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All Journal Farmaka Jurnal Farmasi Klinik Indonesia Pharmacology and Clinical Pharmacy Research
Melisa I. Barliana
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Pharmacology and Clinical Pharmacy Research

 1 
Anti-proliferative Activity of Crotalaria pallida Aiton on MCF-7 Breast Cancer Cells Erladys M. Rumondor; Moelyono Moektiwardoyo; Melisa I. Barliana
Pharmacology and Clinical Pharmacy Research Vol 2, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.873 KB) | DOI: 10.15416/pcpr.v2i3.16218

Abstract

 Crotalaria pallida Aiton (C. pallida Aiton) is empirically used as dietary supplement to treat cancer by the people of North Sulawesi. However, its scientific pharmacology activity has not been explored yet. Therefore, this study was conducted to evaluate anti-proliferative activity of C. pallida Aiton on MCF-7 breast cancer cells. The extraction of leaves and seeds were performed using ethanol, ethyl acetate, n-hexane, and water. Phytochemical screening was then performed to identify secondary metabolites in this extract. Anti-proliferative activity was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicated that ethyl acetate fraction of C. pallida Aiton has the lowest IC50 (29,67). In conclusion, ethyl acetate fraction of C. pallida Aiton is potential to be developed as anti cancer agent.Keywords: Crotalaria pallida Aiton, WST assay, MCF-7 cell line
Potential Nephrotoxicity of Lisinopril and Valsartan on Patients with Congestive Heart Failure Sarini Pani; Melisa I. Barliana; Eli Halimah; Venice Chaeriadi; Mally G. Sholih
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.357 KB) | DOI: 10.15416/pcpr.v2i1.16192

Abstract

Lisinopril (angiotensin converting enzyme inhibitor) and valsartan (angiotensin II receptorblocker) are the first-line treatment for patients with congestive heart failure (CHF). Thesetwo drugs potentially cause side effects on renal functions. However, limited informationwas available regarding the comparison of potential nephrotoxicity of these drugs in IndonesianCHF patients. This research was aimed to compare the potential nephrotoxicitybetween lisinopril and valsartan in outpatients with CHF at a hospital in Palu, Indonesia.This was an observational study conducted during April-May 2015. Potential nephrotoxicitywere assessed by measuring serum creatinin (SCr) and blood urea nitrogen (BUN). Datawere obtained from Cardiology Unit from a hospital in Palu, Indonesia. Statistical analysiswas conducted using T-test and Mann-Whitney test. The increasing trend of SCr and BUNwere observed in lisinopril-treated patients with the mean of increase were 21% and 59%,respectively. Relatively higher increase was observed in valsartan treatment group with 47%and 51% in SCr and BUN, respectively. The analysis showed that there were significant differencesin SCr level between lisinopril and valsartan groups (p=0.001), but the oppositeresults observed in BUN parameter (p=0.697). Therefore, valsartan was potentially morenephrotoxic than lisinopril based on the increase of SCr parameter. Thus, lisinopril is recommendedfor CHF patients who are particularly at high risks of having renal impairment.Keywords: lisinopril, valsartan, nephrotoxicity, congestive heart failure
Co-Authors AJENG DIANTINI Anna Meiliana Aulia Nurlatifah Eli Halimah ELI HALIMAH Erladys M. Rumondor Fitri N. Ramadhani Gianni Yosephine Ivan S. Pradipta Laniyati Hamijoyo Mally G. Sholih Moelyono Moektiwardoyo Muhammad F. Effendi Muhammad Syawal Pratama Nadiya N. Afifah Nurul Annisa Rizky Abdullah Ruri Intania Sarini Pani Sarini Pani Shelly Iskandar Venice Chaeriadi