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All Journal JPM17: Jurnal Pengabdian Masyarakat JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Sciences and Research (PSR)
Melanny Ika Sulistyowaty
Pharmaceutical Sciences Department, Faculty Of Pharmacy, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Arts Humanities Chemistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Perbandingan Metode Sintesis Senyawa 1-benzil-3-(4-etil-benzoil)urea dan 1-benzil-3-(4-klorometil-benzoil)urea sebagai Calon Obat Antikanker Farida Suhud; Daryono Hadi Tjahjono; Tegar Achsendo Yuniarta; Galih Satrio Putra; Melanny Ika Sulistyowaty
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 3 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i32021.277-283

Abstract

Pendahuluan: Pengembangkan obat antikanker yang selektif dari turunan hidroksiurea masih diteliti sampai saat ini. Tujuan: Penelitian ini bertujuan untuk membandingkan metode sintesis senyawa turunan hidroksiurea yaitu 1-benzil-3-(4-etil-benzoil)urea dan 1-benzil-3-(4-klorometil-benzoil)urea. Metode: Optimasi metode sintesis yang dilakukan dengan membandingkan produk hasil sintesis dengan pemanasan refluks dan tanpa pemasanan refluk. Produk yang didapat dilakukan analisis elusidatif meliputi FTIR, 1H-NMR dan 13C-NMR. Hasil: berdasarkan hasil perbandingan metode sintesis menggunakan refluks menyebabkan terbentuknya dua produk samping sehingga perlu dilakukan pemisahan dengan kromatograsi kolom antara produk utama dengan dua produk sampingnya. Metode tanpa pemasanan lebih dipilih karena tidak menghasilkan dua produk hasil samping walaupun rendemen masih dalam rentang 20-30%. Kesimpulan: Metode sintesis senyawa turunan 1-benzil-3-benzoilurea lebih direkomendasikan tanpa pemasanan daripada menggunakan pemanasan refluks, tetapi penelitian kedepannya harus didapatkan metode yang lebih baik untuk mendapatkan rendemen yang lebih besar.
IbM KELOMPOK USAHA BUDIDAYA JAMUR DI KABUPATEN KEDIRI PASCA ERUPSI GUNUNG KELUD Melanny Ika Sulistyowaty; Juni Ekowati; Achmad Toto Poernomo; M. Faris Adrianto
JPM17: Jurnal Pengabdian Masyarakat Vol 2 No 01 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30996/jpm17.v2i01.793

Abstract

The eruption of Mount Kelud, located in Kediri-East Java that occurred inearly of 2014 resulted damages of some public facilities and also agriculturalland. Most of the people who lived that area are working as farmers andranchers. Many of the villagers became unproductive and could not performactivities of farming and ranching. To solve such a problem, we would like toencourage them by training how to cultivate mushroom Pleurotus ostreatus orknown as “Tiram” mushroom. The expectation of this activity is they can beindependently economically by cultivating mushrooms in their area after theeruption of Mount Kelud.Keywords: Pleurotus spp, eruption, cultivate, Tiram mushroom, Kediri
Pemberdayaan Masyarakat melalui Edukasi Cara Pembuatan Pangan Olahan yang Baik, Bahan Tambahan Pangan, dan Kemasan Pangan untuk Penguatan Jaminan Keamanan pada Pelaku UMKM Bidang Makanan di Balikpapan Juni Ekowati; Rosita Handayani; Dewi Melani Hariyadi; Mohammad Rizki Fadhil Pratama; Putri Hamidah Khairunnisa; Melanny Ika Sulistyowaty; Rossa Auli Tasha; Imamatin Nufus Melania; Ersanda Nurma Praditapuspa; Muhamad Ilham Royyan Nafi’
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 6 No 6 (2021): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v6i6.2676

Abstract

Food safety is a complex issue that involves stakeholders in its handling. The point of food safety is growing widely and is becoming a concern in the community because it is related to the quality of consumers' good health and well-being. The community service activities based on quality education focused on Good Processed Food Manufacturing Practices (CPPOB), safe use of Food Additives (BTP), and consideration of packaging selection that ensures food safety. Education is carried out to increase the understanding of SMEs actors regarding regulations of CPPOB, the use of BTP, and provisions on Food Packaging. The education process is carried out online using the Zoom Meeting platform. Learning activity is carried out in one direction through lectures and questions and answers sessions. The increase in participants' understanding was measured by comparing the distribution of average scores, pretest, and post-test statistical tests. The effectiveness and quality of the educational process were measured using an evaluation questionnaire with predetermined indicators. The education carried out related to CPPOB, the use of BTP, and the selection of food packaging performed by the community service team of the Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga to SMEs in Balikpapan has proven to increase the understanding of business actors. It can fulfill their needs and target activity evaluation indicators that have been determined.
Pemodelan Molekul Turunan p-Metoksi sinnamoil Hidrazida Sebagai Inhibitor Checkpoint Kinase 1 dan Inhibitor Aromatase secara In silico Putra, Galih Satrio; Sulistyowatya, Melanny Ika; Ekowati, Juni; Budiati, Tutuk
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The development of anticancer drugs from ethyl p-methoxycinnamate (EPMC) derivatives has been done to compounds high activity in inducing cancer cells apoptosis and minimal side effects. p-Methoxycinnamoyl hydrazide derivates, modified from EPMC structure, were docked into the ligand-binding pocket of Check point kinase 1 enzymes (2YWP) and the aromatase enzyme (3S7S) using software Molegro Virtual Docker (MVD) Ver.5.5. We compared the Rerank score of native ligand with p-Methoxycinnamoyl hydrazide derivates. Rerank scores of compounds 4b and 4c (-99.98 Kcal/mol and -99.80 Kcal/mol) were lower than the native ligand A42 in inhibiting the enzyme checkpoint kinase 1. Rerank values of p-Methoxycinnamoyl hydrazide derivate compounds were greater than the native ligand EXM in inhibiting the enzyme aromatase. p-Methoxycinnamoyl hydrazide derivate compounds, especially compounds 4b and 4c, had anticancer mechanism by inhibiting the checkpoint kinase 1 enzyme pathway and showed no activity in inhibiting the aromatase enzyme.
Co-Authors Achmad Toto Poernomo Daryono Hadi Tjahjono Dewi Melani Hariyadi Farida Suhud Galih Satrio Putra Galih Satrio Putra Galih Satrio Putra, Galih Satrio Imamatin Nufus Melania Juni Ekowati M. Faris Adrianto Mohammad Rizki Fadhil Pratama Muhamad Ilham Royyan Nafi’ Praditapuspa, Ersanda Nurma Putri Hamidah Khairunnisa Rosita Handayani Rossa Auli Tasha Tegar Achsendo Yuniarta Tutuk Budiati