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All Journal Jurnal Sain Veteriner Jurnal Veteriner Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan JBN (Jurnal Bedah Nasional) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Indian Journal of Forensic Medicine & Toxicology Jurnal Rekonstruksi dan Estetik MEDICINUS

Iswinarno Doso Saputro

Departemen Bedah Plastik Rekonstruksi Dan Estetik, Fakultas Kedokteran, Universitas Airlangga/RSUD Dr. Soetomo, Surabaya

Author-ID : 2896269

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary Other

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Profil Klinik Pasien dengan Ulkus Dekubitus di RSUD Dr. Soetomo Surabaya Huvi, Indira; Saputro, Iswinarno Doso; Murtiastutik, Dwi
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 13, No 2 (2019): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Decubitus ulcer or known as pressure ulcer is one of the types of chronic wounds that are often found. The incidences of decubitus ulcers are quite high in some countries, including in Indonesia. The main cause of decubitus ulcer is, long term immobilization, as example the total bedrest patients. Decubitus ulcers are associated with some diseases that causes immobilization such as spinal cord injury, lower extremity fracture, stroke, etc. The aim of this research is to identify the data of patients with decubitus ulcer in RSUD Dr. Soetomo period 1 January 2017 ? 31 December 2017. This research is a descriptive retrospective by collecting 148 secondary data from the medical records in RSUD Dr. Soetomo period 1 January 2017 ? 31 December 2017. Decubitus ulcer mostly be found in elderly (>65 years old) and was dominated by women. The most common disease that associated with decubitus ulcer is trauma (spinal cord injury and lower extremity fracture). The onset of decubitus ulcer in RSUD Dr. Soetomo patients is mostly more than 7 days. The prognosis and outcome of patients with decubitus ulcer are mostly dubia, with 2nd degree of ulcer and in alive condition.

Immune Response to Burn Injury: Hyperinflammation and Immunosuppression Septin Mauludiyana; Aryati; Yoes Prijatna Dachlan; Iswinarno Doso Saputro; Muhaimin Rifa’i
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15936

Burn is an injury to the skin or other tissue. Mostly, it caused by contacting with hot liquids, solids, and flames. The important thing that should be consider in burn incident is the severity of burn and it based on the depth and area of the burn injury. The severity of burns will cause differences of pathophysiological responses. This was a literature review study. Various articles were collected from online database including reports, journals, and published in the last 10 years. The articles were from the scholar journals. The systemic inflammatory response in severe level of burns was not given good response to disappear of lesion burn and initiating tissue repair. Moreover, it was given an organ failure to the patient. The body responded to this incident by releasing antiinflammatory mediators. This response is very strong and prolonged, so it caused immunosuppression and increase the risk of secondary infection to the patients. Burns affects the patient’s immune system. The ratio between pro and antiinflammatory mediators are determining the patient’s subsequent status.

The Role of IL-27 as An Anti-Inflammatory in A Severe Burns Model Waode Fifin Ervina; Aryati; Yoes Prijatna Dachlan; Iswinarno Doso Saputro
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15995

Efektifitas perlakuan awal Tretinoin 0,1% Topikal pada Proses Penyembuhan di Luka Insisi pada Mencit (Mus musculus) Iswinarno Doso Saputro; Hesty Aulia Palupi; Wiwik Misaco Yuniarti
Jurnal Sain Veteriner Vol 36, No 2 (2018): Desember
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Tretinoin has an important role in wound healing process include improve fibroplasia and collagen synthesis, maintening humoral immunity, and neutralize steroid effect.Epithelization and fibroblast proliferation were very important event in wound healing process. The aims of this study were studying epithelization and fibroblas proliferation on incision wound healing process using pre treatment of Tretinoin 0,1% topically on mice. This research used 24 male mice, 3 month of age, with 150 -180 gram of body weight. The mice were divided into 2 groups, control group (K) and treatment group (P). The control group was a group of mice with an incision wound, while the treatment group was a group of mice with an incision wound that received a pretreatment of Tretionin of 0.1% topically. Each group was divided into 2 sub groups K4, K7, P4, P7 based on time of samples collecting. K4 and P4 were examined at day 4, while K7 and P7 were examined at day 7. Epithelialization was observed by measuring the length of the epithelial incision area, whereas fibroblast proliferation was performed by counting the number of fibroblasts in five field of view on histopathologic skin preparations processed by HE staining.In this study,pretreatment of Tretinoin 0,1% topically can increase epithelialization and number of fibroblast significantly (p<0,05).This increase may be due to 1% Tretinoin in the tissues to induce keratinocyte basal proliferation including its migration to the skin surface via retinoic acid receptors ( RARδ)Pretreatment of Tretinoin 0,1% topically can increased epithelialization and number of fibroblast on incision wound healing process of albino rats

