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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Agromedicine and Medical Sciences Majalah Kedokteran Sriwijaya LOGISTA - Jurnal Ilmiah Pengabdian kepada Masyarakat Molekul: Jurnal Ilmiah Kimia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Teknik Kimia Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research
Fatmawati
Bagian Biokimia Dan Kimia Medik, Fakultas Kedokteran, Universitas Sriwijaya, Palembang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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Efek inhibisi infusa daun benalu kersen (dendrophthoe pentandra (L.) miq) terhadap enzim alfa-glukosidase Naomi W Tioline; Sadakata Sinulingga; S Subandrate; F Fatmawati; S Safyudin
Jurnal Teknik Kimia Vol 27 No 3 (2021): Jurnal Teknik Kimia
Publisher : Chemical Engineering Department, Faculty of Engineering, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/jtk.v27i3.767

Abstract

Daun benalu kersen (Dendrophthoe pentandra (L.) Miq) memiliki potensi sebagai antidiabetes dengan cara menghambat enzim α-glukosidase karena memiliki metabolit sekunder berupa, tanin, saponin, alkaloid, terpenoid, dan flavonoid. Penelitian ini bertujuan untuk mengetahui efek inhibisi daun benalu kersen terhadap enzim α-glukosidase. Penelitian ini merupakan penelitian eksperimental laboratorium secara in vitro dengan metode spektrofotometri yang dilakukan di Laboratorium Kimia Dasar Kedokteran, Fakultas Kedokteran, Universitas Sriwijaya. Daun benalu didapatkan dari penduduk lokal di Kota Palembang. Infusa daun benalu kersen dibagi menjadi 5 konsentrasi (100 ppm, 50 ppm, 25 ppm, 12,5 ppm dan 6,25 ppm), kemudian dilakukan uji inhibisi. Penelitian ini menggunkan akarbose sebagai kontrol positif. Hasil uji fitokimia menunjukkan bahwa infusa daun benalu kersen mengandung flavonoid, tanin, terpenoid, dan alkaloid. Infusa daun benalu kersen mampu menghambat enzim α-glukosidase dengan nilai IC50 sebesar 81,27 ppm. Infusa daun benalu kersen memiliki potensi sebagai antidiabetes karena memiliki efek inhibisi terhadap enzim α-glukosidase dengan tingkat kekuatan aktif.
UJI AKTIVITAS ANTIDIABETES AKAR KAYU KUNING (ARCANGELISIA FLAVA) Fatmawati Karim; Susilawati Susilawati; Liniyati D Oswari; Dzakiyah Dzakiyah; Fahira Anindita
JURNAL KEDOKTERAN DAN KESEHATAN Vol 7, No 3 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V7I3.10190

Abstract

 This study used extracts of  Arcangelisia flava  root to see its potential as an antidiabetic activity that can reduce blood glucose levels in male  wistar mice induced by alloxan.The study design was an in vivo experimental study with a post test with control group design approach. The samples were  70 male wistar mice   divided randomly into 14  treatmen groups, which every group contained  five rats : negative control (NaCMC 0.5%), positive control (acarbose 4.5 mg / kgBW), hexane extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW), ethyl acetate extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW), ethanol extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW), and aquadest extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW). All treatmen groups were subjected to alloxan induction to reach a glucose level af approximately 200 mg/dL (pretest). After 15 days, a measurement of blood glucose (posttest) was taken. The results showed that ethanol extract 750 mg/kgBW, ethyl acetate extract (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW) and aquadest extract (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW)  have the ability to reduce blood glucose and only ethyl acetate dose 750 mg/kgBW, aquadest extract dose 500 mg/kgBW and 750 mg/kgBW can reduce blood glucose   likely acarbose. Phytochemical tests found the presence of alkaloids and flavonoids in ethanol extract, ethyl acetate extract and aquadest extract, but tannin contained only in ethanol extract and ethyl acetate extract.
Uji Aktivitas Penghambatan Enzim ?-glucosidase Ekstrak Air dan Ekstrak Etanol Kayu Kuning (Arcangelisia flava) Fatmawati Karim; Susilawati Susilawati; Liniyati D Oswari; Fadiya Fadiya; Nadya Nadya
JURNAL KEDOKTERAN DAN KESEHATAN Vol 8, No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/V8I1.13118

