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Perbandingan uji diagnostik GeneXpert MTB/RIF untuk mendeteksi resistensi rifampicin Mycobacterium tuberculosis pada pasien Tb paru di RSUP dr. Moh. Hoesin Palembang Erizka Rivani; Tia Sabrina; Venny Patricia Patricia
JURNAL KEDOKTERAN DAN KESEHATAN Vol 6, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.v6i1.7236

Abstract

Tuberkulosis (TB) masih menjadi masalah global. TB menduduki peringkat kedua penyebab kematian dari seluruh penyakit infeksi di dunia. Kelemahan dalam mendiagnosis dan pengobatan cepat selain dapat berdampak pada pasien, juga terhadap perkembangan resistensi sekunder dan penyebaran dari penyakit ini. Sebagai alternatif, teknik molekuler diagnostik dapat mempercepat TAT dan meningkatkan sensitifitas dan spesifisitas. Tes GeneXpert MTB/RIF merupakan mesin otomatis dengan penggunaan mudah dan cepat yang menggunakan prinsip nested real-time PCR dan teknologi molekuler untuk mendeteksi M. tuberculosis (MTB) dan resistensi obat rifampicin (RIF). Penelitian ini merupakan studi observasional analitik di laboratorium dengan pendekatan purposive sampling. Penilaian hasil  sensitivitas dan spesifisitas GE memiliki nilai 97% dan 93% terhadap mikroskopis BTA; Sensitivitas dan spesifisitas GE memiliki nilai 97% dan 62% terhadap kultur MTBC; Persentase deteksi Rifampisin resisten pada GE sebesar 167(31%) lebih tinggi dari pada kultur MTBC sebesar 103(21.7%); Ada 3 sampel dari 5 sampel yang hasil BTA positif dan GE negatif yang memiliki gen hsp65 yang menunjukkan adanya bakteri MOTT
The Efficacy of Seluang Fish Oil (Rasbora agrotynea) Related Body Weight, Lipid Profile, Adiponectin and Leptin in Wistar Rats-Induced High Fat Diet Fatmawati Karim; Rachmat Hidayat; Erizka Rivani; Husnul Khotimah; Ester G Pansserga
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 2 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i2.41

Abstract

Background Rasbora agrotynea (local name : Seluang ) is a fish native to Sumatera, Malaya and Borneo. This fish has a potential as a local wisdom for supplementation of omega 3 and omega 6. In Sumatera, Seluang fish was used as traditional food. Aim of Study Aim of this study to explore the efficacy of seluang fish oil in body weight, lipid profile, adiponectin and leptin level in Wistar Rats-Induced High Fat Diet Methods This study was an experimental study , pre-post test with control group design. The sample in this study was 30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and seluang fish oil at dose of 0,1 , 0,2 and 0,4 mL/200 gr BW/day for 2 weeks. Seluang fish oil was extracted by distilation methods. The results of this study were assayed by SPSS 18. Results Seluang fish oil 0,4 mL/200 gr BW was more potent to reduce body weight gain, triglyseride level, leptin and increase adiponectin level than seluang fish oil 0,1 mL/200 gr BW, 0,2 mL/200 gr BW, negative control and positive control. Conclusion Seluang fish oil had a potention to reduce body weight, triglyceride, leptin and increase adiponectin level. Keywords: Seluang fish Oil – body weight- triglyserida – leptin - adiponectin
The Efficacy of Seluang Fish Oil (Rasbora agrotynea) Related Body Weight, Lipid Profile, Adiponectin and Leptin in Wistar Rats-Induced High Fat Diet Fatmawati Karim; Rachmat Hidayat; Erizka Rivani; Husnul Khotimah; Ester G Pansserga
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 2 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i2.41

Abstract

Background Rasbora agrotynea (local name : Seluang ) is a fish native to Sumatera, Malaya and Borneo. This fish has a potential as a local wisdom for supplementation of omega 3 and omega 6. In Sumatera, Seluang fish was used as traditional food. Aim of Study Aim of this study to explore the efficacy of seluang fish oil in body weight, lipid profile, adiponectin and leptin level in Wistar Rats-Induced High Fat Diet Methods This study was an experimental study , pre-post test with control group design. The sample in this study was 30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and seluang fish oil at dose of 0,1 , 0,2 and 0,4 mL/200 gr BW/day for 2 weeks. Seluang fish oil was extracted by distilation methods. The results of this study were assayed by SPSS 18. Results Seluang fish oil 0,4 mL/200 gr BW was more potent to reduce body weight gain, triglyseride level, leptin and increase adiponectin level than seluang fish oil 0,1 mL/200 gr BW, 0,2 mL/200 gr BW, negative control and positive control. Conclusion Seluang fish oil had a potention to reduce body weight, triglyceride, leptin and increase adiponectin level. Keywords: Seluang fish Oil – body weight- triglyserida – leptin - adiponectin