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All Journal UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Journal of Tropical Pharmacy and Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline

Dewi Melani Hariyadi

Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya, Indonesia

Author-ID : 606123

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Preparation and Characterization of Ba-Alginate Microspheres Containing Ovalbumin Hariyadi, Dewi Melani; Hendradi, Esti; Irawan, Mukhlis Bayu
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 1 (2016)
Publisher : Indonesian Research Gateway

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The use of microspheres nowadays is important in the pharmaceuticals formulation. The aim of the present research was to evaluate physical characteristics of ovalbumin-loaded alginate microspheres using aerosolisation technique at various concentrations of alginate and BaCl2. Alginate microspheres were characterized in terms of encapsulation efficiency, yield, particle size, surface morphology and protein integrity. The comparative study between concentrations of BaCl2 and alginate polymer was investigated. Increasing concentration of alginate polymer from 2.5 to 3.5% reduced their particle size and formed smoother and spherical microspheres. Increasing Ba2+ concentration, simultaneous increased the encapsulation efficiency and yield. Scanning electron microscope (SEM) photomicrographs revealed that with the increase in the electrolyte concentration the density of the cross link is also increased. Smoother surface was demonstrated when the electrolyte concentration is increased from 0.5M to 0.75M. Formula prepared using 0.75M BaCl2 and 3.5% alginate polymer resulted the highest encapsulation efficiency (92%), the highest microspheres yield (73%) and the smallest microspheres size (3.73µm). Most of the formulations maintain the integrity of ovalbumin after 2 hours incubation in pH 1.2 followed by 8 hours incubation in pH 7.4. The different formulations produced different physical characteristics of ovalbumin-loaded alginate microspheres.

Preparation and Characterization of Ba-Alginate Microspheres Containing Ovalbumin Hariyadi, Dewi Melani; Hendradi, Esti; Irawan, Mukhlis Bayu
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

The use of microspheres nowadays is important in the pharmaceuticals formulation. The aim of the present research was to evaluate physical characteristics of ovalbumin-loaded alginate microspheres using aerosolisation technique at various concentrations of alginate and BaCl2. Alginate microspheres were characterized in terms of encapsulation efficiency, yield, particle size, surface morphology and protein integrity. The comparative study between concentrations of BaCl2 and alginate polymer was investigated. Increasing concentration of alginate polymer from 2.5 to 3.5% reduced their particle size and formed smoother and spherical microspheres. Increasing Ba2+ concentration, simultaneous increased the encapsulation efficiency and yield. Scanning electron microscope (SEM) photomicrographs revealed that with the increase in the electrolyte concentration the density of the cross link is also increased. Smoother surface was demonstrated when the electrolyte concentration is increased from 0.5M to 0.75M. Formula prepared using 0.75M BaCl2 and 3.5% alginate polymer resulted the highest encapsulation efficiency (92%), the highest microspheres yield (73%) and the smallest microspheres size (3.73Âµm). Most of the formulations maintain the integrity of ovalbumin after 2 hours incubation in pH 1.2 followed by 8 hours incubation in pH 7.4. The different formulations produced different physical characteristics of ovalbumin-loaded alginate microspheres.

PENDIDIKAN KOGNITIF DAN AFEKTIF DAGUSIBU UNTUK PENCEGAHAN RESISTENSI ANTIBIOTIK DI SMA SURABAYA Abhimata Paramanandana; Dini Retnowati; Andang Miatmoko; Dewi Isadiartuti; Sugiyartono1; Mohammad Agus Sjamsur Rijal; Dwi Setiawan; Esti Hendradi; Tutiek Purwanti; Noorma Rosita; Dewi Melani Hariyadi; Tristiana Erawati; Ardhani Dwi Lestari1; Helmy Yusuf; Retno Sari
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2019): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Antibiotics are not only used for humans, but also often used for cattle and livestock which are then been consumed by humans. This over prescribed and missed used of antibiotic is a major factor in antibiotic resistance. Antibiotic resistance is a condition where bacteria are unable to be treated with antibiotics. In fact, the use of antibiotics is the first response in curing infectious diseases (by bacteria) and preventing infectious diseases spreading. With antibiotic resistance, preventing infectious diseases by bacteria became harder. This community service activity came up with a slogan "Antibiotic Resistence Awareness Movement" was carried out in Surabaya 10 Public High Schools and Surabaya 17 Public High Schools with 60 students per school using several methods, namely: (a) giving lecture material using LCD projectors ) the implementation of poster making competitions, and (c) poster presentations that have been made that are accompanied by question and answer, and (d) evaluation activities in the form of written tests covering pre-test and post-test. Concerning the results of posters results, poster presentations and improving the results of this posttest can be concluded as a result of an increase in understanding and or knowledge of students of SMA 10 and SMA 17 Surabaya

