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All Journal Jurnal Berkala Epidemiologi JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) The Indonesian Journal of Public Health The Indonesian Journal of Occupational Safety and Health Health Notions Indian Journal of Forensic Medicine & Toxicology
Soedjajadi Keman
Universitas Airlangga
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Expression of Catalase and Malondialdehyde Levels in Silicon Dioxyde-exposed Lung Tissue of Mice Treated with Moringa oleifera Leaves Extract Kusmiyati, Kusmiyati; Keman, Soedjajadi; Amin, Muhammad; Suwarno, Suwarno
Health Notions Vol 2 No 3 (2018): March 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (616.261 KB)

Abstract

Silica particle such as silicon dioxide (SiO2), is considered as a hazardous and cytotoxic particle. Silica particle exposure leads to oxidative stress in lung tissue. Moringa oleifera is a plant with potential antioxidant compounds. Therefore the aim of this study was to analyze the effect of M. oleifera leaves extract (MLE) on expression of catalase enzyme and malondialdehyde (MDA) levels in lung tissue of mice exposed to silica particles. This study was an experimental study with randomized posttest-only control group design using 30 male Balb/c strain mice, 8-10 weeks of age, 20-30 g body weight (BW), which were randomly divided into five groups. Group 1 was the negative control group, group 2 was exposed to SiO2 particle and set as the positive control group, group 3 was treated with MLE 2 mg/20 g BW, group 4 was treated with MLE 5 mg/20 g BW, and group 5 was treated with MLE 8 mg/20 g BW. After 90 days, mice were sacrificed by cervical dislocation and the lung tissues were examined.  Study results showed that expression of catalase in lung tissues of MLE-treated group was higher than that of positive control group, but not statistically significant. There was a significant difference of MDA level in lung tissue among groups. MDA level of groups treated with MLE 2 mg/20 g BW and 5 mg/20 g BW was lower than that of control group, while group treated with MLE 8 mg/20 g BW showed higher MDA level than control group (One Way ANOVA, p<0.05). It is concluded that administration of MLE indicates to prevent SiO2 inducedoxidative stress in lung tissue of Balb/c mice.    Keywords: Antioxidant, Catalase, Malondialdehyde, Moringa oleifera, Silicon dioxyde 
Influence of Student Behavior on Hepatitis A Incidence and Prevalence in Islamic Boarding School “Sidogiri” Secaria, Bhirawa Odie Prino; Sulistyorini, Lilis; Keman, Soedjajadi
Health Notions Vol 2 No 6 (2018): June 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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abstract
Immunoinformatics Analysis of SARS-CoV-2 Isolated from Karst of Bats in Malang, Indonesia Moch Irfan Hadi; Aditya Sukma Prawira; Khuliyah Candraning Diyanah; Dedy Suprayogi; Soedjajadi Keman; Yudied Agung Mirasa; M Yusuf Alamudi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14805

Abstract

In December 2019, cases of mysterious pneumonia were first reported in Wuhan, Initially, the diseasewas temporarily named as 2019 novel coronavirus (2019-nCoV), then WHO announced a new name onFebruary 11, 2020, namely Coronavirus Disease (COVID-19) which is caused by a virus Severe AcuteRespiratory Syndrome Coronavirus-2 (SARS-CoV-2). This virus can be transmitted from person toperson and has spread widely in China and more than 190 other countries and territories. Meanwhile inIndonesia, up to September 2020, 203 thousand cases of COVID-19 were found and 8336 deaths. Batsact as important disease reservoirs for various etiologic agents of disease that can be transmitted betweenspecies, infecting humans and mammals, both domestic and wild. The purpose of this study was to analyzeSARS-CoV-2 immunoinformatics in bats in Karst Malang Indonesia as the basis for making SARS-CoV-2vaccines. This research method is SARS-CoV-2 amino acid bats in Karst Malang, Indonesia analyzed byimmunoinformatics. From the research results, it was found that SARS-CoV-2 protein from Malang Karstbats were antigen, non-allergen and non-toxin, so that they could be used as vaccine candidates, diagnostickits and immunotherapy.
Expression of Catalase and Malondialdehyde Levels in Silicon Dioxyde-exposed Lung Tissue of Mice Treated with Moringa oleifera Leaves Extract Kusmiyati Kusmiyati; Soedjajadi Keman; Muhammad Amin; Suwarno Suwarno
Health Notions Vol 2, No 3 (2018): March
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (616.261 KB) | DOI: 10.33846/hn.v2i3.146

