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All Journal FITOFARMAKA: Jurnal Ilmiah Farmasi Pharmaceutical Sciences and Research (PSR)
Katrin Katrin
Universitas Indonesia
Chemistry Medicine & Pharmacology

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UJI AKTIVITAS PENGHAMBATAN XANTIN OKSIDASE EKSTRAK ETANOL 80% DARI TANAMAN FAMILI COMBRETACEAE, LAURACEAE, LYTHRACEAE, OXALIDACEAE, PIPERACEAE, PLUMBAGINACEAE, DAN SMILACACEAE wahyuni, Tri; Widuri, Anggita; Mun’im, Abdul; Katrin, Katrin
FITOFARMAKA | Jurnal Ilmiah Farmasi Vol 6, No 2 (2016): Vol.6, No.2, Desember 2016
Publisher : Universitas Pakuan

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Abstract

ABSTRAK Hiperurisemia dapat disebabkan oleh produksi berlebih dan kurangnya ekskresi asam urat dalam tubuh. Xantin oksidase adalah enzim yang memiliki peran mengkatalisis oksidasi hipoxantin dan xantin menjadi asam urat. Tujuan penelitian ini adalah untuk mengetahui tanaman obat yang memiliki aktivitas penghambatan xantin oksidase dan mengidentifikasi golongan senyawa kimianya. Metode yang digunakan adalah Continous Spectrophotometric Rate Determination. Serbuk simplisia diekstrak dengan cara refluks menggunakan pelarut etanol 80%. Dengan uji aktivitas penghambatan xantin oksidase didapatkan ekstrak yang memiliki aktvitas penghambatan, yaitu ekstrak herba suruhan (Peperomia pellucida (L.) Kunth), ekstrak daun blimbing wuluh (Averrhoa bilimbi L.), ekstrak daun sirih (Piper betle L.), dan ekstrak kulit kayu manis (Cinnamomum burmannii Nees ex Blume) yang memiliki nilai IC50 berturut-turut 2621,07 ppm, 1149,113 ppm, 245,30 ppm, dan 1294,58 ppm. Identifikasi kimia pada ekstrak herba suruhan menunjukkan adanya alkaloid, flavonoid, tanin, saponin, dan glikosida. Pada ekstrak daun belimbing wuluh mengandung senyawa flavonoid, tanin, dan saponin. Pada eksktrak daun sirih hijau mengandung senyawa alkaloid, flavonoid, tanin, saponin, dan antrakuinon. Pada ekstrak kulit kayu manis mengandung senyawa alkaloid, flavonoid, tanin, saponin Kata kunci: suruhan, blimbing wuluh, sirih, kayu manis, hiperurisemia, aktivitas inhibitor, xantin oksidase
Uji Aktivitas Penghambatan Enzim Alfaglukosidase Pada Beberapa Tanaman Suku Euphorbiaceae Elya, Berna; Katrin, Katrin; Bangun, Anastasia
Majalah Ilmu Kefarmasian Vol. 9, No. 3
Publisher : UI Scholars Hub

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Diabetes mellitus (types 1 and 2) is recognized as a serious global health problem that characterized by hyperglycemia. Type 2 diabetes is more common in diabetic populations. In type 2 diabetes mellitus, inhibition of α-glucosidase is a useful treatment to delay the absorption of glucose after meals. Avoiding the adverse effects of current agents, it is still necessary to search alternative for better options. Plants have been a rich source of α-glucosidase inhibitors. In this research, screenings based on chemotaxonomic approach to determine the class of chemical constituents and to know α-glucosidase inhibiting activity of some plants from Euphorbiaceae. The simplisia powder was extracted using ethanol 80% by reflux. Measurement of inhibitory activity of α-glucosidase performed using a spectrophotometer UV-VIS. In vitro assays of α-glucosidase activity showed 14 extracts had IC50 values of between 2.34 µg/mL and 64.78 µg/mL, which were lower than that of acarbose (117.20 µg/mL). Leaves extract from Antidesma celebicum had the highest α-glucosidase inhibiting activity with an IC50 of 2.34 µg/mL. The results of phytochemical screening in 15 extracts generally contain glycosides, terpenoids/ sterols, tannins, saponins and alkaloids.
Aktivitas Antioksidan Ekstrak, Fraksi dan Golongan SenyawaKimia Daun Premna oblongata Miq Katrin, Katrin; Bendra, Atika
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Indonesia has many kinds of plants which can be used as natural antioxidant sources. This study was focused on antioxidant activity of Cincau Perdu leaves extract (Premna oblongata Miq.) using 1-Diphenyl-2-picrylhydrazyl (DPPH) methods. P. oblongata leaves was extracted using n-hexane, ethylacetate and methanol. It was found that methanol extract has the highest activity with IC50 value 20.01 μg/mL. The extract with highest antioxidant activity were fractionated with accelerated column chromatography and were earned 6 combination fractions. The antioxidant activity of each combination fractions were tested by DPPH methods. Fraction-5 showed the highest activity as antioxidant with IC50 23.51 μg/mL. The compounds of the active fractions were flavonoid, glikon, saponin and tannin.
Co-Authors Anastasia Bangun, Anastasia Atika Bendra, Atika Berna Elya Mun’im, Abdul tri wahyuni Widuri, Anggita