Abstract

Penelitian ini bertujuan untuk menentukan aktifitas penghambatan kerja enzim  ?-glucosidase oleh ekstrak air dan ekstrak etanol dari daun, batang dan akar dari kayu kuning (Arcangelisia flava) secara in vitro. Aktifitas enzim a-glukosidase diukur pada panjang gelombang 400 nm  berdasarkan jumlah p-nitrofenol yang dihasilkan. Daya hambat kerja enzim a-glukosidase ini dilihat dari nilai IC50. Dari nilai IC50 untuk ekstrak air daun, batang dan akar  sebesar 195,161; 138,9881 dan 48,68632 mg/mL dan ekstrak etanol daun, batang dan akar sebesar 365,8793; 123,0814 dan 66,9616 mg/mL, bagian akar mempunyai potensi yang lebih baik untuk menghambat aktifitas enzim a-glukosidase daripada bagian daun dan batang kayu kuning, dimana ekstrak air akar kayu kuning mempunyai potensi paling baik untuk menghambat kerja enzim a-glukosidase daripada ekstrak lainnya walaupun potensinya lebih rendah dari acarbose.  Dari uji fitokimia didapatkan pada ekstrak  air daun mengandung alkaloid, flavonoid, steroid, saponin dan tanin, dan pada ekstrak etanol daun terdapat alkaloid, flavonoid,  triterpenoid, saponin dan tannin, dan pada ekstrak air maupun ekstrak etanol  batang kayu kuning mengandung alkaloid, flavonoid, triterpenoid, dan saponin, sedangkan pada ekstrak air akar terdapat alkaloid, flavonoid, triterpenoid dan tanin, dan pada ekstrak etanol akar mengandung  alkaloid, flavonoid, triterpenoid, saponin dan tanin. Ekstrak air dan ekstrak etanol dari akar kayu kuning (Arcangelisia flava) berpotensi  menghambat kerja enzim ?-glucosidase.Kata kunci: Kayu kuning (Arcangelisia flava), a-glukosidase, daya hambat enzim, fitokimia
Korelasi Jumlah Cairan Sendi dengan Derajat Nyeri pada Pasien Osteoartritis Genu Alderiantama Akhmad; Radiyati Umi Partan; Fatmawati Fatmawati
Majalah Kedokteran Sriwijaya Vol 51, No 1 (2019): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v51i1.8550

Abstract

Latar Belakang: Osteoartritis (OA) adalah penyakit kronik yang ditandai dengan berkurangnya kartilago di sendi yang mengakibatkan tulang-tulang bergesekan. Gejala yang paling sering dirasakan pasien OA adalah nyeri dan kekakuan pada sendi. OA memicu terjadinya penumpukan cairan pada sendi. Cairan sendi secara tidak langsung berperan menimbulkan nyeri pada artritis. Nyeri pada pasien OA dapat diukur menggunakan Visual Analog Scale (VAS). Penelitian ini dilakukan untuk mengetahui korelasi jumlah cairan sendi dengan derajat nyeri pada pasien OA genu.Metode: Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Sampel penelitian ini adalah pasien OA genu yang mengalami effusi sendi serta memenuhi kriteria inklusi dan eksklusi di Klinik Su’adah pada tahun 2018.Hasil: Dari 80 pasien, didapatkan 73,8% pasien OA genu adalah perempuan dan 30% berusia 56-60 tahun, dan 80% memiliki IMT >25 kg/m2. Rata-rata jumlah cairan sendi pasien OA sebanyak 18,59 mL (+ 1,49) dan rata-rata derajat nyeri adalah 6,33 (+ 0,24). Hasil analisis menggunakan uji korelasi Pearson menunjukkan bahwa terdapat korelasi positif lemah yang signifikan (r= 0,327             , p= 0,003).Kesimpulan: Terdapat korelasi positif lemah dan signifikan antara jumlah cairan sendi dengan derajat nyeri pada pasien OA genu.
PENDAMPINGAN KETERAMPILAN CARA MENDAPATKAN, MENGGUNAKAN, MENYIMPAN, DAN MEMBUANG OBAT (DAGUSIBU) PADA MASYARAKAT Sadakata Sinulingga; Safyudin -; Fatmawati -; Subandrate -; Kusumo Hariyadi; Rini Yana
LOGISTA - Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 3 No 2 (2019)
Publisher : Department of Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Andalas Kampus Limau Manis - Padang, Sumatera Barat Indonesia-25163