Abstract

Silica particle such as silicon dioxide (SiO2), is considered as a hazardous and cytotoxic particle. Silica particle exposure leads to oxidative stress in lung tissue. Moringa oleifera is a plant with potential antioxidant compounds. Therefore the aim of this study was to analyze the effect of M. oleifera leaves extract (MLE) on expression of catalase enzyme and malondialdehyde (MDA) levels in lung tissue of mice exposed to silica particles. This study was an experimental study with randomized posttest-only control group design using 30 male Balb/c strain mice, 8-10 weeks of age, 20-30 g body weight (BW), which were randomly divided into five groups. Group 1 was the negative control group, group 2 was exposed to SiO2 particle and set as the positive control group, group 3 was treated with MLE 2 mg/20 g BW, group 4 was treated with MLE 5 mg/20 g BW, and group 5 was treated with MLE 8 mg/20 g BW. After 90 days, mice were sacrificed by cervical dislocation and the lung tissues were examined. Study results showed that expression of catalase in lung tissues of MLE-treated group was higher than that of positive control group, but not statistically significant. There was a significant difference of MDA level in lung tissue among groups. MDA level of groups treated with MLE 2 mg/20 g BW and 5 mg/20 g BW was lower than that of control group, while group treated with MLE 8 mg/20 g BW showed higher MDA level than control group (One Way ANOVA, p<0.05). It is concluded that administration of MLE indicates to prevent SiO2 inducedoxidative stress in lung tissue of Balb/c mice.Keywords: Antioxidant, Catalase, Malondialdehyde, Moringa oleifera, Silicon dioxyde
Influence of Student Behavior on Hepatitis A Incidence and Prevalence in Islamic Boarding School “Sidogiri” Bhirawa Odie Prino Secaria; Lilis Sulistyorini; Soedjajadi Keman
Health Notions Vol 2, No 6 (2018): June
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn20614

Abstract

Islamic boarding school Sidogiri is one of the school which has 8.400 male students. The sanitary conditions of Islamic boarding school are closely related to the contagion rate of contagious environment-based diseases, one of which is Hepatitis A. Islamic boarding school Sidogiri experiencing Hepatitis A outbreak in 2014, attacked as many as 111 students. This research was conducted to find out the correlation between students behavior (knowledge, attitude, and action) with incident and prevalence of Hepatitis A. The type of research was analytic observational research by analyzing behavior with the occurrence of Hepatitis A (IgG and IgM). The study was conducted in Islamic boarding school Sidogiri Kraton subdistrict in Pasuruan district from July 2017 until March 2018. The population in this study were all students in Islamic boarding school Sidogiri. Sample selection was done randomly so that got sample amount 38 people. The result of this research mentioned that attitude and action factor have significant influence to the occurrence of hepatitis A (IgG) with p-value equal to 0.017. The lower the attitudes and actions, the higher the prevalence of IgG. While the action factor has a significant effect on the incidence of Hepatitis A (IgM) with p value of 0.001. The lower the action, the higher the prevalence of IgM. Socialization, promotion and health education needs to be done to reduce the risk of contracting hepatitis A. Keywords: Islamic boarding school; students behaviour; hepatistis A; IgG; IgM
Relationship of Traffic Noise with High Blood Pressure to Pedicab Drivers Around Purabaya Bus Station Surabaya Shita Addina; Soedjajadi Keman
JURNAL KESEHATAN LINGKUNGAN Vol. 8 No. 1 (2015): Jurnal Kesehatan Lingkungan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v8i1.2015.69-80

