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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmiah Farmasi Farmasyifa Jurnal Riset Farmasi Bandung Conference Series: Pharmacy

Esti Rachmawati Sadiyah

Department Of Pharmacy, Faculty Of Mathematics And Natural Saciences, Universitas Islam Bandung

Author-ID : 2857815

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Immunology & microbiology Medicine & Pharmacology Public Health

Published : 6 Documents Claim Missing Document

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Articles

Sunscreen Activity Testing of Robusta Coffee (Coffea cenephora ex froehner) Leave Extract and Fractions Kiki Mulkiya Yuliawati; Esti Rachmawati Sadiyah; Riski Solehati; Aldi Elgiawan
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Coffee leaves are part of a plant that has not been optimally utilized. The purpose of this study was to explore the potential use of coffee leaves to help maintain skin health. Extraction method was carried out with maceration method using 70% ethanol solvent. Fractionation process was carried out by Liquid-Liquid Extraction method, using different solvents to accumulate the n-hexane, ethyl acetate [A1] and methanol fractions. Activity testing was carried out on all samples at concentrations of 50, 100 and 150 ppm including measurements of Sun Protecting Factor (SPF), Erythema and Pigmentation Transmittance Percentages (%Te [A2] and %Tp[A3] ) using UV-visible spectrophotometry at 290 and 400 nm wavelengths. The results showed that the ethyl acetate [A4] fraction at a concentration of 150 ppm had a higher potential as a sunscreen than other samples with SPF value of 19.82; %Te [A5] 10.96 and %Tp [A6] 18.14 and included in the category of fast tanning sunscreen.Keywords: coffee leaves, sunscreen, sun protecting factor, erythema, pigmentation

SUNSCREEN ACTIVITY OF SUGAR PALM (ARENGA PINNATA (WURMB) MERR.) LEAF STALK ASHES EXTRACT Esti Rachmawati Sadiyah
Jurnal Ilmiah Farmasi Farmasyifa Vol 2, No 1 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v2i1.4225

Sugar palm leaf stalk (petioles) ashes traditionally used as a daily cosmetic by Sundanese women to keep their skin smooth. Sugar palm leaf stalk ashes also used to treat acne, smallpox, and burns. The study was aimed to test the sunscreen activity of ashes extracts from sugar palm leaf stalk. The ashes were extracted using soxhlet and 96% ethanol as solvent. The sunscreen activity test was performed on the extract using UV-Vis spectrophotometer. Determination of Sun Protection Factor (SPF) value was done at 290-320 nm (UV-B wavelength) with 5 nm interval. The ashes extract of sugar palm leaf stalk showed the effectiveness of sunscreen activity at 10,000 ppm (SPF value = 9) as maximum protection. The SPF value was determined using Mansur mathematical equation. The determination of pigmentation transmittant was done at 322.5 – 372.5 nm, with 2.5 nm interval. Based on the result of pigmentation transmittance percentages, the sunscreen profile of sugar palm leaf stalk ashes extract (2000-10.000 ppm) showed the category of extra protection up to sunblock, according to classification from Balsam & Sagarin (1972). To be concluded, the ashes extract of sugar palm leaf stalk was a potential sunscreen. Further in vivo analysis should be done to confirm this potency.

Penelusuran Pustaka Senyawa yang Berpotensi Aktivitas Larvasida dari Tanaman Suku Rutaceae terhadap Larva Nyamuk Aedes aegypti. Muhammad Shofiyanta; Esti Rachmawati Sadiyah
Jurnal Riset Farmasi Volume 1, No. 2, Desember 2021, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Abstract. The Aedes aegypti mosquito is a vector for the spread of Dengue Hemorrhagic Fever, and the use of natural larvicides is needed as an alternative to synthetic larvicides to control its growth. The plant family that is widely used in the development of larvicidal active ingredients is Rutaceae. This literature review was conducted with the aim of collecting and analyzing research results related to the content of compounds that have the potential to produce larvicidal activity in the Rutaceae plant family. There are 11 plant species from the Rutaceae family that have larvicidal activity against Aedes aegypti mosquito larvae based on a literature review, with the plant part commonly used in testing larvicidal activity against Aedes aegypti mosquito larvae, namely the leaf part, and chemical content with high potency of larvacide is essential oils with various components. Abstrak.Nyamuk Aedes aegypti merupakan vektor penyebaran penyakit Demam Berdarah Dengue, dan penggunaan larvasida alami dibutuhkan sebagai alternatif larvasida sintetis untuk mengendalikan pertumbuhannya. Suku tumbuhan yang banyak dimanfaatkan dalam pengembangan bahan aktif larvasida adalah Rutaceae. Penelusuran pustaka yang di lakukan bertujuan untuk mengumpulkan dan menganalisis hasil-hasil penelitian terkait kandungan senyawa yang berpotensi menghasilkan aktivitas larvasida pada keluarga tanaman Rutaceae. Terdapat 11 spesies tanaman dari keluarga Rutaceae yang memiliki aktivitas larvasida terhadap larva nyamuk Aedes aegypti berdasarkan penelaahan literatur, dengan bagian tanaman yang umum digunakan pada pengujian aktivitas larvasida terhadap larva nyamuk Aedes aegypti yaitu bagian daun, dan kandungan senyawa kimia yang berpotensi kuat sebagai larvasida adalah minyak atsiri dengan komponen yang beragam.