EFFECT OF COMBINATION SODIUM ALGINATE-GELATIN 1% : 2% CONTENT IN CHARACTERISTIC AND ANTIMICROBIAL ACTIVITY OF PROBIOTIC MICROSPHERES Lactobacillus acidophilus Regia Nada Asshafa; Tutiek Purwanti; Dewi Melani Hariyadi
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Probiotics is live micro-organisms which whenadministered in adequate amounts, confer ahealth benefit on the host (FAO / WHO, 2002).Probiotics may give therapeutic effect in minimalamounts 106-107cfu/g daily. Some reports in thelast decade have described that probiotic, such asLactobacillus acidophilus, is useful for treating skindisorder such as dermatitis, acne, cellulitis, andpsoriasis. This relates to the content of probioticsmetabolites that protect the skin from mostpathogenic bacteria, such as Staphylococcusaureus, and improve skin structure (Cinque et al.,2011).In topical application, the active ingredient shouldlast a long time on the skin and prolonged release.Meanwhile, Lactobacillus acidophilus unstable toenvirontment factors, such as the hightemperature, oxygen, and humidity (Al-Hurr,2011). Therefore, probiotics encapsulation isneeded. In addition, encapsulation also mayprovide prolonged release so that its effectivenessincreased as antimicrobial activity becomes longer.Encapsulation process that forms microparticles (1-1000 μm) called micro-encapsulation. Sphericalmicroparticles called microspheres (Sahil et al.,2011). The recommended size of microsphereswhich active ingredient site action is in epidermislayer is 5-300 μm (Chadawar and Shaji, 2007).Sodium alginate is widely used as a matrix ofmicroencapsulated probiotics. Microspheres madewith sodium alginate matrix may improve theviability of probiotics during storage. Gelatin alsooften used in microencapsulated probiotics(Solanki et al., 2013). Gelatin is biodegradable,non-toxic, and easy to experience a cross-linking sothat it can be used in the preparation of colloidaldelivery systems, such as microspheres andnanoparticles (Sailaja, et al., 2010).Type of matrix influence the characteristic ofmicrosphere. Microspheres are only made withsodium alginate tend to provide simultaneousrelease. Therefore for prolonged release, sodiumalginate should be combined with gelatin (Lee etal., 2014; Roy et al., 2009). Combination of sodiumalginate and gelatine in the ratio 1: 2 will providesmall particle size that not easily aggregate duringthe process of mixing and drying (Lee et al., 2014).In this study, microspheres were formed by crosslinking between combination of sodium alginateand gelatin (1% : 2%) with CaCl2 as cross linkerusing ionotropic gelation method.OBJECTIVEThe aim of this research was to investigaste theeffect of combination of sodium alginate andgelatin (1% : 2%) content in characteristics andantimicrobial activity of probiotic microspheresLactobacillus acidophilus.