Abstract

Abstract: The existence of bus  station  can  make  some problems, one  of which  is the traffic noise. Traffic noise  can induce an increased blood pressure. Therefore, the purpose of this study was to analyzed the relationship  between level of traffic noise  and increased blood  pressure in pedicab drivers around Purabaya bus station. The study was carried out using  by cross sectional method. Measurement of traffic noise  was carried out around  Purabaya bus station Surabaya with Sound Level Meter. Measurement of blood  pressure with sphygmomanometer. Sampling method used by simple random  sampling with 22 respondents respectively and  then  total of respondents are 44 respondents. The  result of study  indicated there  was  a relationship  between the level traffic noise  with increased blood  pressure (hypertension) (p = 0.034). Another factor related to blood  pressure was descendants of the family history (p = 0.002). It was concluded that traffic noise  related with increased blood pressure in pedicab drivers. Suggested for the next researcher doing  the measurement noise  more than a day to get the actual average noise  level. In addition, other factors related to the blood pressure should examined to get main factor of hypertension.Keywords: traffic noise, blood  pressure, pedicab drivers
Blood Lead Levels and Healthy Complaint in Printing Workers of Unipress Surabaya Mika Vernicia Humairo; Soedjajadi Keman
JURNAL KESEHATAN LINGKUNGAN Vol. 9 No. 1 (2017): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v9i1.2017.48-56

Abstract

Lead is found in the printing ink, it gets into the human body through skin absorption and ingestion. Blood lead level > 10 μg/dL causes health disturbances. The purpose of this study was analyzed blood lead level and healthy complaints in printing worker of Unipress Surabaya. This research was observational analytic with cross sectional approach. The subject was printing production process employees and administration employees. Population of production process employees were 10 people and administration employees were 7 people. Whereas, sample of production process employees were 9 and administration employees were 6. The determination of the sampling used simple random sampling. Data analyzed with chi-square test and t-independent test. Blood lead level of production process employees have  ± SD = 6.16 ± 0.37 μg/dl, whereas the blood lead level of administration employees have ± SD = 6.0±0.18 μg/dl. Based on the results by t-independent test (p = 0.371) which indicated there was no difference blood lead level of production process employees and administration employees. Based on the test results by chi-square (p = 0.005) which indicated there was difference in central nervous system disturbances of study group and control group. It is concluded that blood lead level in printing worker of Unipress Surabaya are normal. Though it can suggested to use gloves while working, increase hygiene and sanitation behavior, reducing smoking habit, as well as routine health check up to see the blood lead leve
Ship Sanitation and Sanitary Behavior of the Crew Influences to the Presence of Rats on Cargo Ship in the Port of Tanjung Perak Surabaya Sofiyan Sofiyan; Soedjajadi Keman
JURNAL KESEHATAN LINGKUNGAN Vol. 9 No. 2 (2017): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v9i2.2017.145-153

Abstract

Sanitary inspection intended to eliminate environmental risk factors in the ships to break the chain disease transmission in order to maintain and enhance the health status. Based on data from 2015 the Port Health Office class I Surabaya, during the ships inspection there are found 23 rats from 2734 ships. The existence of the rats on the cargo ship is very harmful, which can caused disease and damaged food material in cargo ship. The tendency of rats existence on board as media transmission of the disease, is the reason for researchers to identify the level of sanitation review and behavior of crew that affecting the existence of rats on cargo ship in the Port of Tanjung Perak Surabaya. That research aimed to analyze the level of sanitation and behavior of crew that affects the existence of rats. This study was an observational study with cross sectional study design, sampling for ship sanitation in research using accidental sampling, behavior of crew using the proportional random sampling method. The research variables are behavior of crew and ship sanitation. The primary data were collected by observation, indepth interviews, and questionnaires. Secondary data collected from the Port Health Office Class I Surabaya. Statistical test with multiple regression showed that behavior of crew significant effect on the existence of rat in cargo ship. The results using ship sanitation level variables sig. 0.043 means that the behavior of crew variable significant effect on the presence of rats on a cargo ship, while for the ship sanitation variables sig. 0.0002, means that the variable ship sanitation very significantly affected on the presence of rats on a cargo ship. The conclusion of this study be found influences of the ship sanitation and behavior of crew against the presence of rats in cargo ship, so it needs to be disseminated to the crew of cargo ship in order to increase knowledge about ship sanitation, and the health effects of the presence of rats on a cargo ship.
The Differences of Improving Leukosit in Radiographers at Islamic Hospital Jemursari Surabaya Farida Giyartika; Soedjajadi Keman
JURNAL KESEHATAN LINGKUNGAN Vol. 12 No. 2 (2020): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v12i2.2020.97-106