Studi Literatur Tanaman yang Memiliki Potensi terhadap Penyembuhan Luka Akut Khaerunnisa; Indra Topik Maulana; Esti Rachmawati Sadiyah
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Abstract. Wound is a condition characterized by damage to body tissue, damage to body tissue can involve connective tissue, muscles, skin, nerves and tearing of blood vessels which will interfere with the body's hemostasis. Wound healing process consists of various complex processes to restore tissue integrity. During this process, blood clots, acute and chronic inflammatory responses, neovascularization, cell proliferation and apoptosis occur. This literature study aims to examine the potential of various types of plants that can accelerate wound healing and examine the mechanism of action of secondary metabolites in plants that play a role in the wound healing process from several articles. Leaves of red andong (Cordyline fruticosa) (L) A.Chev; Ixora coccinea root; papaya stem (Carica papaya); Ficus deltoidea leaves; neem leaves (Azadirachta indica A. Juss); javan bark (Lannea coromandelica); and betadine leaf (Jatropha muitifida linn) has a class of compounds that play a role in the wound healing process, namely alkaloids, flavonoids, saponins and tannins which have antiseptic, astringent, anti-inflammatory, antioxidant and antibacterial potential. Abstrak. Luka merupakan suatu keadaan yang ditandai dengan terjadinya kerusakan pada jaringan tubuh, kerusakan jaringan tubuh dapat melibatkan jaringan ikat, otot, kulit syaraf dan robeknya pembuluh darah yang akan mengganggu hemeostatis tubuh. Proses penyembuhan luka terdiri dari berbagai proses yang kompleks untuk mengembalikan integritas jaringan. Selama proses ini terjadi pembekuan darah, respon inflamasi akut dan kronis, neovaskularisasi, proliferasi sel hingga apoptosis. Studi literatur ini bertujuan untuk mengkaji potensi berbagai jenis tanaman yang dapat mempercepat penyembuhan luka serta mengkaji mekanisme kerja senyawa metabolit sekunder dalam tanaman yang berperan dalam proses penyembuhan luka dari beberapa artikel. Daun andong merah (Cordyline fruticosa) (L) A.Chev; akar Ixora coccinea; batang pepaya (Carica papaya); daun Ficus deltoidea; daun mimba (Azadirachta indica A. Juss); kulit kayu jawa (Lannea coromandelica); dan daun betadine (Jatropha muitifida linn) memiliki golongan senyawa yang berperan pada proses penyembuhan luka yaitu alkaloid, flavonoid, saponin dan tannin yang memiliki potensi antiseptik, astringen, antiinflamasi, antioksidan dan antibakteri).

