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Intanri Kurniati
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Journal : Medula

 1 
Pendekatan Diagnosis Berbasis Molekuler pada Pasien Talasemia Bagus Pratama; Intanri Kurniati
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.280

Abstract

Thalassemia is a red blood disorder which is one of the causes of death and illness in Indonesia. This disease occurs due to genetic disorder that affect the inability of a person to synthesize globin chains. A globin chain is one of the constituents of hemoglobin so that abnormality of composition of hemoglobin will cause abnormality of elasticity and lysis of the erythrocytes. This disorder has various clinical manifestations ranging from anemia, pale, fatigue, pain, abnormalities in the bone (thalassemic facie) to jaundice and hepatosplenomegaly. Generally, the diagnosis of thalassemia uses a complete blood count including calculating the number of erythrocytes, hemoglobin levels, hematocrit levels, MCV and MCH, blood smear examination and hemoglobin electrophoresis. The genetic examination on molecular-based diagnostic approach is an examination to get a result of changes in gene sequences or genetic mutations that will affect the difference of clinical manifestation and severity of thalassemia patients. Molecular diagnosis can be made in an effort to improve the effective management and the quality of life of patients.
Obstruksi Saluran Nafas Atas grade III ec Kassabach Merrit Syndrome + Bronchopneumonia+DIC Intanri Kurniati; Risti Graharti; Agustyas Tjiptaningrum; Evi Kurniawati
Medula Vol 12 No 3 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i3.346

Abstract

Upper airway obstruction is a blockage in the larynx caused by inflammation, foreign bodies, trauma, tumors so that ventilation is disrupted. One of the causes is hemangioma, which is the most common soft tissue tumor in newborns. In the state of hemangiomas, sometimes also found a syndrome in the form of Kasabach-Merritt Syndrome. As many as 20% of patients with KMS exhibit unusual symptoms compared to cutaneous hemangiomas. Clinical symptoms that can occur in upper respiratory tract obstruction include hoarseness, dysphony to aphony, shortness of breath (dyspnea), stridor (breath sounds) inspiration, suprasternal, epigastric, supraclavicular and intercostal retractions on inspiration. Kasabach-Merritt Syndrome is rare because the diagnosis is often delayed. KMS is more common in boys than girls. Ultrasound examination, Computer Tomography (CT) Scan, Magnetic Resonance Imaging (MRI) can help to determine the nature and extent of the lesion and identify the involvement of organs in the body. Extensive bleeding in KMS can cause consumptive coagulopathy that occurs due to excessive use of coagulation factors such as fibrinogen. Coagulopathy will progress to Disseminated Intravascular Coagulation (DIC) and even death. From this condition, the patient also experienced bronkopneumonia which is an acute infection of the lungs affecting the lung lobules starting from the lung parenchyma which can be caused by various etiologies such as bacteria, viruses, fungi and foreign bodies. This is because patients have a susceptibility to infection due to their condition.
Faktor Risiko Kejadian Stroke di Usia Produktif Rizky Agung Purnomo; Ade Yonata; Intanri Kurniati
Medula Vol 12 No 3 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i3.456

Abstract

Stroke is a disorder due to focal or global brain function disorders that occur triggered by cerebrovascular disorders. Stroke is characterized by paralysis of the face or limbs, difficulty speaking, decreased consciousness, and visual disturbances. Stroke is the number 2 cause of death in the world, which is about 6 million deaths every year. Recently, stroke does not only occur in the elderly population, but also in the productive age. This article is a literature compiled to analyze the risk factors associated with the incidence of stroke in productive age. The references used are articles published between 2016-2022. There are 4 main risk factors for stroke in productive age, namely hypertension, diabetes mellitus, dyslipidemia, and lifestyle. Each factor plays a role in increasing the risk of stroke with its own mechanism. There is no difference between stroke risk factors in the productive age and the general population.
Korelasi Aminotransferase Platelet Ratio Index (APRI) Dengan Kadar Bilirubin Serum Pada Penderita Sirosis Hepatis Akibat Infeksi Virus Hepatitis C Di RSUD Dr. H. Abdul Moeloek Lampung Vira Katya Aurelia; Intanri Kurniati
Medula Vol 12 No 4 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i4.518

Abstract

Hepatitis C is an Inflammation in Liver because of Hepatitis C Virus (HCV). When HCV turning into the bloodstream and enter the liver, HCV will attached to liver cells and starting proliferate. Liver cells becomes broken and causing fibrosis. When in the fibrosis phase, Trombopoietin will in the lower phase and thrombocytopenia will happen. An enzyme that most associated with the destruction of the liver cells is AST and ALT. APRI is apredictor of the cirrhosis progressivity with 81% sensitivity to assess the severity of cirrhosis that APRI is the patients AST value and the platelet. In liver cirrhosis will turns into hyperbillirubine. Intrahepatic phase involves inflammation or abnormalities in the liver that interfere with the removal of bilirubin. This study aims to determine the correlation between APRI and serum bilirubin levels and the mean correlation between AST, ALT, platelets and serum bilirubin levels in patients with hepatic cirrhosis due to hepatitis C virus infection at RSUD Dr . H. Abdul Moeloek Lampung. This study used a consecutive sampling research design and was conducted in June-July 2020. The study sample was 51 subjects. The data used in this study are secondary data, namely medical records. The case group consisted of 27 male patients and 24 female patients. Data were analyzed using Pearson test. : The results of bivariate analysis between APRI and serum bilirubin levels showed a p value of 0.000 which indicates a positive and very strong correlation between APRI and serum bilirubin levels, positive and strong correlation between AST and ALT with serum bilirubin levels, and negative and sufficient correlation between platelets and Serum Bilirubin levels in patients with hepatic cirrhosis due to hepatitis C virus infection at Dr. H. Abdul Moeloek Lampung
Efektivitas Ekstrak Buah Adas (Foeniculum vulgare) Terhadap Penurunan Kadar Glukosa Darah Siti Maharani; Intanri Kurniati; Agustya Tjiptaningrum
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.574

