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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana MNJ (Malang Neurology Journal) Bali Journal of Anesthesiology The Indonesian Journal of Infectious Diseases Callosum Neurology Journal : Jurnal Berkala Neurologi Bali ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Kedokteran Neurosains Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Archives of Biomedical Research (InABR) Cermin Dunia Kedokteran
Raka-Sudewi A. A.
Udayana University, Bali-Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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HIGH PLASMA TNF-? LEVELS AND MONONUCLEAR CELLS iNOS AND TNF-? EXPRESSION AS RISK FACTORS FOR PAINFUL DIABETIC NEUROPATHY Eko Purwata, Thomas; Suastika, Ketut; Raka Sudewi, A. A.; Widjaja, Djoenaidi
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 4, No. 2 Juli 2010
Publisher : Udayana University

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Abstract

Painful Diabetic Neuropathy (PDN) is one of the most common and annoyingcomplications of diabetes mellitus. The pathogenesis of PDN is complex and still unclear.Recently it has become clear that nitric oxide (NO) and proinflammatory cytokines playan important role in the pathogenesis and maintenance of pain in PDN. Based on thisphenomenon, this study was conducted to investigate whether the cytokine tumornecrosis factor-alpha (TNF-?) and NO, in this case inducible Nitric Oxide Synthase(iNOS), play a role in PDN pathogenesis.The study was carried in two steps. The first step was a cross sectional and thesecond step was a case-control study. The study was performed in 110 type-2 diabeticpatients. The plasma TNF-? levels were determined by ELISA while the expression ofTNF-? and iNOS in mononuclear cells were analyzed immunohistochemically.Of 110 subjects, 59 patients suffered from Painful DN (case) and the remaining51 patients were Painless DN (control). Cross sectionally, plasma TNF-? levels andimmunoreactivity for iNOS and TNF-? were higher in patients with more severe pain inthe Visual Analog Scale (VAS). There were statistically significant differences (p <0.05) between mild and severe pain in regard to TNF-? level (15.24 pg/ml ± 5.42 vs.20.44 pg/ml ± 10.34 ); to iNOS immunoreactivity (9.72 % ± 8.61 vs. 15.6% ± 11.84); andto TNF-? immunoreactivity (13.0 % ± 9. 48 vs. 20.44% ± 11.75).The case control study showed that TNF-? had an odd ratio of 5.053 [CI 95%(2.241-11.392); p < 0.001]. TNF-? immunoreactivity of 4.125 [CI 95% (1.805-9.425); p< 0.001]; and iNOS immunoreactivity of 3.546 [CI 95% (1.613-7.795); p = 0.002]. There were correlations between TNF-? level, TNF-? and iNOS immunoreactivity andVAS with coefficient correlation: 0.330; 0.285 and 0.275 (p < 0.05) respectively.It is concluded that Diabetic Neuropathy patients with high TNF-? levels, iNOSand TNF-? immunoreactivity of mononuclear cells have higher risk for painful DN thanpainless DN. The higher TNF-? level, iNOS and TNF-? immunoreactivity the moresevere was the pain. This supports the hypothesis that TNF-? and iNOS have role inPDN pathogenesis. The results of this research could be applied as a basic for furtherresearch in pursuit of better management of PDN.
FLOUXETINE IMPROVED INTRAVAGINAL EJACULATORY LATENCY TIME THROUGH DECREASED LEVELS OF INTERFERON-GAMMA AND INCREASED LEVELS OF SEROTONIN IN PATIENT WITH PREMATURE EJACULATION I M., Nyandra; W, Pangkahila; A. A., Raka-Sudewi; I N. A., Bagiada
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 6 No 2 (2012): Indonesian Journal of Biomedical Sciences
Publisher : Udayana University