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (633.915 KB) | DOI: 10.25077/logista.3.2.119-124.2019

Abstract

Saat ini, akses masyarakat terhadap obat-obatan semakin mudah. Namun, hal tersebut tidak disertai dengan pemahaman yang benar terhadap obat-obatan. Akibatnya, hal tersebut menimbulkan berbagai masalah terkait obat seperti penggunasalahan dan pembuangan obat secara sembarangan. Oleh karena itu, masyarakat perlu diberi pengetahuan dan keterampilan yang benar tentang cara mendapatkan, menggunakan, menyimpan dan membuang obat (DAGUSIBU). Kegiatan pengabdian masyarakat ini berupa pendampingan dengan kegiatan utama penyuluhan dan demonstrasi tentang DAGUSIBU terhadap masyarakat di Kelurahan Keputeraan, Kota Lubuklinggau, Sumatera Selatan. Kegiatan diikuti oleh 34 orang peserta yang terdiri dari masyarakat dan kader kesehatan. Analisis keberhasilan kegiatan dilakukan dengan melakukan evaluasi sebelum dan sesudah penyuluhan. Dari kegiatan tersebut dapat diketahui bahwa hampir seluruh peserta tidak mengetahui tentang DAGUSIBU. Setelah diberikan penyuluhan dan demonstrasi, sebagian beserta dapat memamahi dengan baik dan memiliki keterampilan sederhana dalam DAGUSIBU. Dari hasil tersebut, diharapkan masyarakat dapat menerapkannya dalam kehidupan sehari-hari.Kegiatan pengabdian masyarakat berupa penyuluhan ini telah dapat meningkatkan pengetahuan dan keterampilan masyarakat dalam DAGUSIBU sehingga perlu diupayakan kegiatan yang berkesinambungan guna mencegah penggunasalahan obat dalam masyarakat. Kata kunci: DAGUSIBU, Obat, Pendampingan, Penyuluhan ABSTRACT Today, people's access to medicines is getting easier. However, this is not accompanied by a correct understanding of medicines. As a result, it raises various drug-related problems such as medicines abuse and indiscriminate disposal. Therefore, people need to be given the right knowledge and skills on how to get, use, store and dispose of medicines (DAGUSIBU). This community service activity is in the form of assistance with the main activities of counseling and demonstration about DAGUSIBU to the community in Keputeraan Village, Lubuklinggau City, South Sumatra. About 34 participants consisting of community members and health cadres attended the activity. Analysis of the success of activities carried out by evaluating before and after counseling. From these activities, it can be seen that almost no participants knew about DAGUSIBU. After being given counseling and demonstration, some of them along with be able to understand well and have simple skills in DAGUSIBU. From these results, it is expected that the community can apply it in everyday life. Community service activities in the form of counseling have been able to improve the knowledge and skills of the community in DAGUSIBU so that it needs to be pursued in a sustainable activity to prevent the use of drug problems in the community. Keywords: Assistance, Counseling, DAGUSIBU, Medicines
Assesment of Antioxidant Activity Test of Kersen Leaf (The phenolic.) and Epiphyte with DPPH (2.2-Diphenyl-1-Picrylhidrazyl) Nurlutfiyyah Aini; Nita Parisa; Fatmawati
Archives of The Medicine and Case Reports Vol. 1 No. 2 (2020): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v1i2.9