Uji Aktivitas Tabir Surya Ekstrak Kulit Buah Sirsak (Annona muricata L.) yang Diekstraksi Dengan Metode Ultrasonic Assisted Extraction Jihan Fadillah; Kiki Mulkiya Yuliawati; Esti Rachmawati Sadiyah
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Abstract. Ultraviolet (UV) rays are one of the spectrum of the sun that adversely affects the skin such as erythema or pigmentation, which in long-term effects may cause photoaging and photocarcinogenesis. These adverse effects can be prevented by using sunscreen that can be made from synthetic or natural materials. The peel of soursop fruit (Annona muricata L.) is a natural material that has been known to contain phenol and flavonoid compounds, both of these compounds are reported to have activities as sunscreen. The extraction method uses Ultrasonic Assisted Extraction (UAE) with aquadest as solvent. Time variations of extraction are 15, 30, 45, and 60 minutes. The sunscreen activity test was carried out on all samples at concentrations of 625, 1.250, 1.875, 2.500, 3.125, 3.750, 4.375, and 5000 ppm. Determination of sunscreen activities involves sun protection factor, erythema transmittance percentages (%Te), and pigmentation transmittance percentages (%Tp) by using UV-Vis spectrophotometer (wavelength range 290-375 nm). The result showed that UAE extract of 15 minutes at the concentration 5.000 ppm has the highest sunscreen activities than the other samples with SPF value 12,78 which belongs to the maximum protection type; %Te 5,08% and %Tp 20,00% which belongs to the extra protection category. Abstrak. Sinar Ultraviolet (UV) merupakan salah satu spektrum dari sinar matahari yang dapat memberikan dampak buruk pada kulit seperti eritema atau pigmentasi, yang mana efek jangka panjang dapat menyebabkan photoaging dan photocarcinogenesis. Dampak buruk ini dapat dicegah dengan penggunaan tabir surya, baik tabir surya dengan bahan aktif sintesis maupun alami. Kulit buah sirsak (Annona muricata L.) merupakan salah satu bahan alam yang telah diketahui mengandung senyawa fenol dan flavonoid, dimana kedua senyawa tersebut telah dilaporkan memiliki aktivitas sebagai tabir surya. Metode ekstraksi dilakukan melalui metode Ultrasonic Assisted Extraction (UAE) dengan menggunakan aquadest sebagai pelarut pada beberapa variasi waktu yaitu 15, 30, 45, dan 60 menit. Pengujian aktivitas tabir surya dilakukan terhadap semua sampel pada konsentrasi 625, 1.250, 1.875, 2.500, 3.125, 3.750, 4.375, dan 5000 ppm yang meliputi penentuan nilai Sun Protection Factor (SPF), nilai persen transmisi eritema (%Te), dan nilai persen transmisi pigmentasi (%Tp) dengan menggunakan spektrofotometer UV-Vis (panjang gelombang 290-375 nm). Hasil pengujian menujukkan bahwa ekstrak UAE 15 menit pada konsentrasi 5000 ppm memiliki aktivitas tabir surya lebih tinggi dibandingkan sampel lain dengan nilai SPF sebesar 12,78 yang termasuk ke dalam tipe proteksi maksimal; serta %Te 5,08% dan %Tp 20,00% yang termasuk ke dalam kategori proteksi ekstra.

Kajian Pustaka Potensi Aktivitas Antibakteri Minyak Atsiri Daun Nilam (Pogostemon cablin Benth.) terhadap Bakteri Patogen pada Kulit Nisa Rahma Aniyati; Yani Lukmayani; Esti Rachmawati Sadiyah
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Abstract. Skin infection becomes one of the most common skin problems in Indonesia. It is usually caused by bacterial infections, fungi, and viruses Antibacterial is a compound used to inhibit and kill pathogenic bacteria, one of the examples is patchouli (Pogostemon cablin Benth.) with one of the ingredients called essential oil. The study examined the antibacterial activity of patchouli leaf essential oil against pathogenic bacteria, namely Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, and Pseudomonas aeruginosa, using literature review method. Analysis performed based on inhibition zone diameter and Minimum Inhibition Concentration (MIC) value resulted from selected papers. The results of this literature study indicate that the better diameter of the inhibitor is to inhibit Staphylococcus aureus bacteria by 22.5 mm at a concentration of 2%. So that patchouli essential oil as an antibacterial is more likely to be against Gram positive bacteria than Gram negative bacteria, with the MIC value of Gram positive bacteria (Staphylococcus aureus) ranging from 250-2000 g/mL, while Gram negative bacteria (Pseudomonas aeruginosa) are in the range of 1200 – > 4000 g/mL. Abstrak. Permasalahan kulit yang sering terjadi di Indonesia salah satunya adalah infeksi kulit, biasanya disebabkan karena infeksi bakteri, jamur dan virus. Antibakteri adalah suatu senyawa yang digunakan untuk menghambat dan membunuh bakteri patogen. Salah satu tanaman yang berkhasiat sebagai antibakteri yaitu daun nilam (Pogostemon cablin Benth.) dengan salah satu kandungannya yaitu minyak atsiri. Penelitian ini mengkaji aktivitas antibakteri minyak atsiri daun nilam terhadap bakteri patogen yaitu Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes dan Pseudomonas aeruginosa yang dilakukan dengan metode studi literatur menggunakan data sekunder. Kemudian dilakukan pengamatan berdasarkan hasil pengukuran diameter zona hambat dan nilai KHM. Hasil studi literatur ini menunjukkan bahwa diameter hambat yang lebih baik yaitu menghambat bakteri Staphylococcus aureus sebesar 22,5 mm pada konsentrasi 2%. Sehingga minyak atsiri daun nilam sebagai antibakteri lebih berpotensi terhadap bakteri Gram positif dibandingkan dengan bakteri Gram negatif, dengan nilai KHM bakteri Gram positif (Staphylococcus aureus) berada pada rentang 250-2000 μg/mL, sedangkan bakteri Gram negatif (Pseudomonas aeruginosa) berada pada rentang 1200 - >4000 μg/mL.

Co-Authors Aldi Elgiawan Indra Topik Maulana Jihan Fadillah Khaerunnisa Kiki Mulkiya Yuliawati Muhammad Shofiyanta Nisa Rahma Aniyati Riski Solehati Yani Lukmayani

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