Abstract

Introduction: Health development in Indonesia is influenced by the increasing needs and demands of the community to obtain quality health services. Progress in health service facilities as a form of the use of radiation beams. The utilization of radiation substances in the field of health care is a source of danger for radiation workers in the radiology department. X-ray radiation has an impact on human health, especially the health of radiographers. The purpose of this study was to analyze the increase in leukocytes due to X-ray radiation exposure in workers exposed (radiographers) with unexposed workers (admissions officers) at the Jemursari Islamic Hospital in Surabaya. Methods: This study used an analytic observational study, using a cross sectional research design, and the analysis used was the independent t-test and mann whitney. Research subjects numbered 18 respondents taken from the population in accordance with specified criteria. Result and Discussion: The results showed there was no difference between exposed workers (radiographers) and unexposed workers (admissions officers) on increased leukocytes due to X-ray radiation exposure. Lymphocyte variables were not significantly different (independent t-test p = 0.137), monocyte variable no significant difference (independent t-test p = 0.525), neutrophil variable no significant difference (independent t-test p = 0.137), eosinophil variable no significant difference (mann whitney p = 0.27), there is no significant difference in the basophile variable (independent t-test p = 0.738). Conclusion:X-ray radiation exposure does not affect the increase in leukocytes in the blood in radiology workers. 
Nitrogen Dioxide Concentrations in the Air in Increasing Superoxide Dismutase Enzyme and Malondialdehyde Serum Levels in Bus Terminal Officers Kahar Kahar; Lilis Sulistyorini; Soedjajadi Keman
JURNAL KESEHATAN LINGKUNGAN Vol. 13 No. 3 (2021): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v13i3.2021.166-173

Abstract

Introduction: Free radicals in the air such as NO2 , O3 , PM2,5 induce the production of reactive oxygen species (ROS) in the body and stimulates the production of superoxide dismutase (SOD) enzyme. Imbalanced levels of free radicals and antioxidants will trigger the production of malondialdehyde (MDA). This study aimed to analyze the correlation between NO2 concentrations in the air with SOD and MDA levels in bus terminal officers. Methods: This study was an analytical observational and used a cross-sectional design. The population included terminal operational officers and desk administrative officers in the bus terminal. A number of 12 people was chosen as a sample calculated with averaging formula between case and control. The measurement of NO2 concentrations in the ambient air was performed using the Griess Saltzman method. The ELISA method was utilized to analyze the levels of the SOD enzyme, and the TBARS method was used to analyze the level of MDA serum. A statistical test was conducted using a Mann-Whitney test and Independent-2 Sample T-test. Results and Discussion: The average of NO2 concentrations in the ambient air showed 106.5 µg/Nm3 and in the administration room at 17.8 µg/Nm3 . There was a very significantly higher exposure to NO2 in the air towards the level of SOD enzyme (p < 0.01) and to the level of MDA serum (p < 0.01). Conclusion: The high level of exposure to NO2 in the ambient air will increase SOD enzyme and MDA serum production in the body. It is recommended that the officers consume more fruit and vegetables containing vitamins C and E to fulfill the daily nutritional intake for antioxidants, and for the operational officers, always use a mask
Co-Authors . Suwarno Aditya Sukma Prawira Aini Fadlila Ari Rahmawati Putri Bhirawa Odie Prino Secaria Dedy Suprayogi Fadilatus Sukma Ika Noviarmi Farida Giyartika Kahar Kahar Khuliyah Candraning Diyanah Kusmiyati Kusmiyati Kusmiyati Kusmiyati Leli Indahwati Lilis Sulistyorini M Yusuf Alamudi Mika Vernicia Humairo Moch Irfan Hadi Muhammad Amin Muhammad Amin Saadatuddaroini Saadatuddaroini Saliza Binti Mohd Elias Secaria, Bhirawa Odie Prino Shita Addina Sofiyan Sofiyan Suwarno Suwarno Ursula Yesi Gusti Ayuputri Yudied Agung Mirasa