Hambatan Kolonisasi Methicillin Resistant Staphylococcus Aereus oleh Ekstrak Kulit Delima pada Luka Bakar Derajat-2 pada Tikus (INHIBITION OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS BACTERIA COLONIZATION ON SECOND DEGREE BURN WOUND IN WISTAR RAT BY US Iswinarno Doso Saputro; Lobredia Zarasade; Revita Widya Prasanti
Jurnal Veteriner Vol 17 No 3 (2016)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.184 KB)

Bacterial of Methicillin Resistant Staphylococcus Aureus (MRSA) is a pathogen that plays an importantrole as a nosocomial pathogen. The bacteria can cause outbreaks of nosocomial infection which is becomeserious problems in the management of burns patients because many strains have changed intomultiresistant bacteria to several classes of antibiotics. Treatment of MRSA bacterial infection in burnsis still a problem because its cost is relatively expensive and there is an increased trend of the bacteriaresistance. Therefore, alternatives are needed to deal with these problems. One of the alternatives is byusing topical pomegranate peel extract . This study was aimed to compare the topical administration ofpomegranate peel extract with mupirocin and to evaluate the combination effect of pomegranate peelextract with mupirocin against bacterial colonization of MRSA on the burn wound rat skin. Second degreeof burn was made by placing a nail with length 2 cm and width 2 cm. Before it used, the nail was boiled inboiling water for 10 seconds. Isolates of MRSA bacteria were inoculated on burn wound in male rats strainWistar. The rats were divided into three groups, each group was treated six hours after bacterial inoculation.The first group was given mupirocin on the burn wound; the second group was given topical pomegranatepeel extract, and the third group received a combination of mupirocin with pomegranate peel extracttopically. Swab culture was taken on the third and fifth day post-treatment. The specimen was sent to theMicrobiology Laboratory for microbiological examination to evaluate the efficacy of pomegranate peel extract in inhibiting bacterial colonization of MRSA. Topical pomegranate fruit peel extract significantlyinhibited MRSA bacterial colonization on the rat’s burn wound{p sig.(2-tailed),0,045, P < 0,05). Nosignificant result was found on bacterial count in topical pomegranate fruit peel extract administationcompared to topical mupirocin administration or in combination between topical pomegranate andmupirocin. Topical pomegranate fruit peel extract has antibacterial effect, eventhough it is not moreeffective compared to mupirocin administration or combination between the pomegranate and mupirocin.

Pengaruh Pemberian Ekstrak Jahe Merah (Zingiber officinale var. rubrum) terhadap Jumlah Sel Makrofag dan Pembuluh Darah pada Luka Bersih Mencit (Mus musculus) Jantan (Penelitian Eksperimental pada Hewan Coba) Rahel Yuana Sadikim; Willy Sandhika; Iswinarno Doso Saputro
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 2 (2018): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Jahe merah (Zingiber officinale var. rubrum) telah digunakan sebagai obat tradisional khususnya menyangkut penyembuhan luka karena kandungan oleoresin dan minyak atsiri yang tinggi. Namun penjelasan secara ilmiah masih belum banyak diteliti. Proses penyembuhan luka sangat dipengaruhi oleh jumlah makrofag dan pembuluh darah, sehingga peneliti tertarik untuk mengetahui pengaruh pemberian ekstrak jahe merah terhadap jumlah sel makrofag dan pembuluh darah pada luka. Tujuan: Membuktikan bahwa ekstrak jahe merah dapat menurunkan jumlah makrofag dan meningkatkan jumlah pembuluh darah pada luka bersih mencit jantan. Metode: Penelitian analitik eksperimental dengan the post test only control group design. Luka bersih pada 32 subjek dibagi dalam 4 kelompok. Kelompok pertama diberi konsumsi aquades steril secara oral selama 3 hari dan kelompok kedua selama 5 hari. Kelompok ketiga diberi ekstrak jahe merah (50 mg/kg bb) secara oral selama 3 hari dan kelompok keempat selama 5 hari. Preparat jaringan kulit dibuat menjadi slide histologi. Slide diamati dengan mikroskop pembesaran 400x dan graticulae. Hasil penghitungan makrofag dan pembuluh darah dibandingkan dengan uji t-2 sampel bebas. Hasil: Jumlah makrofag kelompok perlakuan lebih sedikit dibanding kontrol pada hari ke-3 (p=0,008) namun tidak signifikan pada hari ke-5 (p=0,409). Jumlah pembuluh darah kelompok perlakuan dibanding kontrol tidak signifikan pada hari ke-3 (p=0,721) dan ke-5 (p=0,365). Simpulan: Ekstrak etanol jahe merah dapat menurunkan jumlah sel makrofag pada hari ke-3 secara signifikan tetapi jumlah pembuluh darah tidak berbeda secara bermakna.