EFFECT OF PARTICLE SIZE AND SURFACE CHARGE ON THE UPTAKE AND IMMUNE RESPONSE OF OVALBUMIN-ALGINATE MICROSPHERES Dewi Melani Hariyadi; Idha Kusumawati; Fauzia Azzahra
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Microspheres as one of drug and protein deliverysystem have some advantages such as producingsmall particles; protect extreme conditions andother benefits. Microspheres as one ofparticulate systems have benefits in vaccinedelivery systems for enhancing immune responsethrough several mechanisms. As vaccine deliverysystem, the particles can through phagocytosisdeliver antigens to Antigen Presenting Cells (APC)(Foged et al, 2005). Particulate antigens mightmediate the induction of both humoral andcellular immunity.The particle size, surface charge andphysicochemical properties are factors that affectthe uptake of particles from the gut. Zetapotential may also influence the drug releaseprofiles, stability and physicochemical properties.Microparticles or nanoparticle surface is a veryimportant consideration in drug delivery ystem,especially in targeting drug delivery. Surfacemodification of micro/nano-drug delivery systemsis the most common strategy to controlling theopsonization process and thus sustains thesystems for longer period in the blood stream.Zeta potential is one of important propertieswhich contribute to the effectiveness. Zetapotential can be defined as the electrokineticvalue associating a realistic magnitude of surfacecharge and its unit is usually millivolt.There are some investigations that showed thatthe surface charge of nano/microparticles has aneffect on the stimulation of the immuneresponse. Some studies showed that antigenloaded cationically charged particles could bebeneficial for gut up take (Honary S and Zahir F,2013).Peyer's patches (PP) is the main target of oraldelivery systems in the small intestine as a placefor the transport of pathogens to the lymphoidtissue. This function is carried out by M-cellswhich are located between epithelial cells,bringing antigens and microparticles measuringless than 10 μm (Lubben et al, 2001).This study used alginate microspheres containsafe and biodegradable polymer and CaCl2 nontoxic crosslinking agent produced by gelationionotropic technique by aerosolisation. Thistechnique had the advantage of spherical shape,smooth with a small particle size that meets therequirements of particle size for oral deliverysystems (Hariyadi et al, 2014). Maltodextrinlyoprotectant were found to stabilizemicrospheres (Hariyadi et al, 2015). Ovalbuminwas used as model antigen.The hemagglutination assay was used to evaluatethe formation of antibody and ability to stimulateimmune response. Uptake microspheres werestudied using fluorescent label microscopically. Inthe present study we addressed the importanceof particle size and surface charge for efficientinteractions and effect on the immune response.

MICROBIAL ASSAY OF CYPROFLOXACIN IN A BONE IMPLANT (CHITOSAN –BOVINE HYDROXYAPATITE WITH CROSS-LINKER GLUTARALDEHYDE) TOWARDS Staphylococcus aureus ATCC 25923 Esti Hendradi; Dewi Melani Hariyadi; Muhammad Faris Adrianto
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Bone is one part of the body has an important roleto support the body's physiological functions (Porteret al., 2009). Complications of bone diseases andbone disorders caused by traumatic accidents mayresult in a gap (defect) on the bone. The healingprocess of damage or fracture is determined by thelevel of trauma and soft tissue damage (Strobel etal., 2011). Some cases of damage or injury to thebone can not undergo natural recovery (Porter et al.,2009). Therefore, clinical rehabilitation to overcomethe defect on the bone is expected to increase in linewith population growth (Mourino et al., 2010).Treatment rehabilitation of bone cannot beseparated from the risk of infection complications.Complications of bacterial infections can be treatedwith antibiotics. However, in the case of a crack(defect) occurs devascularity of bone tissue so thatthe delivery of antibiotics to the target tissue to beblocked. This resulted in the concentration of theantibiotic to the target so low that it cannotpenetrate the bacteria. The condition can lead tobacterial resistance to antibiotics (Li et al., 2010). Ahigh dose of antibiotics in the long term experiencedproblems because it can cause systemic toxicity andside effects (Mourino et al., 2010). To overcomethese problems, antibiotics can be done locally usinga certain drug delivery systems. The purpose of suchdelivery systems is to provide drug concentration ina specific location and ensure the drug releaseprofile for a certain time period (Dubnika et al.,2012). Drug delivery locally has several advantages,among others, (a) the systemic effects can beavoided, (b) the amount of drugs used less andsecure, and (c) the efficacy and efficiency of drugdelivery locally can be achieved (Harmankaya et al.,2013). Administration of antibiotics locally also tominimize side effects and risk of toxicity comparedto administration of systemic antibiotics. In addition,antibiotics locally also allows conduction in targettissues with high concentration (Mourino et al.,2010). The release of antibiotics on the targetnetwork is expected to last continuously for a certaintime and achieve a greater concentration than theminimum inhibitory concentration (MIC). Drugdelivery systems in a controlled manner (controlledrelease system) can help increase the bioavailabilityof antibiotics in target tissues. The system isdesigned to release the drug at the expectedlocation at a rate appropriate for a certain timeperiod (Mourino et al., 2010). In a previous studyshowed that a good composite is Ciprofloxacin: BHA:Chitosan = 10:30:60. Cross linker withglutaraldehyde (GA) 0.7% and with 10% activeingredient Ciprofloxacin can release Cyprofloxacinfor 30 days (Hendradi et al, 2015). This research willbe seen potency against Staphilococcus aureusATCC25923 Ciprofloxacin for 30 days.