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Pathophysiology of premature ejaculation (PE) is very complex because it is associated with many factors, which can be grouped into biological factors and psychological factors. Various diseases have been found correlate between psychological factors and biological factors through cytokines, one of which is IFN-g (IFN-g). IFN-g affect indolamine dioxygenase enzyme (IDO) and decrease levels of serotonin. Low levels of serotonin leads to PE. The purpose of this study was to prove the relationship of serotonin and IFN-g in pathophysiology of PE. This study was designed as a pretest-posttest double-blind cross-over control group design. Patients with PE were divided into 2 groups: control group and treatment group. Treatment group received flouxetine 20 mg for 30 days. Then the control and treatment groups were crossed after passing a 14-days washout period. Previously as a control group to treatment group and received flouxetine 20 mg per day for 30 days. Before and after treatment in each group was examined the levels of serotonin and IFN-g. Of the 26 subjects, each group there was 13 subjects. Flouxetine 20 mg per day for 30 days increased serotonin levels were significantly (p < 0.05), and decreased levels of IFN-g were significantly (p < 0.05). Increased levels of serotonin and decreased levels of IFN-g was significantly associated with improvements (intravaginal ejaculatory latency time) ejaculation in PE patient. From these results it can be concluded that PE occurs because decreased levels of serotonin. Decreased levels of serotonin are associated with increased levels of IFN-g. Keywords: PE, Serotonin, IFN-g.
Blood hsCRP And PGE2 Content With Clinical Outcome Using Modified Fenestratio-Restorative Spinoplasty Better Than Lamonectomy-Fusion In Lumbar Stenosis Mahadewa, T. B. G.; -, Sri-Maliawan; Raka-Sudewi, A. A.; Wiryana, M
BALI MEDICAL JOURNAL Volume 1, Number 2, May-August 2012
Publisher : BALI MEDICAL JOURNAL

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Objective: Modified Fenestration-Restorative Spinoplasty (MFRS) technique is an alternative to lumbar stenosis treatment, providing the equal decompression comparing with laminectomy techniques, without the implant, less expensive and complication rates. The purpose of this study was to determine which technique gives better inflammation and clinical outcome based on high sensitive C-Reactive Protein biomarker (hsCRP) and Prostaglandin E2 (PGE2), Visual Analog Scale (VAS) of the day 7th postsurgery and ODI scores 3rd month post surgery. Methods: This study design is an experimental pretest-posttest randomized control group design. Results:  This study results showed that the mean levels of hsCRP day 7th postsurgery were differ significantly between MFRS (23,09 ± 15,3 mg/L) compared to LF (39,53 ± 24,4 mg/L). Likewise for the mean levels of PGE2 day 7th postsurgery were differ significantly between MFRS (491,39 ± 528,5 pg/ml) compared to LF (1103,7 ± 1033,6 pg/ml) at the significance level of p <0.05). MFRS clinical outcomes better than LF (p <0.05), for means of VAS value day 7th postsurgery and ODI score 3rd month postsurgery. Perioperative variable analysis shows that MFRS was better than LF in: length of surgery, blood loss, postsurgery Hb and patient length of stay (p<0,05). Conclusions: MFRS technique is an alternative technique of lumbar stenosis treatment better than the LF, in terms of improved levels of hsCRP and PGE2, leading to faster clinical outcomes improvement, less complications and lower costs. MFRS technique should be used as a treatment of lumbar stenosis.
PROFILAKSIS RABIES NM, Susilawathi; AA, Raka Sudewi
Medicina Vol 40 No 1 (2009): Januari 2009
Publisher : Medicina

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Abstract

Rabies merupakan penyakit ensefalitis akut yang disebabkan oleh virus RNA, famili Rhabdoviridae, genus lyssavirus. Anjing adalah reservoir utama penularan rabies, puluhan ribu kematian per tahun disebabkan oleh gigitan anjing rabies. Bila seseorang menunjukkan gejala rabies, biasanya selalu fatal.  Profilaksis terhadap rabies merupakan tindakan efektif dan aman. Mencuci luka dan vaksinasi segera setelah kontak dengan hewan tersangka rabies dapat mencegah timbulnya rabies hampir 100%. Strategi yang paling efektif untuk mencegah rabies adalah mengurangi penularan rabies pada anjing melalui vaksinasi.[MEDICINA 2009;40:55-9].
Udayana One Health Collaborating Center (OHCC) initiated Bali’s first mass, integrated basic life support training Pradhana, Adinda Putra; Sudewi, Anak Agung Raka; Budayanti, Nyoman Sri; Wiryana, Made; Senapathi, Tjokorda Gde Agung; Ryalino, Christopher
Bali Journal of Anesthesiology Vol 3, No 1 (2019)
Publisher : DiscoverSys Inc.