EFFECT OF PLATELET RICH PLASMA (PRP) TO AUTOGENOUS BONE GRAFT Iswinarno Doso Saputro; Magda Rosalina Hutagalung; Siti Isya Wahdini
Folia Medica Indonesiana Vol. 53 No. 1 (2017): JANUARY - MARCH 2017
Publisher : Faculty of Medicine, Universitas Airlangga

Bone graft use in maxillofacial surgery is currently developing, though some problems still persist. One of promising solutions to the problems is application of platelet rich plasma which may accelerate soft tissue healing and bone formation. This study aims to provide basic understanding to the development of PRP application in bone healing where bone graft is applied on human maxillae. Bone defects were made on maxillae of albino rabbits, with an application of bone graft in control group and bone graft plus PRP in treatment group. Histopathological analysis was performed in both groups to assess osteoblast density and collagen tissue area. On day 21st, more osteoblast density and collagen area in treatment group are significantly observed (p<0.05, 95% confidence interval). Observations were made on hard callus formation. In conclusions, platelet rich plasma may increase density of osteoblast in rabbit maxillary bone graft.

A 3-Years Pneumonia Incidence in Burn Cases with Inhalation Injury at the Burn Center of Dr. Soetomo General Hospital Surabaya in 2015-2018 Salsabilla Gina Rania; Lynda Hariani; Helmia Hasan; Iswinarno Doso Saputro
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 1 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I12022.27-30

Introduction: Inhalation injury is one of burns impact. Airway burns due to inhalation injury is a non-specific term which refer to all respiratory tract injuries occurred due to irritative chemicals, including heat and smoke during inspiration. Inhalation injury increases the risk of death in burns. Pneumonia is one of burns-related inhalation injury complications.Methods: This was a descriptive retrospective study aiming to determine the incidence of pneumonia in burn patients with inhalation injury using secondary data at Burn Center Dr. Soetomo General Hospital Surabaya in the period of January 2015 - December 2018.Results: There were 5 cases of pneumonia in 14 burn cases with inhalation injury (35.71%). Respectively, 2 and 3 cases were found in 2017 and 2018. There were 2 female (40%) and 3 male (60%) patients, with age varied within 28-73 years old. The burn area of burn patients with inhalation injury and pneumonia were found by 15%, 20%, 24%, 32% and 71%, or within the classification of 11-20% burn area, and most complication found was hypoalbuminemia, as much as 3 cases (60%).\Conclusion: Most pneumonia in burn cases with inhalation injury was occurred in 2018, dominated by male patients. The age of the patient were ranging from early adulthood to elderly. Most burns were in the range of 11-20% burn area with the most complication found was hypoalbuminemia.

Efek Probiotik Terhadap Interleukin-6 Serum dan Skor Depresi pada Pasien Luka Bakar Nur Aida; Azimatul Karimah; Iswinarno Doso Saputro
Jurnal Psikiatri Surabaya Vol. 6 No. 2 (2017): Desember
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Luka bakarmerupakan respon lokal suatu jaringan dengan atau tanpa respon sistemik terhadap suatu perpindahan energi dari sumber fisik atau kimia. Perawatan luka bakar memerlukan waktu yang lama. Dampak pada individu karena luka bakar dirasakan sejak awal cedera dan meluas di seluruh kehidupan seseorang. Pada luka bakar tejadi pelepasan mediator inflamasi khususnya interleukin-6 dan terganggunya berbagai faal tubuh, salah satunya homeostasis mikrobiota usus. Komorbiditas psikiatrik yang terjadi berkisar 45,5 %, dimana depresi yang hadir akan memperberat kondisi pasien. Probiotik dapat menurunkan kadar interleukin-6 dan mencegah gejala depresi secara langsung maupun tidak langsung. Studi ini untuk menilai efek suplementasi probiotik pada gejala depresi, parameter menggunakan biomarker IL-6 serum.Tujuan: Membuktikan efek probiotik terhadap interleukin-6 serum dan skor depresi pada pasien luka bakar.Metode: Desain penelitian adalah non randomized control trial. Sampel diambil dengan consequtive sampling. Pemberian probiotik pada hari ke 4 sampai hari ke 19 perawatan, kadar interleukin-6 serum diukur pada hari ke-4 (sebelum pemberian probiotik) dan hari ke 19 (setelah pemberian probiotik) dengan ELISA. Kelompok kontrol tidak menerima probiotik. Kriteria depresi diukur dengan Hamilton Depression Rating Scale (HDRS). Kedua alat ukur tersebut telah melalui uji validitas dan reliabilitasnya dari penelitian sebelumnya dan HDRS telah diadaptasi ke dalam bahasa Indonesia. Analisis data menggunakan uji komparatif.Hasil: Hasil uji statistik menunjukkan tidak ada perbedaan yang bermakna antara kelompok perlakuan dan kontrol.Kesimpulan: Pemberian probiotik tidak berpengaruh terhadap kadar interleukin-6 serum dan derajat depresi dibandingkan kontrol.

