkaloid.
AKTIVITAS ANTIMIKROBA EKSTRAK ETIL ASETAT BUAH DAN DAUN BELIMBING WULUH (Averrhoa bilimbi Linn) TERHADAP MIKROBA Salmonella tyhipimurium dan Aspergillus flavus Ana Suliani; Madyawati Latief; Silvi Leila Rahmi
CHEMPUBLISH JOURNAL Vol. 1 No. 2 (2016): Chempublish Journal
Publisher : Universitas Jambi, Fakultas Sains dan Teknologi, Program Studi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (542.923 KB)

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas senyawa antimikroba ekstrak etil asetat buah dan daun belimbing wuluh (Averrhoa bilimbi Linn)  terhadap mikroba Salmonella thypimurium dan Aspergillus flavus. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan konsentrasi ekstrak 0%, 2%, 4%, 6%, 8%, dan 10%  dengan 3 x ulangan. Pengujian aktivitas antimikroba dilakukan dengan metode difusi cakram. Hasil penelitian menunjukkan bahwa penggunaan ekstrak etil asetat buah dan daun belimbing wuluh menunjukkan aktivitas antimikroba terhadap Salmonella thypimurium, tetapi tidak dapat menunjukkan aktivitas antimikroba terhadap Aspergillus flavus. Konsentrasi 6% pada ekstrak etil asetat buah dan daun belimbing wuluh menunjukkan aktivitas antimikroba terhadap Salmonella thypimurium dengan diameter zona hambat 2,83 mm pada buah dan 2 mm pada daun.
Kandungan Kimia dari Fraksi Aktif Antioksidan Ekstrak Kulit Batang Garcinia forbesii King Madyawati Latief; Supriyatna Soetardjo; Husein H. Bahti; Dachriyanus Dachriyanus
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 05 No. 01 April 2007
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Abstract

Penelitian ini dilakukan untuk menentukan aktivitas antioksidan ekstrak kulit batang daun Garcinia forbesii (Guttiferae). Uji aktivitas antioksiodan dari masing-masing ekstrak menggunakan metode pembentukan radikal DPPH (1,1-difenil-2-pikrilhidrazil). Dari fraksi aktif antioksidan telah diisolasi senyawa stigmasterol dengan teknik kromatografi kolom. Identifikasi struktur dilakukan berdasarkan data UV, IR, 1H NMR dan 13C NMR. Ekstrak heksan, diklorometan dan metanol menunjukan persentase inhibisi berturut-turut pada 88%, 93% dan 86%.
Aktivitas Antioksidan Ekstrak Daun Garcinia celebica Linn (Kandis) Madyawati Latief; Supriyatna Soetardjo; Husein H. Bahti; Dachriyanus Dachriyanus
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 05 No. 02 Agustus 2007
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak heksanaa, etil asetat, dan metanol dari daun kandis (Garcinia celebicat Linn), familia Gunttiferae. Uji aktivitas antioksidan menggunakan metode pembentukan radikal DPPH. Pemilihan senyawa yang diisolasi didasarkan pada aktivitas senyawa tersebut pada uji antioksidan. Dari pemeriksaan kandungan kimianya senyawa hasil isolasi termasuk golongan triterpenoid.
Uji Antimikroba Rumput Mutiara (Hedyotis corymbosa) terhadap Bakteri dan Jamur Penyebab Penyakit pada Ternak Unggas Nurhayati Nurhayati; Madyawati Latief; Heru Handoko
Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Vol 23, No 3 (2006)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mib.2006.23.3.172

Abstract

An experiment was conducted to determine the activity of pearl grass (rumput mutiara, Hedyotis corymbosa) in inhibiting growth of bacterial and fungi causing diseases in poultry.The current study used 3000 gram of sorted and cleaned pearl grass from dust and other weeds. This study employed sample collection, extraction, fractionation, preparation of medium of Agar and Mueller Hinton Broth, culturing bacterial, antimicrobial test and measuring minimum inhibitory concentrations. Extraction was conducted by maceration of pearl grass with methanol for five days followed by evaporating in vacuo to get methanol extract. The extract was then fractionated by adding hexane or acetic acid and ethyl acetic or sodium bicarbonate or n-buthanol to get fraction of hexsane, acid ethyl acetic, base ethyl acetic, n-buthanol. Each fraction was then tested with microbial test that were Salmonella sp, Escherichia coli, and Candida albicans. The results showed that each fraction at 2 % of concentration could inhibit bacterial growth except for Candida albicans that was not inhibited by any fraction of pearl grass. The minimum inhibitory concentrations was 0.4 – 0.8% (4 mg/ml – 8 mg/ml) indicating that pearl grass fractions were highly active on inhibiting bacterial growth that cause poultry diseases and the inhibiting activity on E. coli was found higher than that on Salmonella sp.
The Characterization of Active Compound of Pedada Magrove Plants (Sonneratia caseolaris) Which HaveThePotential as Natural Antioxidants Madyawati Latief
Journal of Chemical Natural Resources Vol. 1 No. 1 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (940.714 KB) | DOI: 10.32734/jcnar.v1i1.829

Abstract

The present research aimedto isolate the compound from the acetone fractions of pedada leaves (Sonneratia caseolaris) and test its antioxidant activity. The extraction wasperformed usinga multi-stage maceration method. The separation and purification were done using a vacuum and gravitational column chromatography whereasthe antioxidant activity was tested with theDPPH method. The structural elucidation of the compound was performed by spectroscopy data of UV, IR, alsoone- and two-dimensional NMR. The appearance of the pure isolate was odorless yellow crystal. Based on the spectroscopy data, the compound wasstigmasta-5,22-dien-3-ol. The activity testing of the extract antioxidant and pure isolate with IC50showed a value of 166.2 ppm dan 134.4 ppm, respectively.
Determination of Boric Acid Levels in Food Samples Using the UV-Vis Spectrophotometry Method Anjelli Putri Gunawan; Alidya Fitri Kusuma Wardani; Ria Hikmarina; Rahmi Rahmi; Madyawati Latief
ALKIMIA Vol 6 No 2 (2022): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/alkimia.v6i2.14519

Abstract

Food is a basic need for every human being to grow and maintain life. In food there is what is called BTP or Food Additives. According to the Regulation of the Minister of Health of the Republic of Indonesia No. 033 of 2012 concerning food additives , boric acid or borax is one of the types of food additives that are prohibited from being used in food products. However, in reality many people still use boric acid as BTP in producing food. The purpose of this study was to identify and determine boric acid levels in food samples. Quantititative analysis was performed using the liquid curcumamine addition method, while quantitative analysis used the UV-Vis spectrophotometry method at a maximum wavelength of 540 nm. The results of the identification and determination of boric acid levels showed that sample A had a color change from purplish red to brick red which indicated that the food sample was positive for containing boric acid. The average level of boric acid in sample A was 986.947 ppm. The %RSD value obtained is 1.583% which indicates that this test has good precision.
Co-Authors . Dachriyanus Alidya Fitri Kusuma Wardani Ana Suliani Anjelli Putri Gunawan Heru Handoko Husein Hernadi Bahti Muhaimin Muhaimin Muhammad Irhash Shalihin Nurhayati Nurhayati Rahmi Rahmi Ria Hikmarina Silvi Leila Rahmi Supriyatna Soetardjo