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Abstract

ABSTRACTBasic Life Support (BLS) is a first-aid training that can be utilized in case of emergency until the victims are retained by medical professionals. Mastering BLS skills can be the difference between life and death. A cardiopulmonary resuscitation (CPR) performed by a passer-by is important to ensure a successful resuscitation in out-of-hospital cardiac arrest. Yet, improving the survival rate for out-of-hospital cardiac arrest is still a major problem. Starting in 2019, Udayana One Health Collaborating Center (Udayana OHCC) will implement the first mass and integrated BLS training in Bali. The goals are to introduce BLS to more people and to produce BLS-friendly environment in Bali.
RABIES PERTAMA DI BALI Susilawathi NM*, Satriawan *, Laksmidewi**, Raka Sudewi AA**
NEURONA Vol 26 No. 2 Januari 2009
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

IS ZOONOSIS OF CERTAIN MAMMAL SPECIES ENDEMIC IN ALL CONTINENTS DOGS ARE THE MAJOR RESERVOIRS AND PLAY PIVOTAL ROLE IN RABIES TRANSMISSION RABIES IS AN ACUTE VIRAL ENCEPHALOMYELITIS WHICH IS VIRTUALLY FATAL BALI NUSA TENGGARA BARAT AND PAPUA ARE DECLARED HISTORICALLY FREE OF RABIES HERE WE REPORT THE FIRST RABIES IN BALI KEYWORDS RABIES FIRST CASE BALI
ANGKA CD4 NADIR DAN CURRENT RENDAH SEBAGAI FAKTOR RISIKO GANGGUAN KOGNITIF PADA PENDERITA HIV DI RSUP SANGLAH DENPASAR Widyastuti*, Oka Adnyana**, Raka Sudewi**
NEURONA Vol 29 No. 3 April 2012
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

PENDAHULUAN PENGOBATAN ANTIRETROVIRAL ARV MENYEBABKAN PEMULIHAN SISTEM IMUN YANG DITANDAI DENGAN PENINGKATAN ANGKA CD4 CURRENT CD4 TERBARU TERJADI PENURUNAN INSIDEN HIVASSOCIATED DEMENTIA HAD NAMUN PREVALENSI MILD NEUROCOGNITIVE DISORDER MND SEMAKIN MENINGKAT ANGKA CD4 NADIR CD4 TERENDAH YANG PERNAH TERJADI JUGA DIDUGA BERPERAN PADA TIMBULNYA GANGGUAN KOGNITIF
SINDROM LAMBERT EATON PADA KARSINOMA TIMUS IA Sri Wijayanti*, IGN Purna Putra**, AA Raka Sudewi**
NEURONA Vol 29 No. 3 April 2012
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

PENDAHULUANSINDROM LAMBERTEATON PSEUDOMIASTENIA ATAU SINDROM MIASTENIA ADALAH PENYAKIT AUTOIMUN YANG JARANG TERJADI DITANDAI DENGAN KELEMAHAN PADA OTOT DAN GANGGUAN OTONOM DISEBABKAN OLEH KEADAAN IDIOPATIK ATAU ADANYA SINDROM PARANEOPLASTIK YANG MEMPRODUKSI SUATU ANTIBODI TERHADAP PRESYNAPTIC VOLTAGEGATED PQ CALCIUM CHANNELS VGCC YANG MENGAKIBATKAN PENURUNAN MASUKNYA KALSIUM KE DALAM TERMINAL PRESINAPTIK SEHINGGA TERJADI KEGAGALAN PENGIKATAN VESIKEL PADA MEMBRAN PRESINAPTIK YANG MELEPASKAN ASETILKOLIN ACETYLCHOLINE ASETILKOLIN
HALUSINASI PADA PASIEN MENINGITIS STREPTOCOCCUS SUIS Wahju Handojo Setiawan,* Anak Agung Raka Sudewi,* Ida Ayu Sri Wijayanti,* Ni Ketut Sri Diniari**
NEURONA Vol 33 No 4 September 2016
Publisher : Neurona Majalah Kedokteran Neuro Sains

