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All Journal Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Jurnal Biologi Udayana Jurnal Farmasi Klinik Indonesia
Rasmaya Niruri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education

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Perbedaan Fungsi Ginjal, Hati dan Darah pada Pasien Kanker Serviks dengan Kemoterapi Bleomisin, Oncovin®, Mitomisin dan Karboplatin (Studi Kasus di RSUP Sanglah Denpasar Tahun 2015) Rini Noviyani; I Nyoman G. Budiana; Putu A. Indrayathi; Rasmaya Niruri; I Ketut Tunas
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.142 KB) | DOI: 10.15416/ijcp.2016.5.4.269

Abstract

  Regimen Bleomisin Oncovin® Mitomisin-Karboplatin (BOM-Karboplatin) sebagai kemoterapi tidak terlepas dari efek samping yang ditimbulkan yaitu toksisitas pada organ tubuh diantaranya adalah ginjal, hati, dan darah, dimana terjadinya toksikitas pada organ ginjal dapat diindikatorkan dengan parameter Serum Kreatinin dan Blood Urea Nitrogen (BUN). Terjadinya toksisitas pada organ hati dapat diukur dengan parameter SGOT dan SGPT serta toksisitas pada fungsi darah diindikatorkan dengan nilai hemoglobin, trombosit, leukosit. Belum terdapat data mengenai efek toksik dari kemoterapi BOM-Karboplatin pada pasien kanker serviks sel skuamosa stadium IIB–IIIB di RSUP Sanglah Denpasar, sehingga penelitian ini dilakukan melalui pemantauan terhadap fungsi ginjal, hati dan darah. Penelitian ini merupakan studi kasus observasional terhadap sembilan pasien yang diikuti selama tiga seri kemoterapi dari bulan Februari hingga Agustus 2015. Data serum kreatinin, BUN, SGOT, SGPT, hemoglobin, trombosit, dan leukosit yang diperoleh dianalisis menggunakan uji t berpasangan untuk data yang terdistribusi normal dan uji Wilcoxon untuk data yang tidak terdistribusi normal dengan tingkat kepercayaan 95% dan dikatakan berbeda bermakna bila p<0,05. Hasil studi kasus ini menunjukkan nilai serum kreatinin (p=0,530), BUN (p=0,553), SGOT (p=0,162), SGPT (p=0,054), Hemoglobin (p=0,034), Trombosit (p=0,028), dan Leukosit (p=0,011), sehingga dapat disimpulkan bahwa terdapat penurunan fungsi darah yang signifikan ditandai dengan adanya penurunan signifikan pada parameter hemoglobin, trombosit dan leukosit sebelum kemoterapi I dan sesudah kemoterapi III BOM-Karboplatin, sehingga diperlukan monitoring ketat terhadap fungsi darah pasien yang menerima kemoterapi BOM-Karboplatin di RSUP Sanglah Denpasar.Kata kunci: BOM-Karboplatin, fungsi darah, kanker serviks, kemoterapi, RSUP Sanglah, toksisitasThe Difference of Kidney, Heart and Blood Function on Cervical Cancer Patients with Chemotherapy, Bleomycin, Oncovin®, Mitomycin and Carboplatin (Case Study in Sanglah General Hospital, Denpasar in 2015) Oncovin® bleomycin mitomycin-carboplatin (BOM-carboplatin) regimen as chemotherapy is inseparable from the side effects it can caused which is toxicity to organs including the kidneys, liver, and blood where the toxicity in the kidneys can be indicated by the parameter of Serum Creatinine and Blood Urea Nitrogen (BUN), the occurrence of toxicity in the liver can be measured by the parameters of SGOT and SGPT, and toxicity to blood function can be indicated by the value of hemoglobin, platelets, leukocytes. The absence of data on the toxic effects of chemotherapy BOM-carboplatin in patients with squamous cell cervical cancer stage IIB–IIIB in Sanglah General Hospital in Denpasar, had made this research conducted through monitoring of kidney, liver and blood function. This study is an observational case study of nine patients who were followed for three rounds of chemotherapy from February to August 2015. Data of creatinine serum, BUN, SGOT, SGPT, hemoglobin, platelets, and leukocytes were analyzed using paired t-test for the data that were normally distributed and Wilcoxon test for the data that were not normally distributed with a confidence level of 95% and was said to be significantly different when p<0.05. The results of this case study demonstrated the value of serum creatinine (p=0.530), BUN (p=0.553), SGOT (p=0.162), SGPT (p=0.054), hemoglobin (p=0.034), platelets (p=0.028), and leukocytes (p=0.011) so it could be concluded that there was a significant decrease of blood function which could be characterized by a significant decrease in the parameters of hemoglobin, platelets and leucocytes before chemotherapy I and after chemotherapy III BOM-carboplatin, so it required strict monitoring of the blood function of the patients who received chemotherapy BOM-carboplatin in Sanglah General Hospital in Denpasar.Keywords: BOM-carboplatin, blood function, cervical cancer, chemotherapy, Sanglah General Hospital, toxicity
Evaluasi Nilai Blood Urea Nitrogen dan Serum Kreatinin pada Pemberian Kemoterapi Paklitaksel-Karboplatin pada Pasien Kanker Serviks Sel Skuamosa Stadium IIB-IIIB Rini Noviyani; Ketut Suwiyoga; Anak A. A. W. P. Dewi; Rasmaya Niruri; I. K. Tunas; I N. G. Budiana
Indonesian Journal of Clinical Pharmacy Vol 3, No 2 (2014)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.5 KB) | DOI: 10.15416/ijcp.2014.3.2.55