Dosis Efektif Enoxaparin dalam Mencegah Terjadinya Trombosis pada Anastomosis Arteri Femoralis Tikus I Made Suka Adnyana; Iswinarno Doso Saputro
JBN (Jurnal Bedah Nasional) Vol 1 No 2 (2017): JBN (Jurnal Bedah Nasional)
Publisher : Program Studi Ilmu Bedah, Fakultas Kedokteran Universitas Udayana

Tujuan: untuk mengetahui dosis efektif enoxaparin dalam mencegah terjadinya trombosis pada anastomosis mikrovaskular. Metode: penelitian ini bersifat eksperimental dengan rancangan the randomized post test only control group design. Terdapat 33 tikus jantan Rattus norvegicus Wistar strain yang dikelompokkan menjadi tiga perlakuan yaitu perlakuan A (enoxaparin 0,75 mg/kg), B (enoxaparin 1 mg/kg), dan C (kontrol). Tuck model anastomosis dilakukan pada arteri femoralis, kemudian luas trombus yang terjadi pada pembuluh darah dibandingkan dengan diameter lumen pembuluh darah diukur dengan graticule lens dan dinyatakan dalam persen. Hasil: trombus terbentuk pada semua subyek penelitian baik pada kelompok perlakuan maupun kontrol. Rerata persentase luas trombus pada kelompok enoxaparin 0,75 mg/kg adalah 24,3%, enoxaparin 1 mg/kg sebesar 19,8% dan kelompok NaCl 0,9% sebesar 79,4%. Terdapat perbedaan antara perlakuan pemberian enoxaparin dosis 0,75 mg/kg dan 1 mg/kg dengan kontrol, namun tidak ada perbedaan bermakna rerata persentase luas trombus diantara kelompok enoxaparin dosis 0,75 mg/kg dan dosis 1 mg/kg (p=0,624). Perlu dilakukan penelitian secara klinis guna melihat efektivitas enoxaparin dalam meningkatkan patensi anastomosis pada free flap maupun replantasi. Simpulan: pemberian enoxaparin dosis 0,75 mg/kg dan enoxaparin dosis 1 mg/kg secara subkutan efektif mengurangi persentase luas trombus pada anastomosis arteri femoralis tikus. Tidak terdapat perbedaan efektivitas yang bermakna dalam mengurangi persentase luas trombus pada anastomosis arteri femoralis tikus setelah diberikan dosis enoxaparin 0,75 mg/kg dan 1 mg/kg secara subkutan.

Co-Authors Agus Santoso Budi Arif Tri Prasetyo Aryati Dhitta Aliefia Noverta Dwi Murtiastutik Hasan, Helmia Hesty Aulia Palupi Huvi, Indira I Made Suka Adnyana Karimah, Azimatul Laras Puspita Ningrum Lobredia Zarasade Lobredia Zarasade Lynda Hariani Magda Rosalina Hutagalung Magda Rosalina Hutagalung Marelno Zakanito Medisa Primasari Muhaimin Rifa’i Muhammad Aulia U H Nadia Tamara Putri Nur Aida Priscilla Valentin N Rahel Yuana Sadikim Revita Widya Prasanti Rifqi Kurniawan Salsabilla Gina Rania Septin Mauludiyana Siti Isya Wahdini Sitti Rizaliyana Waode Fifin Ervina Willy Sandhika Wiwik Misaco Yuniarti Yoes Prijatna Dachlan

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