Abstract

Diabetes mellitus is a condition that occurs when blood glucose levels exceed normal limits. This is caused by the pancreas not producing enough insulin or because the insulin produced is not effective in helping the absorption of glucose into the body's cells. The prevalence of diabetes in 2019 in the world is estimated to reach 463 million people aged 20-79 years. Diabetes mellitus affects more men in the world, namely 9.65% of the world's population, while the prevalence of sufferers is female as much as 9%. Indonesia is ranked 7th with the most diabetes mellitus sufferers in the world. Indonesia has as many as 10.7 million people with diabetes mellitus recorded. DKI Jakarta ranks first with the most diabetes mellitus sufferers in Indonesia, namely 3.4% of the population. Diabetes mellitus treatment does not aim to cure the disease completely, but only to control blood sugar levels so that they are within normal limits. One of the causes of diabetes mellitus is due to oxidative stress. One of the herbal plants known to have antioxidant content is fennel fruit (Foeniculum vulgare). occurrence of oxidative stress. Fennel contains flavonoids, saponins, cardiac glycosides, terpenoids, and tannins. These compounds have an antihyperglycemic effect by inhibiting alpha glucosidase. Flavonoids are antioxidant compounds that can play a role in preventing oxidative stress associated with diabetes mellitus.
Hubungan Konsumsi Kafein dengan Kejadian Depresi Indah Salsabila; Putu Ristyaning Ayu Sangging; Intanri Kurniati; Ratna Dewi Puspitasari
Medula Vol 13 No 6 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i6.488

Abstract

Depression is a mood disorder. Depression is characterized by a feeling of sadness that lasts continuously and for a long time, which can interfere with a person's physical condition and social life. Around 121 million people in the world suffer from depression. It is estimated that only 30% of people with depression get proper treatment. This number does not include people who have clinical symptoms of depression but are not actually diagnosed. Some patients are also considered not to get proper treatment. The number of Indonesian populations aged more than 15 years and diagnosed with depression is 12 million sufferers. Pharmacological therapy in depressed patients is antidepressants such as serotonin and noradrenaline reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs). However, there are side effects that can result from long-term use of these drugs. Therefore, other treatments such as giving herbal medicines are needed to reduce symptoms in people with depression. Giving caffeine with the right dose can reduce the risk of depression, because of its ability to block the adenosine receptor subunit. However, caffeine consumption with doses above 68mg and below 509mg per day is assessed to have the opposite effect that increases the risk of developing depression.
Pola Pengobatan Coronavirus Disease-19 (COVID-19) dengan Komorbiditas Tuberkulosis Paru Pada Pasien Rawat Inap RSUD Al-Ihsan Bandung Tahun 2020 Chanief Hassan Widjaja; Novita Carolia; Intanri Kurniati
Medula Vol 13 No 7 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i7.846

Abstract

Coronavirus disease-19 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and attacks the respiratory tract as its main target. Pulmonary tuberculosis (TB) is a disease with high incidence in Indonesia and transmitted through the respiratory tract and attacks lung organs same as COVID-19, allowing the possibility for co-infection of the two microorganisms simultaneously. The purpose of this study was to determine the pattern of treatment for COVID-19 and pulmonary TB at inpatient care facility Al-Ihsan Hospital Bandung. This study was an observational descriptive study with retrospective approach. The number of samples were 15 who had COVID-19 and pulmonary tuberculosis, taken from March until December 2020 at inpatient care facility Al-Ihsan Hospital Bandung. The sample taken using the total sampling technique, then analyzed using univariate test.There are five types of drugs found in this study, which is antibiotics, anti-tuberculosisdrugs, antivirals, corticosteroids, and vitamins. The types of antibiotics used were azithromycin (80%), levofloxacin (80%), ceftazidime (13.33%), ofloxacin (6.67%), and cefotaxime (6.67%). Anti-tuberculosis drugs with fixed dose combination (FDC) were given to 13 samples (86.67%). The types of antiviral drugs used were isoprinosine (80%), oseltamivir (13.33%), and chloroquine (6.67%). The types of corticosteroid drugs used were dexamethasone (33.33%) and bethametasone (6.67%). Types of vitamins used were vitamin C (100%), vitamin B6 (6.67%), vitamin D (73.33%), and zinc supplements (33.33%).
Co-Authors Ade Yonata Agustya Tjiptaningrum Agustyas Tjiptaningrum Arif Yudho Prabowo Bagus Pratama Chanief Hassan Widjaja Evi Kurniawati Indah Salsabila Novita Carolia Nurul Utami Ratna Dewi Puspita Sari Risti Graharti Rizky Agung Purnomo Sangging, Putu Ristyaning Ayu Siti Maharani Vira Katya Aurelia