Abstract

Kemoterapi paklitaksel-karboplatin merupakan salah satu terapi untuk kanker serviks. Toksisitas kemoterapi pada ginjal dapat dinilai menggunakan nilai Blood Urea Nitrogen (BUN) dan serum kreatinin. Pada penelitian potong lintang prospektif ini diperoleh 6 pasien kanker serviks yang memenuhi kriteria penelitian. Pemeriksaan kadar BUN dan serum kreatinin dilakukan sebelum kemoterapi pertama dan sesudah kemoterapi seri ketiga. Rentang waktu kemoterapi pertama ke kemoterapi ketiga adalah tiga minggu. Pengambilan sampel penelitian menggunakan consecutive sampling. Data penelitian dianalisis menggunakan paired test dengan interval kepercayaan 95% dengan SPSS 17.0. Hasil evaluasi nilai BUN dan serum kreatinin sebelum dan sesudah kemoterapi menunjukkan tidak terdapat perbedaan yang bermakna antara sebelum kemoterapi pertama dengan sesudah kemoterapi ketiga (p>0,05). Hasil penelitian ini dapat digunakan dokter sebagai pertimbangan untuk memberikan kemoterapi dengan regimen paklitaksel-karboplatin sesuai prosedur yang berlaku karena terbukti tidak menimbulkan penurunan fungsi ginjal pada pasien kanker serviks skuamosa.Kata kunci: BUN, kanker serviks, kemoterapi, paklitaksel-karboplatin, serum kreatininEvaluation of Blood Urea Nitrogen and Serum Creatinine in Squamous Cell Cervical Cancer Patients Stadium IIb-IIIb Who Receiving Paclitaxel- Carboplatin ChemotherapyPaclitaxel-carboplatin chemotherapy is one of cervical cancer therapy. Renal toxicity from chemotherapy can be assessed using the value of  Blood Urea Nitrogen (BUN) and serum creatinine. In a prospective cross sectional study was obtained 6 cervical cancer patients who met the research criterias. Examination of BUN and serum creatinine performed before first and after third chemotherapy with the interval time of 3 weeks. Sampling method using consecutive sampling. Data were analyzed using paired test with 95% confidence intervals using the SPSS 17.0. BUN and serum creatinine before and after chemotherapy values obtained p>0.05. BUN and serum creatinine values showed no significant difference between before the first chemotherapy to after third chemotherapy. The doctor may consider using this combination chemotherapy in accordance with the procedures in force due to chemotherapy using paclitaxel- carboplatin shown to be effective and not cause renal toxicity in squamous cervical cancer patients.Key words: BUN, cervical cancer, chemotherapy, paclitaxel-carboplatin, serum creatinine
POTENSI TOKSISITAS NEUROLOGIS VINKRISTIN PADA TUBUH YANG TERJADI PADA ANAK DENGAN LEUKEMIA LIMFOSITIK AKUT Ni Made Intan Pertiwi; Ketut Ariawati; Rasmaya Niruri; Rini Noviyani; A.A. Raka Karsana; Mahardika Aprilia Iflahah
Jurnal Kimia (Journal of Chemistry) Vol. 7, No. 2 Juli 2013
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (280.776 KB) | DOI: 10.24843/JCHEM.2013.v07.i02.p10