Abstract

Antioxidant is very important to give protection against free radical activity and highly reactive molecules that could lead in slowing the progression of degenerative disease. In case of degenerative disease, internal antioxidant cannot neutralize the increasing concentration of free radical. Because of that, human needs external antioxidant. Kersen (Muntingia calabura L.) is a plant that is known for its antioxidant content. Plants containing antioxidant experience is kersen (Muntingia calabura L.). Research study to determine the antioxidant activity of Kersen plant and knows the difference of antioxidant activity, based on the process of extract and infusion. Research was done by experimental study which was oriented in testing antioxidant activity in (Morinda citrifolia L.) extract and infusion. Extraction was done by using 96% ethanol as solvent meanwhile infusion was made by using aquadest. Extract and infusion were divided into group of concentration and antioxidant activity was tested by DPPH(2,2-Diphenyl-1-Picrylhidrazyl) method by measuring the absorbance using spectrophotometer at 520 nm wavelength. Percentage of DPPH inhibition and IC50 then analyze d using linear regression analysis. Ethanolic extract of kersen leaf and epiphyte had IC50 value of 113,801 ppm and 98,7802 ppm, respectively. Kersen leaf infusion showed 191,7624 ppm IC50 values, besides its epiphyte had 131,6750 ppm. Antioxidant activity of Muntingia calabura L. in the order from kersen leaf an epiphyte and epiphyte extract has a higher antioxidant content than others.
The Efficacy of Seluang Fish Oil (Rasbora agrotynea) Related Body Weight, Lipid Profile, Adiponectin and Leptin in Wistar Rats-Induced High Fat Diet Fatmawati Karim; Rachmat Hidayat; Erizka Rivani; Husnul Khotimah; Ester G Pansserga
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 2 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i2.41

Abstract

Background Rasbora agrotynea (local name : Seluang ) is a fish native to Sumatera, Malaya and Borneo. This fish has a potential as a local wisdom for supplementation of omega 3 and omega 6. In Sumatera, Seluang fish was used as traditional food. Aim of Study Aim of this study to explore the efficacy of seluang fish oil in body weight, lipid profile, adiponectin and leptin level in Wistar Rats-Induced High Fat Diet Methods This study was an experimental study , pre-post test with control group design. The sample in this study was 30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and seluang fish oil at dose of 0,1 , 0,2 and 0,4 mL/200 gr BW/day for 2 weeks. Seluang fish oil was extracted by distilation methods. The results of this study were assayed by SPSS 18. Results Seluang fish oil 0,4 mL/200 gr BW was more potent to reduce body weight gain, triglyseride level, leptin and increase adiponectin level than seluang fish oil 0,1 mL/200 gr BW, 0,2 mL/200 gr BW, negative control and positive control. Conclusion Seluang fish oil had a potention to reduce body weight, triglyceride, leptin and increase adiponectin level. Keywords: Seluang fish Oil – body weight- triglyserida – leptin - adiponectin
The Efficacy of Combination Extract Andrographis peniculata and Syzygium polyanthum on Glucose Uptake in Skletal Muscle in Diabetic Rats Fatmawati Karim; Ester Gonzales Panserga; Mgs Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.63

Abstract

Insulin resistance is impaired insulin signaling cascade in target cells to respond normal or elevated circulating insulin to the final cellular effect, such as translocation of vesicles containing GLUT4 glucose transporters, which is the major mediator of glucose removal from the circulation and a key regulator of whole-body glucose homeostasis. Among the several plants, Andrographis peniculata (sambiloto) and Syzygium polyanthum (Daun salam). In the present study, a combination was made, Andrographis peniculata (sambiloto) and Syzygium polyanthum (Daun salam), and to determine the effects of combination on tretament insulin resistance. Male Wistar rats (weight, 200-300 g) were randomized into five groups (6 rats/group). Group 1: negative group. Group 2: positive group (metformin 63 mg/kgBW ). Group 3,4 and 5: treatment with extract combination, each group 250 mg/kgBW, 500 mg/kgBW and 1000 mg/kgBW. Rats were induced by high fat diet-glucocorticoid for insulin resistance. Insulin and GLUT-4 were assayed by ELISA. Treatment with extract combination (250, 500 and 1000 mg/kgBW) and metformin for 2 weeks showed a sigificant decrease in fasting plasma insulin compare with the negative control rats with a reduction of 11,2%, 33,6%, 20% and 19,4%, respectively. Two weeks treatment either extract combination or metformin in diabetic rats, significantly increased GLUT 4 level (p<0,05) with a percentage increase of 6,68%, 15,21%, 12,76% and 1,77%.
Antibacterial Efficacy of Aloe vera Sap Against Staphylococcus aureus and Escherichia coli Safira Azahra; Nita Parisa; Fatmawati Fatmawati; Ella Amalia; Venny Larasati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 2 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i2.87