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REPORTED A 51 YEARS OLD MALE WITH DECREASE LEVEL OF CONSCIOUSNESS WITH HIGH FEVER AND INFECTION OF THE LUNG AND DEVELOPED PARTIAL SECONDARY GENERALIZED SEIZURE CEREBROSPINAL FLUID EXAMINATION SHOWED ELEVATED CELLS AND PROTEIN LEVEL AND DECREASED OF BLOODLIQUOR GLUCOSE LEVEL RATIO BLOOD CULTURE WAS POSITIVE FOR STREPTOCOCCUS SUIS TYPE II PATIENT WAS GIVEN ANTIBIOTICS FOR 14 DAYS AND BECAME BETTER AFTERWARDS BUT DEVELOPED DEAFNESS AND HAD TACTIL AND AUDITORY HALLUCINATIONS AS PART OF THE COMPLICATIONS
NEUROSISTISERKOSIS INTRAVENTRIKULAR DENGAN TERAPI PEMBEDAHAN Jackson Sihombing,* Wayan Niryana,** Ni Made Susilawathi,** Anak Agung Raka Sudewi**
NEURONA Vol 34 No. 2 Maret 2017
Publisher : Neurona Majalah Kedokteran Neuro Sains

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NCC IS A PARASITIC INFECTION OF THE BRAIN CAUSED BY LARVAE OF TAENIA SOLIUM IN THE FORM OF CYSTS CYSTISCERCUS INTRAPARENKIM IS OFTEN TO BE FOUND IN THE BRAIN WHEREAS INTRAVENTRICULAR OR SUBARACHNOID RARELY OCCUR 1530 INTRAVENTRICULAR LESION OFTEN CAUSE SYMPTOMS OF HYDROCEPHALUS THUS RISK OF FATAL COMPLICATIONS THIS REQUIRES COMPLEX HANDLING WITH SURGICAL THERAPY
Co-Authors A A.B.N. Nuartha A.A.N. Subawa Adinda Putra Pradhana Akira Ito Angelia Carolin Bagiada I N. A. Christine Ekawati, Christine Christopher Ryalino, Christopher Cokorda Istri Dyah Sintarani Sintarani Dedi Silakarma Desak Gde Diah Dharma Santhi Dewa Ngurah Suprapta Djoenaidi Widjaja Ernesta Ginting Ge Aris Geson Ginting, Ernesta Gitari, Ni Made I Gde Raka Widiana I Gede Ketut Sajinadiyasa I Ketut Suastika I Made Jawi I Nyoman Adi Putra I Putu Eka Widyadharma I Wayan Niryana, I Wayan I Wayan Putu Sutirta Yasa Ida Ayu Jasminarti Dwi Kusumawardani Ida Ayu Sri Wijayanti Wijayanti Ida Bagus Ngurah Rai Imelda, Yuliana Monika Ivan Elisabeth Purba Kade Agus Sudha Naryana Kazuhiro Nakaya M Wiryana Made Nyandra Made Wiryana N ADIPUTRA, N N. S. Budayanti NFN Moestikaningsih Ni Luh Putu Eka Arisanti Ni Made Adi Tarini Ni Wayan Candrawati Oka Adnyana Pangkahila W Paramita, Dyah Pradnya Pusaka, Semerdanta Putra Martin Widanta IGN Putu Yogi Pramana Sanjaya, Feliani Satyarsa, Agung Bagus Sista Senja Decy Ningrum Sri Maliawan Susilawathi NM Thomas Eko Purwata Tjokorda Gde Agung Senapathi Tjokorda Gde Bagus Mahadewa Tjokorda Istri Pramitasuri Toni Wandra Widanta IGN, Putra Martin Yasuhito Sako Yuliana Monika Imelda