Effect of Total Amount of Metformin HCl on the Characteristics of Metformin-Ca Alginate Microspheres Dewi Melani Hariyadi; Noorma Rosita; Tiara Jeni Rosadi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 5 No. 1 (2018): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Introduction: Metformin hydrochloride (metformin HCl) is an antidiabetic drug that is specifically used for type 2 diabetes mellitus (DM) and belongs to the biguanide antidiabetic drugs. Objective: The aim of this research was to determine the effect of total amount of metformin HCl on the characteristics of metformin HCl-Ca alginate microspheres using aerosolization technique. Methods: The total amount of metformin were 0.5 g (F1); 1 g (F2); 1.5 g (F3) and 2 g (F4). Drug was encapsulated into alginate and was crosslinked using CaCl2. Results: The results showed that drug loadings were 5.09%; 9.61%; 13.11%; and 15.09% respectively, while the entrapment efficiencies were 48.35%; 41.99%; 38.67%; and 30.53%. The yields were 80.92%; 74.12%; 68.27%; and 59.11% respectively. Based on the statistical analysis, it was found that there were significant differences between formulas. Particles of formulas decreased as the amount of drug increased. The resulting sizes were 1.82 μm (F1); 1.96 μm (F2); 2.1 μm (F3); and 2.97 μm (F4). Conclusion: It can be concluded that amount of drug significantly affected the characteristics of metformin-alginate microspheres.

Pemberdayaan Masyarakat melalui Edukasi Cara Pembuatan Pangan Olahan yang Baik, Bahan Tambahan Pangan, dan Kemasan Pangan untuk Penguatan Jaminan Keamanan pada Pelaku UMKM Bidang Makanan di Balikpapan Juni Ekowati; Rosita Handayani; Dewi Melani Hariyadi; Mohammad Rizki Fadhil Pratama; Putri Hamidah Khairunnisa; Melanny Ika Sulistyowaty; Rossa Auli Tasha; Imamatin Nufus Melania; Ersanda Nurma Praditapuspa; Muhamad Ilham Royyan Nafi’
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 6 No 6 (2021): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v6i6.2676

Food safety is a complex issue that involves stakeholders in its handling. The point of food safety is growing widely and is becoming a concern in the community because it is related to the quality of consumers' good health and well-being. The community service activities based on quality education focused on Good Processed Food Manufacturing Practices (CPPOB), safe use of Food Additives (BTP), and consideration of packaging selection that ensures food safety. Education is carried out to increase the understanding of SMEs actors regarding regulations of CPPOB, the use of BTP, and provisions on Food Packaging. The education process is carried out online using the Zoom Meeting platform. Learning activity is carried out in one direction through lectures and questions and answers sessions. The increase in participants' understanding was measured by comparing the distribution of average scores, pretest, and post-test statistical tests. The effectiveness and quality of the educational process were measured using an evaluation questionnaire with predetermined indicators. The education carried out related to CPPOB, the use of BTP, and the selection of food packaging performed by the community service team of the Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga to SMEs in Balikpapan has proven to increase the understanding of business actors. It can fulfill their needs and target activity evaluation indicators that have been determined.