Abstract

Abstract Background Aloe vera is a plant that has been used as an alternative drug. This plant contains various compounds, like anthraquinone, saponin, flavonoid, alkaloid, and tannin that has an antibacterial effect against Staphylococcus aureus and Escherichia coli. Both of it were responsible for the infection incident. This study aims to determine the efficacy of Aloe vera sap as an antibacterial against Staphylococcus aureus and Escherichia coli. Methods An experimental study, in vitro using post-test only control group design, has been done at laboratory of Medical Faculty of Sriwijaya University, by examining the antibacterial activity of Aloe vera sap in five different concentration (5%, 10%, 20%, 40%, dan 80%) using well diffusion and solid dillusion method to determine the minimum bactericidal concentration (MBC). And then continued with the phytocemical screening to determine the compound inside the Aloe vera sap. Results Aloe vera sap were able to kill Staphylococcus aureus at 5% and Eshcerichia coli at 80%. Compatibility test showed that Aloe vera sap with concentration of 10%, 20%, 40%, and 80% are compatible with amoxicillin, therefore 80% is compatible with cefotaxime. This ability due to the compound that it contains, which is alkaloid, flavonoid, tannin, quinone, and saponin. Conclusion Aloe vera sap is effective as an antibacterial against Staphylococcus aureus and Escherichia coli. Keyword: Aloe vera sap, antibacterial, efficacy, Staphylococcus aureus, Escherichia coli.
Antioxidant Potential Of Lansium Domesticum Corr. Seed Extract In White Male Rat (Rattus Novergicus) Induced By Alcohol Subandrate Subandrate; Sadakata Sinulingga; Sri Wahyuni; M Fakhri Altiyan; Fatmawati Fatmawati
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.353 KB) | DOI: 10.20884/1.jm.2016.11.1.189

Abstract

Lansium domesticum Corr. is a typical plant of Indonesia. The seeds have a lot of useful compounds, such as flavonoids. Flavonoids are a natural compound that can act as antioxidants. The aim of this study was to determine the antioxidant potential of Lansiumdomesticum Corr. seed extract. This study was an experimental research with posttest control group design. The subjects were 32 white male rats. Rats were randomly divided into 4 groups: negative control group was given suspension of Na CMC 1%, dose group I, II and III were given Lansium domesticum Corr. seed extract with each dose of 100mg/kg, 200 mg/kg, and 300 mg/kg. Observation of the subject's response was done by measuring the levels of glutathione (GSH) and malondialdehyde (MDA). Analysis ANOVA test showed that there was a group that had an average difference both GSH levels (p=0.00) and MDA levels (p=0.00). Post hoc test analysis for GSH levels and MDA levels showed that only a dose of 100 mg/kg which have significant differences (p=0.00). Thus, Lansiumdomesticum Corr. seed extract has antioxidant potential and optimum dose of 100 mg/kg.
Co-Authors Alderiantama Akhmad Anwar, Chairil Dwi Handayani Dzakiyah Dzakiyah Ella Amalia, Ella Erizka Rivani Ester G Pansserga Ester Gonzales Panserga Fadiya Fadiya Fahira Anindita Gita Dwi Prasasty HUSNUL KHOTIMAH Kusumo Hariyadi Liniyati D Oswari Liniyati D Oswari M Fakhri Altiyan Mgs Irsan Saleh Nadya Nadya Naomi W Tioline Nita Parisa Nurlutfiyyah Aini RACHMAT HIDAYAT Radiyati Umi Partan Rifka Purnama Sari Rini Yana Sadakata Sinulingga Safira Azahra Safyudin Sri Wahyuni Subandrate Susilawati Susilawati Susilawati Susilawati Venny Larasati Yundari, Yundari