Abstract

Acute Lymphoblastic Leukemia (ALL) treatment are chemotherapeutic agent and bone marrow transplantation. Treatment with chemotherapeutic agent is the primary curative for leukemia. Vincristine is one of chemotherapeutic agents in ALL. Neurotoxicity is one of the toxicity caused by vincristine. The objective of this study was to find out the potential neurotoxicity of vincristine in children with ALL. Method: This study was observational design. The study was conducted at Sanglah Hospital Denpasar. Patient data was collected from May 2011- March 2013 period. Result: Seventeen patients who fit to the sample criteria were got. Of the 17 childhood with ALL who have treatment with chemotherapeutic agent based on Indonesian Protocol 2006, 3 patients showed neurotoxicity. Patients may suffered from leg pain, foot pain, and walking pain. Conclusion: There are potential neurotoxicity vincristine in children with ALL who have treatment with chemotherapeutic agent. Potential neurotoxicity can be caused by mechanism of action vincristine in microtubules.
PEMBERDAYAAN IBU-IBU, BIDAN DAN KADER POSYANDU MELALUI PENYULUHAN TENTANG PEMBERIAN MAKANAN SEHAT UNTUK MENINGKATKAN GIZI DAN DAYA TAHAN TUBUH BAYI DAN ANAK DI DESA PENGOTAN KABUPATEN BANGLI Rini Noviyani; N. P. Ariantari; Rasmaya Niruri; K. Widyani Astuti; S. Chandra Yowani
Buletin Udayana Mengabdi Vol 13 No 2 (2014): Vol 13, No. 2 (2014)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (502.623 KB)

Abstract

The Community Services was held in Bangli Utara Public Health Facility, Pengotan district, Bangli. The purpose of this activity is to give information about balanced nutition and massage for babies to participants which are housewives, midwifery and posyandu staff in Bangli Utara Public Health Facility, Pengotan. They were expected to have better understanding about balanced nutrition compared to imbalanced nutrition and how to massage their babies. The methods used in this activity were deliver information about balanced nutrition and invited discussion also the baby massage practice trained to them. The result showed that participants were very interested in our program. It could be proved by their activity in discussion.Keywords: information, balanced nutrition, baby massage practice
PENENTUAN Streptococcus Group A PENYEBAB FARINGITIS PADA ANAK MENGGUNAKAN McIsaac SCORE DAN RAPID ANTIGEN DETECTION TEST (RADT) DALAM UPAYA PENGGUNAAN ANTIBIOTIKA SECARA BIJAK AA Agustia Sinta Dewi; Rini Noviyani; Rasmaya Niruri; F.S. Suherman; I Putu Triyasa
Jurnal Biologi Udayana Vol 17 No 1 (2013): Jurnal Biologi
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (353.628 KB)

Abstract

Pharyngitis can be caused by viruses and bacteria. The bacteria that most commonly causes pharyngitis is Streptococcus Group A. In the treatment of pharyngitis, it is very important to ensure the cause for determining the appropriate treatments, therefore unnecessary use of antibiotics can be avoided. Antibiotics should be prescribed in patients with pharyngitis caused by bacteria. Diagnostic test that can be applied to determine the causes of pharyngitis are McIsaac score and Rapid Antigen Detection Test (RADT). The purpose of this study was to investigate the presence of Streptococcus Group A as the cause of pharyngitis applying McIsaac scores and the RADT. This study was cross-sectional. Patients with the inclusion and exclusion criteria were given an initial assessment using the McIsaac score, subsequently tested with the RADT. The results gained from the McIsaac scores and subsequent RADT were compared.  It was found that as many as 124 patients suspected of having bacterial pharyngitis. Forty two of them were scored 3; 55 patients scored 4, and  27 patients scored 5. All patients tested with the RADT, only 18 patients gave positive results. Out of those 18 patients positively tested, 6 patients scored 3; 8 patients scored 4, and 4 patients scored 5. In was concluded that the use of RADT was better than McIsaac scores in determining pharyngitis caused by Streptococcus Group A.
Co-Authors A.A. Raka Karsana AA Agustia Sinta Dewi Anak A. A. W. P. Dewi F.S. Suherman I Ketut Suwiyoga I Ketut Tunas I Nyoman Gede Budiana I Putu Triyasa Ketut Ariawati Ketut Widyani Astuti Mahardika Aprilia Iflahah Ni Made Intan Pertiwi Ni Putu Ariantari Putu Ayu Indrayathi Rini Noviyani Sagun Chandra Yowani