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All Journal BALI MEDICAL JOURNAL (BMJ) Buletin Udayana Mengabdi E-Jurnal Medika Udayana The Indonesian Biomedical Journal JBN (Jurnal Bedah Nasional) ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Jurnal Ilmu Bedah Indonesia Indonesian Archives of Biomedical Research (InABR) Cermin Dunia Kedokteran
Sri Maliawan
Department Of Neurosurgery, Faculty Of Medicine Udayana University/Sanglah General Hospital, Bali-Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Indonesian Archives of Biomedical Research (InABR)

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Sulforaphane as a potential therapy for multiple sclerosis: a review article Gede Febby Pratama Kusuma, Pratama Kusuma; Kadek Dede Frisky Wiyanjana; Sri Maliawan
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (370.969 KB) | DOI: 10.55392/indarcbiores.v1i2.24

Abstract

Multiple Sclerosis (MS) is a chronic immune-mediated Neuroinflammatory disease that attacks the Central Nervous System (CNS). It creates serious physical disabilities characterized by neuronal injury, demyelination, and axonal loss. Several mechanisms are responsible for the progression of MS, including the infiltration of T-cells from the peripheral to the CNS, the autoreactivity of B-cells that contribute to abnormal regulation of antibodies and antigen presentation, and the assault of Macrophage that lead to inflammation and neuron damage. Additionally, oxidative stress plays a more important role in chronic inflammation of MS. Sulforaphane (SFN) is an isothiocyanate derived from glucoraphanin (GRA) that is found mostly in broccoli. SFN can act as an anti-inflammatory and anti-oxidant agent by activating the Nuclear factor-erythroid 2-(NF-E2-) Related Factor 2 (Nrf2). Nrf2 is expressed in the central nervous system and upregulated in response to inflammation and cerebral insults. Nrf2 binds to the antioxidant response element (ARE) which is a DNA promoter region of genes codifying antioxidant enzymes, which in turn can reduce oxidative stress. Several in vitro and in vivo studies show that SFN can increase the anti-inflammatory and anti-oxidant genes. Thus, SFN is very promising as a potential therapy for MS.
Co-Authors A.A. Gde Oka A.A. Ngr. Agung Wistara Widya AA GN Asmara Jaya AAGN Asmarajaya Andi Asadul Islam Astawa N. M., Astawa N. Astawa P., Astawa B. Sinaga D.P.W. Wardhana Dewa Putu Wisnu Wardhana Dian Megasafitri Eka J. Wahjoepramono Ekaputra Ekaputra, Ekaputra G. I. B Bomba Gatot S. Lowrence, Gatot S. Gde Rastu Adi Mahartha Gede Febby Pratama Kusuma Gede Wirya Kusuma Duarsa Hamsu Kadriyan I Dewa Made Sukrama I Gede Budhi Setiawan I Gede Sutawan I Gusti Agung Bagus Krisna Wibawa I Gusti Ayu Agung Laksemi I Gusti Kamasan Arijana I Gusti Putu Hendra Sanjaya I Ketut Suyasa I Ketut Wiargitha I Made Arya Winangun I Made Bakta I Made Gotra I Made Jawi I Nyoman Semadi I W. Sudarsa I Wayan Gede Artawan Eka Putra I Wayan Niryana I Wayan Putu Sutirta Yasa I. B. Tjakra Wibawa Manuaba Ida Bagus Adi Kayana Ilhamjaya Patellongi Iwan Antara Suryadi K.K. Putra Kadek Dede Frisky Wiyanjana Kadek Dede Frisky Wiyanjana Ketut Putu Yasa Ketut Siki Kawiyana Kevin Kristian Putra Koerniawan, Heru Sutanto Komang Ayu Vitriana Gamayanti L. K. Widnyani Wulan Laksmi L. R. M. Lengkong M Wiryana Made Agus Mahendra Inggas, Made Agus Mahendra Made Favian Budi Gunawan Made Indra Erlangga Prathiwindya Made Putri Hendaria Moses Kharisma Setyawan Mumtazah Mardliyah Ni Ketut Susilawati Ni Luh Putu Julita Yanti Ni Putu Enny Pratiwi Suardi Ni Wayan Ariani Vitriasari Nyoman Golden Putu Anda Tusta Adiputra Putu Indah Budi Apsari Putu Primeriana Nugiaswari Raka-Sudewi A. A. Reni Widyastuti Romdhoni, Achmad Chusnu S. Awyono Satoto D., Satoto Stanley-Ketting Oliver Suryadi N. T., Suryadi N. Tjokorda Gde Agung Senapathi Tjokorda Gde Bagus Mahadewa W. A., W. Wayan Suardana Willy Adhimarta, Willy Wiryana M., Wiryana Yutina Himawan