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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Pengabdian Pada Masyarakat Bubungan Tinggi: Jurnal Pengabdian Masyarakat Madaniya Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian Kepada Masyarakat Itekes Bali Journal of Applied Agriculture, Health and Technology
Dian Eka Ermawati
Universitas Sebelas Maret
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Journal : Pharmaciana: Jurnal Kefarmasian

 1 
The effect of propylene glycol and polyethylene glycol 400 on physicochemical properties of peel off mask of nanosilver using bioreductor Sweet Orange Peels (Citrus sinensis L. Osbeck) Dian Eka Ermawati; Fridha Angelina Pamuji; Adi Yugatama
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.473 KB) | DOI: 10.12928/pharmaciana.v11i1.19663

Abstract

Nanosilver (AgNPs) can be synthesized using plant extracts that safe, simple, and environmentally friendly. Sweet orange contains flavonoids and citric acid, which can be a bioreductor and capping agent in silver biosynthesis to increase antimicrobial activity. AgNPs are then dispersed in a gel for acne treatment through a peel-off mask preparation. Humectants provide moisture, prevent skin irritation and regulate the viscosity of the preparation. Propylene Glycol (PG) and Polyethylene Glycol 400 (PEG 400) are humectants combined to obtain good physicochemical properties of the preparation. This study aims to determine the character of AgNPs and the effect of humectant combinations on the physicochemical properties of peel-off mask preparations. AgNPs characterization was performed using UV-VIS Spectrophotometry, Particle Size Analysis, and Scanning Electron Microscope. The PG-PEG 400 combinations are F1 (0: 100%); F2 (25%: 75%); F3 (50%: 50%); F4 (75%: 25%) and F5 (100%: 0). The physical-chemical test for 28 days included organoleptic, viscosity, dry time, and pH. The biosynthesis results produced AgNPs with maximum absorption of nanoparticles at 435 nm, rod morphological shapes measuring 106 ± 10.6 nm, and PI 0.26 ± 0.06. Statistical analysis showed that the PG-PEG 400 combination significantly affected the viscosity, dispersibility, and dry time of the preparation but affected nothing to pH. The combination of PG-PEG 400 decreased the viscosity and increased the dispersibility of peel-off mask preparation. The higher concentration of propylene glycol caused the dry time of preparation to become longer. Formulas with PG-PEG 400 combination of 25%: 75% and 75%: 25% meet the requirements of viscosity, dispersibility, dry time, and pH and not significant changes during 28 days of storage at room temperature.
The effect of zinc oxide and Curcuma heyneana Val. combination on stability and sun protection factor (SPF) of lotion Dian Eka Ermawati; Dita Yuli Budiasih
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (485.054 KB) | DOI: 10.12928/pharmaciana.v12i3.23380

Abstract

Indonesian people risk-averse effects of Ultraviolet (UV) exposure, so they need skin protection agents. Zinc Oxide (ZnO) is an effective UV reflection, but at a concentration of more than 10%, it can cause skin irritation. Combining ZnO with other UV protective agents is necessary, so its concentration can be reduced but still effective. The flavonoid in C. heyneana has potential as a sunscreen because chromophore groups can absorb UV B and UV A light. This study aims to examine the effect of the combination of ZnO and C. heyneana on the stability and SPF value of lotion. The lotion is made in five variations of the composition of ZnO and C. heyneana, F1 of 100: 0%; F2 of 0:100%; F3 of 50:50%; F4 of 25:75%; and F5 of 75:25% respectively. Test parameters include organoleptic, pH, spreadability, viscosity, and SPF. The test is recorded before and after the cycling test. Statistical analysis using Paired Sample T-Test. The combination of ZnO and C. heyneana affected organoleptic, viscosity, spreadability, and SPF value but did not affect pH. The higher concentration of ZnO will increase the viscosity, pH, and SPF but decrease the spreadability. The formula with a combination of ZnO and C. heyneana of 50%:50% is selected because it has an SPF value of 13.24 and; a viscosity of 48.67 d.Pas; pH of 7.1; and spreadability of 3.81 cm. 
Co-Authors Adi Yugatama Anang Kuncoro Rahmat S Anif Nur Artanti Dita Yuli Budiasih Diyah Tri Utami Fridha Angelina Pamuji Heru Sasongko Lutfan Prastyo Adi M Fiqri Zulpadly M. Fiqri Zulphadly M.Fiqri Zulpadly Nindita Clourisa Amaris Susanto Priscilla Noveri Sholichah Rohmani Sutarno Sutarno Villian Septiana Wisnu Kundarto Yeni Farida