Pengembangan Sistem Nanostructured Lipid Carriers (NLC) Meloxicam dengan Lipid Monostearin dan Miglyol 808 Menggunakan Metode Emulsifikasi Rahmi Annisa; Esti Hendradi; Dewi Melani
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 3 (2016): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

The aim this study was to determine the effect of Monostearin and Miglyol 808 lipid ratio in NLC system formulation resulting in physicochemical characteristics, release rate, and penetration rate. The NLC making was done by using emulsification method. In the formulation of NLC meloxicam, 3 different lipid ratios were used, including ratios of 6:4, 7:3, 8:2. Meloxicam served as active ingredient, monostearin served as solid lipid, miglyol 808 served as a liquid lipid, and tween 80 was surfactant. NLC meloxicam physicochemical characteristics include tests of organoleptic, pH, viscosity, particle size, particle morphology and entrapment efficiency. NLC meloxicam belongs to semisolid preparations with pH value range of 5,72-5,87. Increasing viscosity of NLC system are cause by increase of solid lipid. The measurement results of particle size of three different lipid formulas indicated that the lipid particle size was <1000 nm. Test of NLC particle morphology by using Transmission Electron Microscopy (TEM) indicated the spherical particle shape (round). Entrapment efficiency test of all NLC-lipid compositions revealed quite high result (> 80%). The determination of release rate (flux) and penetration rate (flux) was conducted by using Franz diffusion cells with a cellophane membrane for the release and Wistar ratâ€™s skin membrane for the penetration. The release rate values of three NLC meloxicam formulas showed p value (sig) 0,005, while the penetration rate obtained p value (sig) 0,091. Keywords: NLC, meloxicam, physicochemical characterization, release rate and penetration rate

Effect of Sodium Alginate Concentration on Characteristics, Stability and Drug Release of Inhalation Quercetin Microspheres Tekla Kalalo; Andang Miatmoko; Hanafi Tanojo; Tristiana Erawati; Dewi Melani Hariyadi; Noorma Rosita
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.107-114

Background: Quercetin is a flavonoid compound that has anti-inflammation activity. However, poor stability presents significant problems for the formulation into dosage forms. Microspheres are one of the potential lung delivery systems because of their ability to encapsulate various types of drugs, protect drugs from environmental effects and can release drugs in a sustained release. Objective: In the present study, the microsphere inhalation system of the anti-inflammation drug, quercetin was developed and evaluated to achieving the targeted delivery of these drugs to the lung. Method: The drug-loaded ca-alginate microspheres were prepared by aerosolization ionic gelation technique followed by freeze-drying. Result: The result of this study showed that particle size was less than 2 µm, the yield ranged from 41.33-76.14%, drug loading was less than 6%, entrapment efficiency ranged from 74.153% - 93.805% and flow properties showed that all formula had an excellent flow. Spherical microspheres were demonstrated by formulations containing 1 and 1.5% sodium alginate. A drug release study showed that the highest drug release of 30.649% was from the formulation with 2.5% sodium alginate, and the lowest drug release of 26.625% was from the formulation with 2% sodium alginate. , A stability study at temperatures of 25ᵒC and 40ᵒC for 28 days showed a decrease in drug loading and entrapment efficiency but an increase in particle size. The formulation containing 1.5% sodium alginate showed the optimal formula. Conclusion: These findings indicated that quercetin ca-alginate microspheres are the potential for inhalation to be delivered to the lung.

Co-Authors Abhimata Paramanandana Andang Miatmoko Ardhani Dwi Lestari1 Bambang Tri Purwanto Dewi Isadiartuti Dini Retnowati Dwi Setiawan Esti Hendradi Fauzia Azzahra Hanafi Tanojo I NYOMAN WIJAYA Idha Kusumawati Imamatin Nufus Melania Irawan, Mukhlis Bayu Irawan, Mukhlis Bayu Juni Ekowati Melanny Ika Sulistyowaty Mohammad Agus Sjamsur Rijal Mohammad Rizki Fadhil Pratama Muhamad Ilham Royyan Nafi’ Muhammad Faris Adrianto Noorma Rosita Praditapuspa, Ersanda Nurma Putri Hamidah Khairunnisa Rahmi Annisa Regia Nada Asshafa Retno Sari Rosita Handayani Rossa Auli Tasha Siti Rahmah Sugiyartono1 Suzana Tekla Kalalo Tiara Jeni Rosadi Tristiana Erawati Tutiek Purwanti Yusuf, Helmy

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